公开(公告)号：US09848973B2

公开(公告)日：2017-12-26

申请号：US15362223

申请日：2016-11-28

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC: A61F2/00 ,  A61F2/44 ,  A61F2/28 ,  A61L31/06 ,  B29C67/20 ,  C08J9/00 ,  C08J9/26 ,  A61L27/18 ,  A61B90/00 ,  A61B6/00 ,  A61L27/50 ,  A61L27/56 ,  B29C44/04 ,  B29C44/34 ,  A61B6/12 ,  B29K71/00 ,  B29L31/00

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

公开(公告)号：US20170312949A1

公开(公告)日：2017-11-02

申请号：US15653047

申请日：2017-07-18

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S.D. Lee

IPC: B29C43/04 ,  B29C67/20 ,  C08J9/26 ,  B29C44/58 ,  B29C33/00 ,  B29L31/00 ,  B29K71/00

CPC classification number: B29C43/04 ,  B29C33/00 ,  B29C44/58 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7532 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2300/22 ,  C08J2371/00

Abstract: In general, in various embodiments, the present disclosure is directed systems and methods for producing a porous surface from a solid piece of polymer. In particular, the present disclosure is directed to systems that include a track assembly, mold assembly, press assembly, and methods for using the same for producing a porous surface from a solid piece of polymer. In some embodiments, the present systems and methods are directed to processing a polymer at a temperature below a melting point of the polymer to produce a solid piece of polymer with an integrated a porous surface.

公开(公告)号：US09504550B2

公开(公告)日：2016-11-29

申请号：US14752762

申请日：2015-06-26

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC: A61F2/30 ,  A61F2/28 ,  A61F2/00 ,  A61L31/06 ,  B29C67/20 ,  C08J9/00 ,  C08J9/26 ,  B29K71/00

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将固体聚合物片的表面加热至加工温度并保持加工温度，同时使致孔剂层通过聚合物的表面移动，以形成包含聚合物的固体聚合物主体的基质层，以及 致孔剂层。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。

公开(公告)号：US09353235B1

公开(公告)日：2016-05-31

申请号：US14747660

申请日：2015-06-23

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC: B29C67/20 ,  C08J9/26 ,  A61F2/02

CPC classification number: B29C67/202 ,  A61F2/02 ,  A61F2/32 ,  A61F2/38 ,  A61F2002/30065 ,  A61F2002/30316 ,  A61F2210/0076 ,  A61F2240/001 ,  B29K2071/00 ,  B29K2105/04 ,  C08J9/0085 ,  C08J9/26 ,  C08J9/32 ,  C08J2201/0446 ,  C08J2361/16 ,  C08J2371/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将聚合物固体片的表面加热至低于聚合物熔点的加工温度，并保持加工温度，同时使致孔剂层通过聚合物表面移动以形成基体层 包含聚合物和致孔剂层的固体聚合物体。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。

公开(公告)号：US20150064435A1

公开(公告)日：2015-03-05

申请号：US14389481

申请日：2013-03-28

Applicant: Sekisui Chemical Co., Ltd.

Inventor： Kazuyuki Yahara ,  Yozo Toei ,  Akihito Dohi ,  Yuji Tanikawa

IPC: C08J9/14 ,  C08J9/12

CPC classification number: C08J9/142 ,  C08J9/0042 ,  C08J9/0061 ,  C08J9/0066 ,  C08J9/12 ,  C08J9/141 ,  C08J9/26 ,  C08J2201/026 ,  C08J2201/0446 ,  C08J2203/12 ,  C08J2203/14 ,  C08J2205/05 ,  C08J2205/06 ,  C08J2207/00 ,  C08J2323/16 ,  C08J2423/16 ,  C09K3/1006 ,  C09K2200/0642

Abstract: Provided is a porous body, which is formed of a resin obtained by crosslinking a copolymer of ethylene, an α-olefin, and a non-conjugated diene, wherein porosity of the porous body is in the range of 50 to 95% by volume, strength of the porous body at 50% compression is 300 kPa or less, and compression set (A) under atmosphere at a temperature of 80° C. and a relative humidity of 90% is 20% or less.

Abstract translation: 提供一种多孔体，其由通过交联乙烯，α-烯烃和非共轭二烯的共聚物而获得的树脂形成，其中多孔体的孔隙率在50体积％至95体积％的范围内， 50％压缩时多孔体的强度为300kPa以下，在80℃，相对湿度90％的气氛下，压缩永久变形（A）为20％以下。

公开(公告)号：US20140013974A1

公开(公告)日：2014-01-16

申请号：US13756315

申请日：2013-01-31

Applicant: SHACHIHATA INC.

Inventor： Ikuzo MATSUSHITA ,  Yoshiaki NAGATA

IPC: C08L9/06 ,  C08L23/06 ,  C08J9/00 ,  C08L23/08 ,  C08L33/00 ,  B41K1/40 ,  C08L31/04

CPC classification number: C08L9/06 ,  B41K1/40 ,  C08J9/00 ,  C08J9/0061 ,  C08J9/0066 ,  C08J9/26 ,  C08J2201/022 ,  C08J2201/026 ,  C08J2201/0446 ,  C08J2323/04 ,  C08J2323/16 ,  C08J2331/04 ,  C08J2333/08 ,  C08J2409/06 ,  C08J2425/10 ,  C08J2453/02 ,  C08L23/06 ,  C08L23/08 ,  C08L31/04 ,  C08L33/00

Abstract: A porous stamp material allows only resin in a region thereof irradiated with a laser beam during laser engraving in a production process of an ink stamp to be burnt and vaporized while preventing melting in any other unwanted region. The porous material for ink stamps comprises: at least one thermoplastic resin selected from the group consisting of low-density polyethylene, linear low-density polyethylene, high-density polyethylene, ethylene-alpha-olefin copolymer, ethylene-vinyl acetate copolymer, and ethylene-acrylic copolymer; at least one thermoplastic elastomer selected from a plurality of different hydrogenated styrene based thermoplastic elastomers; and at least one filler selected from a plurality of different inorganic compounds, wherein the thermoplastic resin and/or the thermoplastic elastomer are cross-linked, and formed in a continuous pore structure.

Abstract translation: 在油墨印版的制造过程中，激光雕刻期间，多孔印模材料仅允许在激光雕刻区域中的树脂被烧焦和汽化，同时防止任何其它不想要的区域中的熔化。 用于墨迹的多孔材料包括：至少一种选自低密度聚乙烯，线性低密度聚乙烯，高密度聚乙烯，乙烯-α-烯烃共聚物，乙烯 - 乙酸乙烯酯共聚物和乙烯的热塑性树脂 丙烯酸共聚物; 至少一种选自多种不同氢化苯乙烯的热塑性弹性体的热塑性弹性体; 和选自多种不同的无机化合物的至少一种填料，其中所述热塑性树脂和/或所述热塑性弹性体是交联的，并形成为连续的孔结构。

公开(公告)号：US08383024B2

公开(公告)日：2013-02-26

申请号：US12092487

申请日：2006-11-06

Applicant: Daniel Morrissette ,  Patrick Croteau

Inventor： Daniel Morrissette ,  Patrick Croteau

IPC: B01D67/00 ,  B29C44/00 ,  B29C44/60

CPC classification number: B32B5/145 ,  A61L27/18 ,  A61L27/48 ,  A61L27/56 ,  B32B5/22 ,  B32B27/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249981 ,  Y10T428/249991 ,  C08L71/00

Abstract: A method for fabricating a porous structure from a first material. The method comprises the acts of mixing the first material with a second material to form a mixture, the first material having a melting point which is lower than the second material, heating the mixture under pressure to a temperature between a melting point of the first material and a melting point of the second material, cooling the molten mixture until it hardens and removing the second material from the first material. The method may also include a subsequent annealing step. There is also described a material suitable for implant, illustratively vertebral or spinal implants, comprising a rigid biocompatible polymer such as PEEK comprising a plurality of interconnected pores. The polymer illustratively has a porosity of between 50% and 85% by volume and in a particular embodiment is able to withstand pressures of up to 20 MPa. The porous PEEK material may also have a minimum thickness in any dimension of one (1) inch.

Abstract translation: 一种从第一材料制造多孔结构的方法。 该方法包括将第一材料与第二材料混合以形成混合物的行为，第一材料具有低于第二材料的熔点，将压力下的混合物加热到第一材料的熔点之间的温度 和所述第二材料的熔点，冷却所述熔融混合物直到其硬化并从所述第一材料除去所述第二材料。 该方法还可以包括随后的退火步骤。 还描述了适合于植入物，例如脊椎或脊髓植入物的材料，其包含刚性生物相容性聚合物，例如包含多个互连孔的PEEK。 该聚合物示例性地具有50体积％至85体积％之间的孔隙率，并且在特定实施方案中能够承受高达20MPa的压力。 多孔PEEK材料也可以具有一（1）英寸的任何尺寸的最小厚度。

公开(公告)号：US20120202064A1

公开(公告)日：2012-08-09

申请号：US13446827

申请日：2012-04-13

Applicant: Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu

IPC: C08G63/91 ,  A61K9/14

CPC classification number: C08G63/912 ,  C08J3/14 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A short term controlled release composition which comprises poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN) is provided. The PLGA-ALN is constructed into 3D scaffolds (PLGA-ALN-3D) with pores size of 150-300 μm and average porosity of 85%, or microspheres (PLGA-ALN-M) with 50-100 μm in diameter. The released alendronate concentration is in the range of 5×10−7 M to 5×10−8 M.

Abstract translation: 提供了包含聚（乳酸 - 共 - 乙醇酸）交联阿仑膦酸盐（PLGA-ALN）的短期控释组合物。 将PLGA-ALN构建成孔径为150-300μm，平均孔隙率为85％的3D支架（PLGA-ALN-3D）或直径为50-100μm的微球（PLGA-ALN-M）。 释放的阿仑膦酸盐浓度在5×10-7M至5×10-8M的范围内。

公开(公告)号：US20090081265A1

公开(公告)日：2009-03-26

申请号：US12328626

申请日：2008-12-04

Applicant: Nicholas A. Peppas

Inventor： Nicholas A. Peppas

IPC: A61K8/04 ,  C08J9/00 ,  A61K8/11 ,  C11D17/00 ,  A61Q13/00 ,  A23L1/48 ,  A61L9/012 ,  A61K9/10

CPC classification number: C08J9/26 ,  A61K9/7007 ,  A61K31/137 ,  A61K47/32 ,  C08J2201/044 ,  C08J2201/0444 ,  C08J2201/0446

Abstract: The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.

Abstract translation: 本发明包括组合物，方法，制备包含一种或多种活性剂的组合物的体系; 识别聚合物基质; 和一种porosigen，其中该组合物包含在低水或湿度条件下解离的多孔识别的可溶胀水凝胶。

公开(公告)号：US20080004368A1

公开(公告)日：2008-01-03

申请号：US11718962

申请日：2005-11-18

Applicant: Shanfeng Wang ,  Michael Yaszemski ,  Lichun Lu ,  Bradford Currier

Inventor： Shanfeng Wang ,  Michael Yaszemski ,  Lichun Lu ,  Bradford Currier

IPC: A61F2/00 ,  A61K31/77 ,  B32B27/00 ,  C08F20/00 ,  C08G63/02 ,  C08G65/332 ,  C08J9/26 ,  C08K3/32 ,  C12N5/06

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

Abstract: Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(ε-caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(ε-caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of UV light).

Abstract translation: 聚（丙烯酸富马酸酯）与聚（己内酯）二醇共聚以制备聚（丙烯酸富马酸酯）和聚（ε-己内酯）的嵌段共聚物。 聚（丙烯酸富马酸酯）和聚（ε-己内酯）的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。 嵌段共聚物可以通过氧化还原或光引发交联，具有或不具有另外的交联剂。 因此，共聚物既可自交联（不使用任何交联剂）和可光交联（在UV光的存在下）。