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    수분 증발 방지막이 함유된 아토피 피부염 치료용 수화겔
    91.
    发明授权
    수분 증발 방지막이 함유된 아토피 피부염 치료용 수화겔 有权
    含有覆盖层的地理位置用于防止水损失的治疗水压

    公开(公告)号：KR100808552B1

    公开(公告)日：2008-02-29

    申请号：KR1020070010605

    申请日：2007-02-01

    Applicant: 한국원자력연구원

    Inventor： 노영창 ,  임윤묵 ,  안성준 ,  김윤혜

    IPC: A61K31/765 ,  A61K31/045 ,  A61K36/78 ,  A61P29/00

    Abstract: A hydrogel for treating atopic dermatitis is provided to be easy for preparation, inhibit the moisture evaporation by laminating a hydrophilic non-woven fabric and an air-permeable polyethylene film, continuously deliver a drug, show excellent gel strength, prevent the infection of bacteria, and have the satisfactory storage property and sterilizing effect by irradiation of radioactive rays without the remaining toxicity caused by a crosslinking agent, thereby being effectively used for treating contagious dermatitis or atopic dermatitis. A hydrogel for treating atopic dermatitis comprises: at least one biocompatible polymer selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, and carrageenan; glycerin as a polyhydric alcohol; an extract of at least one medicinal herb selected from the group consisting of Houttuynia cordata, Ulmus davidiana var. japonica, persimmon leaves, Chelidonium majus var. asiaticum, pine needles, Canavalia gladiata and herb; and a moisture evaporation preventing film which is a laminated produce of a hydrophilic non-woven fabric and an air-permeable polyethylene film. A method for preparing the hydrogel comprises the steps of: (a) dissolving the biocompatible polymer and the polyhydric alcohol in the extract of the medicinal herb to prepare an aqueous solution; (b) coating the aqueous solution on the moisture evaporation preventing film and casting it to mold a pre-hydrogel; (c) packing the pre-hydrogel; and (d) applying radioactive rays to the packed gel to sterilize it. Further, the hydrogel for treating atopic dermatitis contains the 1-50 wt.% of biocompatible polymer, the 1-20 wt.% of polyhydric alcohol and the 1-30 wt.% of extract.

    Abstract translation: 提供用于治疗特应性皮炎的水凝胶易于制备，通过层压亲水性无纺布和透气性聚乙烯膜来抑制水分蒸发，连续输送药物，显示出优异的凝胶强度，防止细菌感染， 并且通过放射线射线具有令人满意的保存性和消毒效果，而不会由交联剂引起残留的毒性，从而有效地用于治疗传染性皮炎或特应性皮炎。 用于治疗特应性皮炎的水凝胶包括：至少一种选自聚乙烯醇，聚乙烯吡咯烷酮和角叉菜胶的生物相容性聚合物; 甘油为多元醇; 至少一种药草的提取物，其选自鱼腥草，榆树， 粳稻，柿子叶，onium onium us。 积雪草，松针，卡纳瓦维亚gladiata和草本; 以及作为亲水性无纺布和透气性聚乙烯膜的叠层体的水分蒸发防止膜。 制备水凝胶的方法包括以下步骤：（a）将生物相容性聚合物和多元醇溶解在药草提取物中以制备水溶液; （b）将水溶液涂覆在水分蒸发防止膜上并浇铸以模制预水凝胶; （c）包装预水凝胶; 和（d）向放置的凝胶施加放射线以使其消毒。 此外，用于治疗特应性皮炎的水凝胶含有1-50重量％的生物相容性聚合物，1-20重量％的多元醇和1-30重量％的提取物。

    헤파린이 도입된 고분자 재료의 제조방법 및 이를 이용하여 제조된 고분자 재료
    96.
    发明授权
    헤파린이 도입된 고분자 재료의 제조방법 및 이를 이용하여 제조된 고분자 재료 有权

    公开(公告)号：KR101891688B1

    公开(公告)日：2018-08-24

    申请号：KR1020170001541

    申请日：2017-01-04

    Applicant: 한국원자력연구원

    Inventor： 임윤묵 ,  정성린 ,  박종석 ,  권희정 ,  안성준

    IPC: C08J7/18 ,  A61L33/00 ,  A61L33/06

    Abstract: 본발명은헤파린이도입된고분자재료의제조방법및 이를이용하여제조된고분자재료에관한것으로, 보다상세하게는고분자재료를아크릴계단량체가용해된용액에담지하는단계, 방사선을조사하여아크릴계단량체를고분자재료에이합체이상의아크릴계중합체형태로그라프팅하는단계, 및상기그라프팅하는단계와동시에또는후속적으로헤파린을도입하는단계를포함하는, 헤파린이도입된고분자재료의제조방법; 및이와같은방법에의해제조되어헤파린이결합된이합체이상의아크릴계중합체가고분자재료에그라프팅된, 헤파린이도입된고분자재료에관한것이다.

    소수성 단량체가 그래프트된 폴리우레탄의 제조방법
    97.
    发明授权
    소수성 단량체가 그래프트된 폴리우레탄의 제조방법 有权

    公开(公告)号：KR101837583B1

    公开(公告)日：2018-03-13

    申请号：KR1020160025487

    申请日：2016-03-03

    Applicant: 한국원자력연구원

    Inventor： 박종석 ,  임윤묵 ,  정진오 ,  정성린 ,  안성준

    IPC: C08F283/00 ,  C08F2/46

    Abstract: 본발명은소수성단량체가그래프트된폴리우레탄의제조방법에관한것으로, 보다상세하게는폴리우레탄을유기용매에용해시키는단계, 폴리우레탄이용해된유기용매에소수성단량체를추가하고혼합하여혼합물을획득하는단계및 상기혼합물에방사선을조사하는단계를포함하는소수성단량체가그래프트된폴리우레탄의제조방법; 및이러한방법에의해소수성단량체가그래프트된폴리우레탄에관한것이다.

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