公开(公告)号：WO1991000081A2

公开(公告)日：1991-01-10

申请号：PCT/US1990003271

申请日：1990-06-14

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： THE CATHOLIC UNIVERSITY OF AMERICA ,  RATHOD, Pradipsinh, K.

IPC: A61K0

CPC classification number: A61K31/70 ,  A61K31/00 ,  A61K31/505 ,  A61K31/513 ,  A61K45/06 ,  Y02A50/411 ,  Y10S514/885 ,  A61K2300/00

Abstract: Anti-malarial compositions for prophylactic or therapeutic treatment of vertebrates exposed to malaria parasites are disclosed. These compositions comprise one or more pyrimidine analogue inhibitors of nucleic acid biosynthesis, e.g., 5-fluoro-orotic acid, alone or together with one or more ''rescue'' compounds, e.g., a normal pyrimidine base or nucleoside that can be used by the host vertebrate, but not by malaria-causing parasites, for nucleic acid biosynthesis. Also claimed are methods of prophylactic and therapeutic use of these compositions.

Abstract translation: 公开了用于预防或治疗暴露于疟疾寄生虫的脊椎动物的抗疟剂组合物。 这些组合物包含一种或多种核酸生物合成的嘧啶类似物抑制剂，例如5-氟乳清酸，单独或与一种或多种“营救”化合物一起使用，例如正常的嘧啶碱基或核苷，可以由 宿主脊椎动物，但不是由引起疟疾的寄生虫，用于核酸生物合成。 还要求保护这些组合物的预防和治疗方法。