公开(公告)号：AU2001238441B2

公开(公告)日：2006-10-26

申请号：AU2001238441

申请日：2001-02-16

Applicant: MAHIDOL UNIV ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH

Inventor： BUTRAPET SIRITORN ,  BHAMARAPRAVATI NATTH ,  KINNEY CLAIRE Y H ,  KINNEY RICHARD M ,  GUBLER DUANE L

IPC: C07K14/18 ,  C12N15/09 ,  A61K31/7088 ,  A61K39/12 ,  A61K39/20 ,  A61K39/29 ,  A61K48/00 ,  A61P31/12 ,  A61P37/02 ,  C12N7/04

Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.

公开(公告)号：AU2006213981A1

公开(公告)日：2006-10-19

申请号：AU2006213981

申请日：2006-09-14

Applicant: ORTHO MCNEIL PHARM INC ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： KAFRISSEN MICHAEL E

IPC: A61K31/00 ,  A61K45/00 ,  A61K31/505 ,  A61K31/519 ,  A61K31/565 ,  A61K31/57 ,  A61P5/24 ,  A61P9/00 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00

Abstract: This invention provides folic acid-containing pharmaceutical compositions comprising either an oral contraceptive or a hormone replacement composition. This invention also provides methods of administering folic acid to a subject using the instant pharmaceutical compositions. Finally, this invention provides a drug delivery system useful for administering the instant pharmaceutical compositions.

公开(公告)号：AU2005324479A1

公开(公告)日：2006-07-20

申请号：AU2005324479

申请日：2005-04-07

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： ADHYA SANKAR ,  EDGAR ROTEM ,  MCKINSTRY MICHAEL ,  SCHOLL DEAN ,  MERRIL CARL R

IPC: C12N15/10 ,  C12N15/70 ,  C12Q1/68

Abstract: The invention is related to a transducing particle that comprises a bacteriophage coat and a DNA core that comprises plasmid DNA comprising: a) a host-specific bacteriophage packaging site wherein the packaging site is substantially in isolation from sequences naturally occurring adjacent thereto in the bacteriophage genome, b) a reporter gene, c) a bacteria-specific promoter operably linked to said reporter gene, d) a bacteria-specific origin of replication, and optionally e) an antibiotic resistance gene. The invention includes phage transducing particles, methods of making transducing particles, and methods of using the transducing particles in bacterial detection.

公开(公告)号：AU2005279799A1

公开(公告)日：2006-03-09

申请号：AU2005279799

申请日：2005-08-29

Applicant: UNIV EMORY ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND

Inventor： MOSS BERNARD ,  ROBINSON HARRIET L ,  WYATT LINDA

IPC: C07K14/16 ,  A61K39/21 ,  C12N15/863

公开(公告)号：AP1459A

公开(公告)日：2005-08-22

申请号：AP2002002472

申请日：2000-10-06

Applicant: TIBOTEC PHARM LTD ,  JANSSEN SCIENCES IRELAND UC ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVIC ,  JANSSEN R&D IRELAND

Inventor： WIGERINCK PIET TOM BERT PAUL ,  WANG GUANGYANG ,  EISSENSTAT MICHAEL ,  ERICKSON JOHN W

IPC: A61K31/34 ,  A61K31/36 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P43/00 ,  C07D493/04

Abstract: The present invention relates to novel bis-tetrahydrofuran benzodioxolyl sulfonamide compounds which are surprisingly effective protease inhibitors. The invention also relates to pharmaceutical compositions, methods of inhibiting retrovirus proteases, in particular multidrug resistant retrovirus proteases, methods of treating or combating infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication.

公开(公告)号：AU2005201556A1

公开(公告)日：2005-05-05

申请号：AU2005201556

申请日：2005-04-13

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： HANCOCK KATHY ,  WILKINS PATRICIA P ,  GREENE RYAN M ,  TSANG VICTOR C W

IPC: G01N33/569

公开(公告)号：AU2003200964B2

公开(公告)日：2004-11-11

申请号：AU2003200964

申请日：2003-02-21

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH

Inventor： ROBBINS JOHN B ,  GU XIN-XING

IPC: A61K39/02 ,  A61K39/116 ,  A61K39/295 ,  A61K39/385 ,  A61P27/16 ,  A61P31/04 ,  C08B37/00 ,  C12P19/04 ,  A61K039/02 ,  C08B037/00 ,  A61K039/385

Abstract: A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce a detoxified oligosaccharide (OS), which is linked to an immunogenic carrier. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.

公开(公告)号：AU2004210162A1

公开(公告)日：2004-08-19

申请号：AU2004210162

申请日：2004-01-29

Applicant: PANACOS PHARMACEUTICALS INC ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： SALZWEDEL KARL ,  LI FENG ,  WILD CARL T ,  ALLAWAY GRAHAM P ,  FREED ERIC O

IPC: A01N37/02 ,  A01N37/06 ,  A01N37/08 ,  A01N37/10 ,  A01N45/00 ,  A61K20060101 ,  A61K6/00 ,  A61K31/56 ,  A61K38/55 ,  A61K39/42 ,  A61K45/00 ,  A61K45/06 ,  A61M1/14 ,  A61M37/00 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C12N7/00 ,  C12N7/01 ,  C12N15/48 ,  C12P21/02 ,  C12Q1/37 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/567 ,  G01N33/569

Abstract: Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to the Gag proteolytic cleavage site rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.

公开(公告)号：AU2003245317A8

公开(公告)日：2003-12-12

申请号：AU2003245317

申请日：2003-05-20

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH

Inventor： KREITMAN ROBERT J ,  PASTAN IRA H ,  WILSON WYNDHAM ,  MATSUSHITA KAKUSHI

IPC: A61B20060101 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574

Abstract: Disclosed herein are methods of using previously unknown soluble forms of CD22 (sCD22) present in the serum of subjects with B-cell leukemias and lymphomas to assess tumor burden in the subjects. Also disclosed are methods of diagnosing or prognosing development or progression of a B-cell lymphoma or leukemia in a subject, including detecting sCD22 in a body fluid sample taken or derived from the subject, for instance serum.

公开(公告)号：AU2003248320A8

公开(公告)日：2003-11-20

申请号：AU2003248320

申请日：2003-09-24

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： MIELE LUCIO ,  RUCHS CHANA ,  SHIELDS LESLIE S

IPC: A61K31/16 ,  A61K31/337 ,  A61K31/475 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N5/06 ,  C12N5/08 ,  C12N5/20 ,  C12N15/11 ,  G01N33/574 ,  G01N33/577