公开(公告)号：US20150141665A1

公开(公告)日：2015-05-21

申请号：US14570705

申请日：2014-12-15

Applicant: Nektar Therapeutics

Inventor： Michael D. Bentley ,  Sean M. Culbertson ,  Samuel P. McManus

IPC: C08G65/338 ,  C07D207/46

CPC classification number: A61K47/60 ,  A61K31/765 ,  A61K38/26 ,  A61K38/28 ,  C07C235/68 ,  C07D207/46 ,  C07K14/575 ,  C08G61/02 ,  C08G65/33396 ,  C08G65/3348 ,  C08G65/338 ,  C08G65/48 ,  C08K5/13 ,  C08K2201/012

Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.

Abstract translation: 本发明提供制备聚合物试剂的方法，其中所述方法包括（a）提供带有羟基，第一氨基和第二氨基的芳族部分; （b）使官能团试剂与羟基反应以产生具有能够与活性剂的氨基反应的官能团的羟基，得到可水解的氨基甲酸酯; 和（c）使具有反应性基团的多个聚（亚烷基二醇）水溶性聚合物与第一氨基和第二氨基反应，以产生（i）通过间隔基部分含有水溶性聚合物的第一个氨基 ，和（ii）通过间隔基部分带有第二水溶性聚合物的第二个氨基。

公开(公告)号：US09017416B2

公开(公告)日：2015-04-28

申请号：US12819540

申请日：2010-06-21

Applicant: Derek J. McMinn

Inventor： Derek J. McMinn

IPC: A61F2/32 ,  A61F2/34 ,  A61F2/30 ,  A61F2/46 ,  A61L27/14 ,  A61L27/50 ,  B32B1/00 ,  B32B3/00 ,  B32B7/12 ,  B32B15/08 ,  C08J3/00 ,  C08J3/24 ,  A61F2/38

CPC classification number: A61F2/34 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/4609 ,  A61F2002/30026 ,  A61F2002/30112 ,  A61F2002/30143 ,  A61F2002/30324 ,  A61F2002/30331 ,  A61F2002/30352 ,  A61F2002/30378 ,  A61F2002/30448 ,  A61F2002/30462 ,  A61F2002/3052 ,  A61F2002/30561 ,  A61F2002/30685 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/30904 ,  A61F2002/30971 ,  A61F2002/30986 ,  A61F2002/344 ,  A61F2002/4681 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0004 ,  A61F2230/0017 ,  A61L27/14 ,  A61L27/50 ,  A61L27/505 ,  B29C43/003 ,  B29C43/146 ,  B29C2043/147 ,  B29C2043/148 ,  B29K2023/06 ,  B29K2105/0044 ,  B29L2031/7532 ,  B32B1/00 ,  B32B3/00 ,  B32B7/12 ,  B32B15/08 ,  B32B2535/00 ,  B33Y80/00 ,  C08J3/00 ,  C08J3/24 ,  C08J3/28 ,  C08J2300/00 ,  C08J2323/06 ,  C08K5/1545 ,  C08K2201/012

Abstract: This invention relates to a method of forming a polymer component and comprises blending polymer particles with antioxidant to form a mixture in which the antioxidant coats the polymer particles, irradiating the mixture to cross-link the polymer particles therein and forming the irradiated mixture into a consolidated component. The invention also relates to a method of forming an articular surface for a prosthesis and a prosthesis having a polymer articular bearing surface wherein at least one pre-determined portion of the bearing surface is provided with cross-linked polymer bonds.

Abstract translation: 本发明涉及形成聚合物组分的方法，并且包括将聚合物颗粒与抗氧化剂混合以形成其中抗氧化剂涂覆聚合物颗粒的混合物，照射该混合物以使其中的聚合物颗粒交联并将经辐射的混合物形成固结 零件。 本发明还涉及形成用于假体的关节表面的方法和具有聚合物关节轴承表面的假体，其中轴承表面的至少一个预定部分具有交联的聚合物键。

公开(公告)号：US09012562B2

公开(公告)日：2015-04-21

申请号：US13142775

申请日：2008-12-30

Applicant: Davide Ciampini ,  Lucia Giovanola ,  Cristina Panciatichi ,  Oriana Rossotto ,  Duccio Spartaco Sassano

Inventor： Davide Ciampini ,  Lucia Giovanola ,  Cristina Panciatichi ,  Oriana Rossotto ,  Duccio Spartaco Sassano

IPC: C08L27/12 ,  C08F8/30 ,  C09J4/00 ,  B01L3/00 ,  C09J133/06

CPC classification number: C09J135/02 ,  A61L24/06 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/12 ,  B01L2300/16 ,  C08F2/46 ,  C08F4/36 ,  C08K5/13 ,  C08K5/18 ,  C08K5/5425 ,  C08K2201/012 ,  C09J4/00 ,  C09J129/00 ,  C09J133/06 ,  Y10T156/10 ,  Y10T428/1352

Abstract: The present invention relates to acrylic adhesive composition comprising a mixture of at least one polyol tri(meth)acrylate monomer and at least one polyalkylene glycol mono(meth)acrylate monomer for assembling elements made of plastic materials, like PMMA or SAN, or inorganic material, like glass or metals, employed for manufacturing of devices for the distribution or containment of biological substances, like proteins, enzymes, antibodies, antigens, DNA, and the like. The present invention also relates to devices for the distribution or containment of biological substances assembled with the above mentioned acrylic adhesive composition, and particularly thermal or piezoelectric ejecting devices, and biochip microarray, as well as to a method for assembling thereof.

Abstract translation: 本发明涉及包含至少一种多元醇三（甲基）丙烯酸酯单体和至少一种聚亚烷基二醇单（甲基）丙烯酸酯单体的混合物的丙烯酸粘合剂组合物，用于组装由诸如PMMA或SAN的塑料材料制成的元件或无机材料 如玻璃或金属，用于制造用于分配或抑制生物物质如蛋白质，酶，抗体，抗原，DNA等的装置。 本发明还涉及用上述丙烯酸粘合剂组合物，特别是热或压电喷射装置和生物芯片微阵列组装的生物物质的分配或容纳装置，以及其组装方法。

公开(公告)号：US20140370248A1

公开(公告)日：2014-12-18

申请号：US14364161

申请日：2012-12-13

Applicant: Stephen Anthony Hall ,  Kirsty Margaret McVean

Inventor： Stephen Anthony Hall ,  Kirsty Margaret McVean

IPC: C09D11/00 ,  C08K5/32 ,  B41J11/00 ,  C08K5/3435 ,  C08K5/529 ,  C09D11/10 ,  C08K5/3415

CPC classification number: C09D11/38 ,  B41J11/002 ,  C08K5/32 ,  C08K5/3415 ,  C08K5/3435 ,  C08K5/529 ,  C08K2201/012 ,  C09D11/101 ,  C09D11/107 ,  Y10T428/24802

Abstract: An energy curable inkjet ink includes a nitroxy inhibitor, a compound having an ethylenic unsaturated bond, a photoinitiator, a coloring agent, and a stray light resistance index of at least 7. A method of preparing an energy curable inkjet ink with stray light resistance includes providing a nitroxy inhibitor; providing a mixture of a compound having an ethylenic unsaturated bond, and a photoinitiator, and a coloring agent; combining the nitroxy inhibitor and the mixture to obtain the energy curable inkjet ink and thereby to increase a stray light resistance index of the energy curable inkjet ink to at least 7.

Abstract translation: 能量可固化喷墨油墨包括硝基氧抑制剂，具有烯键式不饱和键的化合物，光引发剂，着色剂和杂散光阻力指数为至少7.一种制备具有杂散光阻的能量可固化喷墨油墨的方法包括 提供硝基氧抑制剂; 提供具有烯属不饱和键的化合物和光引发剂的混合物和着色剂; 结合硝基氧抑制剂和混合物以获得能量固化喷墨油墨，从而将能量可固化喷墨油墨的杂散光阻力指数提高至至少7。

公开(公告)号：US20140107349A1

公开(公告)日：2014-04-17

申请号：US14109302

申请日：2013-12-17

Applicant: Nektar Therapeutics

Inventor： Michael D. Bentley ,  Sean M. Culbertson ,  Samuel P. McManus

IPC: C08G65/48

CPC classification number: A61K47/60 ,  A61K31/765 ,  A61K38/26 ,  A61K38/28 ,  C07C235/68 ,  C07D207/46 ,  C07K14/575 ,  C08G61/02 ,  C08G65/33396 ,  C08G65/3348 ,  C08G65/338 ,  C08G65/48 ,  C08K5/13 ,  C08K2201/012

Abstract: The present invention provides among other things methods for preparing polymeric reagents, wherein the method comprises (a) providing an aromatic moiety bearing a hydroxy group, a first amino group and a second amino group; (b) reacting a functional group reagent with the hydroxy group to result in a hydroxy group bearing a functional group capable of reacting with an amino group of an active agent and resulting in a hydrolyzable carbamate; and (c) reacting a plurality of poly(alkylene glycol) water-soluble polymers bearing a reactive group with the first amino group and second amino group to result in (i) a first amino group bearing a water-soluble polymer through a spacer moiety, and (ii) a second amino group bearing a second water-soluble polymer through a spacer moiety.

Abstract translation: 本发明提供制备聚合物试剂的方法，其中所述方法包括（a）提供带有羟基，第一氨基和第二氨基的芳族部分; （b）使官能团试剂与羟基反应，得到具有能够与活性剂的氨基反应的官能团的羟基，得到可水解的氨基甲酸酯; 和（c）使具有反应性基团的多个聚（亚烷基二醇）水溶性聚合物与第一氨基和第二氨基反应，以产生（i）通过间隔基部分含有水溶性聚合物的第一个氨基 ，和（ii）通过间隔基部分带有第二水溶性聚合物的第二个氨基。

公开(公告)号：US20140027339A1

公开(公告)日：2014-01-30

申请号：US13849797

申请日：2013-03-25

Applicant: Constar International, Inc.

Inventor： Girish Nilkanth Deshpande ,  Paul David Weipert ,  Michael W. Ensley

IPC: B65D81/26

CPC classification number: C07D207/00 ,  B01J20/06 ,  B01J20/22 ,  B01J20/262 ,  B65D65/38 ,  B65D81/266 ,  C07D209/46 ,  C07D209/48 ,  C07D471/04 ,  C08K5/00 ,  C08K5/0091 ,  C08K5/098 ,  C08K5/3417 ,  C08K5/3432 ,  C08K2201/012 ,  C08L67/02

Abstract: The invention relates to compounds of the structure of formula I and II: where X is selected from the group consisting of O, S and NH; Y, A and B are independently selected from the group consisting of N and CH; D, E and F are independently selected from the group consisting of CH, N, O and S; the symbol — represents a single or a double bond; and R1, R2 and R3 are independently selected from the group consisting of H, electron withdrawing groups and electron releasing groups. In other embodiments, the compounds are used as oxygen scavengers and in barrier compositions and articles.

Abstract translation: 本发明涉及式I和II结构的化合物：其中X选自O，S和NH; Y，A和B独立地选自N和CH; D，E和F独立地选自CH，N，O和S; 符号 - 表示单键或双键; 并且R 1，R 2和R 3独立地选自H，吸电子基团和电子释放基团。 在其它实施方案中，化合物用作除氧剂和阻隔组合物和制品。

公开(公告)号：US20130268083A1

公开(公告)日：2013-10-10

申请号：US13775533

申请日：2013-02-25

Applicant: Derek James Wallace McMinn

Inventor： Derek James Wallace McMinn

IPC: A61F2/34

CPC classification number: A61F2/34 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/4609 ,  A61F2002/30026 ,  A61F2002/30112 ,  A61F2002/30143 ,  A61F2002/30324 ,  A61F2002/30331 ,  A61F2002/30352 ,  A61F2002/30378 ,  A61F2002/30448 ,  A61F2002/30462 ,  A61F2002/3052 ,  A61F2002/30561 ,  A61F2002/30685 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/30904 ,  A61F2002/30971 ,  A61F2002/30986 ,  A61F2002/344 ,  A61F2002/4681 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0004 ,  A61F2230/0017 ,  A61L27/14 ,  A61L27/50 ,  A61L27/505 ,  B29C43/003 ,  B29C43/146 ,  B29C2043/147 ,  B29C2043/148 ,  B29K2023/06 ,  B29K2105/0044 ,  B29L2031/7532 ,  B32B1/00 ,  B32B3/00 ,  B32B7/12 ,  B32B15/08 ,  B32B2535/00 ,  B33Y80/00 ,  C08J3/00 ,  C08J3/24 ,  C08J3/28 ,  C08J2300/00 ,  C08J2323/06 ,  C08K5/1545 ,  C08K2201/012

Abstract: This invention related to a method of forming a polymer component and comprises blending polymer particles with antioxidant to form a mixture in which the antioxidant coats the polymer particles, irradiating the polymer particles to cross-link the polymer particles therein and forming the irradiated mixture into a consolidated component. The invention also relates to a method of forming an articular surface for a prosthesis and a prosthesis having a polymer articular bearing surface wherein at least one predetermined portion of the bearing surface is provided with cross-linked polymer bonds.

Abstract translation: 本发明涉及形成聚合物组分的方法，并且包括将聚合物颗粒与抗氧化剂混合以形成其中抗氧化剂涂覆聚合物颗粒的混合物，照射聚合物颗粒以使其中的聚合物颗粒交联并将其形成为 综合成分。 本发明还涉及形成用于假体的关节表面的方法和具有聚合物关节轴承表面的假体，其中支承表面的至少一个预定部分具有交联的聚合物键。

公开(公告)号：US20130165559A1

公开(公告)日：2013-06-27

申请号：US13808272

申请日：2011-07-11

Applicant: Rüdiger Wissemborski ,  Rainer Schnee ,  Gideon Rath ,  David Kümmet

Inventor： Rüdiger Wissemborski ,  Rainer Schnee ,  Gideon Rath ,  David Kümmet

IPC: C08K3/00

CPC classification number: C08K5/0008 ,  C08J3/22 ,  C08J2400/00 ,  C08K3/014 ,  C08K2201/012

Abstract: A composition which includes a plastic matrix, an acid-activatable metal component selected from aluminium (Al), magnesium (Mg), zinc (Zn), copper (Cu), iron (Fe), tin (Sn), cobalt (Co) and manganese (Mn); and at least one acid carrier which in the RoO test has a rate of oxidation (RoO=rate of oxidation) of less than 1000 ppm of iron with a reaction time of 60 min.

Abstract translation: 一种组合物，其包含塑料基质，可以从铝（Al），镁（Mg），锌（Zn），铜（Cu），铁（Fe），锡（Sn），钴（Co） 和锰（Mn）; 和至少一种在RoO试验中具有小于1000ppm铁的氧化速率（RoO =氧化速率）的酸性载体，反应时间为60分钟。

公开(公告)号：US20130072603A1

公开(公告)日：2013-03-21

申请号：US13677345

申请日：2012-11-15

Applicant: M&G USA CORPORATION

Inventor： Kevin Rollick ,  Gianluca Ferrari

IPC: C08K5/098 ,  C08L67/00

CPC classification number: C08K5/098 ,  C08K5/42 ,  C08K2201/012 ,  C08L67/00 ,  C08L67/02 ,  C08L77/10

Abstract: The present invention is to a composition made from a polyester produced by the acid or ester polyester process, a cobalt salt and a base, preferably an alkaline metal base. The composition can be made by blending a cobalt salt with a polyester which has been polymerized in the presence a alkaline metal ion derived from a basic alkaline metal compound, e.g. alkaline metal base or basic alkaline metal salt. The composition may optionally comprise an ionic compatibilizer, which may further be blended with a partially aromatic polyamide. This blend can be processed into a container having both active and passive oxygen barrier with an improved color and clarity than that achieved by cobalt alone. The use of the cobalt salt in combination with the base can also be used to improve the color of recycled polyester durin processing.

Abstract translation: 本发明是由酸或酯类聚酯方法制得的聚酯，钴盐和碱，优选碱金属碱制成的组合物。 该组合物可以通过将钴盐与在碱性碱金属化合物的碱金属离子存在下聚合的聚酯混合来制备， 碱金属碱或碱性碱金属盐。 组合物可以任选地包含离子增容剂，其可以进一步与部分芳族聚酰胺共混。 该混合物可以被加工成具有主动和被动氧气屏障的容器，其颜色和透明度比单独使用钴获得的更好的颜色和透明度。 使用钴盐与碱组合也可以用于改善再循环聚酯干燥剂加工的颜色。

公开(公告)号：US20130017400A1

公开(公告)日：2013-01-17

申请号：US13636847

申请日：2011-03-18

Applicant: Kazuko Imai ,  Yumiko Oomori

Inventor： Kazuko Imai ,  Yumiko Oomori

IPC: B32B9/04 ,  B32B23/02 ,  B32B5/16 ,  B82Y30/00

CPC classification number: B32B27/08 ,  B32B7/12 ,  B32B27/322 ,  B32B27/36 ,  C08J7/047 ,  C08J2367/02 ,  C08J2401/02 ,  C08J2429/04 ,  C08K3/16 ,  C08K5/3435 ,  C08K5/5419 ,  C08K2201/008 ,  C08K2201/012 ,  C08L1/02 ,  C08L29/04 ,  C08L2205/16 ,  Y10T428/31663 ,  Y10T428/31971

Abstract: A gas barrier laminate is provided that can maintain excellent gas barrier properties of a cellulose film even under high humidity and that can suppress entry or permeation of water vapor or dirt, which cause deterioration, into the film. The gas barrier laminate includes a base material, and a gas barrier layer provided on at least one side of the base material. The gas barrier layer contains at least cellulose fibers and one or more kinds of water-soluble polymer. Additionally, the fiber width of the cellulose fibers falls within a range of 3 nm to 50 nm.

Abstract translation: 即使在高湿度下也能够保持纤维素膜的优异的气体阻隔性，能够抑制导致劣化的水蒸汽或污物的进入或渗透。 阻气层叠体包括基材，以及设置在基材的至少一侧的阻气层。 阻气层至少含有纤维素纤维和一种以上的水溶性聚合物。 此外，纤维素纤维的纤维宽度在3nm〜50nm的范围内。