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公开(公告)号：WO2008091848A3
公开(公告)日：2008-09-12
申请号：PCT/US2008051627
申请日：2008-01-22
Applicant: ADVANCED LIQUID LOGIC INC , SUDARSAN ARJUN , POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY
Inventor： SUDARSAN ARJUN , POLLACK MICHAEL G , PAMULA VAMSEE K , SRINIVASAN VIJAY
IPC: B05B5/00
CPC classification number: B01L3/0241 , B01F13/0071 , B01F13/0076 , B01L3/502792 , B01L2300/0819 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427
Abstract: The present invention relates to surface assisted fluid loading and droplet dispensing on a droplet micro actuator. A droplet actuator is provided and includes one or more electrodes configured for conducting one or more droplet operations on a droplet operations surface of the substrate. The droplet actuator further includes a wettable surface defining a path from a fluid reservoir into a locus which is sufficiently near to one or more of the electrodes that activation of the one or more electrodes results in a droplet operation. Methods and systems are also provided.
Abstract translation: 本发明涉及表面辅助流体加载和液滴微致动器上的液滴分配。 提供液滴致动器并且包括一个或多个电极，该一个或多个电极被配置用于在衬底的液滴操作表面上进行一个或多个液滴操作。 液滴致动器还包括可润湿表面，该可润湿表面限定从流体储存器到轨迹的路径，该轨迹与一个或多个电极充分接近，以致一个或多个电极的激活导致液滴操作。 还提供了方法和系统。
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92.发明申请METHODS OF IMPROVING ACCURACY AND PRECISION OF DROPLET METERING USING AN ON-ACTUATOR RESERVOIR AS THE FLUID INPUT 审中-公开使用致动器储存器作为流体输入的提高精度和精度的方法
公开(公告)号：WO2015023747A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/050885
申请日：2014-08-13
Applicant: ADVANCED LIQUID LOGIC, INC.
Inventor： YI, Uichong B. , SRINIVASAN, Vijay
CPC classification number: B05B5/0255 , B05B12/082 , G01F23/22 , G01F23/24 , G01F23/26
Abstract: The present invention is directed to methods of improving accuracy of droplet metering using at least one on-actuator reservoir as the fluid input. In some embodiments, the on-actuator reservoir that is used for metering droplets includes a loading port, a liquid storage zone, a droplet metering zone, and a droplet dispensing zone. The on-actuator reservoirs are designed to prevent liquid flow-back into the loading port and to prevent liquid from flooding into the droplet operations gap in the dispensing zone.
Abstract translation: 本发明涉及使用至少一个致动器容器作为流体输入来提高液滴计量精度的方法。 在一些实施例中，用于计量液滴的致动器储存器包括装载端口，液体存储区域，液滴计量区域和液滴分配区域。 致动器容器被设计成防止液体回流到装载口中并防止液体溢出到分配区域中的液滴操作间隙中。
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公开(公告)号：WO2014062551A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/064797
申请日：2013-10-14
Applicant: ADVANCED LIQUID LOGIC, INC.
Inventor： POLLACK, Michael
CPC classification number: G01N27/44791 , B01L3/0241 , B01L3/502792 , B01L2300/0816 , B01L2300/0867 , B01L2300/088 , B01L2300/0883 , B01L2300/1827 , B01L2400/0427 , B01L2400/043 , B01L2400/0457 , G01N27/44743
Abstract: A liquid handling system for supplying liquids to a flow cell (FC). The system may include a droplet actuator cartridge, wherein the droplet actuator and a flow cell are fluidly coupled to, or situated within, a droplet operations gap of the droplet actuator.
Abstract translation: 一种用于向流动池（FC）供应液体的液体处理系统。 该系统可以包括液滴致动器盒，其中液滴致动器和流动池流体耦合到液滴致动器的液滴操作间隙或位于液滴致动器的液滴操作间隙内。
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94.发明申请
公开(公告)号：WO2014004908A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/048319
申请日：2013-06-27
Applicant: ADVANCED LIQUID LOGIC INC.
Inventor： DELATTRE, Cyril , RIVAL, Arnaud , SRINIVASAN, Vijay
CPC classification number: B01L3/502784 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/5029 , B01L3/52 , B01L2200/06 , B01L2200/0605 , B01L2300/0645 , B01L2300/0816 , B01L2300/088 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0427 , B01L2400/043 , B01L2400/0442 , B01L2400/0448
Abstract: During droplet operations in a droplet actuator, bubbles often form in the filler fluid in the droplet operations gap and interrupt droplet operations. The present invention provides methods and systems for performing droplet operations on a droplet in a droplet actuator comprising maintaining substantially consistent contact between the droplet and an electrical ground while conducting multiple droplet operations on the droplet in the droplet operations gap and/or reducing the accumulation of electrical charges in the droplet operations gap during multiple droplet operations. The methods and systems reduce or eliminate bubble formation in the filler fluid of the droplet operations gap, thereby permitting completion of multiple droplet operations without interruption by bubble formation in the filler fluid in the droplet operations gap.
Abstract translation: 在液滴致动器中的液滴操作期间，液滴操作间隙中的气泡通常在填充液中形成并且中断液滴操作。 本发明提供了用于在液滴致动器中的液滴上进行液滴操作的方法和系统，包括在液滴操作间隙内对液滴进行多个液滴操作并且/或减少 在多个液滴操作期间液滴操作间隙中的电荷。 所述方法和系统减少或消除了液滴操作间隙的填充流体中的气泡形成，从而允许完成多个液滴操作，而不会由于液滴操作间隙中的填充流体中的气泡形成而中断。
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公开(公告)号：WO2013116039A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/022503
申请日：2013-01-22
Applicant: ADVANCED LIQUID LOGIC INC , LEITNER, Thomas
Inventor： LEITNER, Thomas
CPC classification number: C12Q1/703 , C12Q2600/112
Abstract: The present invention relates to amplification oligonucleotides (primers) and detection probes for the detection of human immunodeficiency virus type-1 (HIV-1) in a test sample. The primers and probes may be used in an assay for the detection and/or quantitation of HIV-1 nucleic acid. In various embodiments, the primers and detection probes may be used for real-time reverse transcription polymerase chain reaction (RT-PCR) assays for detection of HIV-1 nucleic acid. The detection probes may, for example, be fluorescently-labeled TaqMan® probes. In one embodiment, amplification primers and probes may be specific for the pol region of the HIV-1 genome. In another embodiment, the amplification primers and probes may be specific for the env region of the HIV-1 genome. "Cocktails" of multiple amplification primers and/or probes may be used to achieve maximal coverage of different HIV-1 subtypes.
Abstract translation: 本发明涉及用于在测试样品中检测人类免疫缺陷病毒1型（HIV-1）的扩增寡核苷酸（引物）和检测探针。 引物和探针可以用于检测和/或定量HIV-1核酸的测定中。 在各种实施方案中，引物和检测探针可用于检测HIV-1核酸的实时逆转录聚合酶链反应（RT-PCR）测定。 检测探针可以是例如荧光标记的TaqMan探针。 在一个实施方案中，扩增引物和探针可以对于HIV-1基因组的pol区域是特异性的。 在另一个实施方案中，扩增引物和探针可能对HIV-1基因组的env区域是特异的。 可以使用多个扩增引物和/或探针的“鸡尾酒”来实现不同HIV-1亚型的最大覆盖。
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Patent Agency Ranking
公开(公告)号：WO2013040562A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055769
申请日：2012-09-17
Applicant: ADVANCED LIQUID LOGIC INC , YI, Uichong , SRINIVASAN, Vijay , WHITE, Andrew
Inventor： YI, Uichong , SRINIVASAN, Vijay , WHITE, Andrew
CPC classification number: B01L3/0241 , B01L3/502715 , B01L3/502792 , B01L2200/0647 , B01L2200/0684 , B01L2200/0689 , B01L2200/143 , B01L2300/024 , B01L2300/025 , B01L2300/18 , B01L2400/0406 , B01L2400/043 , B01L2400/0457 , G01N35/10
Abstract: The present invention relates to apparatuses for delivering one or more volumes of fluids to one or more microfluidics devices. The invention further relates to methods for delivering one or more volumes of fluids to one or more microfluidics devices. Additionally, the invention relates to systems that include apparatuses for delivering one or more volumes of fluids to one or more microfluidics devices.
Abstract translation: 本发明涉及用于将一个或多个体积的流体输送到一个或多个微流体装置的装置。 本发明还涉及将一个或多个体积的流体输送到一个或多个微流体装置的方法。 另外，本发明涉及包括用于将一个或多个体积的流体输送到一个或多个微流体装置的装置的系统。
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公开(公告)号：WO2012151192A3
公开(公告)日：2013-03-21
申请号：PCT/US2012035963
申请日：2012-05-01
Applicant: ADVANCED LIQUID LOGIC INC , BORT DONOVAN , GRAHAM CARRIE , PAMULA VAMSEE , POLLACK MICHAEL , SISTA RAMAKRISHNA , SRINIVASAN VIJAY
Inventor： BORT DONOVAN , GRAHAM CARRIE , PAMULA VAMSEE , POLLACK MICHAEL , SISTA RAMAKRISHNA , SRINIVASAN VIJAY
CPC classification number: G01N27/44791 , B01F1/0027 , B01F13/0071 , B01F13/0076 , B01F2001/0055 , B01F2215/0037 , B01L3/502761 , B01L3/502792 , B01L2200/0605 , B01L2200/0668 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/089 , B01L2400/0406 , B01L2400/0418 , B01L2400/0427 , B01L2400/043 , B01L2400/0487 , B81B1/004
Abstract: A method of mixing a droplet, the method comprising providing a droplet on a surface, forming the droplet into a first "U" shape having a bottom region and two terminal ends, and simultaneously merging the terminal ends and splitting the droplet at the bottom region to form a second "U" shape which is substantially opposite the first "U" shape.
Abstract translation: 一种混合液滴的方法，所述方法包括在表面上提供液滴，将所述液滴形成为具有底部区域和两个末端的第一“U”形状，并同时合并末端并在底部区域分离液滴 以形成与第一“U”形大体相反的第二“U”形状。
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公开(公告)号：WO2013022745A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/049507
申请日：2012-08-03
Applicant: ADVANCED LIQUID LOGIC INC , YI, Uichong , COHEN, David , BORT, Donovan , WHITE, Andrew
Inventor： YI, Uichong , COHEN, David , BORT, Donovan , WHITE, Andrew
CPC classification number: G05B15/02 , B01L3/502792 , B01L7/52 , B01L2200/0673 , B01L2300/069 , B01L2300/0816 , B01L2400/0406 , B01L2400/0427 , G01N27/453
Abstract: Methods, devices and systems for transporting a droplet along a droplet operations gap of a droplet actuator into contact with absorbent material to dispose of the droplet from the gap or from a region of the gap.
Abstract translation: 用于沿着液滴致动器的液滴操作间隙输送液滴以与吸收材料接触以将液滴从间隙或间隙的区域处理的方法，装置和系统。
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公开(公告)号：WO2013009927A2
公开(公告)日：2013-01-17
申请号：PCT/US2012046333
申请日：2012-07-11
Applicant: ADVANCED LIQUID LOGIC INC , WINGER THEODORE
Inventor： WINGER THEODORE
IPC: G01N15/02 , G01N27/02 , G01N33/53 , G01N33/573
CPC classification number: G01N27/447 , B01L3/502792 , B01L2300/0816 , B01L2300/12 , B01L2400/0424 , B01L2400/0427 , G01N2800/044
Abstract: A method of conducting an assay, the method comprising incubating a droplet in oil, the droplet comprising an umbelliferone substrate, a sample potentially comprising an enzyme which cleaves the umbelliferone substrate, and zwitterionic surfactant and detecting a signal emitted from the droplet.
Abstract translation: 一种进行测定的方法，所述方法包括在油中孵育液滴，所述液滴包含伞形酮底物，潜在地包含切割伞形酮底物的酶的样品和两性离子表面活性剂，并检测从液滴发射的信号。
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公开(公告)号：WO2012154745A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/036949
申请日：2012-05-08
Applicant: ADVANCED LIQUID LOGIC, INC. , STURMER, Ryan , SRINIVASAN, Vijay , SUDARSAN, Arjun
Inventor： STURMER, Ryan , SRINIVASAN, Vijay , SUDARSAN, Arjun
IPC: B01J19/00 , G01N27/02 , G01N1/10 , G01N33/483
CPC classification number: B01L3/50273 , B01L3/502792 , B01L2200/0621 , B01L2200/10 , B01L2200/14 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0829 , B01L2300/087 , B01L2300/089 , B01L2400/0427 , G01N27/048 , G01R27/16
Abstract: A method, comprising receiving an output voltage signal produced by a power supply superimposing an excitation signal onto the output voltage signal to produce a superimposed signal; connecting the superimposed signal to an electrode in a droplet actuator; suppressing the output voltage signal when detecting an impedance of the electrode; and measuring the impedance of the electrode produced by the excitation signal, wherein the impedance indicates presence of liquid at the electrode.
Abstract translation: 一种方法，包括：将由激励信号叠加的电源产生的输出电压信号接收到所述输出电压信号上以产生叠加信号; 将叠加的信号连接到液滴致动器中的电极; 当检测到电极的阻抗时，抑制输出电压信号; 并测量由激发信号产生的电极的阻抗，其中阻抗表示在电极处存在液体。
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