公开(公告)号：ZA982467B

公开(公告)日：1999-09-27

申请号：ZA982467

申请日：1998-03-24

Applicant: BASF AG

Inventor： LERCHL JENS ,  MOELLER ACHIM ,  SCHMIDT RALF-MICHAEL ,  SCHIFFER HELMUT ,  RABE UDO ,  CONRAD UDO

IPC: A01H5/00 ,  C07K16/44 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/13 ,  C12N15/82 ,  G06Q50/20 ,  A01H ,  C12N ,  A01N

Abstract: Process for production of herbicide-tolerant plants by expressing an exogenous herbicide-binding polypeptide in plants or plant organs. The invention furthermore relates to the use of the corresponding nucleic acids which encode a polypeptide, an antibody or parts of an antibody with herbicide-binding properties in transgenic plants, and the thus transformed plant itself.

公开(公告)号：ZA9802467B

公开(公告)日：1999-09-27

申请号：ZA9802467

申请日：1998-03-24

Applicant: BASF AG

Inventor： LERCHL JENS ,  MOELLER ACHIM ,  SCHMIDT RALF-MICHAEL ,  SCHIFFER HELMUT ,  RABE UDO ,  CONRAD UDO

IPC: A01H5/00 ,  C07K16/44 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/13 ,  C12N15/82 ,  A01H ,  A01N ,  C12N

CPC classification number: C07K16/44 ,  C07K2319/00 ,  C12N15/8209 ,  C12N15/8258 ,  C12N15/8274

公开(公告)号：TR199900819T2

公开(公告)日：1999-06-21

申请号：TR9900819

申请日：1997-09-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOELLER ACHIM ,  DELZER JUERGEN

IPC: A61K31/445 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/5355 ,  A61P9/10 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D211/62 ,  C07D213/40 ,  C07D295/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14

Abstract: Piperidineketocarboxylic acid derivatives of the general formula Iand their tautomeric and isomeric forms, and physiologically tolerable salts thereof, where the variables have the meanings given in the description, preparation of these compounds and their use as drugs.

公开(公告)号：NO992770D0

公开(公告)日：1999-06-08

申请号：NO992770

申请日：1999-06-08

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOELLER ACHIM ,  TREIBER HANS-JOERG

IPC: A61K31/403 ,  A61K31/4035 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D209/48 ,  C07D209/66 ,  C07D239/70 ,  C07D239/96 ,  C07D401/12 ,  C07D471/04 ,  C07D475/02 ,  A61K31/40

Abstract: Heterocyclically substituted benzamides of the formula Iare described, where R1, R2, R3, R4, R5, X, m and n have the meanings given in the description. The novel compounds are useful for controlling diseases.

公开(公告)号：BG62229B2

公开(公告)日：1999-05-31

申请号：BG9860294

申请日：1994-02-28

Applicant: BASF AG

Inventor： MOELLER ACHIM ,  EMLING FRANZ

IPC: G01N33/53 ,  A61K39/395 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07H21/04 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C07K14/525 ,  C07K16/00 ,  C07K16/24 ,  C12N5/10 ,  C12N5/20 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

Abstract: The invention relates to hybridome cellular line synthetizinghighly specific monoclonal antibodies (mAK) against tumournecrotic factor (TNF), to monoclonal antibodies, to a method forproducing the hybridome cellular line and the antibodies, as wellas to their application.5 claims

公开(公告)号：ZA9710569B

公开(公告)日：1999-05-25

申请号：ZA9710569

申请日：1997-11-25

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MOELLER ACHIM ,  TREIBER HANS-JOERG

IPC: A61K31/16 ,  A61K31/166 ,  A61K31/18 ,  A61K31/4045 ,  A61K31/435 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/47 ,  A61P9/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P27/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C233/76 ,  C07C235/42 ,  C07C235/46 ,  C07C235/58 ,  C07C235/60 ,  C07C235/84 ,  C07C237/42 ,  C07C311/08 ,  C07C311/21 ,  C07C317/44 ,  C07C323/42 ,  C07C323/60 ,  C07D209/14 ,  C07D209/16 ,  C07D213/30 ,  C07D213/56 ,  C07D213/71 ,  C07D213/82 ,  C07D215/36 ,  C07C ,  C07D ,  C12N

Abstract: Compounds of the formulawhere R1, R2, R3, X and n are as defined in the description, are inhibitors of cysteine protease.

公开(公告)号：CA2288432A1

公开(公告)日：1998-11-05

申请号：CA2288432

申请日：1998-04-16

Applicant: BASF AG

Inventor： LORENZ GISELA ,  AMMERMANN EBERHARD ,  BUTTERFIELD EARLE ,  LERCHL JENS ,  MOELLER ACHIM ,  CONRAD UDO ,  SCHMIDT RALF-MICHAEL ,  RABE UDO

IPC: A01H5/00 ,  C07K14/00 ,  C07K16/44 ,  C12N15/09 ,  C12N15/13 ,  C12N15/82 ,  C12P21/02 ,  A01N63/00

Abstract: The invention relates to a method for producing fungicide-tolerant plants by expressing a fungicide-binding antibody therein.

公开(公告)号：CA1337717C

公开(公告)日：1995-12-12

申请号：CA546724

申请日：1987-09-11

Applicant: BASF AG

Inventor： MOELLER ACHIM ,  EMLING FRANZ

IPC: G01N33/53 ,  A61K39/395 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07H21/04 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C07K14/525 ,  C07K16/00 ,  C07K16/24 ,  C12N5/10 ,  C12N5/20 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  C12N5/18 ,  G01N33/566

Abstract: The invention relates to hybridoma cell lines which synthesize highly specific monoclonal antibodies (mAb) against human tumor necrosis factor (H-TNF), to monoclonal antibodies against H-TNF having an affinity constant for H-TNF greater than 109 l/mol, which does not cross react with lymphotoxin and neutralizing the cytotoxic activities of H-TNF, to methods isolating and detecting H-TNF in samples using said antibodies, and to pharmaceutical compositions which contain them. The present invention also relates to the hybrid cell line ECACC 87 050801 and to the monoclonal antibody AM-195 produced by this hybrid cell line. The present invention also relates to methods for isolating and detecting human tumor necrosis factor-alpha using the AM-195 antibody. The present invention further relates to pharmaceutical compositions which contain the monoclonal antibody AM-195.

公开(公告)号：FI91421B

公开(公告)日：1994-03-15

申请号：FI873948

申请日：1987-09-11

Applicant: BASF AG

Inventor： MOELLER ACHIM ,  EMLING FRANZ

IPC: G01N33/53 ,  A61K39/395 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07H21/04 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C07K14/525 ,  C07K16/00 ,  C07K16/24 ,  C12N5/10 ,  C12N5/20 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  C12N5/00 ,  C07K15/04

Abstract: The monoclonal antibodies are directed highly specifically against human tumour necrosis factor and are synthesised by hybridoma cell lines prepared as described. … …

公开(公告)号：AU608677B2

公开(公告)日：1991-04-11

申请号：AU2749288

申请日：1988-12-23

Applicant: BASF AG

Inventor： HERR DIETER ,  DOERPER THOMAS ,  DAUM LOTHAR ,  GEISS KARL-HEINZ ,  MOELLER ACHIM

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725