公开(公告)号：US08839212B2

公开(公告)日：2014-09-16

申请号：US14042699

申请日：2013-09-30

Applicant: Texas Tech University System

Inventor： Daniel E. Cooke ,  J. Nelson Rushton ,  Brad Nemanich

IPC: G06F9/45 ,  G06F9/44

CPC classification number: G06F8/443 ,  G06F8/30 ,  G06F8/456

Abstract: A code generator and multi-core framework are executable in a computer system to implement methods as disclosed herein, including a method for the code generator to automatically generate multi-threaded source code from functional specifications, and for the multi-core framework, which is a run time component, to generate multi-threaded task object code from the multi-threaded source code and to execute the multi-threaded task object code on respective processor cores. The methods provide transparency to the programmer, and during execution, provide automatic identification of processing parallelisms. The methods implement Consume-Simplify-Produce and Normalize-Transpose-Distribute operations to reduce complex expression sets in a functional specification to simplified expression sets operable in parallel processing environments through the generated multi-threaded task object code. The result is a code generator which compiles transparent declarative code into multi-threaded code and that in the process identifies and assigns parallel processing paths to improve overall processing performance.

Abstract translation: 代码生成器和多核框架可在计算机系统中执行以实现本文所公开的方法，包括用于代码生成器从功能规范自动生成多线程源代码的方法，以及用于多核框架 运行时组件，用于从多线程源代码生成多线程任务对象代码，并在相应的处理器内核上执行多线程任务对象代码。 这些方法为程序员提供了透明度，并且在执行期间提供了处理并行性的自动识别。 该方法实现消费简化生产和规范化 - 转置 - 分发操作，以减少功能规范中的复杂表达式集，以通过生成的多线程任务对象代码在并行处理环境中可操作的简化表达式集。 结果是代码生成器，它将透明的声明性代码编译成多线程代码，并且在该过程中识别并分配并行处理路径以提高整体处理性能。

公开(公告)号：US20140109039A1

公开(公告)日：2014-04-17

申请号：US14042699

申请日：2013-09-30

Applicant: Texas Tech University System

Inventor： Daniel E. Cooke ,  J. Nelson Rushton ,  Brad Nemanich

IPC: G06F9/45 ,  G06F9/44

CPC classification number: G06F8/443 ,  G06F8/30 ,  G06F8/456

Abstract: A code generator and multi-core framework are executable in a computer system to implement methods as disclosed herein, including a method for the code generator to automatically generate multi-threaded source code from functional specifications, and for the multi-core framework, which is a run time component, to generate multi-threaded task object code from the multi-threaded source code and to execute the multi-threaded task object code on respective processor cores. The methods provide transparency to the programmer, and during execution, provide automatic identification of processing parallelisms. The methods implement Consume-Simplify-Produce and Normalize-Transpose-Distribute operations to reduce complex expression sets in a functional specification to simplified expression sets operable in parallel processing environments through the generated multi-threaded task object code. The result is a code generator which compiles transparent declarative code into multi-threaded code and that in the process identifies and assigns parallel processing paths to improve overall processing performance.

Abstract translation: 代码生成器和多核框架可在计算机系统中执行以实现本文所公开的方法，包括用于代码生成器从功能规范自动生成多线程源代码的方法，以及用于多核框架 运行时组件，用于从多线程源代码生成多线程任务对象代码，并在相应的处理器内核上执行多线程任务对象代码。 这些方法为程序员提供了透明度，并且在执行期间提供了处理并行性的自动识别。 该方法实现消费简化生产和规范化 - 转置 - 分发操作，以减少功能规范中的复杂表达式集，以通过生成的多线程任务对象代码在并行处理环境中可操作的简化表达式集。 结果是代码生成器，它将透明的声明性代码编译成多线程代码，并且在该过程中识别并分配并行处理路径以提高整体处理性能。

公开(公告)号：US20140105961A1

公开(公告)日：2014-04-17

申请号：US14053091

申请日：2013-10-14

Applicant: Texas Tech University System

Inventor： Harvinder S. Gill ,  Shashwati Atwe ,  Yunzhe Ma

IPC: A61K9/16 ,  A61K39/00

CPC classification number: A61K9/167 ,  A61K39/00 ,  A61K39/07 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55588 ,  C12N2740/16034

Abstract: The present invention includes compositions, methods of making and using the compositions for modulating the immune response in a subject by providing a vaccine composition having a pollen/spore disposed in a pharmaceutical carrier for delivery to a subject, wherein the pollen/spore comprises multiple pores that connect an outer surface of the pollen/spore to an inner cavity and one or more antigens disposed on the outer surface, in the inner cavity, in the multiple pores, or a combination thereof, wherein the one or more antigens modulate an immune responses in the subject.

Abstract translation: 本发明包括组合物，制备和使用该组合物以调节受试者的免疫应答的方法，其方法是提供一种疫苗组合物，该疫苗组合物具有置于药物载体中的用于递送至受试者的花粉/孢子，其中所述花粉/孢子包含多个孔 其将花粉/孢子的外表面连接到内腔和设置在外表面，内腔中，多孔中或其组合中的一种或多种抗原，其中所述一种或多种抗原调节免疫应答 在主题。

公开(公告)号：US20140048270A1

公开(公告)日：2014-02-20

申请号：US13970880

申请日：2013-08-20

Applicant: Texas Tech University System

Inventor： Mohamed Soliman ,  Mehdi Rafiee ,  Elias Pirayesh

IPC: E21B43/26

CPC classification number: E21B43/26

Abstract: The present invention provides a method of optimizing the placement of fractures along deviated wellbores by identifying at least two parallel lateral wellbores in a subterranean formation comprising at least a first wellbore and a second wellbore; introducing a first fracture and a second fracture in the first wellbore; introducing a third fracture in the second wellbore between the first fracture and the second fracture, wherein the third fracture extends to an intermediate area between the first two fractures and alters the stress field in that region; and forming one or more complex fractures extending from the first fracture, the second fracture, the third fracture or a combination thereof to form a complex fracture network.

Abstract translation: 本发明提供了一种通过在包括至少第一井孔和第二井眼的地下地层中识别至少两个平行的侧向井筒来优化沿着偏斜井眼的断裂位置的方法; 在第一井筒中引入第一断裂和第二断裂; 在所述第一裂缝和所述第二断裂之间在所述第二井眼中引入第三裂缝，其中所述第三裂缝延伸到所述前两个裂缝之间的中间区域并改变所述区域中的应力场; 并形成从第一断裂，第二断裂，第三断裂或其组合延伸的一个或多个复合断裂，以形成复合断裂网络。

公开(公告)号：US12286452B2

公开(公告)日：2025-04-29

申请号：US17119301

申请日：2020-12-11

Applicant: Texas Tech University System ,  Utah University

Inventor： Guillermo A. Altenberg ,  Cheng-Wei Tom Chang

IPC: C07H15/234

Abstract: The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4″, O-6″, or O-4″ and O-6″ positions having reduced antimicrobial activity for targeting Connexin Hemichannels.

公开(公告)号：US20250093491A1

公开(公告)日：2025-03-20

申请号：US18728142

申请日：2023-01-13

Applicant: Texas Tech University System

Inventor： Changzhi Li ,  Davi Valerio de Queiroz Rodrigues ,  Dongyang Tang

IPC: G01S13/62 ,  A61B5/0507

Abstract: A microwave passive sensor includes a microwave receiver, a low noise amplifier coupled to the microwave receiver, a mixer coupled to the low noise amplifier, and a baseband amplifier coupled to the mixer.

公开(公告)号：US20250034018A1

公开(公告)日：2025-01-30

申请号：US18909776

申请日：2024-10-08

Applicant: Texas Tech University System

Inventor： Gerardine G. BOTTE ,  Eshan ABBASI ,  Christian E. ALVAREZ-PUGLIESE

IPC: C02F11/00 ,  C02F103/20 ,  C02F103/32 ,  C05F3/00 ,  C05F7/00 ,  C05F9/00

Abstract: Methods and systems for pre-treatment of sludge and biosolids in preparation for electrochemical valorization is disclosed herein. Such methods can include selecting a sludge source; preparing a slurry, where the slurry comprises the sludge source and an electrolyte; adjusting a pH of the slurry, where the adjusting the pH of the slurry results in the slurry having an adjusted pH in a range between approximately 8 and 13; flowing the slurry through a first electrochemical cell, where the first electrochemical cell enables partial oxidation of the sludge via hydroxyl radicals; and flowing the partially oxidized slurry from the first electrochemical cell to a second electrochemical cell for selective conversion, where the second electrochemical cell includes an anode, a cathode, and a catalyst.

公开(公告)号：US20250011390A1

公开(公告)日：2025-01-09

申请号：US18712507

申请日：2022-12-02

Applicant: Texas Tech University System

Inventor： Roger B. Sutton ,  Matthew Hirsch

IPC: C07K14/74 ,  A61K38/00 ,  A61P27/02 ,  C12N15/86

Abstract: Provided herein is a fusion protein, expression vector, nucleic acid, or method of making and using a first HLA-G monomer and a second HLA-G monomer connected by a linker peptide expressed as a single chain, and optionally, comprising a providence virus globulin domain to prevent or reduce neovascularization.

公开(公告)号：US20240407712A1

公开(公告)日：2024-12-12

申请号：US18741371

申请日：2024-06-12

Applicant: Texas Tech University System

Inventor： James Yang ,  Ritwik Rakshit

IPC: A61B5/00 ,  A61B5/11 ,  G16H20/30 ,  G16H50/20

Abstract: Embodiments pertain to a computer-implemented method of predicting muscle fatigue in a subject by: (1) receiving data related to muscle fatigue in a muscle of the subject; (2) feeding the data into an algorithm to predict the muscle fatigue; and (3) outputting the predicted muscle fatigue. The algorithm my include: (a) an active compartment (M_A) model representing individual motor units (MUs) generating force at full capacity, (b) a resting compartment (M_R) model representing inactive MUs capable of rapid activation into force production, (c) a centrally fatigued compartment (M_FC) model representing fatigued MUs due to a central mechanism dominant at zero or near-zero joint velocities, with rapid recovery, and (d) a peripherally fatigued compartment (M_FP) model representing fatigued MUs due to a peripheral mechanism dominant at higher velocities, with slow recovery. Further embodiments pertain to a computing device for predicting muscle fatigue in a subject in accordance with such methods.

公开(公告)号：US12134962B2

公开(公告)日：2024-11-05

申请号：US18317621

申请日：2023-05-15

Applicant: Texas Tech University System

Inventor： James J. Sheng

IPC: E21B43/16 ,  E21B47/06

Abstract: Methods for optimization of liquid oil production by huff-n-puff in shale reservoirs to achieve an improved (and optimal) oil recovery factor. The process determines and utilizes the optimum huff and puff times, number of cycles and soaking time under practical operation and reservoir conditions. The huff time in the process is a period so long that the pressure near the wellbore reaches the set maximum injection pressure during the huff period. The puff time in the process is the time required for the pressure near the wellbore to reach the set minimum production pressure during the puff period. Soaking is typically not necessary during the huff-n-puff gas injection in shale oil reservoirs. The number of huff-n-puff cycles is determinable by the time in which the economic rate cut-off is reached.