公开(公告)号：AU4677097A

公开(公告)日：1998-02-12

申请号：AU4677097

申请日：1997-11-28

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M ,  YOUNG JAMES W

IPC: C07D211/62 ,  A61K31/445 ,  A61K31/4468 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P1/14

公开(公告)号：NZ257993A

公开(公告)日：1997-05-26

申请号：NZ25799393

申请日：1993-11-02

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: C07D405/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/496 ,  A61K31/505 ,  A61K31/517 ,  A61P9/10 ,  A61P13/08 ,  A61P35/00 ,  C07D237/10

Abstract: Methods are disclosed utilizing the optically pure (+) isomer of doxazosin. This compound is a potent drug for the treatment of benign prostatic hyperplasia while avoiding the concomitant liability of hypotensive effects associated with the racemic mixture of doxazosin.

公开(公告)号：AU7182296A

公开(公告)日：1997-01-30

申请号：AU7182296

申请日：1996-11-19

Applicant: SEPRACOR INC

Inventor： YOUNG JAMES W ,  WOOSLEY RAYMOND L ,  GRAY NANCY M ,  CHEN YIWANG

IPC: C07D211/22 ,  A61K9/48 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：GB2284351B

公开(公告)日：1996-11-27

申请号：GB9502183

申请日：1993-08-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  WOOSLEY RAYMOND L ,  GRAY NANCY M ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：HUT73678A

公开(公告)日：1996-09-30

申请号：HU9501286

申请日：1993-11-02

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: C07D405/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/496 ,  A61K31/505 ,  A61K31/517 ,  A61P9/10 ,  A61P13/08 ,  A61P35/00 ,  C07D237/10

Abstract: Methods are disclosed utilizing the optically pure (+) isomer of doxazosin. This compound is a potent drug for the treatment of benign prostatic hyperplasia while avoiding the concomitant liability of hypotensive effects associated with the racemic mixture of doxazosin.

公开(公告)号：GR960300024T1

公开(公告)日：1996-05-31

申请号：GR960300024

申请日：1996-05-31

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.

公开(公告)号：AU2644295A

公开(公告)日：1995-12-18

申请号：AU2644295

申请日：1995-05-22

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: C07D403/06 ,  A61K31/415 ,  A61K31/4184 ,  A61P35/00 ,  A61P35/02

公开(公告)号：HU9501286D0

公开(公告)日：1995-06-28

申请号：HU9501286

申请日：1993-11-02

Applicant: SEPRACOR INC

Inventor： GRAY NANCY M

IPC: C07D405/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/496 ,  A61K31/505 ,  A61K31/517 ,  A61P9/10 ,  A61P13/08 ,  A61P35/00 ,  C07D237/10

Abstract: Methods are disclosed utilizing the optically pure (+) isomer of doxazosin. This compound is a potent drug for the treatment of benign prostatic hyperplasia while avoiding the concomitant liability of hypotensive effects associated with the racemic mixture of doxazosin.

公开(公告)号：GB2284351A

公开(公告)日：1995-06-07

申请号：GB9502183

申请日：1993-08-03

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  WOOSLEY RAYMOND L ,  GRAY NANCY M ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00

Abstract: A pharmaceutical composition comprising a compound of formula (I): wherein Z is COOH, COOCH3 or CH2 OH, or a pharmaceutically acceptable salt thereof, for use in an anti-histaminic treatment which does not induce any significant cardiac arrhythmia, comprising administering a therapeutically effective amount of a compound of formula (I) to a human patient.

公开(公告)号：FI950467A

公开(公告)日：1995-03-31

申请号：FI950467

申请日：1995-02-02

Applicant: SEPRACOR INC ,  UNIV GEORGETOWN

Inventor： YOUNG JAMES W ,  GRAY NANCY M ,  WOOSLEY RAYMOND L ,  CHEN YIWANG

IPC: A61K9/48 ,  C07D211/22 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/451 ,  A61K31/60 ,  A61K45/00 ,  A61K45/06 ,  A61P17/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00 ,  A61K

Abstract: Use of a composition comprising a compound of formula I: or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in providing symptomatic relief from dermal irritation, wherein the induction of cardiac arrhythmia is avoided, said treatment comprising administering a therapeutically effective amount of a compound of formula I to a human patient whose hepatic function is not impaired.