公开(公告)号：US20090217418A1

公开(公告)日：2009-08-27

申请号：US12390485

申请日：2009-02-22

Applicant: John Howard ,  Erin Engelkrout

Inventor： John Howard ,  Erin Engelkrout

IPC: C12N15/82 ,  A01H5/00 ,  C07H21/04 ,  C12N5/10

CPC classification number: C12N15/8234 ,  C07K14/36 ,  C07K14/465 ,  C12N15/8267

Abstract: A method of controlling germination of seed is provided in which a nucleic acid encoding a protein which causes inhibition of germination is transformed into a plant, operably linked with a promoter that expresses during germination. The protein is one in which a restoring substance can be applied to the seed and restores germination. Also provided is an amylase germination preferred promoter.

Abstract translation: 提供了一种控制种子发芽的方法，其中将编码引起抑制发芽的蛋白质的核酸转化到植物中，与在发芽过程中表达的启动子可操作地连接。 该蛋白质可以将恢复物质应用于种子并恢复萌发。 还提供了淀粉酶发芽优选的启动子。

公开(公告)号：US07541515B2

公开(公告)日：2009-06-02

申请号：US10252732

申请日：2002-09-23

Applicant: Elizabeth Hood ,  John Howard ,  Donna Delaney

Inventor： Elizabeth Hood ,  John Howard ,  Donna Delaney

IPC: C12N15/82

CPC classification number: C12N15/8216 ,  C12N15/8257

Abstract: Increased expression of heterologous proteins in a plant is achieved by introducing the nucleotide sequence encoding the heterologous protein into a plant that has high oil seed content compared to low oil seed and/or is introduced into a plant having reduced alcohol soluble proteins in the endosperm. The nucleotide sequence may be introduced by direct transformation into the plant, or by direct transformation into another plant, and crossing with the high oil plant or plant have reduced levels of alcohol soluble protein in the endosperm. Further, the nucleotide sequences may be introduced into one or both of the high oil plant and the plant having reduced levels of alcohol soluble proteins, and the plants may be crossed to result in a progeny having even further increased expression levels of the heterologous protein.

Abstract translation: 通过将编码异源蛋白质的核苷酸序列引入与低油种子相比具有高油种子含量的植物和/或被引入具有在胚乳中具有降低的可溶性蛋白质的植物中来实现植物中异源蛋白质的表达增加。 核苷酸序列可以通过直接转化到植物中，或通过直接转化到另一种植物中，并与高油植物或植物杂交在胚乳中具有降低的可溶性蛋白质水平。 此外，可以将核苷酸序列引入高油植物和具有降低的可溶性蛋白质水平的植物中的一个或两个中，并且可以使植物杂交以产生具有甚至进一步增加异源蛋白质表达水平的后代。

公开(公告)号：US07490255B2

公开(公告)日：2009-02-10

申请号：US11428266

申请日：2006-06-30

Applicant: Paul Diefenbaugh ,  John Howard

Inventor： Paul Diefenbaugh ,  John Howard

IPC: G06F1/32 ,  G06F13/00

CPC classification number: G06F13/385 ,  G06F2213/0042 ,  Y02D10/14 ,  Y02D10/151

Abstract: Embodiments comprising a memory and a USB host controller coupled to the memory. The power efficiency of a USB during asynchronous transfers is increased by limiting usage of an asynchronous schedule stored in the memory when servicing a scheduled asynchronous transfer endpoint. Other embodiments may be described and claimed.

Abstract translation: 包括存储器和耦合到存储器的USB主机控制器的实施例。 在维护调度的异步传输端点时，通过限制存储在存储器中的异步调度的使用来增加异步传输期间USB的功率效率。 可以描述和要求保护其他实施例。

公开(公告)号：US07291497B2

公开(公告)日：2007-11-06

申请号：US10937872

申请日：2004-09-10

Applicant: Elizabeth A. Holmes ,  Shaunak Roy ,  John Howard ,  Chengwang Wang

Inventor： Elizabeth A. Holmes ,  Shaunak Roy ,  John Howard ,  Chengwang Wang

IPC: A61M31/00 ,  A61M25/00 ,  A61M5/32 ,  A61M5/00 ,  C12Q1/00 ,  G01N33/53 ,  G01N15/06 ,  C12M1/34 ,  A61F13/00

CPC classification number: A61B5/073 ,  A61B5/0024 ,  A61B5/0031 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150251 ,  A61B5/150282 ,  A61B5/150343 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/157 ,  A61B5/417 ,  A61B5/4238 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/6865 ,  A61B5/7282 ,  A61B2560/0412 ,  A61M5/14276 ,  A61M37/0015 ,  A61M2005/14513 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2205/0244 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0472 ,  B01L2400/0487 ,  G01N2035/00158

Abstract: The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

Abstract translation: 本发明涉及一种可摄入的，可植入的或可穿戴的医疗装置，其包括微阵列，其包含能够与疾病标记生物分析物相互作用的生物活性剂; 储存器，其包含至少一种治疗剂并能够从所述医疗装置释放所述治疗剂; 以及多个微芯片，其包括微阵列扫描装置，其能够获得疾病标记生物分析物与生物活性剂之间的相互作用的物理参数数据; 能够将物理参数数据与分析物相互作用分布进行比较的生物识别装置; 任选的能够控制治疗剂从储存器释放的治疗剂释放装置; 能够促进微阵列扫描装置，生物识别装置和治疗剂释放装置之间的通信的接口装置; 以及为医疗装置供电的能量源。 具体地说，本发明涉及一种能够检测体液中分析物的医疗装置，其包含能够获得体液样品的至少一个微针，所述样品流过的第一微通道至少与所述至少一个微流体连通 一个微针，与第一微通道流体连通的第二微通道，缓冲液流过其中，其中第二通道包含具有生物活性剂的微阵列，微阵列扫描装置，用于检测身体中生物活性剂和分析物之间的相互作用 流体; 和接口设备。

公开(公告)号：US07276051B1

公开(公告)日：2007-10-02

申请号：US09743737

申请日：1999-08-06

Applicant: Alan Wayne Henley ,  Leigh Marie Moses ,  Ronald Leslie Sanderson ,  John Howard ,  James H. Price ,  Russell W. Bessette

Inventor： Alan Wayne Henley ,  Leigh Marie Moses ,  Ronald Leslie Sanderson ,  John Howard ,  James H. Price ,  Russell W. Bessette

IPC: A61F13/00

CPC classification number: A61M1/0031 ,  A61F2013/0017 ,  A61M1/0025 ,  A61M1/0027 ,  A61M1/0058 ,  A61M1/0088 ,  A61M3/0229 ,  A61M35/00 ,  A61M2205/07 ,  A61M2205/15 ,  A61M2205/3344 ,  A61M2205/3653 ,  A61M2205/366 ,  A61M2205/368

Abstract: A wound treatment apparatus for treatment of surface wounds with a bandage system configured to control the environment adjacent the wound. The apparatus includes a bandage configured to cover a wound and provide a seal about the perimeter of the wound and cavity over the wound. A fluid supply conduit and a fluid drainage conduit are each in communication with the cavity. A nebulizer is coupled to the supply conduit to supply medicinal fluid to the wound. A waste receptacle is coupled to the drainage conduit to remove the fluid away from the wound.

Abstract translation: 一种用于用绷带系统治疗表面​​伤口的伤口治疗装置，其构造成控制伤口附近的环境。 该装置包括构造成覆盖伤口并且围绕伤口周围的伤口和空腔周围提供密封的绷带。 流体供应管道和流体排放导管各自与空腔连通。 喷雾器联接到供应管道以将药液供应到伤口。 废物容器连接到排水管道以除去离开伤口的流体。

公开(公告)号：US20060151665A1

公开(公告)日：2006-07-13

申请号：US10528213

申请日：2002-09-17

Applicant: John Howard ,  Stephen Mildenstein

Inventor： John Howard ,  Stephen Mildenstein

IPC: B64C27/22

CPC classification number: B64D27/26 ,  B64C27/14 ,  B64C27/28 ,  B64C29/0033 ,  B64D27/12 ,  B64D2027/266 ,  B64F5/60 ,  F02C7/20 ,  F02C7/36 ,  Y02T50/44 ,  Y02T50/671

Abstract: A torsionally de-coupled engine mount system (13) for use in tilt rotor aircraft (11) applications is disclosed, in which an engine is mounted at its forward end to a prop rotor gear box by means of a forward mount (303) that is a simple adapter fitting, and at its aft end to a pylon assembly by an aft mount (305) that is a simple bi-pod fitting. The forward mount (303) counteracts forces and moments in six degrees of freedom, but the aft mount (305) only counteracts lateral and vertical loads. The contribution from the engine to the overall dynamic response of the aircraft is tuned by selectively tailoring the size, shape, weight, and material of the forward mount (303). The engine mount system torsionally de-couples the engines from the prop rotors, thereby preventing rotor torque from being induced into the engines. In addition, the contribution from the engines to the overall dynamic response of the aircraft can be tuned by selectively tailoring the size, shape, weight, and material of the forward mounts between the engines and the transmissions.

Abstract translation: 公开了一种用于倾斜转子飞机（11）应用中的扭转解耦发动机安装系统（13），其中发动机借助于前部安装件（303）在其前端安装到支柱转子齿轮箱， 是一个简单的适配器配件，并在其后端通过一个简单的双荚配件的尾座（305）连接到一个塔架组件。 前支架（303）在六自由度上抵抗力和力矩，但是后部安装座（305）仅抵消横向和垂直载荷。 通过选择性地调整前悬架（303）的尺寸，形状，重量和材料来调节从发动机到飞行器整体动态响应的贡献。 发动机安装系统使发动机与支承转子扭转地解耦，从而防止转子扭矩被引入发动机。 此外，可以通过选择性地调整发动机和变速器之间的前悬架的尺寸，形状，重量和材料来调节来自发动机对飞行器的整体动态响应的贡献。

公开(公告)号：US20050177529A1

公开(公告)日：2005-08-11

申请号：US11055359

申请日：2005-02-09

Applicant: John Howard ,  Dan Scott

Inventor： John Howard ,  Dan Scott

IPC: G06F15/18 ,  G09G5/00

CPC classification number: G06Q40/08 ,  G06T17/05

Abstract: The invention teaches evaluating geographical information, typically from at least two sources, and defining the nature of the information so that it can be applied to a risk management system. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract translation: 本发明教导通常从至少两个来源评估地理信息，并且定义信息的性质，使得其可以应用于风险管理系统。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

公开(公告)号：US06363235B1

公开(公告)日：2002-03-26

申请号：US09773070

申请日：2001-01-31

Applicant: Daniel A. Chiesa ,  Thomas W. Claessens ,  Karl E. Kurz ,  John Howard

Inventor： Daniel A. Chiesa ,  Thomas W. Claessens ,  Karl E. Kurz ,  John Howard

IPC: G03G1508

CPC classification number: G03G15/087 ,  G03G2215/0678

Abstract: A toner-dispensing container assembly for attachment to a toner compartment cover device on an electrographic printing machine to supply toner composition to the toner receiving compartment while avoiding detachment and spillage. The toner-dispensing container assembly is fastenable over the toner compartment cover device and rotatable to a first position to open the cover to the toner compartment while the toner-dispensing container remains sealed. Further rotation of the toner dispensing container opens it to the toner-receiving compartment to dispense toner thereinto.

Abstract translation: 一种调色剂分配容器组件，用于连接到电印机上的调色剂室盖装置，以将调色剂组合物供应到调色剂容纳室，同时避免分离和溢出。 调色剂分配容器组件可紧固在调色剂室盖装置上并且可旋转到第一位置以在调色剂分配容器保持密封的同时将盖打开到调色剂室。 调色剂分配容器的进一步旋转将其打开到调色剂容纳室以分配调色剂。

公开(公告)号：US06297426B1

公开(公告)日：2001-10-02

申请号：US09059958

申请日：1998-04-14

Applicant: Marc C. Albertsen ,  Larry R. Beach ,  Gary A. Huffman ,  John Howard

Inventor： Marc C. Albertsen ,  Larry R. Beach ,  Gary A. Huffman ,  John Howard

IPC: A01H500

CPC classification number: C12N15/8289 ,  C07K14/415

Abstract: A controllably constitutively female sterile plant is provided. A gene critical to female fertility is identified and the native gene inactivated. The gene is cloned, linked to an inducible promoter and inserted into the plant. The result is a plant that is constitutively female sterile with inducible female fertility.

Abstract translation: 提供了可控的组成型雌性不育植物。 鉴定出对雌性生殖力至关重要的基因，天然基因失活。 将该基因克隆，连接到诱导型启动子并插入植物中。 结果是一种具有诱导性雌性生殖力的组成型雌性不育的植物。

公开(公告)号：US06265640B1

公开(公告)日：2001-07-24

申请号：US09211416

申请日：1998-12-10

Applicant: Marc C. Albertsen ,  Larry R. Beach ,  John Howard ,  Gary A. Huffman

Inventor： Marc C. Albertsen ,  Larry R. Beach ,  John Howard ,  Gary A. Huffman

IPC: A01H500

CPC classification number: A01H1/02 ,  C07K14/415 ,  C12N5/04 ,  C12N9/0004 ,  C12N15/82 ,  C12N15/8289 ,  Y10S47/01

Abstract: Fertility in a plant is controlled by inactivating a gene critical to fertility, and inserting into the plant the criticial gene linked to an inducible promoter.

Abstract translation: 通过灭活对生殖力至关重要的基因并将与诱导型启动子连接的突变基因插入植物来控制植物中的生育力。