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91.发明专利
公开(公告)号：JP2009027952A
公开(公告)日：2009-02-12
申请号：JP2007193477
申请日：2007-07-25
Inventor： YAMAMOTO TAKUO , AKASHI MAKOTO , YAMASHITA YUKIISA , ABE TOMOTERU , NAKAGAWA KAZUHIRO , SOMA ATSUHIKO , NOIDE KOICHI , KISHII NORIYUKI , HAYAKAWA TOMOHIRO
CPC classification number: C12Q1/6881 , C12Q1/6876 , C12Q2600/158
Abstract: PROBLEM TO BE SOLVED: To provide a simple and low-invasive method for obtaining information on the biological rhythm in an individual organism. SOLUTION: The method for obtaining the information on the biological rhythm in the individual organism based on the change in expression level of a clock gene in a hair follicle cell in the individual organism over time is provided. According to the method, the phase shift in the biological rhythm in the individual organism can be detected by producing and checking a molecular clock table on the individual organism two or more times. Further, the phase shift in the biological rhythm in the individual organism can be detected by checking the expression level of the clock gene at a predetermined clock time against the molecular clock table. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供用于获得关于个体生物体中的生物节律的信息的简单且低侵入性的方法。 提供了基于个体生物体中的毛囊细胞中时钟基因的表达水平随时间的变化获得个体生物体中的生物节律信息的方法。 根据该方法，可以通过在个体生物体上生成和检查分子时钟表来检测个体生物体中的生物节律的相移两次或更多次。 此外，可以通过相对于分子时钟表在预定时钟时间检查时钟基因的表达水平来检测单个生物体中生物节律的相移。 版权所有（C）2009，JPO＆INPIT
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92.发明专利
公开(公告)号：JP2008304440A
公开(公告)日：2008-12-18
申请号：JP2007168866
申请日：2007-06-27
Inventor： TAKEDA MINORU , KISHII NORIYUKI , ICHIMURA MARI , ABE TOMOTERU , NAKAGAWA KAZUHIRO , YASUDA AKIO , SHIONO MAYUMI , ONISHI MICHIHIRO , YAMAMOTO TAKUO
IPC: G01N33/543 , G01N21/64 , G01N33/53 , G01N33/566
CPC classification number: G01N21/645 , C12Q1/6869 , G01N33/54313 , Y10T436/143333 , C12Q2563/149
Abstract: PROBLEM TO BE SOLVED: To significantly improve the type of the discriminable bead, and to provide an application analysis technique of utilizing the bead. SOLUTION: Each bead has a surface permitting immobilization thereon of a substance that takes part in a predetermined reaction or interaction. A bead set capable of being distinguished into a plurality of groups by analyzing a photographed image of the bead with a computer, a suitable production process of the beads constituting the bead set, and a biochemical analysis technology of utilizing the bead set are provided. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：为了显着改善可辨别珠的类型，并提供利用珠的应用分析技术。 解决方案：每个珠粒具有允许在其上固定参与预定反应或相互作用的物质的表面。 提供了一种能够通过用计算机分析珠粒的拍摄图像来区分为多个组的珠组，提供了构成珠组的珠的合适的制造方法以及利用珠组的生化分析技术。 版权所有（C）2009，JPO＆INPIT
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93.发明专利Surface for detecting interaction between substances, dna chip, another sensor chip, probe and reduction method of background noise fluorescence 有权用于检测物质，DNA芯片，其他传感器芯片之间的相互作用的表面，背景噪声荧光的探测和还原方法
公开(公告)号：JP2006313118A
公开(公告)日：2006-11-16
申请号：JP2005136164
申请日：2005-05-09
Inventor： KISHII NORIYUKI
IPC: G01N33/543 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N33/542 , G01N33/566 , G01N37/00
Abstract: PROBLEM TO BE SOLVED: To simplify a series of assay processes reaching detection from interaction and to achieve the enhancement of an S/N ratio by simply and certainly removing fluorescence noise. SOLUTION: A detection surface is a surface for detecting the interaction between a probe substance (1a) and a target substance (2a) and is equipped with the probe substance (1a), which is labelled with a fluorescent substance (F 1 ) and keeps the unlabeled terminal fixed to the surface S of a solid phase, and a fluorescence altering substance (Q 1 ) for suppressing or modulating the emission of the fluorescent substance (F 1 ). The surface is constituted so as to perform the emission or modulation release of the fluorescent substance (F 1 ) by the above interaction. A sensor chip equipped with the detection surface, etc. are also provided. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：为了简化从相互作用到达检测的一系列测定过程，并且通过简单且肯定地去除荧光噪声来实现S / N比的增强。 检测表面是用于检测探针物质（1a）和目标物质（2a）之间的相互作用的表面，并且配备有用荧光物质标记的探针物质（1a）（F < SB> 1 ），并且将未标记的末端固定在固相的表面S上，以及用于抑制或调节荧光物质的发射的荧光改变物质（Q
1 ） ˚F 1 ）。 该表面构成为通过上述相互作用进行荧光物质的发射或调制释放（F 1 ）。 还提供了配备有检测表面等的传感器芯片。 版权所有（C）2007，JPO＆INPIT -
94.发明专利
公开(公告)号：JP2006191844A
公开(公告)日：2006-07-27
申请号：JP2005005994
申请日：2005-01-13
Inventor： OTO YASUNORI , KISHII NORIYUKI
Abstract: PROBLEM TO BE SOLVED: To provide a means for estimating the amounts of expression of target genes even in the case of hybridization of one kind of a nucleic acid for detection with a plurality of kinds of target nucleic acids.
SOLUTION: The method for estimating the contents of target nucleic acids in a sample from assayed values of hybridization between a nucleic acid for detection immobilized on a reacting area set on a substrate surface and target nucleic acids to be hybridized with the nucleic acid for detection comprises using each bond strength between one nucleic acid for detection and one of a plurality of target nucleic acids and obtaining the degree of contribution of the content of each target nucleic acid.
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题：即使在将一种用于检测的核酸与多种目标核酸杂交的情况下，也可以提供用于估计靶基因的表达量的方法。 解决方案：用于从固定在设置在底物表面上的反应区域上的检测用核酸与待与核酸杂交的靶核酸之间的杂交测定值的测定值来估计样品中靶核酸含量的方法 用于检测包括使用一种用于检测的核酸与多种靶核酸中的一种之间的每个键强度，并获得每种靶核酸的含量的贡献程度。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2005178079A
公开(公告)日：2005-07-07
申请号：JP2003419581
申请日：2003-12-17
Inventor： TSUBOI HISANORI , KURIHARA KENICHI , KISHII NORIYUKI
IPC: B41M5/337 , B41M5/26 , B41M5/28 , B41M5/30 , B41M5/46 , G11B7/0045 , G11B7/24 , G11B7/254 , G11B7/257
Abstract: PROBLEM TO BE SOLVED: To provide an optical recording medium having a thermal recording layer which enables recording by means of laser light common to the laser light for recording on and reproduction from an optical recording layer. SOLUTION: The optical recording medium 10 provided herein has the optical recording layer 12 on the main surface of a support base 11 and a label recording layer 14 is formed on the optical recording layer 12 with an intermediate layer 13 interlaid. In the label recording layer 14, a thermally coloring composition which colors with heat and a photo-thermal conversion material which absorbs light and generates heat are contained at least. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 要解决的问题：提供一种具有热记录层的光学记录介质，其能够借助于激光共有的激光进行记录，以记录和再现光学记录层。 解决方案：本文提供的光记录介质10具有在支撑基座11的主表面上的光学记录层12，并且标记记录层14形成在光记录层12上，中间层13被插入。 在标签记录层14中，至少含有热吸收着的热着色组合物和吸收光而产生热的光热转换材料。 版权所有（C）2005，JPO＆NCIPI
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Patent Agency Ranking
公开(公告)号：JP2005144952A
公开(公告)日：2005-06-09
申请号：JP2003388033
申请日：2003-11-18
Inventor： TSUBOI HISANORI , KURIHARA KENICHI , KISHII NORIYUKI
Abstract: PROBLEM TO BE SOLVED: To provide a recording method in which an image with higher density can be formed at the same recording speed. SOLUTION: The recording method comprises a step for using a laser beam in which the 1/e 2 spot diameter in the sub-scanning direction to a reversible multicolor recording medium 10 is D, and selecting the speed of the laser beam in the main scanning direction so that the line width L of a recording line recorded when a recording layer is irradiated with the laser beam at an output for recording with the deepest color lies in a range of 0.2D≤L≤0.8D. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 要解决的问题：提供可以以相同的记录速度形成具有较高密度的图像的记录方法。 解决方案：记录方法包括使用其中副扫描方向上的1 / e
2 光点直径与可逆多色记录介质10为D的激光束的步骤，并且选择 激光束在主扫描方向上的速度使得当在具有最深颜色的记录的输出处用激光束照射记录层时记录的记录线的线宽度L在0.2D≤L的范围内 ≤0.8D。 版权所有（C）2005，JPO＆NCIPI -
公开(公告)号：JP2004249541A
公开(公告)日：2004-09-09
申请号：JP2003041281
申请日：2003-02-19
Inventor： TSUBOI HISANORI , KURIHARA KENICHI , KISHII NORIYUKI
CPC classification number: B41J2/471 , B41J2/4753
Abstract: PROBLEM TO BE SOLVED: To provide a recorder for a reversible multicolor recording medium capable of recording/erasing information repeatedly. SOLUTION: The recorder for a reversible multicolor recording medium comprises a laser beam oscillating means 31a-31c irradiating a plurality of laser beams having different wavelengths modulated based on recording information, an optical system for converging the laser beam linearly in the main scanning direction, a laser beam deflector 36 located at the condensing position of laser beam, and a mirror 38 having a free curved surface designed such that a laser beam deflected by the deflector 36 is condensed on the reversible multicolor recording medium 10(20) in order to scan the recording medium at a uniform speed. COPYRIGHT: (C)2004,JPO&NCIPI
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公开(公告)号：JP2004249540A
公开(公告)日：2004-09-09
申请号：JP2003041280
申请日：2003-02-19
Inventor： TSUBOI HISANORI , KURIHARA KENICHI , KISHII NORIYUKI
IPC: B41J2/32
Abstract: PROBLEM TO BE SOLVED: To provide a recorder for a reversible multicolor recording medium capable of recording/erasing information repeatedly. SOLUTION: The recorder for a reversible multicolor recording medium comprises a rotary means for rotating a reversible multicolor recording medium 10(20) secured onto a tubular circumferential surface about a tubular shaft, a plurality of laser beam oscillating means irradiating laser beams having different wavelengths, an optical system for irradiating the surface of the reversible multicolor recording medium with a laser beam, a shifting means for shifting the irradiating position of laser beam relatively in the rotational direction of the reversible multicolor recording medium, and a modulation means for modulating the output of laser beam selectively depending on the irradiating position of laser beam and recording information. COPYRIGHT: (C)2004,JPO&NCIPI
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公开(公告)号：JP2004249539A
公开(公告)日：2004-09-09
申请号：JP2003041279
申请日：2003-02-19
Inventor： TSUBOI HISANORI , KURIHARA KENICHI , KISHII NORIYUKI
IPC: B41J2/32
Abstract: PROBLEM TO BE SOLVED: To provide a recorder for a reversible multicolor recording medium capable of recording/erasing information repeatedly. SOLUTION: The recorder for recording/erasing information on a reversible multicolor recording medium 10(20) comprises a rotary means 79 for rotating the recording medium in the same plane as the surface of the medium, a laser beam oscillating means irradiating a plurality of laser beams having different wavelengths, a lens system for irradiating the surface of the reversible multicolor recording medium with a laser beam, a shifting means for shifting the irradiating position of laser beam in the direction perpendicular to the rotational axis of the reversible multicolor recording medium, and a modulation means for modulating the output of laser beam selectively depending on the irradiating position of laser beam and recording information. COPYRIGHT: (C)2004,JPO&NCIPI
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公开(公告)号：JP2004155011A
公开(公告)日：2004-06-03
申请号：JP2002322106
申请日：2002-11-06
Inventor： TSUBOI HISANORI , KISHII NORIYUKI , KURIHARA KENICHI
Abstract: PROBLEM TO BE SOLVED: To provide a high speed recording method to reversible multicolor recording media, to and from which signals can be repeatedly recorded and erased. SOLUTION: Recording layers 11-13, each of which includes one of a plurality of reversible thermosensitive color developing compositions having developing color tones different from one another, are separatingly and laminatingly formed to the planar direction of a supporting board 1. In a plurality of the reversible thermosensitive color developing compositions, the reversible multicolor recording media each including a photothermally converting material generating heat through the absorption of infrared radiation in wavelength ranges different from one another are employed. First of all, the whole recording layers are put in advance under decolorized states through the application of heating treatment. Next, heating treatment is applied to the recording layers in the order that no color state change develops. Then, in response to the desired image information, exposure is executed through the irradiation of infrared radiation on the wavelength region selected in response to that selected in the recording layer so as to heat the recording layer in order to selectively form color, resulting in recording image information. COPYRIGHT: (C)2004,JPO
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