公开(公告)号：AU2002319786A1

公开(公告)日：2003-02-24

申请号：AU2002319786

申请日：2002-08-07

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： GARRETT JAMES E ,  BANDYOPADHYAY PRADIP K

IPC: C12N9/00 ,  C12N9/10 ,  C12Q1/48 ,  C12N1/20 ,  C07K1/00 ,  C07H21/04 ,  C12N15/00

Abstract: The present invention is relates to a gamma-carboxylase from Conus snails, a nucleic acid sequence encoding the Conus gamma-carboxylase and to a method for using the nucleic acid or protein sequences for preparing gamma-carboxylated proteins.

公开(公告)号：AU2002245340A1

公开(公告)日：2002-08-12

申请号：AU2002245340

申请日：2002-01-29

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  JONES ROBERT M ,  WATKINS MAREN ,  GARRETT JAMES E

IPC: A61K51/00 ,  A61K51/08 ,  C07H21/04 ,  C07K14/435 ,  C12N15/12 ,  A61K38/04 ,  G01N33/566 ,  C07K7/08 ,  G01N33/53 ,  A61K38/17

Abstract: The present invention is directed to beta-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the beta-superfamily conotoxin peptides and encoding beta-superfamily conotoxin propeptides, as well as the beta-superfamily conotoxin propeptides.

公开(公告)号：AU7896301A

公开(公告)日：2002-02-05

申请号：AU7896301

申请日：2001-07-20

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  MCCABE R TYLER ,  GARRETT JAMES E ,  LAYER RICHARD T ,  WAGSTAFF JOHN D ,  JONES ROBERT M

IPC: A61K38/00 ,  A61K38/17 ,  C07K14/435 ,  C12N15/12

公开(公告)号：AU6867701A

公开(公告)日：2002-01-08

申请号：AU6867701

申请日：2001-06-22

Applicant: COGNETIX INC

Inventor： JONES ROBERT M

IPC: A61K31/395 ,  A61K31/40 ,  A61K31/407 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/55

Abstract: The invention relates to the use of MT2 selective melatonergics as anticonvulsant agents and as analgesic agents. More specifically, the invention relates to the use of 6H-isoindolo[2,1-a]indoles or 5,6-dihydroindolo[2,1-a]isoquinolines as described herein which have melatonin agonist activity and which are selective for the MT2 receptor as anticonvulsant agents or analgesic agents. The invention further relates to the use of 5,6-dihydroindolo[2,1-a]isoquinolines and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles as described herein which have melatonin antagonist activity and which are selective for the MT2 receptor as pharmacological tools for delineation of physiological responses governed by MT2 receptor activation either by melatonin or selective agonists disclosed herein and for treatment of disorders associated with overproduction of melatonin such as seasonal affective disorder (SAD) and shift work syndrome. Such melatonin antagonists are also useful for treating Parkinson's Disease.

公开(公告)号：AU2740401A

公开(公告)日：2001-07-16

申请号：AU2740401

申请日：2000-12-28

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  CARTIER G EDWARD ,  WATKINS MAREN ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  LAYER RICHARD T ,  JONES ROBERT M

IPC: G01N33/50 ,  A61K38/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P11/06 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/20 ,  A61P25/28 ,  A61P25/36 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P39/00 ,  A61P43/00 ,  C07K14/435 ,  C12N15/09 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K38/17 ,  C12N15/12

Abstract: The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

公开(公告)号：AU1771101A

公开(公告)日：2001-05-30

申请号：AU1771101

申请日：2000-11-17

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： HOOPER DAVID ,  GARRETT JAMES E ,  CORPUZ GLORIA P ,  CRUZ LOURDES J ,  OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  JONES ROBERT M

IPC: A61K38/00 ,  A61K49/00 ,  C07K14/435 ,  C12N15/12 ,  A61K38/17 ,  A61K49/14 ,  G01N33/53

Abstract: The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.

公开(公告)号：CA2376357A1

公开(公告)日：2000-12-21

申请号：CA2376357

申请日：2000-06-09

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： OLIVERA BALDOMERO M ,  LAYER RICHARD T ,  WAGSTAFF JOHN D ,  MCINTOSH J MICHAEL ,  MCCABE R TYLER ,  JONES ROBERT M ,  GARRETT JAMES E

IPC: C12N15/09 ,  A61K38/00 ,  A61P23/02 ,  A61P25/02 ,  A61P29/00 ,  C07K14/435 ,  C12N15/12 ,  C07K14/00

Abstract: The present invention is directed to the new .mu.O-conopeptides, their codin g sequences and their propeptides and to the use of .mu.O-conopeptides as a local anesthetic for treating pain. The .mu.O-conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, eithe r administered acutely for post-operatively pain or via an intrathecal pump fo r severe chronic pain situations or for treatment of pain in epithelial tissue .

公开(公告)号：CA2743116A1

公开(公告)日：2000-08-03

申请号：CA2743116

申请日：2000-01-28

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WATKINS MAREN ,  HILLYARD DAVID R ,  MCINTOSH J MICHAEL ,  JONES ROBERT M ,  OLIVERA BALDOMERO M

IPC: C07K14/435 ,  C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K7/08

公开(公告)号：CA2347713A1

公开(公告)日：2000-04-27

申请号：CA2347713

申请日：1999-10-20

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST

Inventor： IMPERIAL JULITA ,  GRIFFEN DAVID ,  MCCABE R TYLER ,  OLIVERA BALDOMERO M ,  JONES ROBERT M ,  WATKINS MAREN ,  CRUZ LOURDES J ,  WAGSTAFF JOHN D ,  LAYER RICHARD T ,  CRAIG A GREY ,  HILLYARD DAVID R

IPC: C12N15/09 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575 ,  C12N15/12 ,  A61K38/10

Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10- contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti- inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti- psychotic, Parkinson's disease, gastrointestinal disorders, depressive state s, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti- arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

公开(公告)号：AU1114399A

公开(公告)日：1999-05-17

申请号：AU1114399

申请日：1998-10-23

Applicant: UNIV CASE WESTERN RESERVE ,  COGNETIX INC ,  SALK INSTITUTE THE ,  UNIV UTAH RES FOUND

Inventor： SHON KI-JOON ,  OLIVERA BALDOMERO M ,  RIVIER JEAN E ,  KOERBER STEVEN C ,  SHEN GREGORY S ,  MCINTOSH J MICHAEL ,  CARTIER G EDWARD ,  YOSHIKAMI DOJU

IPC: G01R33/465 ,  A61K38/00 ,  C07K7/08 ,  C07K14/435 ,  C12N15/09 ,  G01N33/566 ,  G01N33/574 ,  G06F17/30 ,  G06F19/00 ,  G01N24/08 ,  G01N33/68

Abstract: This invention relates to derivatives of the conopeptide MII, an alpha -4/7 conotoxin peptide, in which amino acid residues are substituted as described herein while maintaining the basic activity of MII. The present invention also relates to the discovery of the 3-dimensional structure of MII, and the relationship of its structure to its specificity to the alpha 3 beta 2 subtype of the neuronal nicotinic acetylcholine receptor (nAChR). The present invention also relates to computer based programs for the expression of the three-dimensional structure of MII and peptide analogs, peptide mimetics or non-peptide mimetics thereof. The structural characteristics may be correlated with biological activity to enable the design of alpha -4/7 conotoxin peptide analogs and peptide mimetics which demonstrate the same specificity to neuronal nAChR. Such analogs and peptide mimetics are useful as cardiovascular agents and for treating or detecting small-cell lung carcinoma (SCLC).