公开(公告)号：EP2803366B1

公开(公告)日：2018-08-01

申请号：EP14180734.7

申请日：2005-06-15

Applicant: OxThera Intellectual Property AB

Inventor： Sidhu, Harmeet

IPC: A61K38/44 ,  A61K38/45 ,  A61K38/51

CPC classification number: A61K35/74 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/51 ,  A61K38/54 ,  A61K45/06 ,  C12Y102/03004 ,  C12Y208/03016 ,  C12Y401/01002 ,  C12Y401/01008

Abstract: The present invention relates to a pharmaceutical composition comprising one or more oxalate-degrading enzymes, wherein the one or more enzymes are entrapped in a three-dimensional mesh structure made from polymers having pore sizes that allow the enzyme substrates to penetrate the mesh structure to reach the enzymes.

公开(公告)号：EP2270138B1

公开(公告)日：2018-03-28

申请号：EP09164430.2

申请日：2009-07-02

Applicant: OxThera Intellectual Property AB

Inventor： Cowley, Aaron Blake ,  Gölander, Carl-Gustaf ,  Li, Qingshan ,  Sidhu, Harmeet

IPC: C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  A61K9/16 ,  A61K38/44 ,  A61K38/45 ,  A61K38/51 ,  A61K38/00 ,  C12P21/02

CPC classification number: C12N9/13 ,  A61K9/1623 ,  A61K9/1635 ,  A61K38/00 ,  C12N9/0008 ,  C12N9/88 ,  C12Y102/03004 ,  C12Y208/03016 ,  C12Y401/01002 ,  C12Y401/01008

Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.

公开(公告)号：EP1965816B1

公开(公告)日：2017-04-05

申请号：EP06848618.2

申请日：2006-12-14

Applicant: OxThera Intellectual Property AB

Inventor： SIDHU, Harmeet ,  KAUL, Poonam

IPC: A61K9/19 ,  A61K35/74 ,  A61K47/26 ,  A61K47/36 ,  A61K47/18 ,  A61K47/10 ,  A61K47/46 ,  A61K9/48 ,  A61K9/16 ,  A23L33/135

CPC classification number: A61K35/74 ,  A23L33/135 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/4816 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4891

Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing pharmaceutical compositions to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.

公开(公告)号：EP2803366A2

公开(公告)日：2014-11-19

申请号：EP14180734.7

申请日：2005-06-15

Applicant: OxThera Intellectual Property AB

Inventor： Sidhu, Harmeet

IPC: A61K47/30 ,  A61K38/44 ,  A61K38/45 ,  A61K38/51

CPC classification number: A61K35/74 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/51 ,  A61K38/54 ,  A61K45/06 ,  C12Y102/03004 ,  C12Y208/03016 ,  C12Y401/01002 ,  C12Y401/01008

Abstract: The present invention relates to a pharmaceutical composition comprising one or more oxalate-degrading enzymes, wherein the one or more enzymes are entrapped in a three-dimensional mesh structure made from polymers having pore sizes that allow the enzyme substrates to penetrate the mesh structure to reach the enzymes.

Abstract translation: 本发明涉及包含一种或多种草酸盐降解酶的药物组合物，其中所述一种或多种酶被截留在由具有允许酶底物穿透网状结构的孔径的聚合物制成的三维网状结构中 酶。

公开(公告)号：EP2449098A1

公开(公告)日：2012-05-09

申请号：EP10744865.6

申请日：2010-07-01

Applicant: OxThera Intellectual Property AB

Inventor： SIDHU, Harmeet ,  LI, Qingshan ,  COWLEY, Aaron, Blake ,  GÖLANDER, Carl-Gustaf

IPC: C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  A61K38/44 ,  A61K38/45 ,  A61K38/51 ,  C12P21/02

CPC classification number: C12N9/13 ,  C07K1/14 ,  C12N9/0008 ,  C12N9/88

Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.

公开(公告)号：EP3860628A1

公开(公告)日：2021-08-11

申请号：EP19868730.3

申请日：2019-10-04

Applicant: OxThera Intellectual Property AB

Inventor： LINDNER, Elisabeth ,  DEHMEL, Bastian ,  ÅKERMAN, Maria

IPC: A61K35/74 ,  A61P1/00 ,  A61P9/00 ,  A61K9/48 ,  A61P13/12

公开(公告)号：EP3468572A1

公开(公告)日：2019-04-17

申请号：EP17730457.3

申请日：2017-06-13

Applicant: OxThera Intellectual Property AB

Inventor： LINDNER, Elisabeth ,  ÅKERMAN, Maria ,  SJÖGREN, Anna ,  MCCALLION, Orla

IPC: A61K35/74 ,  A61P1/16 ,  A61P13/00 ,  A61P13/12

公开(公告)号：EP2449098B1

公开(公告)日：2016-12-07

申请号：EP10744865.6

申请日：2010-07-01

Applicant: OxThera Intellectual Property AB

Inventor： SIDHU, Harmeet ,  LI, Qingshan ,  COWLEY, Aaron, Blake ,  GÖLANDER, Carl-Gustaf

IPC: C07K1/14 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  A61K38/44 ,  A61K38/45 ,  A61K38/51 ,  C12P21/02

CPC classification number: C12N9/13 ,  C07K1/14 ,  C12N9/0008 ,  C12N9/88

公开(公告)号：EP3016669A1

公开(公告)日：2016-05-11

申请号：EP14747997.6

申请日：2014-07-03

Applicant: OxThera Intellectual Property AB

Inventor： LINDNER, Elisabeth ,  COWLEY, Helena ,  COWLEY, Aaron

IPC: A61K38/00 ,  A61K35/74 ,  A61P3/00 ,  A61P3/10

CPC classification number: C07K14/195 ,  A61K35/74 ,  A61K38/00 ,  A61K38/164 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0051 ,  C12N9/1014 ,  C12N9/1085 ,  C12N9/14 ,  C12N9/88 ,  C12Y101/0106 ,  C12Y104/01016 ,  C12Y108/01 ,  C12Y201/02001 ,  C12Y205/01006 ,  C12Y205/01009 ,  C12Y205/01047 ,  C12Y303/01001 ,  C12Y402/01003

Abstract: The present invention relates to a secretagogue compound derived from oxalate degrading bacteria, for use in the treatment of an oxalate related disease and/or oxalate related imbalance in a subject, wherein the administration of the secretagogue results in a reduction of urinary oxalate and/or plasma oxalate in the subject. The invention further relates to a pharmaceutical composition comprising such a secretagogue compound, a method for treating a subject suffering from an oxalate related disease, and to a method for preparing a secretagogue.

公开(公告)号：EP2803366A3

公开(公告)日：2015-02-18

申请号：EP14180734.7

申请日：2005-06-15

Applicant: OxThera Intellectual Property AB

Inventor： Sidhu, Harmeet

IPC: A61K47/30 ,  A61K38/44 ,  A61K38/45 ,  A61K38/51

CPC classification number: A61K35/74 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/51 ,  A61K38/54 ,  A61K45/06 ,  C12Y102/03004 ,  C12Y208/03016 ,  C12Y401/01002 ,  C12Y401/01008

Abstract: The present invention relates to a pharmaceutical composition comprising one or more oxalate-degrading enzymes, wherein the one or more enzymes are entrapped in a three-dimensional mesh structure made from polymers having pore sizes that allow the enzyme substrates to penetrate the mesh structure to reach the enzymes.