公开(公告)号：EP0602515A1

公开(公告)日：1994-06-22

申请号：EP93119734.7

申请日：1993-12-08

Applicant: BASF Aktiengesellschaft

Inventor： Fischer, Rolf, Dr. ,  Pinkos, Rolf, Dr.

IPC: C07D307/32 ,  C07D207/26 ,  C07D201/02

CPC classification number: C07D201/02 ,  C07D207/267 ,  C07D307/33 ,  C07D315/00

Abstract: Verfahren zur Herstellung von 5-Ringheterocyclen der allgemeinen Formel I

in der

R¹ Methyl oder Hydroxyethyl,
R²,R³,R⁴,R⁵,R⁶ Wasserstoff, C₁- bis C₁₂-Alkyl, C₂- bis C₁₂-Alkenyl, Aryl, C₃- bis C₈-Cycloalkyl, C₁- bis C₁₂-Alkoxy, Halogen, C₂- bis C₂₀-Alkoxycarbonyl-alkyl, C₂-bis C₂₀-Alkylcarbonyloxy, Formyl, C₂- bis C₂₀-Formylalkyl, Benzoyl, -CH (OR³) (OR⁵) oder R³ und R⁵ gemeinsam eine gegebenenfalls ein- bis fünffach durch R⁴ substituierte C₂- bis C₇-Alkylenkette oder eine gegebenenfalls ein- bis vierfach durch R⁴ substituierte =CH-CH=CH-CH= Einheit,
X Sauerstoff oder N-R⁴
bedeuten, indem man 5-Ringheterocyclen der allgemeinen Formel II

in denen R² R³, R⁴, R⁵, R⁶ und X die obengenannte Bedeutung haben und Y Wasserstoff, Acetyl oder C₂- bis C₂₀-Alkoxycarbonyl bedeutet, mit Dimethyl- oder Ethylencarbonat in Gegenwart einer stickstoffhaltigen Base bei Temperaturen von 50 bis 300°C und Drücken von 0,01 bis 50 bar umsetzt.

Abstract translation: 制备通式Ⅰ的5元杂环的方法，其中R 1是甲基或羟乙基，R 2，R 3，R 4，R 5和R 5， C 1 -C 12烷基，C 2〜C 12链烯基，芳基，C 3〜C 8环烷基，C 1〜C 12烷氧基，卤素，C 2〜C 20烷氧基羰基烷基，C 2〜C 20 - 烷基羰基氧基，甲酰基，C 2 -C 20甲酰基烷基，苯甲酰基，-CH（OR 3）（OR 5）或R 3和R 5一起是C 2至C 7亚烷基链， 任选被R 4或a = CH-CH = CH-CH =被R 4单取代至四取代的单元单取代至五取代，且X为氧或NR 4时，通过使5-元杂环 其中R 2，R 3，R 4，R 5，R 6和X具有上述含义的通式II ，Y是氢，乙酰基或C 2 -C 20 - 烷氧基羰基与碳酸二甲酯或碳酸亚乙酯在含氮碱的存在下在50-300℃的温度和0.01至50巴的压力下反应。

公开(公告)号：EP0563878A3

公开(公告)日：1994-04-27

申请号：EP93105239.3

申请日：1993-03-30

Applicant: SUNTORY LIMITED ,  NIPPON SODA CO., LTD.

Inventor： Nakajima, Masashi ,  Kimura, Yasuharu ,  Imai, Kiyohito

IPC: C07D205/09 ,  C07D405/12 ,  C07D403/12

CPC classification number: C07D403/12 ,  C07D201/02 ,  C07D205/09 ,  C07D405/12

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]:

(wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]:

(wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]:
        HSCO-(CH₂) n -Y   [II]
(wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

Abstract translation: 一种生产由下列通式[Ⅲ]代表的4-取代氮杂环丁酮衍生物的方法：（其中OR是被保护的羟基，Y是烷基，烷氧基，甲硅烷氧基，氨基甲酰氧基，氨基 ，取代或未取代的芳族基团或取代或未取代的杂环基团，并且n是0或1的整数，条件是当Y是烷氧基，甲硅烷氧基，氨基甲酰氧基或氨基时，n不代表O） 其中由以下通式[I]表示的2-氮杂环丁酮衍生物（其中OR如上定义，X​​是烷基或取代或未取代的芳基）与由下列通式 [II]：HSCO-（CH 2）nY [II]（其中Y和n分别如上定义）在铜化合物存在下在有机溶剂中反应。 与现有方法相比，上述方法可缩短生产工艺。 从工业角度来看，它也是非常有利的，因为它不使用汞盐。

公开(公告)号：KR1020010006335A

公开(公告)日：2001-01-26

申请号：KR1019997009420

申请日：1998-04-14

Applicant: 유니온 카바이드 케미칼즈 앤드 플라스틱스 테크날러지 엘엘씨

Inventor： 마허,존,마이클 ,  브리얀트,데이비드,로버트 ,  홀라데이,조나단,유진 ,  아이젠스치미드,토마스,칼 ,  브릭스,존,로버트 ,  올슨,커트,다마

IPC: C07D201/02

CPC classification number: C07D201/02 ,  C07C45/49 ,  C07C45/50 ,  C07C45/68 ,  C07C47/19 ,  C07D201/08 ,  C07F9/65744 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

Abstract: This invention relates to a composition commprising (a) epsilon caprolactam and (b) one or more of 5-[4,5-di(3-carboxypropyl)-2- pyridyl]pentanoic acid or salt or amide, 4-[4,5-di(2-carboxypropyl)-2- pyridyl]-2-methylbutanoic acid or salt or amide, 2-[2-(2-carboxybutyl)-5- (1-carboxypropyl)-4-pyridyl] butanoic acid or salt or amide, 5-[3,5-di(3- carboxypropyl)-2-pyridyl]pentanoic acid or salt or amide, 4-[3,5-di(2- carboxypropyl)-2-pyridyl]-2-methylbutanoic acid or salt or amide, 2-[2-(2- carboxybutyl)-5-(1-carboxypropyl)-3-pyridyl] butanoic acid or salt or amide, 5-amino-4-methylpentanamide, 4-amino-3- ethylbutanamide, 5-[4,5- di(4-hydroxybutyl)-2-pyridyl]pentanol, 4-[4,5-di(2-methoxypropyl)- 2- pyridyl]-2-methylbutanol, 2-[2-(2-methoxybutyl)-5-(1-methoxypropyl)-4- pyridyl]butanol, 5-[3,5-di(4-hydroxybutyl)-2-pyridyl]pentanol, 4-[3,5- di(2-methoxypropyl)-2-pyridyl]-2-methylbutanol, 2[2-(2-methoxybutyl)-5-(1- methoxypropyl)-3-pyridyl]butanol, 5-amino-4-methyl-1-pentanol, 5-imino-2- methyl-1-pentanamine, 5-amino-2-methyl-1-pentanol, 5-imino-4-methyl-1- pentanamine and 2-butyl-4,5-dipropylpyridine, wherein the weight ratio of component a) to component b) is at least about 99 to 1. The epsilon caprolactam compositions are useful in the preparation of nylon 6.

Abstract translation: 本发明涉及一种令人满意的（a）ε己内酰胺和（b）5- [4,5-二（3-羧基丙基）-2-吡啶基]戊酸或其盐或酰胺中的一种或多种的组合物， 2-（2-羧基丙基）-2-吡啶基] -2-甲基丁酸或盐或酰胺，2- [2-（2-羧基丁基）-5-（1-羧丙基）-4-吡啶基]丁酸或盐 或酰胺，5- [3,5-二（3-羧丙基）-2-吡啶基]戊酸或盐或酰胺，4- [3,5-二（2-羧丙基）-2-吡啶基] -2-甲基丁酸 酸或盐或酰胺，2- [2-（2-羧基丁基）-5-（1-羧丙基）-3-吡啶基]丁酸或盐或酰胺，5-氨基-4-甲基戊酰胺，4-氨基-3- 乙基丁酰胺，5- [4,5-二（4-羟基丁基）-2-吡啶基]戊醇，4- [4,5-二（2-甲氧基丙基）-2-吡啶基] -2-甲基丁醇，2- [2- （2-甲氧基丁基）-5-（1-甲氧基丙基）-4-吡啶基]丁醇，5- [3,5-二（4-羟基丁基）-2-吡啶基]戊醇，4- [3,5-二 - 甲氧基丙基）-2-吡啶基] -2-甲基丁醇，2 [2-（2-甲氧基丁基）-5-（1-甲氧基丙基）-3-吡啶基]丁醇，5-氨基-4-甲基-1-戊醇，5 亚胺-2- 戊基-1-戊胺，5-氨基-2-甲基-1-戊醇，5-亚氨基-4-甲基-1-戊胺和2-丁基-4,5-二丙基吡啶，其中组分a）与组分 b）至少约99至1。ε-己内酰胺组合物可用于制备尼龙6。

公开(公告)号：KR1020010006329A

公开(公告)日：2001-01-26

申请号：KR1019997009414

申请日：1998-04-14

Applicant: 유니온 카바이드 케미칼즈 앤드 플라스틱스 테크날러지 엘엘씨

Inventor： 에이센스츠미드토마스칼 ,  브리지스존로버트 ,  팩케트다이안리 ,  올손커트다머 ,  마허존마이클

IPC: C07D201/08

CPC classification number: C07D201/02 ,  C07D201/08 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprises: (a) subjecting one or more substituted or unsubstituted alkadienes to hydroxycarbonylation in the presence of a hydroxycarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and neutralization with a base to produce one or more substituted or unsubstituted pentenoic acid salts; (b) subjecting said one or more substituted or unsubstituted pentenoic acid salts to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted formylvaleric acid salts and/or one or more substituted or unsubstituted epsilon caprolactam precursors; and (c) subjecting said one or more substituted or unsubstituted formylvaleric acid salts and/or said one or more substituted or unsubstituted epsilon caprolactam precursors to reductive amination in the presence of a reductive amination catalyst and cyclization optionally in the presence of a cyclization catalyst to produce said one or more substituted or unsubstituted epsilon caprolactams. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as the principal product(s) of reaction.

Abstract translation: 本发明部分地涉及用于制备一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括：（a）在羟基羰基化催化剂存在下使一种或多种取代或未取代的烷撑二醇进行羟基羰基化， 金属有机磷配体络合物催化剂，并用碱中和以产生一种或多种取代或未取代的戊烯酸盐; （b）使所述一种或多种取代或未取代的戊烯酸盐在加氢甲酰化催化剂（例如金属 - 有机磷配体配合物催化剂）存在下进行加氢甲酰化，以产生一种或多种取代或未取代的甲酰基戊酸盐和/或一种或多种 更多取代或未取代的ε己内酰胺前体; 和（c）在还原胺化催化剂存在下使所述一种或多种取代或未取代的甲酰基戊酸盐和/或所述一种或多种取代或未取代的己内酰胺前体进行还原胺化，任选地在环化催化剂存在下进行环化， 产生所述一种或多种取代或未取代的ε己内酰胺。 本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为反应主要产物的反应混合物。

公开(公告)号：US09643153B2

公开(公告)日：2017-05-09

申请号：US14714985

申请日：2015-05-18

Applicant: Ralf Meier ,  Kévin Micoine ,  Peter Kreis ,  Frederik Gluth ,  Markus Priske

Inventor： Ralf Meier ,  Kévin Micoine ,  Peter Kreis ,  Frederik Gluth ,  Markus Priske

IPC: C07D301/32 ,  B01J19/24 ,  C07D225/02 ,  B01D61/02 ,  B01J31/40 ,  C07D301/12

CPC classification number: B01J19/2475 ,  B01D61/027 ,  B01D2311/02 ,  B01J31/4061 ,  B01J2219/24 ,  B01J2231/72 ,  B01J2531/56 ,  B01J2531/64 ,  B01J2531/66 ,  B01J2531/985 ,  B01J2540/42 ,  C07D201/02 ,  C07D225/02 ,  C07D301/12 ,  C07D301/32 ,  Y02P20/584

Abstract: A homogeneous catalyst system is removed from a reaction mixture of two liquid phases by separating the two liquid phases with a membrane having at least one separation-active layer in such a way that the homogeneous catalyst system is at least partially concentrated in a membrane retentate; wherein the reaction mixture contains at least one partially epoxidized cyclic unsaturated compound having twelve carbon atoms; and wherein the membrane separation-active layer contains crosslinked a silicone acrylate and/or polydimethylsiloxane and/or polyimide.

公开(公告)号：US08283466B2

公开(公告)日：2012-10-09

申请号：US12527848

申请日：2008-02-20

Applicant: John W. Frost

Inventor： John W. Frost

IPC: C07D201/02 ,  C07D201/08

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

Abstract translation: 从赖氨酸或α-氨基-ε-己内酰胺起始原料制备己内酰胺，哌可啶酸及其衍生物的催化方法，以及由此产生的产物。 一种制备己内酰胺或其衍生物的方法，该方法包括在溶剂存在下使包含赖氨酸或α-氨基己内酰胺的反应物与催化剂和包含氢气的气体接触。 催化剂可以设置在载体材料如过渡金属上。

公开(公告)号：US06989444B2

公开(公告)日：2006-01-24

申请号：US10488238

申请日：2002-09-10

Applicant: Asima Sultana ,  Hajime Nagahara ,  Yuichi Fujii ,  Ken Suzuki

Inventor： Asima Sultana ,  Hajime Nagahara ,  Yuichi Fujii ,  Ken Suzuki

IPC: C07D201/02

CPC classification number: C07D223/10 ,  B01J21/08 ,  B01J21/12 ,  B01J23/22 ,  B01J23/24 ,  B01J23/28 ,  B01J29/0308 ,  B01J29/035 ,  B01J29/041 ,  B01J29/85 ,  B01J35/1061 ,  C07D201/02 ,  Y02P20/52

Abstract: A method for producing a lactam, which comprises subjecting an alicyclic primary amine to an oxidation reaction in the presence of a catalyst comprising a silicon oxide, to thereby obtain a lactam. A catalyst comprising a silicon oxide which is for use in the above-mentioned method.

Abstract translation: 一种内酰胺的制造方法，其特征在于，在含有氧化硅的催化剂的存在下，使脂环式伯胺进行氧化反应，得到内酰胺。 一种催化剂，其包含用于上述方法的氧化硅。

公开(公告)号：US20030125570A1

公开(公告)日：2003-07-03

申请号：US10280622

申请日：2002-10-25

Inventor： Todd Werpy ,  John G. Frye JR. ,  Yong Wang ,  Alan H. Zacher

IPC: C07D207/267 ,  B01J023/00

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.

公开(公告)号：US20030120087A1

公开(公告)日：2003-06-26

申请号：US10280462

申请日：2002-10-25

Inventor： Todd Werpy ,  John G. Frye JR. ,  Yong Wang ,  Alan H. Zacher

IPC: C07D207/267 ,  B01J023/00

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.

Abstract translation: 本发明提供了通过氢化制备N-甲基吡咯烷和类似化合物的方法。 还描述了用于该方法的新型催化剂和新的条件/收率。 其他工艺改进可以包括提取和水解步骤。 一些优选的反应发生在水相中。 用于制备N-甲基吡咯烷的原料可包括琥珀酸，N-甲基琥珀酰亚胺及其类似物。

公开(公告)号：US20030097006A1

公开(公告)日：2003-05-22

申请号：US09884602

申请日：2001-06-18

Inventor： Todd Werpy ,  John G. Frye JR. ,  Yong Wang ,  Alan H. Zacher

IPC: C07D207/267

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.