公开(公告)号：JP2013252147A

公开(公告)日：2013-12-19

申请号：JP2013185920

申请日：2013-09-09

Applicant: UCB PHARMA SA

Inventor： RAPECKI STEPHEN EDWARD ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: C12N15/09 ,  A61K39/395 ,  A61K45/00 ,  A61K47/34 ,  A61K47/48 ,  A61P11/00 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08

Abstract: PROBLEM TO BE SOLVED: To provide an antibody molecule having specificity to an antigenic determinant of IL-17, to provide a therapeutic use of the antibody molecule, and to provide a method for forming the antibody molecule.SOLUTION: A neutralizing antibody including a heavy chain and binding to human IL-17 is regulated so that the variable domain of the heavy chain may contain at least one of a CDR having a sequence represented by SEQ ID NO: 1 as the CDR-H1, a CDR having a sequence represented by SEQ ID NO: 2 as the CDR-H2, and a CDR having a sequence represented by SEQ ID NO: 3 as the CDR-H3.

公开(公告)号：WO2008047134A3

公开(公告)日：2008-06-12

申请号：PCT/GB2007003983

申请日：2007-10-18

Applicant: UCB PHARMA SA ,  ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C12N15/13

CPC classification number: C07K16/468 ,  A61K39/3955 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。

公开(公告)号：ME01810B

公开(公告)日：2014-09-20

申请号：MEP3314

申请日：2005-11-16

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER

IPC: A61K39/395 ,  A61K47/48 ,  A61P43/00 ,  C07K14/54 ,  C07K16/24 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

公开(公告)号：ES2456669T3

公开(公告)日：2014-04-23

申请号：ES05803526

申请日：2005-11-16

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61P43/00 ,  C07K14/54 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

Abstract: Un anticuerpo neutralizante que tiene especificidad para IL-17 humana, con una cadena pesada que comprende la secuencia gH11 (SEC ID Nº: 11) y una cadena ligera que comprende la secuencia gL3 (SEC ID Nº: 13).

公开(公告)号：AU2007311689B2

公开(公告)日：2013-05-16

申请号：AU2007311689

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH ,  RAPECKI STEPHEN EDWARD

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：AU2005305677B2

公开(公告)日：2012-02-02

申请号：AU2005305677

申请日：2005-11-16

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  RAPECKI STEPHEN EDWARD ,  TICKLE SIMON PETER ,  POPPLEWELL ANDREW GEORGE

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61P43/00 ,  C07K14/54 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL- 17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.

公开(公告)号：CA2666458A1

公开(公告)日：2008-04-24

申请号：CA2666458

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： RAPECKI STEPHEN EDWARD ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antige nic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：EA029953B1

公开(公告)日：2018-06-29

申请号：EA200900492

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C12N15/13

Abstract: Описанымолекулыантител, обладающихспецифичностьюв отношенииантигенныхдетерминанткак IL-17A, таки IL-17F, терапевтическиеприменениямолекулантители способыполучениямолекулантител.

公开(公告)号：BRPI0717768A2

公开(公告)日：2013-11-05

申请号：BRPI0717768

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：BRPI0713300A2

公开(公告)日：2012-04-17

申请号：BRPI0713300

申请日：2007-06-25

Applicant: UCB PHARMA SA

Inventor： RAPECKI STEPHEN EDWARD ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: C07K16/24 ,  A61K39/395 ,  C12N5/20 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods of producing the antibody molecules.