公开(公告)号：EP0659056A1

公开(公告)日：1995-06-28

申请号：EP93918307.0

申请日：1993-07-26

Applicant: UNIVERSITY OF FLORIDA

Inventor： BRIGGS, Richard, W. ,  LIEBIG, Thomas ,  ROS, Pablo ,  BALLINGER, J., Ray

IPC: A61K49 ,  A61B5 ,  G01R33

CPC classification number: G01R33/5601 ,  A61K49/1806

Abstract: A contrast agent useful for imaging a sample comprising a suspension in a medium acceptable for imaging (a) particles of a contrast agent possessing paramagnetic characteristics and (b) particles of a contrast agent possessing diamagnetic characteristics. Also disclosed is a method of imaging a sample which comprises introducing into the sample the above-described contrast agent and generating a substantially artifact-free image thereof. The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components which eliminates susceptibility artifacts even with gradient echo pulse sequences. The relaxation properties which make the SPIO suspension a useful negative contrast agent are retained.

公开(公告)号：EP0659056B1

公开(公告)日：1998-09-30

申请号：EP93918307.5

申请日：1993-07-26

Applicant: UNIVERSITY OF FLORIDA

Inventor： BRIGGS, Richard, W. ,  LIEBIG, Thomas ,  ROS, Pablo ,  BALLINGER, J., Ray

IPC: G01R33/28 ,  G01R33/56 ,  A61K49/00

CPC classification number: G01R33/5601 ,  A61K49/1806

Abstract: A contrast agent useful for imaging a sample comprising a suspension in a medium acceptable for imaging (a) particles of a contrast agent possessing paramagnetic characteristics and (b) particles of a contrast agent possessing diamagnetic characteristics. Also disclosed is a method of imaging a sample which comprises introducing into the sample the above-described contrast agent and generating a substantially artifact-free image thereof. The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components which eliminates susceptibility artifacts even with gradient echo pulse sequences. The relaxation properties which make the SPIO suspension a useful negative contrast agent are retained.

公开(公告)号：WO1994003107A1

公开(公告)日：1994-02-17

申请号：PCT/US1993006888

申请日：1993-07-26

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BRIGGS, Richard, W. ,  LIEBIG, Thomas ,  ROS, Pablo ,  BALLINGER, J., Ray

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/1806

Abstract: A contrast agent useful for imaging a sample comprising a suspension in a medium acceptable for imaging (a) particles of a contrast agent possessing paramagnetic characteristics and (b) particles of a contrast agent possessing diamagnetic characteristics. Also disclosed is a method of imaging a sample which comprises introducing into the sample the above-described contrast agent and generating a substantially artifact-free image thereof. The combination of diamagnetic barium sulfate and superparamagnetic iron oxide (SPIO) in one suspension produces a macroscopic cancellation of positive and negative magnetic susceptibility components which eliminates susceptibility artifacts even with gradient echo pulse sequences. The relaxation properties which make the SPIO suspension a useful negative contrast agent are retained.

Abstract translation: 用于成像包含在可接受的培养基中的悬浮液的样品的造影剂（a）具有顺磁特性的造影剂颗粒和（b）具有抗磁特性的造影剂颗粒。 还公开了一种对样品成像的方法，其包括向样品中引入上述造影剂并产生其基本上无伪影的图像。 一个悬浮液中的抗磁性硫酸钡和超顺磁性氧化铁（SPIO）的组合产生了正和负磁化率成分的宏观消除，即使使用梯度回波脉冲序列也消除了敏感性伪影。 使SPIO悬浮液成为有用的负造影剂的松弛性能得以保留。