一种电子束激发荧光大范围直接探测成像装置及其方法

    公开(公告)号:CN108279247A

    公开(公告)日:2018-07-13

    申请号:CN201611261465.8

    申请日:2016-12-30

    Applicant: 北京大学

    Inventor: 朱瑞 徐军 刘亚琪

    Abstract: 本发明公开了一种电子束激发荧光大范围直接探测成像装置及其方法。本发明的成像装置包括:扫描电子显微镜系统、扫描信号发生器、荧光收集耦合系统、半导体光探测器、扫描同步信号采集器、协同控制与数据处理输出系统;本发明采用模块化的构架,各模块的配置调整及后续升级非常灵活便利;通过引入半导体光探测器的大面积半导体光电探测芯片,使得在扫描电子显微镜系统在大成像视野范围内所激发的荧光均能够以相同的高收集效率会聚耦合至半导体光探测器,解决了大范围荧光扫描成像所得到的图像难以使用统一的标准来测算和比较不同位置处的荧光激发强度或荧光激发产率的问题,能够完成基于电子束激发荧光信号的大范围快速检测分析。

    LASER NOISE ELIMINATION IN TRANSMISSION THERMOMETRY
    7.
    发明申请
    LASER NOISE ELIMINATION IN TRANSMISSION THERMOMETRY 审中-公开
    传感器热噪声消除噪声

    公开(公告)号:WO2013148119A1

    公开(公告)日:2013-10-03

    申请号:PCT/US2013/029973

    申请日:2013-03-08

    Abstract: Apparatus and methods for measuring the temperature of a substrate are disclosed. The apparatus includes a source of temperature-indicating radiation, a detector for the temperature-indicating radiation, and a decorrelator disposed in an optical path between the source of temperature-indicating radiation and the detector for the temperature-indicating radiation. The decorrelator may be a broadband amplifier and/or a mode scrambler. A broadband amplifier may be a broadband laser, Bragg grating, a fiber Bragg grating, a Raman amplifier, a Brillouin amplifier, or combinations thereof. The decorrelator is selected to emit radiation that is transmitted, at least in part, by the substrate being monitored. The source is matched to the decorrelator such that the emission spectrum of the source is within the gain bandwidth of the decorrelator, if the decorrelator is a gain-driven device.

    Abstract translation: 公开了用于测量衬底温度的装置和方法。 该装置包括温度指示辐射源,用于温度指示辐射的检测器,以及设置在温度指示辐射源和温度指示辐射检测器之间的光路中的去相关器。 去相关器可以是宽带放大器和/或模式扰频器。 宽带放大器可以是宽带激光器,布拉格光栅,光纤布拉格光栅,拉曼放大器,布里渊放大器或其组合。 选择去相关器以发射至少部分由被监测的衬底透射的辐射。 如果解相关器是增益驱动装置,则源与去相关器匹配,使得源的发射光谱在解相关器的增益带宽内。

    APPARATUS AND METHOD FOR DETECTING OVERHEATING DURING LASER SURGERY
    8.
    发明申请
    APPARATUS AND METHOD FOR DETECTING OVERHEATING DURING LASER SURGERY 审中-公开
    用于检测激光手术过热的装置和方法

    公开(公告)号:WO2010053575A2

    公开(公告)日:2010-05-14

    申请号:PCT/US2009/006021

    申请日:2009-11-06

    Abstract: A method and apparatus for improving the safety of a surgical procedure involving delivery of laser energy to a tissue, involves enhancing or increasing the detectability of radiation emitted by the tissue or any portion of a surgical instrument or device by providing a sacrificial material that absorbs radiation emitted during the surgical procedure, increasing the temperature of a surface on which the material is disposed and/or causing damage radiation to be emitted in a way that can be detected by monitoring the temperature of the surface and/or radiation, including infrared and/or visible light, emitted by the surface. In a preferred embodiment of the invention, the radiation absorbing material is a sheath arranged to surround the fiber.

    Abstract translation: 用于改善涉及将激光能量递送至组织的外科手术的安全性的方法和设备包括增强或增加由组织或手术器械或装置的任何部分发射的辐射的可检测性 通过提供吸收在外科手术过程中发射的辐射的牺牲材料,以可以通过监测表面的温度来检测的方式来增加其上布置材料的表面的温度和/或引起损伤辐射的发射,并且 /或辐射,包括由表面发射的红外和/或可见光。 在本发明的优选实施例中,辐射吸收材料是布置成围绕光纤的护套。

    OPTICAL SENSOR MODULE AND PACKAGING METHOD THEREOF

    公开(公告)号:US20230228619A1

    公开(公告)日:2023-07-20

    申请号:US18067066

    申请日:2022-12-16

    CPC classification number: G01J1/0271 G01J1/0459 G01J1/0474 G01J2001/0276

    Abstract: An optical sensor module and a packaging method thereof are disclosed, wherein the optical sensor module comprises a substrate having a light sensing element; and a housing made of a transparent material. The housing is connected to the substrate and covers the light sensing element. The housing has a light-receiving area facing the light sensing element, and the inner surface of the housing toward the substrate is provided with a light-shielding coating in a portion outside of the light-receiving area. In this way, optical components such as the light sensor can be effectively protected, and still retain the effect of avoiding noise light interference with the light sensor module.

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