公开(公告)号：WO2012058573A1

公开(公告)日：2012-05-03

申请号：PCT/US2011/058354

申请日：2011-10-28

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  KIM, Isaac, Yi ,  ERCOLANI, Matthew, C.

Inventor： KIM, Isaac, Yi ,  ERCOLANI, Matthew, C.

IPC: A61K31/497 ,  A61K47/00 ,  A01N25/00

CPC classification number: A61K9/0014 ,  A61K31/497 ,  A61K31/519 ,  A61K47/38

Abstract: Disclosed is a method for treating postradical prostatectomy erection dysfunction in a patient using a PDE-5 and/or PDE-60 inhibitor, wherein the PDE inhibitor is delivered at the incision site via an adhesion barrier.

Abstract translation: 公开了一种使用PDE-5和/或PDE-60抑制剂治疗患者的前列腺切除术勃起功能障碍的方法，其中PDE抑制剂通过粘附屏障在切口部位递送。

公开(公告)号：WO2011159926A1

公开(公告)日：2011-12-22

申请号：PCT/US2011/040744

申请日：2011-06-16

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LAVOIE, Edmond, J. ,  PARHI, Ajit, K. ,  PILCH, Daniel, S.

Inventor： LAVOIE, Edmond, J. ,  PARHI, Ajit, K. ,  PILCH, Daniel, S.

IPC: A01N43/42 ,  A61K31/47

CPC classification number: C07D217/14 ,  C07D217/16 ,  C07D217/22

Abstract: The invention provides a compound of formula I: or a salt or prodrug thereof, wherein R 1 , R 4 -R 8 , R 10 , R 2' -R 6' , W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

Abstract translation: 本发明提供式I化合物或其盐或前药，其中R1，R4-R8，R10，R2'-R6'，W和A具有说明书中描述的任何值，以及包含 该化合物可用作抗菌剂。

公开(公告)号：WO2011142901A1

公开(公告)日：2011-11-17

申请号：PCT/US2011/030893

申请日：2011-04-01

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  NAGELE, Robert, G.

Inventor： NAGELE, Robert, G.

IPC: G01N33/53

CPC classification number: G01N33/6854 ,  G01N33/564 ,  G01N33/6896 ,  G01N2800/2821

Abstract: The present invention provides methods, compositions and kits for the detection of Alzheimer's disease (AD) diagnostic biomarkers, for the diagnosis of AD, for the identification of a subject at risk for developing AD, and for the generation of patient-specific AD diagnostic biomarker profiles.

Abstract translation: 本发明提供用于检测阿尔茨海默病（AD）诊断生物标志物，用于诊断AD，用于鉴定处于发展中的AD风险中的受试者以及产生患者特异性AD诊断生物标志物的方法，组合物和试剂盒 配置文件。

公开(公告)号：WO2011063371A1

公开(公告)日：2011-05-26

申请号：PCT/US2010/057718

申请日：2010-11-23

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  MARKOWITZ, Kenneth

Inventor： MARKOWITZ, Kenneth

IPC: A61K6/00

CPC classification number: A61K6/0067 ,  A61K6/083 ,  A61K6/093 ,  C08L21/02 ,  C08L83/04

Abstract: The present invention is a dentinal drug delivery composition composed of cationic and/or neutral porous particles containing an effective amount of a therapeutic agent and a method for using the same to provide a dental treatment.

Abstract translation: 本发明是由含有有效量的治疗剂的阳离子和/或中性多孔颗粒构成的牙本质药物递送组合物，以及使用该组合物提供牙科治疗的方法。

公开(公告)号：WO2010120329A1

公开(公告)日：2010-10-21

申请号：PCT/US2009/064143

申请日：2009-11-12

Applicant: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  BANERJEE, Debabrata ,  MISHRA, Pravin J. ,  MISHRA, Prasun J. ,  GAO, Hui ,  GLOD, John

Inventor： BANERJEE, Debabrata ,  MISHRA, Pravin J. ,  MISHRA, Prasun J. ,  GAO, Hui ,  GLOD, John

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  C12N2533/90 ,  G01N33/5011

Abstract: Extracellular matrix bioscaffolds capable of supporting the formation and growth of tumors from tumor cells introduced thereto containing tumor associated macrophages and carcinoma-associated fibroblast-like cells cultured under conditions effective to provide a cellular matrix capable of supporting the formation and growth of tumors from tumor cells introduced to the matrix. Bioscaffold kits and methods for using the bioscaffolds for testing, identifying and development of known or novel anticancer therapeutics are also disclosed.

Abstract translation: 能够支持肿瘤细胞形成和生长的细胞外基质生物支架，所述生物支架能够在有效提供能够支持肿瘤细胞形成和生长的细胞基质的条件下培养的肿瘤相关巨噬细胞和癌相关成纤维细胞样细胞引入的肿瘤细胞 引入矩阵。 还公开了生物支架试剂盒和使用生物支架来测试，鉴定和开发已知或新型抗癌治疗剂的方法。

公开(公告)号：WO2010118340A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/030566

申请日：2010-04-09

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  GUO, Suqin

Inventor： GUO, Suqin

IPC: A61K38/00

CPC classification number: A61K31/138 ,  A61K31/433

Abstract: This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using a beta blocker along with a corticosteroid or an alpha adrenergic receptor agonist for the treatment of hemangiomas.

Abstract translation: 本发明涉及一种通过将β-阻滞剂直接应用于血管瘤来治疗血管瘤与β受体阻滞剂的方法。 本发明还涉及通过使用β受体阻滞剂以及皮质类固醇或α肾上腺素能受体激动剂治疗血管瘤的组合疗法。

公开(公告)号：WO2010102219A1

公开(公告)日：2010-09-10

申请号：PCT/US2010/026381

申请日：2010-03-05

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LAVOIE, Edmond, J. ,  FENG, Wei ,  LIU, Leroy, F.

Inventor： LAVOIE, Edmond, J. ,  FENG, Wei ,  LIU, Leroy, F.

IPC: C07D491/04 ,  A61K31/4355 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D491/04 ,  A61K31/4355

Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.

Abstract translation: 本发明提供了式I化合物：其中A，B，X和Y具有说明书中定义的任何值，以及包含这些化合物的药物组合物，制备这些化合物的方法，以及用于治疗癌症和其它的治疗方法 拓扑异构酶介导的条件。

公开(公告)号：WO2010083436A1

公开(公告)日：2010-07-22

申请号：PCT/US2010/021237

申请日：2010-01-15

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  PILCH, Daniel S. ,  LAVOIE, Edmond J. ,  KAUL, Malvika ,  PARHI, Ajit

Inventor： PILCH, Daniel S. ,  LAVOIE, Edmond J. ,  KAUL, Malvika ,  PARHI, Ajit

IPC: C07D221/12 ,  A61K31/473 ,  A61P31/04

CPC classification number: C07D221/12

Abstract: The present invention provides compounds of formula I: formula (I) wherein X 1 - X 4 and R 1 -R 12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.

Abstract translation: 本发明提供式I化合物：式（I）其中X 1 -X 4和R 1 -R 12具有说明书中定义的任何值，以及其盐和前药，其抑制与细菌细胞分裂相关的主要分子机制， 增殖，从而可用于治疗和/或预防细菌感染。 本发明还提供包含这些化合物的组合物以及使用这些化合物抑制细菌细胞分裂和增殖并治疗细菌感染的方法。

公开(公告)号：WO2010030671A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/056366

申请日：2009-09-09

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  YEDA RESEARCH & DEVELOPMENT CO. LTD. ,  LANGER, Jerome ,  SCHREIBER, Gideon

Inventor： LANGER, Jerome ,  SCHREIBER, Gideon

IPC: C07K14/52

CPC classification number: C07K14/555

Abstract: Disclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-1 such that the binding affinity of the interferon to the IFNAR-1 subunit is reduced as compared to the native interferon, and corresponding compositions and methods of treatment thereof.

Abstract translation: 在某些实施方案中公开的是制备1型干扰素拮抗剂的方法，包括在与干扰素受体亚基IFNAR-1相互作用的位点处修饰1型干扰素，使得干扰素与IFNAR-1亚基的结合亲和力降低为 与天然干扰素相比，以及相应的组合物和治疗方法。

公开(公告)号：WO2010022236A3

公开(公告)日：2010-02-25

申请号：PCT/US2009/054464

申请日：2009-08-20

Applicant: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  JIN, Shengkan

Inventor： JIN, Shengkan

IPC: A61K31/44

Abstract: The present invention relates to methods of mitigating, preventing or treating weight gain or obesity in patients by administering one or more autophagy inhibitors, thereby, preventing the differentiation process of pre-adipocyte cells into a mature adipocytes. Specifically, the present invention relates to the surprising discovery that autophagy is critical for the cellular remodeling required during pre-adipocyte differentiation into mature adipocyte. By targeting and inhibiting one or more mechanisms in autophagy, adipocyte maturation is also inhibited, thus, providing a novel a pathway to prevent, mitigate and/or treat weight gain, obesity and associated diseases, such as type II diabetes.