公开(公告)号：KR1020080036411A

公开(公告)日：2008-04-28

申请号：KR1020060102962

申请日：2006-10-23

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  김정기 ,  신현정 ,  이상준

IPC: A61K31/35 ,  A61P3/06

Abstract: A composition comprising gallocatechin gallate(GCG) is provided to increase expression of cholesterol 7alpha-hydroxylase and expression of a low density lipoprotein receptor(LDLR) and show better binding increase efficacy between a low density lipoprotein(LDL) and the LDLR than that of epigallocatechin gallate(EGCG), thereby showing excellent hyperlipidemia improving effect. A composition for improving hyperlipidemia comprises GCG as an effective ingredient, active ingredient, wherein the GCG is derived from green tea. A food or a pharmaceutical formulation comprises the composition for improving hyperlipidemia. Further, the composition for improving hyperlipidemia reduces a number of tyighlycerides in blood and increases a high density lipoprotein.

Abstract translation: 提供包含没食子儿茶素没食子酸酯（GCG）的组合物以增加胆固醇7α-羟化酶的表达和低密度脂蛋白受体（LDLR）的表达，并且在低密度脂蛋白（LDL）和LDLR之间显示出比表没食子儿茶素更好的结合增加功效 没食子酸酯（EGCG），从而显示优异的高脂血症改善作用。 用于改善高脂血症的组合物包括GCG作为有效成分，活性成分，其中GCG来自绿茶。 食品或药物制剂包含用于改善高脂血症的组合物。 此外，用于改善高脂血症的组合物可减少血液中的多种甘油三酸酯并增加高密度脂蛋白。

公开(公告)号：KR1020070095709A

公开(公告)日：2007-10-01

申请号：KR1020060026238

申请日：2006-03-22

Applicant: (주)아모레퍼시픽

Inventor： 신현정 ,  이종찬 ,  김정기 ,  이병곤 ,  장이섭

IPC: A61K8/49 ,  A61Q19/00

CPC classification number: A61K8/498 ,  A61K8/97 ,  A61K2800/782 ,  A61Q19/00

Abstract: A cosmetic composition is provided to inhibit the amount of sebum produced from sebocytes by inhibiting the formation and activity of SREBP-1(Sterol Regulatory Element Binding Protein-1), thereby capable of effectively improving sebum metabolism and acne. A cosmetic composition comprises 0.001-30 wt.% of at least one selected from the group consisting of catechin such as epigallocatechin gallate(EGCG), gallocatechin gallate(GCG) and a mixture thereof and flavonols such as quercetin, kaempferol and myricetin as effective ingredients and is characterized in that it inhibit the formation and activity of SREBP-1 which is a transcription factor.

Abstract translation: 提供化妆品组合物，通过抑制SREBP-1（甾醇调节元件结合蛋白-1）的形成和活性来抑制由皮脂细胞产生的皮脂的量，从而能够有效地改善皮脂代谢和痤疮。 化妆品组合物包含0.001-30重量％的选自儿茶素如表没食子儿茶素没食子酸酯（EGCG），没食子儿茶素没食子儿茶素（GCG）及其混合物中的至少一种，和黄酮醇如槲皮素，山奈酚和杨梅素作为有效成分 其特征在于它抑制作为转录因子的SREBP-1的形成和活性。

公开(公告)号：KR1020070091964A

公开(公告)日：2007-09-12

申请号：KR1020060021797

申请日：2006-03-08

Applicant: (주)아모레퍼시픽

Inventor： 김정기 ,  김수남 ,  신현정 ,  이병곤 ,  장이섭

IPC: A61K8/49 ,  A61Q19/08

Abstract: A skin external composition is provided to inhibit TNF-alpha(Tumor Necrosis Factor-alpha) and the expression of MMP-1 through activation of PPAR-alpha(Peroxisome Proliferator Activated Receptor-alpha), thereby inhibiting skin aging. A skin external composition comprises 0.001-10 wt.% of at least one kind selected from the group consisting of epigallocatechin(EGCG), gallocatechingallate(GCG), epicatechin gallate(ECG), catechin gallate(CG), catechin(C), gallic acid, quercetin, kaempferol, theobromine, theophylline, theanine, quinic acid, an ethanol extract of green tea leaves, an aqueous extract of green tea leaves, an extract of catechin 1 including 70% of catechin and an extract of catechin 2 including 50% of EGCG as an effective ingredient.

Abstract translation: 提供皮肤外用组合物以通过激活PPAR-α（过氧化物酶体增殖剂活化受体-α）抑制TNF-α（肿瘤坏死因子-α）和MMP-1的表达，从而抑制皮肤老化。 皮肤外用组合物包含0.001-10重量％的选自下组的至少一种：表没食子儿茶素（EGCG），gallocatechingallate（GCG），表儿茶素没食子酸酯（ECG），儿茶素没食子酸酯（CG），儿茶素（C） 酸，槲皮素，山奈酚，可可碱，茶碱，茶氨酸，奎尼酸，绿茶叶的乙醇提取物，绿茶叶的水提物，儿茶素1的提取物，其中儿茶素含量为70％，儿茶素2提取物含50％ 的EGCG作为有效成分。

公开(公告)号：KR1020070028901A

公开(公告)日：2007-03-13

申请号：KR1020050083665

申请日：2005-09-08

Applicant: (주)아모레퍼시픽

Inventor： 신현정 ,  김수남 ,  김정기 ,  이병곤 ,  장이섭

IPC: A61K8/49 ,  A61Q19/08

Abstract: A skin external composition comprising optimal concentration of catechins and theanine is provided to increase biosynthesis of collagen in the inner skin, restore elasticity of the skin, and improve wrinkles in the skin by containing low concentration of catechins and theanine at a fixed ingredient rate. The skin external composition for promoting biosynthesis of collagen and improving skin aging and elasticity comprises 0.0004-0.025 wt.% of catechins and 0.008-2.5 wt.% of theanine based on the total weight of the composition, wherein the weight ratio of catechins to theanine is 1:20 to 1:100, and the catechin is EGCG(epigallocatechin gallate), GCG(gallocatechin gallate), ECG(epicatechin gallate) or CG(catechin gallate).

Abstract translation: 提供包含最佳浓度的儿茶素和茶氨酸的皮肤外用组合物以增加内皮中胶原的生物合成，恢复皮肤的弹性，并通过以固定的成分速率含有低浓度的儿茶素和茶氨酸来改善皮肤的皱纹。 用于促进胶原蛋白的生物合成和改善皮肤老化和弹性的皮肤外用组合物包含基于组合物总重量的0.0004-0.025重量％的儿茶素和0.008-2.5重量％的茶氨酸，其中儿茶素与茶氨酸的重量比 是1:20至1:100，儿茶素是EGCG（表没食子儿茶素没食子酸酯），GCG（没食子儿茶素没食子酸酯），ECG（表儿茶素没食子酸酯）或CG（儿茶素没食子酸酯）。

公开(公告)号：KR1020040058851A

公开(公告)日：2004-07-05

申请号：KR1020020085364

申请日：2002-12-27

Applicant: (주)아모레퍼시픽

Inventor： 신현정 ,  황재성 ,  최현정 ,  이병곤

IPC: A61K36/78 ,  A61P25/00 ,  A61P25/28

Abstract: PURPOSE: Provided is a composition for inhibiting phagocytosis containing Saururus Chinesis(Lour) Bail extract that effectively inhibits the phagocytosis of the keratinocyte activated by exposure to ultraviolet rays. Further, provided is a pharmaceutical composition which prevents and treats various kinds of diseases associated with phagocytosis. CONSTITUTION: A phagocytosis inhibiting composition is characterized by containing, as an active ingredient, Saururus Chinesis(Lour) Bail extract in the amount of 0.0001-10 wt.%. It is used for prevention and treatment of phagocytosis related diseases.

Abstract translation: 目的：提供一种用于抑制吞噬作用的组合物，其含有SaururusChinesis（Lour）保释提取物，其有效抑制通过暴露于紫外线而活化的角质形成细胞的吞噬作用。 此外，提供了防止和治疗与吞噬作用相关的各种疾病的药物组合物。 构成：吞噬抑制组合物的特征在于以0.0001-10重量％的量含有SaururusChinesis（Lour）保释提取物作为活性成分。 用于预防和治疗吞噬相关疾病。