CYCLIC DI-GUANYLATE METABOLIC ENZYMES
    2.
    发明申请
    CYCLIC DI-GUANYLATE METABOLIC ENZYMES 审中-公开
    循环代谢代谢酶

    公开(公告)号:WO1993011244A1

    公开(公告)日:1993-06-10

    申请号:PCT/US1992008756

    申请日:1992-10-14

    CPC classification number: C12N9/16 C12N9/1051 C12N9/88 C12N15/52 C12P19/04

    Abstract: The present invention provides the nucleotide sequences of Acetobacter operons, cdg operons encoding genes for the biosynthesis and degradation of cyclic diguanosine monophosphate (c-di-GMP). Specifically, the nucleotide sequences and deduced amino acid sequences of 3 phosphodiesterases isozymes, 3 diguanylate cyclase isozymes, and 2 polypeptides of unidentified function are provided. Also provided for are various strains of microorganisms, including Acetobacter cells genetically manipulated so as to produce elevated and/or reduced levels of one or more cdg operon encoded proteins.

    Abstract translation: 本发明提供了醋酸杆菌操纵子的核苷酸序列,编码用于生物合成和环状二磷酸腺苷(c-di-GMP)的降解的基因的cdg操纵子。 具体地,提供了3种磷酸二酯酶同工酶,3种二环戊烯酸酯环化酶同工酶和2种未鉴定功能的多肽的核苷酸序列和推导的氨基酸序列。 还提供了各种微生物菌株,包括遗传操纵的醋杆菌细胞,以便产生升高和/或降低的一种或多种cdg操纵子编码的蛋白质的水平。

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