公开(公告)号：WO1995005202A1

公开(公告)日：1995-02-23

申请号：PCT/US1994009251

申请日：1994-08-16

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  WILBUR, D., Scott

IPC: A61K49/04

CPC classification number: C07H23/00 ,  A61K49/0438 ,  C07F5/027

Abstract: Highly iodinated borane and carborane cage molecules, having from 60 % to 90 % w/w iodine, are disclosed as new and useful X-ray contrast media when combined with a pharmaceutically acceptable carrier. The inclusion of appropriate functional group substituents, such as hydrophilic moieties, increases solubility and lowers toxicity.

Abstract translation: 当与药学上可接受的载体组合时，公开了具有60％至90％（重量/重量）碘的高度碘化的硼烷和碳硼烷笼分子作为新的和有用的X射线造影剂。 包括适当的官能团取代基，例如亲水部分，增加了溶解性并降低了毒性。

公开(公告)号：WO1994002601A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006830

申请日：1993-07-23

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  UNIVERSITY OF WASHINGTON ,  CHILDREN'S HOSPITAL MEDICAL CENTER

Inventor： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  UNIVERSITY OF WASHINGTON ,  CHILDREN'S HOSPITAL MEDICAL CENTER ,  BRINSTER, Ralph, L. ,  PALMITER, Richard, D. ,  DEGAN, Jay, L. ,  SANDGREN, Eric, P.

IPC: C12N15/00

CPC classification number: A01K67/0271

Abstract: Animals with impaired native liver function harboring a functioning non-native liver derived from implanted non-native cells, and a method of producing such animals are described.

Abstract translation: 描述了具有源自植入的非天然细胞的功能性非天然肝脏的具有受损的本地肝功能的动物及其生产方法。