公开(公告)号：US2474902A

公开(公告)日：1949-07-05

申请号：US2474902D

CPC classification number: C07C201/00 ,  C07C201/04 ,  C07C207/00

公开(公告)号：US2419976A

公开(公告)日：1947-05-06

申请号：US2419976D

CPC classification number: C07C201/04 ,  C07C201/00 ,  C07C207/02

公开(公告)号：EP3886834B1

公开(公告)日：2024-08-07

申请号：EP19813750.7

申请日：2019-11-27

IPC: A61K31/21 ,  A61P9/12 ,  C07C201/04 ,  C07C203/00 ,  A61K31/047

CPC classification number: C07C201/04 ,  C07C203/00 ,  C07B2200/0720130101 ,  A61P9/12 ,  A61K31/047

公开(公告)号：EP2004576A1

公开(公告)日：2008-12-24

申请号：EP07716121.4

申请日：2007-03-14

Applicant: Gustafsson, Lars E. ,  Linnarsso, Dag ,  Nilson, Kristofer

Inventor： Gustafsson, Lars E. ,  Linnarsso, Dag ,  Nilson, Kristofer

IPC: C07B43/02 ,  A61K31/70 ,  A61K31/7016 ,  A61P11/06 ,  A61P17/02 ,  A61P9/10 ,  A61P9/12 ,  C07C201/04 ,  C07H3/02 ,  C07H3/04

CPC classification number: C07C201/04 ,  C07B43/02 ,  C07C203/00

Abstract: Organic nitrites can be produced from a compound which is a mono/polyhydric alcohol or an aldehyde- or ketone-derivate thereof after de-aeration of the same, using NO gas, and stored in an environment saturated with gaseous NO. Organic nitrites produced according to the invention exhibit less impurities and improved storage stability compared to conventionally produced nitrites. The organic nitrites of the invention can easily be formulated into pharmaceutical compositions and have utility for the treatment of various conditions.

公开(公告)号：EP1419134A1

公开(公告)日：2004-05-19

申请号：EP02794543.5

申请日：2002-08-02

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： KUDIS, Steffen ,  LOCHTMAN, Rene ,  EHRESMANN, Manfred ,  KEIL, Michael ,  GEBHARDT, Joachim ,  RACK, Michael ,  SCHIMETZEK, Ralf

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: The invention relates to a continuous method for producing alkyl nitrites and alkyl dinitrites. According to said method, (i) an alkanol or dialkanol is mixed with an aqueous solution of a mineral acid, whereby on average no more than 1.01 mol acid equivalents per mol hydroxyl group of alkanol or dialkanol is used, (ii) in a reaction zone, an aqueous solution of an inorganic nitrite is continuously added to the aqueous mixture obtained in step (i), (iii) the organic phase is optionally isolated.

公开(公告)号：EP0911316A2

公开(公告)日：1999-04-28

申请号：EP98119669.4

申请日：1998-10-17

Applicant: Ube Industries, Ltd.

Inventor： Nishihira, Keigo c/o Ube Production Center, ,  Tanaka, Shuji c/o Ube Production Center, ,  Yoshida, Shinichi c/o Ube Production Center,

IPC: C07C201/04

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: An alkyl nitrite can be produced on an industrial scale with a high efficiency and with a low yield of by-products by the process wherein nitrogen oxide-containing feed gas is brought into an alkyl alcohol liquid in a distillation column reactor while circulating a liquid fraction, produced in the reactor and containing the alkyl alcohol, through a circulation path including a lower section of the reactor and a cooler to remove the reaction heat vigorously generated in the reactor, and while controlling the weight ratio of the circulating liquid fraction to the total alkyl alcohol fed into the reactor to 50:1 to 200:1, the molar ratio of the total alkyl alcohol fed to the reactor and contained in the circulating liquid fraction to nitrogen oxide in the feed gas to 20:1 to 150:1, and the content of the alkyl alcohol in the liquid fraction to 15 to 60% by weight; and the resultant gas fraction containing the target alkyl nitrite is collected from the reactor.

Abstract translation: 亚硝酸烷基酯可以在工业规模上以高效率和低产率的副产物生产，其中将含氮氧化物的进料气体在蒸馏塔反应器中进入烷基醇液体，同时使液体馏分 在反应器中生产并含有烷基醇，通过包括反应器的下部的循环路径和冷却器，以除去在反应器中剧烈产生的反应热，同时控制循环液体馏分与总量的重量比 将进料到反应器中的烷基醇与进料气体中的氮氧化物进料至反应器中的总烷基醇与进料气体中的氮氧化物的摩尔比为20:1-150:1， 并且液体馏分中的烷基醇的含量为15〜60重量％ 从反应器收集含有目标亚硝酸烷基酯的所得气体馏分。

公开(公告)号：EP0614878A1

公开(公告)日：1994-09-14

申请号：EP94102780.7

申请日：1994-02-24

Applicant: BAYER AG

Inventor： Landscheidt, Heinz, Dr. ,  Wagner, Paul, Dr. ,  Kricsfalussy, Zoltan, Dr. ,  Klausener, Alexander, Dr.

IPC: C07C201/04 ,  C07C203/00

CPC classification number: C07C201/04 ,  C07C203/00

Abstract: C₁-C₄-Alkyl-nitrite können durch Umsetzung von C₁-C₄-Alkanolen mit Stickstoffoxiden unter Beteiligung von Sauerstoff in einem als Wäscherkolonne ausgebildeten Reaktor hergestellt werden, wobei Stickstoffoxide mit einem Anteil von mehr als 50 % NO an der Gesamtmenge von Grammatomen N der Stickstoffoxide, Sauerstoff und gegebenenfalls Inertgas im unteren Teil des Reaktors eingesetzt werden. Das C₁-C₄-Alkanol wird zu 5 bis 60 % seiner gesamten Einsatzmenge ebenfalls im unteren Teil des Reaktors in dampfförmiger oder verdüster Form eingesetzt, während das restliche C₁-C₄-Alkanol auf den Kolonnenkopf gegeben wird.

Abstract translation: C1-C4烷基亚硝酸盐可以通过使C1-C4-链烷醇与涉及氧的氮氧化物反应来制备，该方法在设计为洗涤塔的反应器中进行，含有超过总量的NO的50％ 克原子氮的氮氧化物，氧气和（如果合适的话）在反应器的下部使用惰性气体。 使用的C 1 -C 4烷醇的总量的5〜60％也以蒸气或喷雾的形式用于反应器的下部，而将剩余的C1-C4链烷醇施加到塔头 。

公开(公告)号：EP0046983B1

公开(公告)日：1987-04-29

申请号：EP81106636.4

申请日：1981-08-26

Applicant: UBE INDUSTRIES, LTD.

Inventor： Tahara, Susumu ,  Fujii, Kozo ,  Nishihira, Keigo ,  Matsuda, Masaoki ,  Mizutare, Katsuhiko

IPC: C07C31/20 ,  C07C69/36 ,  C07C67/36 ,  C07C67/54 ,  C07C76/00 ,  C07C77/00 ,  C07C29/136 ,  C07C29/80

CPC classification number: C07C29/149 ,  C07C29/80 ,  C07C201/04 ,  C07C31/202 ,  C07C203/00

公开(公告)号：EP0046983A1

公开(公告)日：1982-03-10

申请号：EP81106636.4

申请日：1981-08-26

Applicant: UBE INDUSTRIES, LTD.

Inventor： Tahara, Susumu ,  Fujii, Kozo ,  Nishihira, Keigo ,  Matsuda, Masaoki ,  Mizutare, Katsuhiko

IPC: C07C31/20 ,  C07C69/36 ,  C07C67/36 ,  C07C67/54 ,  C07C76/00 ,  C07C77/00 ,  C07C29/136 ,  C07C29/80

CPC classification number: C07C29/149 ,  C07C29/80 ,  C07C201/04 ,  C07C31/202 ,  C07C203/00

Abstract: There is disclosed a process for continuously preparing ethylene glycol, which comprises (1) a first step of contacting a gas containing carbon monoxide and an ester of nitrous acid with a solid catalyst of platinum group metal series in the gaseous phase thereby to obtain a product containing a diester of oxalic acid, (2) a second step of condensing the product of the first step thereby to separate a non-condensed gas containing nitrogen monoxide formed by the catalytic reaction of the first step from a condensed liquid containing the diester of oxalic acid, (3) a third step of contacting the non-condensed gas of the second step with a gas containing molecular oxygen and an alcohol, and recycling the resulting gas containing an ester of nitrous acid to the first step, (4) a fourth step of contacting the condensed liquid of the second step containing the diester of oxalic acid and hydrogen with a catalyst for hydrogenation in the gaseous phase thereby to obtain a product containing ethylene glycol, (5) a fifth step of distilling the product of the fourth step thereby to distil out the alcohol and to obtain ethylene glycol, and (6) a sixth step of recycling the alcohol of the fifth step as an alcohol source for the third step.

公开(公告)号：US20180251420A1

公开(公告)日：2018-09-06

申请号：US15747510

申请日：2016-09-14

Applicant: LONZA LTD

Inventor： Christoph Taeschler ,  Ulrich Mayerhoeffer ,  Christophe Girard ,  Michael Bittel ,  Rolf Kalbermatten ,  Claudio Arnold ,  Stefan Garms ,  Christian Schnider ,  Stefan Tille ,  Manuel Favre ,  Guy Raboud ,  Kilian Schnydrig ,  Martin Venetz ,  Thomas Eggel

IPC: C07C201/04 ,  C07C203/00 ,  B01J19/18

CPC classification number: C07C201/04 ,  B01J19/1881 ,  B01J2219/00033 ,  B01J2219/00162 ,  B01J2219/00166 ,  C07C203/00

Abstract: The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are mixed in a mixing device which provides for a pressure drop of at least 1 bar; the acid is selected from the group consisting of HCI, H2SO4, formic acid, methanesulfonic acid, and mixtures thereof; and the amount of HCI is at least 1.02 molar equivalent based on the molar amount of n-butanol.