公开(公告)号：EP2734299A4

公开(公告)日：2016-05-11

申请号：EP12815389

申请日：2012-07-18

Applicant: UNIV ALBERTA

Inventor： BERGENS STEVEN ,  JOHN JEREMY M

IPC: B01J31/18 ,  B01J31/24 ,  C07B31/00

CPC classification number: C07F15/0053 ,  B01J31/1805 ,  B01J31/189 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/643 ,  B01J2531/0244 ,  B01J2531/0255 ,  B01J2531/0266 ,  B01J2531/821 ,  C07B31/00 ,  C07B2200/07 ,  C07C29/149 ,  C07C41/26 ,  C07C209/50 ,  C07C213/00 ,  C07C231/08 ,  C07C303/40 ,  C07D201/02 ,  C07D295/023 ,  C07D295/027 ,  C07F15/0046 ,  C07C233/18 ,  C07C311/04 ,  C07C215/16 ,  C07C215/08 ,  C07C211/55 ,  C07C211/48 ,  C07C211/04 ,  C07C33/22 ,  C07C43/23 ,  C07C31/08

公开(公告)号：CA2842647A1

公开(公告)日：2013-01-24

申请号：CA2842647

申请日：2012-07-18

Applicant: UNIV ALBERTA

Inventor： BERGENS STEVEN ,  JOHN JEREMY M

IPC: B01J31/00 ,  C07B31/00

Abstract: There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.