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公开(公告)号：MA55609A
公开(公告)日：2022-02-16
申请号：MA55609
申请日：2020-04-08
Applicant: SANOFI SA , THE UNITED STATES OF AMERICA REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES
Inventor： ASOKAN MANGAIARKARASI , BEIL CHRISTIAN , BENINGA JOCHEN , BIRKENFELD JOERG , CONNORS MARK , KOUP RICHARD A , KWON YOUNG DO , KWONG PETER D , LIU QINGBO , LUSSO PAOLO , MASCOLA JOHN R , NABEL GARY J , PEGU AMARENDRA , RAO ERCOLE , WEI RONNIE , XU LING , YANG ZHI-YONG
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公开(公告)号：IL233186A
公开(公告)日：2019-05-30
申请号：IL23318614
申请日：2014-06-17
Applicant: UNIV MIAMI , UNITED STATES OF AMERICA REPRESENTED BY THE DEPT OF VETERANS AFFAIRS , THE UNITED STATES OF AMERICA REPRESENTED BY THE UNITED STATES DEPT OF VETERANS AFFAIRS
Abstract: There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their physiological activity in solution for extended periods of time and resist enzymic degradation in the body. These novel and useful properties appear to be due to novel substitution patterns ant at the 1, 15, 27 and 29 positions on the peptide.
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公开(公告)号：CA2872424C
公开(公告)日：2017-03-07
申请号：CA2872424
申请日：1999-06-23
Applicant: THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES , UNIV ILLINOIS
Inventor： ERICKSON JOHN W , GULNICK SERGEI V , MITSUYA HIROAKI , GHOSH ARUN K
IPC: A61K31/34 , G01N33/15 , A61K31/4525 , A61P31/18 , A61P37/04 , A61P43/00 , C07D493/04 , C12Q1/02 , C12Q1/37
Abstract: Disclosed are compounds of the formulas: (see formula IA) and (see formula IB) wherein R1, X, Y, Z, m, n, R3, R5, and R6 are herein defined, or a pharmaceutically acceptable salt thereof, for use in the preparation of a medicament for treating a human immunodeficiency virus (HIV) infection in an antiretroviral treatment-experienced mammal, for inhibiting a mutant retroviral infection in a mammal infected with a mutant retrovirus, and for preventing the development of drug resistance in an HIV-infected mammal.
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公开(公告)号：PT2336134T
公开(公告)日：2016-10-19
申请号：PT10179052
申请日：1999-06-23
Applicant: THE BOARD OF TRUSTEES OF THE UNIV OF ILLIONIS , THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES
Inventor： JOHN W ERICKSON , SERGEI V GULNIK , HIROAKI MITSUYA , ARUN K GHOSH
IPC: C07D493/04 , G01N33/15 , A61K31/34 , A61K31/445 , A61K31/4525 , A61P31/18 , A61P37/04 , A61P43/00 , C07D491/04 , C07D495/04 , C12Q1/02 , C12Q1/37
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Patent Agency Ranking
公开(公告)号：AU2008270735C1
公开(公告)日：2014-03-06
申请号：AU2008270735
申请日：2008-06-20
Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY , INST NAT SANTE RECH MED
Inventor： KIM YOONKYUNG , HECHLER BEATRICE , GACHET CHRISTIAN , KLUTZ ATHENA , JACOBSON KENNETH A
IPC: A61K47/48 , A61K49/00 , A61P1/00 , A61P9/00 , A61P13/00 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00
Abstract: Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an
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公开(公告)号：AU2013267082A1
公开(公告)日：2014-01-09
申请号：AU2013267082
申请日：2013-12-09
Inventor： GREIG NIGEL H , MATTSON MARK P , HABERMAN FRANK , YU QIAN-SHENG , ARUMUGAM THIRUMA
IPC: A61K31/52 , A61K31/522 , A61P17/02 , A61P25/00
Abstract: Disclosed is a method of treating or preventing an oxidative stress related disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (1) to the mammal, wherein R1-R4 5 and X1-X3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound. Figure 1A I=o Code X E R R4 m UA H H H H uric acid mUAl H H H Me 9-methyl uric acid mUA2 Me H Me H 1,7-dimethyl mic acid mUA3 Me Me Me H 1,3,7-trimethyl uric acid -H sUA S 0 0 6-monothiouric acid sUA2 S 0 S 6,8-dithiouric acid sUA3 0 S S 2,8-dithiouric acid sUA4 S S S 2,6,8-trithiouric acid
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公开(公告)号：AU2007289149B2
公开(公告)日：2013-08-15
申请号：AU2007289149
申请日：2007-08-30
Inventor： LOUKINOV DMITRI , LOBANENKOV VICTOR V , PUGACHEVA ELENA
IPC: G01N33/574 , A61K31/7088
Abstract: A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.
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99.发明专利
公开(公告)号：AU2008202491A1
公开(公告)日：2008-08-28
申请号：AU2008202491
申请日：2008-06-04
Applicant: UNIV IOWA STATE RES FOUND INC , THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY OF AGRICULTURE
Inventor： PETRICH JACOB W , CASEY THOMAS A , RASMUSSEN MARK A
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公开(公告)号：AU2006332044A8
公开(公告)日：2008-08-07
申请号：AU2006332044
申请日：2006-01-10
Inventor： MURPHY BRIAN R , COLLINS PETER L , SKIADOPOULOS MARIO H , NOLAN SHEILA
IPC: C12N15/00
Abstract: The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
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