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公开(公告)号：JP2013117529A
公开(公告)日：2013-06-13
申请号：JP2012252081
申请日：2012-11-16
Inventor： WIDZGOWSKI BERND
CPC classification number: G01J1/44 , G01N21/6408 , G01N21/6458 , G02B21/0076 , G02B21/0084
Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus for inspecting a sample.SOLUTION: Disclosed is a method and an apparatus for inspecting a sample. The apparatus includes: a light source for generating excitation rays of light with a pulse to be continuously generated with an excitation pulse frequency for illuminating a sample area with the excitation pulse; and a detector for detecting detection rays of light to be emitted from the sample area. In the apparatus, the detector generates an electric pulse and an electric pulse sequence based on the electric pulse for each of the detection photons of the detection rays of light. The apparatus includes an analog/digital converter for generating a digital data sequence by sampling the electric pulse sequence at a sampling speed.
Abstract translation: 要解决的问题：提供一种用于检查样品的方法和装置。 解决方案：公开了一种用于检查样品的方法和装置。 该装置包括：用于产生具有用激发脉冲频率连续产生的脉冲的激发光线的光源，用于用激发脉冲照射样本区域; 以及用于检测从样品区域发射的光的检测光的检测器。 在该装置中，检测器基于用于检测光线的每个检测光子的电脉冲产生电脉冲和电脉冲序列。 该装置包括用于通过以采样速度采样电脉冲序列来产生数字数据序列的模拟/数字转换器。 版权所有（C）2013，JPO＆INPIT
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92.发明专利Device for distributing illumination light and detection light in microscope and its method 审中-公开用于分布照明灯的设备和微光检测灯及其方法
公开(公告)号：JP2013057931A
公开(公告)日：2013-03-28
申请号：JP2012178023
申请日：2012-08-10
Inventor： SCHREIBER FRANK
CPC classification number: G02B21/0032 , G02B21/0068 , G02B21/0076 , G02B21/16 , G02B27/283
Abstract: PROBLEM TO BE SOLVED: To provide a device for distributing illumination light and detection light in a microscope, and its method.SOLUTION: The device has a light distribution optical system 12 that guides illumination light 14 to a sample 18 and guides detection light 20 from the sample 18 to at least one of detectors. The light distribution optical system 12 comprises: polarization units 28, 30, and 32 arranged in a first optical path and configured to convert the illumination light 14 directed to the sample 18 into a first polarization state; a beam splitter 34 having such polarization dependability that while the illumination light 14 converted into the first polarization state is guided to the sample 18, a first portion 20a of detection light from the sample 18, which exhibits a first polarization state, is guided so as to return to the first optical path, a second portion 20b of the detection light, which has a second polarization state different from the first polarization state, is guided to a second optical path; and a beam combiner 38 configured to combine the first portion 20a and the second portion 20b of the detection light together and to guide the combined portions to the detector.
Abstract translation: 要解决的问题：提供一种用于在显微镜中分配照明光和检测光的装置及其方法。 解决方案：该装置具有将照明光14引导到样品18并将检测光20从样品18引导到至少一个检测器的配光系统12。 光分配光学系统12包括：布置在第一光路中并被配置为将指向样本18的照明光14转换成第一偏振状态的偏振单元28,30和32。 具有这种极化依赖性的分束器34，当将转换成第一偏振态的照明光14引导到样品18时，来自样品18的具有第一偏振态的检测光的第一部分20a被引导为 为了返回到第一光路，具有与第一偏振态不同的第二偏振状态的检测光的第二部分20b被引导到第二光路; 以及组合器38，被配置为将检测光的第一部分20a和第二部分20b组合在一起，并将组合部分引导到检测器。 版权所有（C）2013，JPO＆INPIT
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93.发明专利
公开(公告)号：JP2013003585A
公开(公告)日：2013-01-07
申请号：JP2012133714
申请日：2012-06-13
Inventor： KNEBEL WERNER , ULRICH HEINRICH
IPC: G02B21/06
CPC classification number: G02B21/367 , G02B21/0032 , G02B21/0076 , G02B21/10 , G02B21/16
Abstract: PROBLEM TO BE SOLVED: To improve a scanning microscope so that an optical microscope is able to perform imaging free from collision even in a difficult geometric condition.SOLUTION: In order to incline each illuminating focus (16, 84) with respect to the optical axis (O) of an illuminating optical system (10), a scanner (33) directs an illuminating light beam (12) to a partial area away from the pupil center of the incident pupil (14) of the illuminating optical system (10). Also, in order to move the illuminating focus (16, 84) over an illuminating target area, the scanner changes the direction of incidence of the illuminating light beam (12) within the partial area. An observation objective lens (38) spatially separated from the illuminating optical system (10) is provided. The observation objective lens (38) is arranged so that its optical axis (O) is located substantially perpendicular to the illuminating target area and so that this axis forms an acute angle (α) with respect to the optical axis (O) of the illuminating optical system (10).
Abstract translation: 要解决的问题：为了改善扫描显微镜，使得光学显微镜即使在困难的几何条件下也能够进行没有碰撞的成像。 解决方案：为了相对于照明光学系统（10）的光轴（O
1 ）倾斜每个照明聚焦（16,84），扫描仪 （33）将照明光束（12）引导到远离照明光学系统（10）的入射光瞳（14）的光瞳中心的部分区域。 此外，为了将照明聚焦（16,84）移动到照明目标区域上，扫描器改变部分区域内的照明光束（12）的入射方向。 提供了与照明光学系统（10）在空间上分离的观察物镜（38）。 观察物镜38设置为使其光轴（O 3 ）基本上垂直于照明目标区域，并且使得该轴形成锐角（α ）相对于照明光学系统（10）的光轴（O 1 ）。 版权所有（C）2013，JPO＆INPIT -
公开(公告)号：JP2012145939A
公开(公告)日：2012-08-02
申请号：JP2012001076
申请日：2012-01-06
Inventor： BIRK HOLGER , WIDZGOWSKI BERND , HOLGER NISSLE
CPC classification number: G02B21/008 , G01N21/6458 , G02B21/0076
Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus which image a sample with a scanning microscopy.SOLUTION: Disclosed are a method and an apparatus for imaging a sample (28) with a scanning microscopy. Multiple sample points are scanned with a scanning beam (14) in consecutive scanning time sections. An intensity of light emitted from each of the scanned sample points is sensed repeatedly within each of the related scanning time sections. Based on intensities sensed at each of the scanned sample points, an intensity average value is found as an average value image point signal. Then, by synthesizing such average value image point signals, an average value raster image signal is generated. Further, in addition, based on intensities sensed at each of the scanned sample points, an intensity variance value is found as a variance image point signal. Then, by synthesizing such variance image point signals, a variance raster image signal is generated.
Abstract translation: 要解决的问题：提供一种用扫描显微镜对样品进行成像的方法和装置。 解决方案：公开了一种用扫描显微镜对样品（28）进行成像的方法和装置。 在连续扫描时间段内用扫描光束（14）扫描多个采样点。 在每个相关的扫描时间段内重复地感测从每个扫描的采样点发射的光的强度。 基于在每个扫描采样点处感测到的强度，发现强度平均值作为平均值图像点信号。 然后，通过合成这样的平均值图像点信号，生成平均值光栅图像信号。 此外，另外，基于在每个扫描采样点处感测到的强度，发现强度方差值作为方差图像点信号。 然后，通过合成这样的方差图像点信号，生成方差光栅图像信号。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2012113308A
公开(公告)日：2012-06-14
申请号：JP2011256034
申请日：2011-11-24
Inventor： MICHAEL GANZER
CPC classification number: G02B21/26 , G02B21/241
Abstract: PROBLEM TO BE SOLVED: To provide a device for focusing a microscope objective on a sample.SOLUTION: A device for focusing a microscope objective (26) on a sample (18) is disclosed. The device has a positioning unit (20) having: a main body (22); an objective holder (24) movably supported on the main body and adapted to hold the microscope objective (26); and an actuator (27) for moving the objective holder (24) along the optical axis (O) of the microscope objective. The objective holder holds the microscope objective (26) only at a front portion of the microscope objective facing the sample (18).
Abstract translation: 要解决的问题：提供用于将显微镜物镜聚焦在样品上的装置。 公开了一种用于将显微镜物镜（26）聚焦在样品（18）上的装置。 该装置具有定位单元（20），该定位单元具有：主体（22）; 可移动地支撑在主体上并适于保持显微镜物镜（26）的物镜支架（24）; 以及用于沿着显微镜物镜的光轴（O）移动物镜保持器（24）的致动器（27）。 目标支架仅在面向样品（18）的显微镜物镜的前部保持显微镜物镜（26）。 版权所有（C）2012，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP2012093757A
公开(公告)日：2012-05-17
申请号：JP2011231661
申请日：2011-10-21
Inventor： KNEBEL WERNER , OESTREICHER WOLFGANG
CPC classification number: G02B21/0084 , G01N21/6402 , G01N21/6458 , G01N2021/6463 , G01N2201/06113 , G02B21/002 , G02B21/0032 , G02B21/0076 , G02B21/06 , G02B21/16
Abstract: PROBLEM TO BE SOLVED: To provide a SPIM microscope with a STED light sheet.SOLUTION: A SPIM microscope (Selective Plane Imaging Microscopy) having a y-direction illumination light source and a z-direction detection light camera is disclosed. An x-scanner generates a sequential light sheet by scanning the illumination light beam in the x-direction. By optionally turning on a STED deactivation light beam, the light sheet can optionally be made thinner and therefore the optical resolution can be increased.
Abstract translation: 要解决的问题：提供具有STED光片的SPIM显微镜。 公开了具有y方向照明光源和z方向检测光照相机的SPIM显微镜（选择平面成像显微镜）。 x扫描仪通过沿x方向扫描照明光束来生成顺序光照片。 通过可选地打开STED去激活光束，光片可以可选地变薄，因此可以提高光学分辨率。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2012058733A
公开(公告)日：2012-03-22
申请号：JP2011193841
申请日：2011-09-06
Applicant: Leica Microsystems (Schweiz) Ag , ライカ ミクロジュステムス(シュヴァイツ)アーゲー
Inventor： HERBERT STUETTLER , SANDER ULRICH
CPC classification number: G02B21/16 , A61B90/20 , A61B2090/371 , G02B21/22 , G02B21/36
Abstract: PROBLEM TO BE SOLVED: To provide a special-illumination surgical video stereomicroscope that employs special effects with simple illumination.SOLUTION: A special-illumination surgical video stereomicroscope of the present invention includes: at least one light source for illuminating an in-vivo specimen; and at least one video imaging unit for obtaining a fluorescence image of the specimen. The spectral sensitivity of the at least one video imaging unit exhibits a higher spectral sensitivity in at least one light wavelength range of a special radiation to be expected, for example, a fluorescence radiation, than in another light wavelength ranges.
Abstract translation: 要解决的问题：提供采用特殊效果的特殊照明手术视频立体显微镜，具有简单的照明。 解决方案：本发明的特殊照明手术视频立体显微镜包括：用于照射体内样品的至少一个光源; 以及用于获得样本的荧光图像的至少一个视频成像单元。 所述至少一个视频成像单元的光谱灵敏度在比另一个光波长范围期望的特定辐射的至少一个光波长范围（例如，荧光辐射）中表现出更高的光谱灵敏度。 版权所有（C）2012，JPO＆INPIT
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98.发明专利Image vibration proof-imaging apparatus for imaging system of surgical microscope 有权图像振动成像装置，用于成像外科手术显微镜系统
公开(公告)号：JP2012032813A
公开(公告)日：2012-02-16
申请号：JP2011164085
申请日：2011-07-27
Applicant: Leica Microsystems (Schweiz) Ag , ライカ ミクロジュステムス(シュヴァイツ)アーゲー
Inventor： SANDER ULRICH
CPC classification number: G02B21/0012 , G02B27/646 , H04N5/23258 , H04N5/2328
Abstract: PROBLEM TO BE SOLVED: To provide an image vibration proof device for the imaging system of a surgical microscope, which is excellent in space efficiency and has little response time.SOLUTION: An image vibration proof-imaging apparatus comprises: support substrates (101, 102; 201) for regulating sensor surfaces; a plurality of opto-electronic imaging cells (110; 210); and at least one of movement means (120; 220) for moving the opto-electronic imaging cells (110; 210) relative to the support substrates (101, 102; 201).
Abstract translation: 要解决的问题：提供一种用于外科显微镜的成像系统的图像防振装置，其空间效率优异并且响应时间很小。 图像防振成像装置包括：用于调节传感器表面的支撑基板（101,102; 201）; 多个光电成像单元（110; 210）; 以及用于相对于支撑基板（101,102; 201）移动光电成像单元（110; 210）的移动装置（120; 220）中的至少一个。 版权所有（C）2012，JPO＆INPIT
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99.发明专利Method for scanning region-of-interest (roi)-scan with high temporal resolution 有权用高速分辨率扫描感兴趣区域（ROI）的方法
公开(公告)号：JP2010181886A
公开(公告)日：2010-08-19
申请号：JP2010030333
申请日：2010-02-15
Inventor： KNEBEL WERNER , WAWROWSKY KOLJA
CPC classification number: G02B21/0084 , G02B21/0032
Abstract: PROBLEM TO BE SOLVED: To provide a simple method for fundamentally improving temporal resolution and changing illumination conditions relating to a specimen. SOLUTION: In the method for scanning the specimen, by using illumination light beams emitted from at least one light source, a scanning process, wherein first scanning lines 21 are generated by scanning a desired portion of the specimen with illumination light beams of a first illumination condition, and then second scanning lines 22 are generated by scanning the desired portion with illumination light beams of a second illumination condition, is repeated several times, while changing the desired portion, and a first display 20a is acquired, based on a plurality of acquired first scanning lines 21, while a second display 20b is acquired based on a plurality of second scanning lines 22. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 要解决的问题：提供一种从根本上改善与样本有关的时间分辨率和改变照明条件的简单方法。 解决方案：在用于扫描样本的方法中，通过使用从至少一个光源发射的照明光束，扫描过程，其中通过用照射光束扫描样本的期望部分来产生第一扫描线21， 第一照明条件，然后通过用第二照明条件的照明光束扫描所需部分来产生第二扫描线22，在改变期望部分的同时重复多次，并且基于 多个获取的第一扫描线21，而基于多个第二扫描线22获取第二显示器20b。（C）2010年，JPO和INPIT
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公开(公告)号：JP2009187014A
公开(公告)日：2009-08-20
申请号：JP2009088763
申请日：2009-04-01
Applicant: Leica Microsystems (Schweiz) Ag , ライカ ミクロジュステムス(シュヴァイツ)アーゲー
Inventor： SANDER ULRICH
CPC classification number: G02B27/144 , A61B3/132 , G02B21/08 , G02B27/143 , G02B27/145
Abstract: PROBLEM TO BE SOLVED: To provide a lighting device that can be made compact, as much as possible so as to prevent increase in the structural height of a microscope in an undesired mode, and that (completely) enables a more uniform illumination of the light field which is freer in vignetting than the conventional devices of this kind. SOLUTION: The lighting device for the microscope, in particular a surgical microscope, has at least one observation beam path. The lighting device includes an illumination system, and a deflection device 8 for deflecting light emitted from the illumination system onto an object to be observed, for example an eye to be operated on. The deflection device 8 performs an illumination of the object under various illumination angles, with regard to at least one observation beam path. The deflection device 8 includes two deflection elements (16, 17), each being at least partially a physical beam splitter. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：为了尽可能提供可以制造得紧凑的照明装置，以防止在不期望的模式下显微镜的结构高度的增加，并且（完全）能够实现更均匀的照明 的光场比这种常规装置在渐晕中更自由。
解决方案：用于显微镜的照明装置，特别是手术显微镜，具有至少一个观察光束路径。 照明装置包括照明系统和用于将从照明系统发射的光偏转到待观察对象的偏转装置8，例如要操作的眼睛。 关于至少一个观察光束路径，偏转装置8对各种照明角度的物体进行照明。 偏转装置8包括两个偏转元件（16,17），每个偏转元件至少部分地是物理分束器。 版权所有（C）2009，JPO＆INPIT
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