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公开(公告)号：EP4277660A1
公开(公告)日：2023-11-22
申请号：EP22700261.5
申请日：2022-01-13
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： KHOPADE, Ajay Jaysingh , HALDER, Arindam
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公开(公告)号：EP3997094A1
公开(公告)日：2022-05-18
申请号：EP20742937.4
申请日：2020-07-13
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： PATEL, Jiten Ranchhodbhai , PATEL, Gopalkumar Chimanlal , GORE, Omkar Prakash , SENGUPTA, Prabal , CHITTURI, Trinadha Rao
IPC: C07D491/22 , A61K31/497 , A61P35/00
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93.发明公开METHOD OF INCREASING BIOAVAILABILITY AND/OR PROLONGING OPHTHALMIC ACTION OF A DRUG 审中-公开方法以提高生物利用度和/或延长产品的眼科影响
公开(公告)号：EP3179982A1
公开(公告)日：2017-06-21
申请号：EP15827671.7
申请日：2015-07-24
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： KHOPADE, Ajay Jaysingh , HALDER, Arindam
IPC: A61K9/00 , A61K9/10 , A61K47/32 , A61K31/498
CPC classification number: A61K31/498 , A61K9/0048 , A61K9/0051 , A61K9/08 , A61K9/1635 , A61K9/5176 , A61K45/06 , B01J39/20 , A61K2300/00
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
Abstract translation: 本发明涉及提高的生物利用度和/或延长药物的眼用动作的方法，包括灌输wässrige悬浮液，其包含负载药物的纳米树脂颗粒的可逆簇的眼睛的方法，所述具有在D50值的簇 至少2微米和所述药物装载纳米树脂粒子具有在其特征做的D90值是70纳米至900纳米的颗粒尺寸分布。 本发明还涉及在wässrige悬浮液包含负载药物的纳米树脂颗粒的可逆集群，所述集群具有至少2微米，所述药物加载纳米树脂颗粒的D50值的颗粒尺寸分布在DASS模具D90值为特征的 是70纳米米至900纳米米。
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94.发明公开
公开(公告)号：EP3122336A1
公开(公告)日：2017-02-01
申请号：EP15769601.4
申请日：2015-03-25
Applicant: Sun Pharma Advanced Research Company Ltd
CPC classification number: A61K9/2081 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2846 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/433 , A61K31/5517 , A61K2300/00
Abstract: An abuse deterrent immediate release biphasic matrix solid dosage form that releases the drug at a desired rate for quick onset of action when a single unit or prescribed units of the dosage form are orally administered but exhibits a reduced rate of release when more than the prescribed number of units, are administered.
Abstract translation: 滥用威慑力立即释放涂层储存器固体剂型，当口服给药单一单位或剂型的规定单位时，以期望的速率释放药物以快速起效，但当超过规定数量时显示降低的释放速率 的单位，被管理。
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公开(公告)号：EP2697219A1
公开(公告)日：2014-02-19
申请号：EP12714674.4
申请日：2012-04-10
Applicant: Bioprojet , Sun Pharma Advanced Research Company Ltd
Inventor： CAPET, Marc , BERREBI-BERTRAND, Isabelle , ROBERT, Philippe , SCHWARTZ, Jean-Charles , LECOMTE, Jeanne-Marie , THENNATI, Rajamannar , PAL, Ranjan, Kumar , SAMANTA, Biswajit , PILLAI, Muthukumaran, Natarajan , DESAI, Japan, Nitinkumar , RANA, Dijixa, Chandubhai , PRAJAPATI, Kaushik, Dhanjubhai , PATHAK, Sandeep, Pankajbhai , PANCHAL, Bhavesh, M. , ARADHYE, Jayraj, D.
IPC: C07D413/10 , A61K31/454 , A61P9/10 , A61P29/00 , A61P37/06 , A61P35/00 , C07D413/14 , A61K31/5377
CPC classification number: C07D413/10 , A61K31/454 , A61K45/06 , C07D271/06
Abstract: The present invention relates to novel compounds acting as agonists at S1P (sphingosine-1-phosphate) receptors, compositions containing these compounds, use of these compounds in medicine and their process of preparation.
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Patent Agency Ranking
公开(公告)号：EP2118052A2
公开(公告)日：2009-11-18
申请号：EP08720166.1
申请日：2008-03-14
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： THENNATI, Rajamannar , SAMANTA, Biswajit , PAL, Ranjan Kumar , KILARU, Srinivasu , JIVANI, Jignesh , KUMBHANI, Savajibhai Anil , ADHYAPAK, Jay Prakashchandra
IPC: C07C251/60
CPC classification number: C07C271/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/34 , C07D277/40 , C07D295/185 , C07D401/12
Abstract: The present invention describes novel prodrugs of formula (I) or their salts, process of preparation and uses thereof.
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公开(公告)号：EP4255440A1
公开(公告)日：2023-10-11
申请号：EP21824046.3
申请日：2021-12-03
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： KHOPADE, Ajay Jaysingh , HALDER, Arindam
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公开(公告)号：EP3954362A1
公开(公告)日：2022-02-16
申请号：EP21199143.5
申请日：2015-07-24
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： KHOPADE, Ajay Jaysingh , HALDER, Arindam
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D 50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D 90 value is 70 nanometer to 900 nanometer.
The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D 50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D 90 value is 70 nanometers to 900 nanometers.-
公开(公告)号：EP3328361A1
公开(公告)日：2018-06-06
申请号：EP16829974.1
申请日：2016-07-27
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： KHOPADE, Ajay Jaysingh , HALDER, Arindam , UPADHYAY, Shivam Umeshkumar
CPC classification number: A61K9/146 , A61K9/0014 , B82Y5/00
Abstract: The present invention relates to nano-resin particles that are suitable for pharmaceutical use and their use in the pharmaceutical field. The present invention provides nano-sized resin particles having a particle size distribution characterized in that D90 value is between 200 nanometers to 900 nanometer and D10 value is not less than 50 nanometers, wherein the nano-resin particles are in pure form and safe for pharmaceutical use. The present invention further relates to pharmaceutical compositions comprising these purified nano-resin particles and their use in the treatment of diseases. The present invention further provides a process for preparing purified, nano-sized resin particles that are suitable for pharmaceutical use, the process comprising steps of: (i) washing an ion exchange resin and suspending in an aqueous liquid, (ii) subjecting the suspension of (i) to wet milling for a period such that the particles have a particle size distribution characterized in that the D90 value is between 200 nanometers to 900 nanometers and D10 value is not less than 50 nanometers, (iii) subjecting the suspension of (ii) to purification to remove impurities, (iv) drying the purified suspension to obtain nano-resin particles in the form of dry powder.
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100.发明公开MULTIPLE PILL ABUSE-RESISTANT IMMEDIATE RELEASE SOLID DOSAGE FORM OF HYDROCODONE 审中-公开多丸抗滥用药立即释放氢可酮固体剂型
公开(公告)号：EP3319605A1
公开(公告)日：2018-05-16
申请号：EP16824006.7
申请日：2016-07-08
Applicant: Sun Pharma Advanced Research Company Ltd
Inventor： DHARMADHIKARI, Nitin B , ZALA, Yashoraj R , HANAMANNAVAR, Bramhanand
IPC: A61K31/485 , A61K47/32
CPC classification number: A61K9/2013 , A61K9/2027 , A61K9/2095 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/485 , A61K47/32 , A61K2300/00
Abstract: An immediate-release, abuse-resistant solid dosage form comprising melt extrudates of a mixture of: ∙ hydrocodone or its pharmaceutically acceptable salt, ∙ release inhibiting agent comprising one or more reverse enteric polymer and one or more alkalizer and ∙ one or more stabilizers.
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