公开(公告)号：DE60232613D1

公开(公告)日：2009-07-30

申请号：DE60232613

申请日：2002-01-11

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  ISHIGURO TAKAHIKO ,  HORIE RYUICHI

IPC: C12Q1/68 ,  C07H21/00 ,  C07H21/04 ,  C09B23/06 ,  C12Q1/6816 ,  G01N33/533

Abstract: A compound represented by the formula 1, a salt, hydrate, solvate or stereoisomer thereof.

公开(公告)号：AU1023192A

公开(公告)日：1992-07-23

申请号：AU1023192

申请日：1992-01-15

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI ,  TAKASU YASUHITO

IPC: A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26 ,  C07D405/04 ,  C07D405/10

Abstract: Tetrahydroisoquinoline derivatives useful as fungicides are disclosed of formula [I]: [I] wherein R1 represents C1-C5 linear or branched alkyl, C2-C5 linear or branched alkenyl, C2-C5 linear or branched alkynyl; R2, R3, R4, R5 and R6, the same or different, represent hydrogen, C1-C10 linear or branched alkyl, C3-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, C1-C10 linear or branched alkoxy, C2-C10 linear or branched alkenyloxy, C2-C10 linear or branched alkynyloxy, benzyloxy, hydroxy, haloalkyl, amino, mono- or di-substituted amino substituted with C1-C4 linear or branched alkyl, phenyl or halogen; R2 and R3 may be bonded through a group of the formula -O-CH2)mO- wherein m represents integer of 1 or 2 or -CH=CH)2 to form a ring; and R4 and R5 may be bonded through a group of the formula -O-CH2)mO- wherein m represents an integer of 1 or 2 or -CH=CH)2- to form a ring.

公开(公告)号：CA2059388A1

公开(公告)日：1992-07-17

申请号：CA2059388

申请日：1992-01-15

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI ,  TAKASU YASUHITO

IPC: A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26 ,  C07D405/04 ,  C07D217/14

Abstract: Tetrahydroisoquinoline derivatives useful as fungicides are disclosed. One of the tetrahydroisoquinoline derivatives of the present invention is represented by the formula ¢I!: ¢I! (wherein R1 represents C1 - C5 linear or branched alkyl, C2 - C5 linear or branched alkenyl, C2 - C5 linear or branched alkynyl; R2, R3, R4, R5 and R6, the same or different, represent hydrogen, C1 - C10 linear or branched alkyl, C3 - C10 linear or branched alkenyl, C2 C10 linear or branched alkynyl, C1 - C10 linear or branched alkoxy, C2 - C10 linear or branched alkenyloxy, C2 - C10 linear or branched alkynyloxy, benzyloxy, hydroxy, haloalkyl, amino, mono- or di-substituted amino substituted with C1 - C4 linear or branched alkyl, phenyl or halogen; R2 and R3 may be bonded through a group of the formula (wherein m represents aninteger of 1 or 2) or to form a ring; and R4 and R5 may be bonded through a group of the formula (wherein m represents an integer of 1 or 2 ) or to form a ring.

公开(公告)号：DE60024906T2

公开(公告)日：2006-09-14

申请号：DE60024906

申请日：2000-03-06

Applicant: TOSOH CORP

Inventor： HORIE RYUICHI ,  ISHIGURO TAKAHIKO ,  TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  SAITOH JUICHI ,  TAYA TOSHITAKA

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6844

Abstract: A nucleic acid probe which is a single-stranded nucleic acid complementary to a specific nucleic acid sequence and is labeled so as to give off a measurable fluorescent signal on hybridization with a nucleic acid containing the specific nucleic acid sequence, wherein the 3' end of the probe is modified as represented by the following formula (1): wherein R is -COOH, -CONH2, -(CH2)nOH, -CH(OH)-CH2OH or - CHÄ(CH2)n-NHR1Ü-CH2OH, R1 is H, a dye, or an amino-protecting group such as Fmoc, and n is an integer of at least 1.

公开(公告)号：DE60024906D1

公开(公告)日：2006-01-26

申请号：DE60024906

申请日：2000-03-06

Applicant: TOSOH CORP

Inventor： HORIE RYUICHI ,  ISHIGURO TAKAHIKO ,  TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  SAITOH JUICHI ,  TAYA TOSHITAKA

IPC: C07H21/00 ,  C12Q1/68 ,  C12Q1/6844

Abstract: A nucleic acid probe which is a single-stranded nucleic acid complementary to a specific nucleic acid sequence and is labeled so as to give off a measurable fluorescent signal on hybridization with a nucleic acid containing the specific nucleic acid sequence, wherein the 3' end of the probe is modified as represented by the following formula (1): wherein R is -COOH, -CONH2, -(CH2)nOH, -CH(OH)-CH2OH or - CHÄ(CH2)n-NHR1Ü-CH2OH, R1 is H, a dye, or an amino-protecting group such as Fmoc, and n is an integer of at least 1.

公开(公告)号：DE69220389T2

公开(公告)日：1998-01-29

申请号：DE69220389

申请日：1992-01-14

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI ,  TAKASU YASUHITO

IPC: A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26 ,  C07D405/04 ,  C07D217/14

公开(公告)号：ES2102453T3

公开(公告)日：1997-08-01

申请号：ES92300281

申请日：1992-01-14

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI ,  TAKASU YASUHITO

IPC: A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26 ,  C07D405/04 ,  C07D217/14

公开(公告)号：DE69220389D1

公开(公告)日：1997-07-24

申请号：DE69220389

申请日：1992-01-14

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI ,  TAKASU YASUHITO

IPC: A01N43/42 ,  A01N47/06 ,  A01N47/22 ,  C07D217/04 ,  C07D217/12 ,  C07D217/16 ,  C07D217/24 ,  C07D217/26 ,  C07D405/04 ,  C07D217/14

公开(公告)号：JP2000026452A

公开(公告)日：2000-01-25

申请号：JP19389498

申请日：1998-07-09

Applicant: TOSOH CORP ,  YOSHITOMI PHARMACEUTICAL

Inventor： TOKUNAGA TAKUMI ,  YAMAMOTO TAKASHI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  HANAZAKI YASUAKI ,  KATSUURA KIMIO ,  SHINSAN HIROSHI ,  EGI YASUHARU ,  ISHIDA NAOMICHI ,  INOUE YOSHIHISA ,  YAMAUCHI KENJI

IPC: C07D333/20 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/495 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07D333/28 ,  C07D409/12

Abstract: PROBLEM TO BE SOLVED: To obtain a new ethylenediamine derivative having a higher safety compared with conventional medicines, a inhibitory activity to a squalene epoxidase originating from a mammalian animal and an excellent anti- cholesterol activity, and useful as an anti-hyperlipidemic agent, etc. SOLUTION: This new ethylenediamine derivative is a compound of formula I [R1, R2 are each H, a lower alkyl or a lower cyclic alkyl; R3 is H, a lower alkyl or a lower acryl; R2 and R3 form a ring by bonding each other; R4 is a (substituted) thienyl; A is formula II (R5 is H, a halogen, a lower alkoxy or the like; G1 to G3 are each CH or N); (m), (n) are each 0, 1; E is carbonyl or the like; F is carbonyl or the like; Z1 to Z4 are each CH or N; X is O or S], e.g. N-[3-[2-[N'-methyl-N'-(3-thienylmethyl)amino]ethylamino]phenyl]-N- methylthiocarbamic acid O-(4-tert-butylphenyl)ester. Further, the compound of formula I is obtained by reacting a halogenated formate derivative of formula III (V is a halogen) with a compound of formula IV.

公开(公告)号：JPH0641085A

公开(公告)日：1994-02-15

申请号：JP21855292

申请日：1992-07-25

Applicant: TOSOH CORP

Inventor： TOKUNAGA TAKUMI ,  IDE TERUHIKO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI

IPC: A01N43/42 ,  C07D217/24 ,  C07D217/26

Abstract: PURPOSE:To provide a new derivative useful as an intermediate for pharmaceuticals and agricultural chemicals and an intermediate for organic compounds. CONSTITUTION:The derivative of formula I (R is a 1-5C alkyl, 2-5C alkenyl, etc.; R is H, a 1-10C alkyl, etc.; R to R are each H, a 1-10C alkyl, halogen, etc.; R to R are not H at the same time), e.g. 3-(4-t-butylphenyl)-7-isopropyl-2- methyl-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid. The compound of formula I can be produced e.g. by reacting 1mol equivalent of an imine derivative of formula II with 0.1-10mol equivalent of a homophthalic anhydride derivative of formula III in a solvent (e.g. acetonitrile) preferably at 0-100 deg.C for 30min to 60hr.