公开(公告)号：US20190150463A1

公开(公告)日：2019-05-23

申请号：US16317684

申请日：2017-08-15

Applicant: Meiji Co., Ltd. ,  Tokushima University

Inventor： Hiroshi KIDO ,  Etsuhisa TAKAHASHI ,  Seiya MAKINO ,  Hiroshi KANO ,  Jun HENMI

IPC: A23C9/123 ,  A23L33/135 ,  A61K35/20 ,  A61P31/16 ,  A61P37/04

Abstract: A composition for suppressing deterioration of an acquired immune function according to the present invention includes, as an active ingredient, lactic acid bacteria products from lactic acid bacteria of the genus Lactobacillus. This composition for suppressing deterioration of the acquired immune function suppresses deterioration of the acquired immune function due to the use of an anti-influenza drug. The lactic acid bacteria of the genus Lactobacillus is preferably a bulgaricus bacterium. For example, the lactic acid bacteria of the genus Lactobacillus may be Lactobacillus delbrueckii subsp. bulgaricus. In the production method according to the present invention, a milk raw material is supplied to lactic acid bacteria of the genus Lactobacillus in order to produce the composition for suppressing deterioration of the acquired immune function to suppress deterioration of the acquired immune function due to the use of an anti-influenza drug.

公开(公告)号：US20180217054A1

公开(公告)日：2018-08-02

申请号：US15748264

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Michio YAMAJI ,  Nobukazu IKEDA ,  Kouji NISHINO ,  Masayoshi KAWASHIMA ,  Kazuteru TANAKA

IPC: G01N21/31 ,  G01N21/59 ,  G01J3/42 ,  G01J3/10

CPC classification number: G01N21/3103 ,  G01J3/10 ,  G01J3/42 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/59 ,  G01N2021/157 ,  G01N2021/3133 ,  G01N2201/0627 ,  G01N2201/08 ,  G01N2201/1211

Abstract: A concentration measurement device for measuring the concentration of a measured fluid within a measurement cell by detecting transmitted light that has passed through the measurement cell having a light incidence window and a light emission window disposed opposing to each other, comprising a reflected-light detector for detecting reflected light of the light incidence window.

公开(公告)号：US20180064073A1

公开(公告)日：2018-03-08

申请号：US15551791

申请日：2016-02-18

Applicant: Masakazu HASHIMOTO ,  Tokushima University ,  BEX Co., Ltd.

Inventor： Masakazu Hashimoto ,  Tatsuya Takemoto

IPC: A01K67/027 ,  C12N15/09 ,  C12N9/16

CPC classification number: A01K67/0275 ,  A01K67/027 ,  C12N9/16 ,  C12N15/09

Abstract: The disclosure relates to a method of introducing mRNA encoding Cas9 protein (Cas9 mRNA) into a mammalian embryo, comprising the steps of; (a) placing a mixture of the mammalian embryo and a solution comprising Cas9 mRNA in the gap between a pair of electrodes, and (b) applying a voltage to the electrodes for a voltage application duration, wherein the voltage and the voltage application duration achieve the efficiency of mRNA introduction (R) higher than the minimum required efficiency of mRNA introduction (Rmin) that is calculated on the basis of the concentration of Cas9 mRNA (ng/μl).

公开(公告)号：US20170199117A1

公开(公告)日：2017-07-13

申请号：US15321398

申请日：2015-07-23

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Nobukazu IKEDA ,  Michio YAMAJI ,  Tadayuki YAKUSHIJIN

IPC: G01N21/27 ,  G01N21/15 ,  G01N21/05

CPC classification number: G01N21/27 ,  G01N21/05 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/08

Abstract: An inline concentration measurement device comprises: a measurement cell main body with a gas flow path formed; a light incident part with a window member connected to the main body; and a light receiving part with a window member connected to the main body, wherein the gas flow path includes a gas flow path for an optical path extending straight between the window members of the light incident part and the light receiving part, a first communication part making a gas inlet formed in the main body communicate with the gas flow path part for the optical path, and a second communication part making a gas outlet formed in the main body communicate with the gas flow path part for the optical path, and the first communication part obliquely extends from the gas inlet towards the window member of the light incident part.

公开(公告)号：US20150343429A1

公开(公告)日：2015-12-03

申请号：US14654996

申请日：2014-02-04

Applicant: TOKUSHIMA UNIVERSITY ,  MITSUBISHI RAYON CO., LTD.

Inventor： Shigeru SUGIYAMA ,  Yuuki KATOU ,  Toshiya YASUKAWA ,  Shuji AKIHARA ,  Wataru NINOMIYA

IPC: B01J29/03 ,  B01J35/10 ,  C07C45/52

CPC classification number: B01J29/0308 ,  B01J29/035 ,  B01J35/1061 ,  C07C45/52 ,  C07C47/02

Abstract: Provided is a method that produces a saturated aldehyde from a 1,2-alkanediol in high yield. Disclosed is a method for producing a saturated aldehyde from a 1,2-alkanediol in the presence of a regular mesoporous material.

Abstract translation: 提供了以高产率从1,2-链烷二醇生产饱和醛的方法。 公开了一种在常规介孔材料存在下由1,2-链烷二醇生产饱和醛的方法。

公开(公告)号：EP4163304A1

公开(公告)日：2023-04-12

申请号：EP21822923.5

申请日：2021-06-04

Applicant: Tohoku University ,  Tokushima University

Inventor： OKUMURA, Masaki ,  MATSUSAKI, Motonori ,  INABA, Kenji ,  SAIO, Tomohide ,  KANEMURA, Shingo

IPC: C07K19/00 ,  C12N15/61 ,  C12N15/62 ,  C12N9/90

Abstract: An object to be achieved by the present invention is to prepare a droplet using a protein that has not been known heretofore to form a droplet. The present invention provides a droplet including an assembly of a protein, wherein the protein is a PDI family protein and/or an artificial protein, and contains a thioredoxin-like domain.

公开(公告)号：EP3971174A1

公开(公告)日：2022-03-23

申请号：EP20825528.1

申请日：2020-06-04

Applicant: Chemical Denshi Co., Ltd. ,  Tokushima University

Inventor： YAMADA, Shoichi ,  HYUGA, Toshio ,  NEMOTO, Hisao

IPC: C07D319/06 ,  C09K3/18 ,  C23C26/00

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient.

wherein R 1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n + 1 valent linker group, n is an integer of 1 or more and 5 or less.

公开(公告)号：EP3892299A1

公开(公告)日：2021-10-13

申请号：EP19892481.3

申请日：2019-12-06

Applicant: ONO Pharmaceutical Co., Ltd. ,  Tokushima University

Inventor： OKAZAKI, Taku ,  SUGIURA, Daisuke ,  MAEDA, Takeo ,  SHIBAYAMA, Shiro

IPC: A61K39/395 ,  A61P37/06 ,  A61P37/08 ,  C07K16/28

Abstract: The present application provides an immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-Ll antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：EP3878987A1

公开(公告)日：2021-09-15

申请号：EP20869680.7

申请日：2020-09-24

Applicant: Tanaka Kikinzoku Kogyo K.K. ,  Tokushima University

Inventor： OKUBO Michimasa ,  GOTO Kenji ,  TANAKA Kunihiro ,  SHIRAISHI Kojiro ,  SHIMA Kunihiro ,  KATO Yuya ,  HAMADA Kenichi ,  HONDA Eiichi ,  TAKEGAWA Emi

IPC: C22C5/02 ,  C22F1/00 ,  C22F1/14 ,  A61L29/02 ,  A61L31/02

Abstract: The present invention relates to a medical Au-Pt-Pd alloy including Au, Pt, Pd, and inevitable impurities. The Au-Pt-Pd alloy has an alloy composition inside a polygon (A1-A2-A3-A4) surrounded by straight lines connected at point A1 (Au: 53 atom%, Pt: 4 atom%, and Pd: 43 atom%), point A2 (Au: 70 atom%, Pt: 4 atom%, and Pd: 26 atom%), point A3 (Au: 69.9 atom%, Pt: 30 atom%, and Pd: 0.1 atom%), and point A4 (Au: 49.9 atom%, Pt: 50 atom%, and Pd: 0.1 atom%) in a Au-Pt-Pd ternary state diagram. In a metal structure of the alloy, at least one of a Au-rich phase and a Pt-rich phase is distributed, and the total of the area ratio of the Au-rich phase and the area ratio of the Pt-rich phase is 1.5% or more and 25.4% or less.

公开(公告)号：EP3260539A1

公开(公告)日：2017-12-27

申请号：EP16752551.8

申请日：2016-02-18

Applicant: Tokushima University ,  Hashimoto, Masakazu ,  Bex Co., Ltd.

Inventor： HASHIMOTO, Masakazu ,  TAKEMOTO, Tatsuya

IPC: C12N15/09 ,  A01K67/027 ,  C12N9/16

CPC classification number: A01K67/0275 ,  A01K67/027 ,  C12N9/16 ,  C12N15/09

Abstract: The disclosure relates to a method of introducing mRNA encoding Cas9 protein ( Cas9 mRNA) into a mammalian embryo, comprising the steps of;
(a) placing a mixture of the mammalian embryo and a solution comprising Cas9 mRNA in the gap between a pair of electrodes, and
(b) applying a voltage to the electrodes for a voltage application duration, wherein the voltage and the voltage application duration achieve the efficiency of mRNA introduction (R) higher than the minimum required efficiency of mRNA introduction (R min ) that is calculated on the basis of the concentration of Cas9 mRNA (ng/µl).

Abstract translation: 本公开涉及将编码Cas9蛋白的mRNA（Cas9 mRNA）导入哺乳动物胚胎的方法，包括以下步骤： （a）将哺乳动物胚胎和包含Cas9 mRNA的溶液的混合物置于一对电极之间的间隙中，以及（b）在电压施加持续时间内向电极施加电压，其中电压和电压施加持续时间实现 mRNA导入效率（R）高于基于Cas9 mRNA浓度（ng /μl）计算的mRNA导入最小所需效率（Rmin）。