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91.发明申请MICROORGANISMS FOR PRODUCING PUTRESCINE AND METHOD FOR PRODUCING PUTRESCINE USING SAME 审中-公开用于生产聚氨酯的微生物和使用它们生产聚氨酯的方法
公开(公告)号：WO2012077995A3
公开(公告)日：2012-09-07
申请号：PCT/KR2011009478
申请日：2011-12-08
Applicant: CJ CHEILJEDANG CORP , CHOI HYANG , LEE KYOUNG MIN , KANG MIN SUN , JHON SUNG HOO , UM HYE WON , CHOI SU JIN , LEE HAN WON , SHIN SOO AN
Inventor： CHOI HYANG , LEE KYOUNG MIN , KANG MIN SUN , JHON SUNG HOO , UM HYE WON , CHOI SU JIN , LEE HAN WON , SHIN SOO AN
CPC classification number: C12P13/001 , C07K14/34 , C12N9/0008 , C12N9/1018 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/88 , C12R1/15 , C12Y102/01038 , C12Y201/03003 , C12Y203/01035 , C12Y206/01013 , C12Y207/02008 , C12Y401/01017
Abstract: The present invention relates to microorganisms for producing putrescine and a method for producing putrescine using the same, and more specifically to microorganisms with an ability to produce putrescine and a method for producing putrescine using the microorganisms by: blocking a biosynthetic pathway from ornithine to arginine; increasing the amount of glutamate within a cell; enhancing the activity of the biosynthetic pathway which produces ornithine from glutamate; and introducing ornithine decarboxylase from the exotic enzymes.
Abstract translation: 本发明涉及用于制造腐胺的微生物和使用该腐胺的腐胺的制造方法，特别涉及具有产生腐胺的能力的微生物和使用微生物产生腐胺的方法，其特征在于：将生物合成途径从鸟氨酸封闭为精氨酸; 增加细胞内谷氨酸的量; 增强从谷氨酸生成鸟氨酸的生物合成途径的活性; 并从外来酶引入鸟氨酸脱羧酶。
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公开(公告)号：WO2012077995A2
公开(公告)日：2012-06-14
申请号：PCT/KR2011/009478
申请日：2011-12-08
CPC classification number: C12P13/001 , C07K14/34 , C12N9/0008 , C12N9/1018 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/88 , C12R1/15 , C12Y102/01038 , C12Y201/03003 , C12Y203/01035 , C12Y206/01013 , C12Y207/02008 , C12Y401/01017
Abstract: 본 발명은 퓨트레신을 생산하는 미생물 및 이를 이용한 퓨트레신의 생산 방법에 관한 것으로, 보다 구체적으로 본 발명은 오르니틴으로부터 아르기닌으로의 생합성 경로를 차단하고, 세포 내 글루타메이트의 양을 증가시키고, 글루타메이트로부터 오르니틴을 생산하는 생합성 경로의 활성을 강화시키며, 오르니틴 디카르복실라아제(ornithine decarboxylase)를 외래로부터 도입함으로써 퓨트레신 생산능이 부여된 미생물 및 상기 미생물을 이용하여 퓨트레신을 생산하는 방법에 관한 것이다.
Abstract translation:
腐胺的发明微生物和大约生产使用相同的用于制造鞋腐胺神方法，更具体地说，本发明是阻止来自鸟氨酸精氨酸的生物合成途径，和胞内谷氨酸 增加的量和时，它通过使用该微生物从外源腐胺能力引入（鸟氨酸脱羧酶）增强的生物合成途径从谷氨酸，鸟氨酸脱羧酶鸟氨酸生产锡的活性，并且所述微生物给定的生产 在这种情况下，
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公开(公告)号：WO2016144247A1
公开(公告)日：2016-09-15
申请号：PCT/SE2016/050193
申请日：2016-03-10
Applicant: BIOPETROLIA AB
Inventor： QIN, Jiufu , KRIVORUCHKO, Anastasia , DAVID, Florian , JIANG, Bo , NIELSEN, Jens
CPC classification number: C12P13/10 , C12N9/0008 , C12N9/1018 , C12N9/1096 , C12N9/1217 , C12N9/78 , C12N9/88 , C12N15/52 , C12P13/001 , C12Y102/01038 , C12Y201/03003 , C12Y206/01011 , C12Y207/02008 , C12Y305/03001 , C12Y401/01017 , C12Y403/02001
Abstract: The present invention relates to the provision of genetically modified microbial cells, such as yeast cells with an improved ability for producing L-ornithine and its derivatives. Overproduction of L-ornithine is obtained in the first place by the down-regulation or attenuation of specially selected genes, wherein said genes encode enzymes involved in the L-ornithine consumption and/or degradation pathways. Further L-ornithine production ability is improved by down-regulation, attenuation, deletion or overexpression of specially selected genes, wherein said genes encode enzymes and/or proteins involved in the L-ornithine 'acetylated derivatives cycle', L-glutamate synthesis pathways, subcellular trafficking, TCA cycle, pyruvate carboxylation pathway, respiratory electron- transport chain, and the carbon substrates' assimilation machinery. The invention additionally provides a method to produce L-ornithine with said modified eukaryotic cells.
Abstract translation: 本发明涉及提供具有改进的生产L-鸟氨酸及其衍生物的能力的转基因微生物细胞，例如酵母细胞。 首先通过特异选择的基因的下调或减弱获得L-鸟氨酸的过度产生，其中所述基因编码参与L-鸟氨酸消耗和/或降解途径的酶。 通过特异选择的基因的下调，减弱，缺失或过表达来改善L-鸟氨酸的生产能力，其中所述基因编码参与L-鸟氨酸'乙酰化衍生物循环'的酶和/或蛋白质，L-谷氨酸合成途径， 亚细胞运输，TCA循环，丙酮酸羧化途径，呼吸电子传递链和碳底物的同化机制。 本发明另外提供了用所述修饰的真核细胞产生L-鸟氨酸的方法。
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公开(公告)号：WO2015139093A1
公开(公告)日：2015-09-24
申请号：PCT/AU2015/050125
申请日：2015-03-23
Applicant: THE SYDNEY CHILDREN'S HOSPITALS NETWORK (RANDWICK AND WESTMEAD) (INCORPORATING THE ROYAL ALEXANDRA HOSPITAL FOR CHILDREN) , CHILDREN'S MEDICAL RESEARCH INSTITUTE , MOUNT SINAI HOSPITAL
Inventor： ALEXANDER, Ian , CUNNINGHAM, Sharon , NAGY, Andras
CPC classification number: A61K48/0066 , A61K48/0041 , A61K48/005 , C12N9/1018 , C12N9/1241 , C12N9/14 , C12N9/93 , C12N15/86 , C12N2750/14143 , C12N2800/90 , C12N2840/007 , C12Y201/03003 , C12Y207/07 , C12Y306/03044 , C12Y603/04005
Abstract: Provided herein are methods for facilitating or inducing stable transgene integration and expression in a proliferating cell, comprising administering to the cell (i) a recombinant AAV (rAAV) vector comprising the transgene flanked by transposon-derived inverted terminal repeat sequences, which sequences are in turn flanked by AAV-derived inverted terminal repeat regions, and (ii) a source of a transposase that recognises said transposon-derived inverted terminal repeat sequences and directs the genomic integration of the transgene into the genome of the proliferating cell. Also provided are methods and transgene delivery systems for the treatment or prevention of diseases affecting, associated with or characterised by proliferating cells, including paediatric liver diseases, bone marrow diseases and cancer.
Abstract translation: 本文提供了促进或诱导在增殖细胞中稳定的转基因整合和表达的方法，包括向细胞施用（i）包含转座子的重组AAV（rAAV）载体，其侧翼为转座子衍生的反向末端重复序列，该序列位于 转化为侧翼为AAV衍生的反向末端重复区，以及（ii）识别所述转座子衍生的反向末端重复序列并指导转基因的基因组整合进入增殖细胞基因组的转座酶的来源。 还提供了用于治疗或预防影响与细胞增殖相关或特征在于包括儿科肝脏疾病，骨髓疾病和癌症的细胞的疾病的方法和转基因递送系统。
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95.发明申请COMPOSITIONS USEFUL IN TREATMENT OF ORNITHINE TRANSCARBAMYLASE (OTC) DEFICIENCY 审中-公开用于治疗异丙肾上腺素（OTC）缺乏症的组合物
公开(公告)号：WO2015138348A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019513
申请日：2015-03-09
Inventor： WANG, Lili , WILSON, James M.
CPC classification number: C12N9/1018 , A61K48/0058 , C12N15/86 , C12N2710/10343 , C12N2740/15043 , C12N2750/14032 , C12N2750/14033 , C12N2750/14043 , C12N2750/14071 , C12N2750/14143 , C12N2800/22 , C12Y201/03003
Abstract: Viral vectors comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis cirrhosis in OTCD patients by administering hOTC.
Abstract translation: 提供包含工程化hOTC DNA和RNA序列的病毒载体，其在递送至有需要的受试者时可用于治疗高氨血症，鸟氨酸转氨甲酰酶转氨基甲酰酶缺乏症和与之相关的症状。 还提供了通过施用hOTC在OTCD患者中使用hOTC治疗肝纤维化肝硬化的方法。
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Patent Agency Ranking
公开(公告)号：WO2012170889A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041663
申请日：2012-06-08
Applicant: SHIRE HUMAN GENETIC THERAPIES, INC. , HEARTLEIN, Michael , GUILD, Braydon, Charles , DEROSA, Frank , ZHANG, Jerry, Chi
Inventor： HEARTLEIN, Michael , GUILD, Braydon, Charles , DEROSA, Frank , ZHANG, Jerry, Chi
IPC: C07D233/64 , C07C323/00 , A61K9/127 , A61K31/4164
CPC classification number: A61K9/19 , A61K9/1271 , A61K9/1272 , A61K9/5123 , A61K31/7088 , A61K38/45 , A61K38/465 , A61K38/47 , A61K38/50 , C07C323/25 , C07C323/27 , C07C323/44 , C07D233/64 , C07J41/0055 , C07J43/003 , C12N15/88 , C12Y201/03003 , C12Y203/01 , C12Y207/08015 , C12Y301/06 , C12Y302/01022 , C12Y302/01035 , C12Y302/01046 , C12Y302/01076 , C12Y305/03001
Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent iransfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
Abstract translation: 本文公开了新化合物，包含这些化合物的药物组合物及其使用的相关方法。 本文所述的化合物是有用的，例如作为促进将包封的多核苷酸递送至靶细胞并随后对所述靶细胞进行染色的脂质体递送载体，并且在某些实施方案中，其特征在于具有一种或多种提供此类化合物相对于 其他类似分类的脂质。
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公开(公告)号：WO2012077994A2
公开(公告)日：2012-06-14
申请号：PCT/KR2011/009477
申请日：2011-12-08
CPC classification number: C12P13/10 , C07K14/34 , C12N9/0008 , C12N9/1018 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12R1/15 , C12Y102/01038 , C12Y201/03003 , C12Y203/01035 , C12Y206/01013 , C12Y207/02008
Abstract: 본 발명은 오르니틴으로부터 아르기닌으로의 생합성 경로를 차단하고, 세포 내 글루타메이트의 양을 증가시키며, 글루타메이트로부터 오르니틴을 생산하는 생합성 경로의 활성을 강화시킴으로써, 오르니틴 생산능이 향상된 미생물 및 상기 미생물을 이용하여 오르니틴을 생산하는 방법에 관한 것이다.
Abstract translation:
本发明鸟氨酸块从锡精氨酸的生物合成途径，并且通过增加谷氨酸盐的细胞的量，提高的生物合成途径的活性从谷氨酸，鸟氨酸生产鸟氨酸生产锡 以及使用该微生物生产鸟氨酸的方法。
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公开(公告)号：KR101813759B1
公开(公告)日：2018-01-02
申请号：KR1020150090021
申请日：2015-06-24
Applicant: 씨제이제일제당 (주)
CPC classification number: C12P13/10 , C12N9/1018 , C12N9/1025 , C12N9/88 , C12P13/001 , C12Y201/03003 , C12Y203/03001 , C12Y401/01017
Abstract: 본발명은퓨트레신또는오르니틴을생산하기위한재조합미생물및 이를이용하여퓨트레신또는오르니틴을생산하는방법에관한것이다. 구체적으로, 당대사전사조절자(transcriptional regulator of sugar metabolism, SugR)의활성을약화하거나시트레이트신타아제(citrate synthase, GltA)의활성을강화하거나상기모두적용된퓨트레신또는오르니틴을생산하는코리네박테리움속 미생물및 이를이용하여퓨트레신또는오르니틴을생산하는방법에관한것이다.
Abstract translation: 本发明涉及用于产生腐胺或鸟氨酸的重组微生物以及使用该重组微生物生产腐胺或鸟氨酸的方法。 具体而言，生产当代之前有四个调节削弱（糖代谢，SUGR的转录调节）的活性或增强柠檬酸合酶的施加腐胺或鸟氨酸的活性（柠檬酸合酶，GLTA）或所有的刚度 以及使用该微生物生产腐胺或鸟氨酸的方法。
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公开(公告)号：KR1020140115244A
公开(公告)日：2014-09-30
申请号：KR1020140017243
申请日：2014-02-14
Applicant: 씨제이제일제당 (주)
CPC classification number: C12P13/001 , C12N9/0008 , C12N9/1018 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/88 , C12N15/52 , C12Y102/01038 , C12Y201/03003 , C12Y203/01035 , C12Y206/01011 , C12Y207/02008 , C12Y401/01007 , C12N1/20 , C12N15/63 , C12N15/77 , C12N2330/50 , C12N2500/46 , C12P13/00
Abstract: The present invention relates to a recombinant microorganism capable of producing putrescine and a method for producing putrescine using the same. According to the present invention, NCgl2522 activity of the microorganism, which is transformed to be able to produce putrescine, is enhanced. Therefore, the recombinant microorganism can produce putrescine with a high yield. The recombinant microorganism capable of producing putrescine is characterized in that the microorganism is transformed to have enhanced activity of protein including amino acid with SEQ ID: 21 or 23.
Abstract translation: 本发明涉及能够产生腐胺的重组微生物和使用其的腐胺的制造方法。 根据本发明，可以提高转化为能够产生腐胺的微生物的NCgl2522活性。 因此，重组微生物可以高产率生产腐胺。 能够产生腐胺的重组微生物的特征在于将微生物转化成具有增强的包含SEQ ID：21或23的氨基酸的蛋白质的活性。
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公开(公告)号：KR20210032438A
公开(公告)日：2021-03-24
申请号：KR1020217004180A
申请日：2019-07-16
Applicant: 셀렉타 바이오사이언시즈, 인크.
Inventor： 피터 켈러 , 타카시 케이 키시모토 , 안드레스 무로 , 줄리아 드 사바타
CPC classification number: A61K48/0058 , A61K35/76 , A61K31/436 , A61K47/6937 , A61K48/005 , C12N15/86 , C12N9/1018 , C12Y201/03003 , A61K45/06 , B82Y5/00 , C12N2750/14132 , C12N2750/14143
Abstract: 오르니틴 트랜스카르브아밀라제 (OTC)를 코딩하는 핵산, 예컨대 OTC 코돈-최적화된 서열을 포함하는 핵산, 뿐만 아니라 관련 벡터, 예컨대 AAV 벡터와 관련된 방법 및 조성물이 본원에 제공된다. 또한, 요소 회로 장애와 연관된 효소를 코딩하는 서열 및 발현 제어 서열을 포함하는 AAV 벡터를 면역억제제에 커플링된 합성 나노담체와 조합하여 투여하는 방법이 제공된다.
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