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    EMETINE DERIVATIVES, PRODRUGS CONTAINING SAME, AND METHODS OF TREATING CONDITIONS USING SAME
    92.
    发明申请
    EMETINE DERIVATIVES, PRODRUGS CONTAINING SAME, AND METHODS OF TREATING CONDITIONS USING SAME 审中-公开
    EMETINE衍生物，含有该产品的产品以及使用该方法处理条件的方法

    公开(公告)号：WO2012162175A1

    公开(公告)日：2012-11-29

    申请号：PCT/US2012/038655

    申请日：2012-05-18

    Applicant: HOWARD UNIVERSITY ,  BAKARE, Oladapo

    Inventor： BAKARE, Oladapo

    IPC: C07D455/08

    CPC classification number: C07D455/08 ,  C07D401/06 ,  C07K7/06

    Abstract: Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2'-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

    Abstract translation: 本文提供的化合物是可用作在特定细胞条件下选择性地进行活化以释放emetine的前药的依米亚衍生物。 一方面，通过在癌/肿瘤微环境中可通过水解选择性除去的部分衍生出N2'-位，将阻断基团并入到埃米亚分子上。 这些化合物的细胞毒性小于埃米汀，并且在非癌细胞中基本上是无活性的。 一方面，本文所述的化合物可用于治疗转移性和非转移性癌症，包括例如乳腺癌，前列腺癌，肺癌和白血病。

    5-OXOPYRROLIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS
    94.
    发明申请
    5-OXOPYRROLIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS 审中-公开
    作为HIV整合酶抑制剂的5-氧代吡咯烷衍生物

    公开(公告)号：WO2015130958A1

    公开(公告)日：2015-09-03

    申请号：PCT/US2015/017810

    申请日：2015-02-26

    Applicant: HOWARD UNIVERSITY

    Inventor： WANG, Xiang Simon

    IPC: A61K31/506 ,  C07D401/14

    CPC classification number: C07D403/06 ,  A61K31/404

    Abstract: Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having an N-indol heteroarylcarboxamide scaffold which is represented by the formula (1) wherein, independent of each other, R independently represents hydrocarbyl, halogeno, amino, substituted alkoxy, R 1 represents di-valent hydrocarbyl, substituted or unsubstituted, and R 2 represents an ether moiety.

    Abstract translation: 用于在靶细胞或患者中治疗逆转录病毒感染或抑制HIV整合酶的方法涉及向目标细胞或需要治疗的患者施用有效量的至少一种具有由式（1）表示的N-吲哚杂芳基羧酰胺支架的物质 1）其中独立地为R独立地表示烃基，卤代，氨基，取代的烷氧基，R1表示二价烃基，取代或未取代的，R2表示醚部分。

    INHIBITORS OF PROTEIN PHOSPHATASE-1 AND USES THEREOF
    95.
    发明申请
    INHIBITORS OF PROTEIN PHOSPHATASE-1 AND USES THEREOF 审中-公开
    蛋白磷酸化酶-1的抑制剂及其用途

    公开(公告)号：WO2014028051A1

    公开(公告)日：2014-02-20

    申请号：PCT/US2013/031659

    申请日：2013-03-14

    Applicant: HOWARD UNIVERSITY ,  NEKHAI, Sergei

    Inventor： NEKHAI, Sergei

    IPC: A61K31/473

    CPC classification number: C07D219/04 ,  A61K31/473 ,  C07D221/16 ,  C07D409/06 ,  C07D417/12

    Abstract: Inhibitors of protein phosphatase-1 (PP-1 ) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-l in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.

    Abstract translation: 公开了蛋白质磷酸酶-1（PP-1）的抑制剂及其在用于治疗或预防由HIV或埃博拉病毒引起的病毒感染的方法中的用途。 蛋白磷酸酶-1的抑制剂有效量已被证明可减缓接触埃博拉病毒或含有埃博拉病毒的细胞时的病毒复制。

    NANOTHERMOCOUPLE DETECTOR BASED ON THERMOELECTRIC NANOWIRES
    96.
    发明申请
    NANOTHERMOCOUPLE DETECTOR BASED ON THERMOELECTRIC NANOWIRES 审中-公开

    公开(公告)号：WO2010135439A3

    公开(公告)日：2010-11-25

    申请号：PCT/US2010/035426

    申请日：2010-05-19

    Applicant: HOWARD UNIVERSITY ,  HUBER, Tito

    Inventor： HUBER, Tito

    IPC: B82B1/00 ,  G01J1/02 ,  H01L31/10

    Abstract: A nanothermocouple detector includes a nanowire coupled across two electrodes. The two electrodes are electrically connected to an amplifier. The two electrodes generally have a separation of about five micrometers to about thirty micrometers across which the nanowire is coupled. A focusing element is disposed to admit photons that fall on the focusing element onto the nanowire to heat it. A voltage change across the nanowire caused by the heating of the nanowire by the light is detected by the amplifier. The voltage change corresponds to the energy absorbed from the light by the nanowire. The color of a single photon can be detected using such device. An array of such devices can be used for sensing light on a two-dimensional scale, thereby providing an image showing small variances in the energies of the light impinging upon the detector array.

    SYSTEM AND METHOD OF DETECTING AND LOCATING INTERMITTENT AND OTHER FAULTS
    97.
    发明申请
    SYSTEM AND METHOD OF DETECTING AND LOCATING INTERMITTENT AND OTHER FAULTS 审中-公开

    公开(公告)号：WO2010132353A3

    公开(公告)日：2010-11-18

    申请号：PCT/US2010/034228

    申请日：2010-05-10

    Applicant: HOWARD UNIVERSITY ,  KIM, Charles J.

    Inventor： KIM, Charles J.

    IPC: H04L12/26 ,  H04B10/08

    Abstract: A signal is conducted from a controller module onto a network via a first coupling. The signal is transmitted across the network and received at one or more receiver modules via one or more second couplings. At the one or more receiver modules, the received signal is analyzed and based upon the analysis, a determination is made as to whether a fault has occurred in the network and/or where the occurrence occurred.

    SYSTEM AND METHOD OF MONITORING AND OPTIMIZING POWER QUALITY IN A NETWORK
    99.
    发明申请
    SYSTEM AND METHOD OF MONITORING AND OPTIMIZING POWER QUALITY IN A NETWORK 审中-公开

    公开(公告)号：WO2010120606A3

    公开(公告)日：2010-10-21

    申请号：PCT/US2010/030244

    申请日：2010-04-07

    Applicant: HOWARD UNIVERSITY ,  MOMOH, James

    Inventor： MOMOH, James

    IPC: H04L12/12 ,  H04L12/26

    Abstract: The operation of a power distribution network is modeled. At least one quality of the operation of the power distribution network is measured. The future operational performance of the power distribution network is predicted based at least in part upon the modeling. When the at least one measure of the quality of the operation of the power distribution network or the predicted future operational performance do not meet the predetermined performance criteria, corrective action is taken with respect to the power distribution network.

    SYSTEM AND METHOD OF DETECTING AND LOCATING INTERMITTENT ELECTRICAL FAULTS IN ELECTRICAL SYSTEMS
    100.
    发明申请
    SYSTEM AND METHOD OF DETECTING AND LOCATING INTERMITTENT ELECTRICAL FAULTS IN ELECTRICAL SYSTEMS 审中-公开
    检测和定位电气系统中的间歇性电气故障的系统和方法

    公开(公告)号：WO2010051224A1

    公开(公告)日：2010-05-06

    申请号：PCT/US2009/061779

    申请日：2009-10-23

    Applicant: HOWARD UNIVERSITY ,  KIM, Charles, J.

    Inventor： KIM, Charles, J.

    IPC: G01R31/02

    CPC classification number: G01R31/024 ,  G01R31/008 ,  G01R31/086 ,  H04B3/46 ,  H04B3/546

    Abstract: Signals are transmitted from at least one transmitter that is positioned in an electrical network. The signals that have been transmitted are received by the at least one single receiver at a single receiver positioned within the electrical network. At the single receiver, the received signals are analyzed and a determination from the analyzing the received signals is made as to whether a fault has occurred in the electrical network.

    Abstract translation: 信号从位于电网中的至少一个发射机传输。 已发送的信号由位于电网内的单个接收机的至少一个单个接收机接收。 在单个接收机处，对接收的信号进行分析，并且从接收到的信号的分析确定电网中是否发生故障。

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