公开(公告)号：WO1994022367A1

公开(公告)日：1994-10-13

申请号：PCT/US1994000093

申请日：1994-01-06

Applicant: PFIZER INC. ,  FOSSA, Anthony, A.

Inventor： PFIZER INC.

IPC: A61B05/05

CPC classification number: A61B5/0538 ,  A61B5/0031 ,  A61B5/027 ,  A61B5/0295 ,  A61B5/0535

Abstract: A radiotelemetry device for the measurement of blood flow rates in a mammal by measuring changes in bioimpedance. The device comp rises an elongated flexible catheter adapted to be inserted into a mammal's vessels, and a pair of current source electrodes and a pair of sensing electrodes disposed on the outer surface of the catheter. The pair of sensing electrodes is spaced apart along the catheter surface and disposed between the pair of current source electrodes. An implantable housing is connected to the catheter. A source of measured current is connected to the transmitting electrodes and a means for transmitting a radio signal is connected to the pair of sensing electrodes. The measured current source and the radio transmission means are contained within the housing. The device may be used advantageously in a system which comprises the above described catheter in conjunction with a receiver means for receiving the radio signal and transforming the radio signal into an electrical signal, and a signal processor means for transforming the electrical signal into a blood flow rate measurement signal.

Abstract translation: 一种用于通过测量生物阻抗的变化来测量哺乳动物血流速度的无线电测量装置。 装置组合件上升适于插入哺乳动物血管的细长柔性导管，以及设置在导管外表面上的一对电流源电极和一对感测电极。 一对感测电极沿着导管表面间隔开并且设置在该对电流源电极之间。 可植入的外壳连接到导管。 测量电流源连接到发射电极，并且用于发射无线电信号的装置连接到该对感测电极。 测量的电流源和无线电传输装置被包含在壳体内。 该装置可以有利地用于包括上述导管的系统，其结合用于接收无线电信号并将无线电信号转换成电信号的接收机装置，以及用于将电信号转换成血流量的信号处理器装置 速率测量信号。

公开(公告)号：WO1994012101A1

公开(公告)日：1994-06-09

申请号：PCT/US1992010321

申请日：1992-11-30

Applicant: HYPERTHERM CORP. ,  SIEVERT, Chester, E. ,  TUCKER, Robert, D. ,  LOENING, Stefen

Inventor： HYPERTHERM CORP.

IPC: A61B05/05

CPC classification number: A61N2/00 ,  A61N1/406

Abstract: Disclosed is apparatus and method for treating prostate tumors. The apparatus includes a platform (11) on which the patient may be seated. An electromagnetic coil (12) is disposed beneath the platform (11) and creates a field that acts on thermoseeds placed in the tumor. The method includes inductively heating the thermoseeds which heat the tumor cells to a temperature of between 45 and 50 DEG C.

Abstract translation: 公开了用于治疗前列腺肿瘤的装置和方法。 该装置包括一个平台（11），患者可坐在该平台上。 电磁线圈（12）设置在平台（11）下方，并产生作用于放置在肿瘤中的热源的场。 该方法包括将加热肿瘤细胞的热源感应加热到45至50℃的温度。

公开(公告)号：WO1994002067A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006011

申请日：1993-06-23

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HAYES, James, Patrick ,  TIEFENTHAL, James, Lawrence ,  McCAMISH, Mark, Anthony ,  ROSS, Jeffrey, R.

IPC: A61B05/05

CPC classification number: A61B5/1106 ,  A61B5/4519 ,  A61B5/6826

Abstract: An apparatus (10) is disclosed which may be employed for determining the relaxation rate of a muscle which has been caused to contract in response to an electrical stimulus. The apparatus comprises a means (13) for supporting the forearm and wrist of a person in a particular palm-up position with the wrist extended; a means (47) for measuring the force exerted upon a load cell (43) by the person's thumb during a test cycle, a means (70) for providing an electrical stimulus to the person's ulnar nerve, and a computer (65) for receiving, storing, plotting and analyzing the force data collected by the transducer (43).

Abstract translation: 公开了一种可用于确定响应于电刺激而导致收缩的肌肉松弛率的装置（10）。 该装置包括一个装置（13），用于在手腕延伸的情况下，以特定的掌声位置来支撑人的前臂和手腕; 一种用于在测试循环期间测量由人的拇指施加在测力传感器（43）上的力的装置（47），用于向人的尺神经提供电刺激的装置（70），以及用于接收 ，存储，绘制和分析由换能器（43）收集的力数据。

公开(公告)号：WO1993012717A2

公开(公告)日：1993-07-08

申请号：PCT/EP1993000006

申请日：1993-01-04

Applicant: COCKBAIN, Julian, Roderick, Michaelson ,  NYCOMED IMAGING AS ,  KLAVENESS, Jo

Inventor： COCKBAIN, Julian, Roderick, Michaelson ,  NYCOMED IMAGING AS

IPC: A61B05/05

CPC classification number: A61B5/0536 ,  A61K49/0002 ,  Y10S514/974 ,  Y10T436/24

Abstract: Agents for use in improving tissue/tissue contrast in electrical impedance tomography are described. In particular triiodophenyl compounds, metal chelates, magnetic particles, conducting particles and microbubbles may be used.

Abstract translation: 描述了用于改善电阻抗层析成像中的组织/组织对比度的试剂。 特别地，可以使用三碘苯基化合物，金属螯合物，磁性颗粒，导电颗粒和微泡。

公开(公告)号：WO1993000038A1

公开(公告)日：1993-01-07

申请号：PCT/GB1992001156

申请日：1992-06-26

Applicant: BRITISH TECHNOLOGY GROUP LIMITED ,  BROWN, Brian, Hilton ,  BARBER, David, Charles ,  McARDLE, Francis, Joseph

Inventor： BRITISH TECHNOLOGY GROUP LIMITED

IPC: A61B05/05

CPC classification number: A61B5/0536 ,  A61B5/04085

Abstract: In an APT method, the surface-contact electrodes are located in a closed loop or rosette array on one planar, or nominally planar, skin surface of a body to be investigated, and electrically connected to data acquisition and processing equipment. The invention also includes apparatus for carrying out this method, comprising an array of surface-contact electrodes (8), adapted to be applied to the skin of a body to be investigated, the electrodes (8) being arranged on a flexible carrier (10) in a closed loop, or rosette formation on one common plane, or nominal plane.

Abstract translation: 在APT方法中，表面接触电极位于待研究的身体的一个平面或标称平面的皮肤表面上的闭环或玫瑰花阵列中，并且电连接到数据采集和处理设备。 本发明还包括用于执行该方法的装置，包括适于施加到被研究体的皮肤上的表面接触电极阵列（8），所述电极（8）布置在柔性载体（10 ），或在一个公共平面或标称平面上形成玫瑰花结。

公开(公告)号：WO1992019156A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003559

申请日：1992-04-29

Applicant: OCCUPATIONAL PREVENTIVE DIAGNOSTICS, INC.

Inventor： OCCUPATIONAL PREVENTIVE DIAGNOSTICS, INC. ,  SPITZ, Lawrence, K. ,  JAEGER, Scott, N. ,  MUSSER, Scott, N.

IPC: A61B05/05

CPC classification number: A61B5/05 ,  A61B5/4041

Abstract: A portable system for substantially automated monitoring of nerve conduction velocity through the carpal tunnel of a patient includes an electrode supporting structure (10) which supports stimulating (44) and pickup (40) electrodes in a predetermined spatial relationship so as to contact the patient's arm and hand. The electrode supporting structure (10) is a part of a housing which contains stimulating signal generating (42) and response signal processing (28) circuitry, which operates substantially automatically under control of a microprocessor (30). The microprocessor controls generation of stimulating pulses and determines the elapsed time until the occurrence of a predetermined response signal characteristic, such as its peak. Data relating to nerve conduction time or velocity measurements and response signal waveform are stored in a removable memory (34) to permit later analysis and treatment recommendation by a physician. The system is useful for screening large groups of people at remote locations, such as workers at an employer's facilities, for evaluating their median nerve condition and likelyhood of developping carpal tunnel syndrome.

公开(公告)号：WO1991019454A1

公开(公告)日：1991-12-26

申请号：PCT/GB1991000915

申请日：1991-06-07

Applicant: BROWN, Brian, Hilton ,  BARBER, David, Charles

IPC: A61B05/05

CPC classification number: A61B5/0536

Abstract: A method of, and apparatus for, real-time imaging are described employing a plurality of contact electrodes (1) located for example around the thorax (2) with simultaneous measurement of voltage differences at adjacent pairs of electrodes (1), digital demodulation of the voltages, and measurement and division of the drive current into the voltage measurements before image reconstruction by the use of transputers (20, 22, 24 and 26).

公开(公告)号：WO1991011957A1

公开(公告)日：1991-08-22

申请号：PCT/US1991000888

申请日：1991-02-14

Applicant: GEORGETOWN UNIVERSITY

Inventor： GEORGETOWN UNIVERSITY ,  McRAE, Donald, A.

IPC: A61B05/05

CPC classification number: A61F7/00 ,  A61B5/053 ,  A61B5/0535 ,  A61N1/403

Abstract: A method of evaluating tissue changes in a mammal occurring durint therapeutic hyperthermia, comprising: a) applying therapeutic hyperthermia to said mammal and monitoring the changes in tissue electrical impendance before, during and after said therapeutic hyperthermia, or any combination thereof, and b) determining the extent of tissue change in said mammal from the changes in tissue electrical impedance.

公开(公告)号：WO1991010396A1

公开(公告)日：1991-07-25

申请号：PCT/SU1990000014

申请日：1990-01-15

Applicant: BERLIN, Jury Valentinovich ,  VOLKOV, Vasily Evgenievich ,  KORNEVA, Raisa Borisovna ,  SEMENOV, Sergei Viktorovich ,  SKORIK, Valery Ivanovich

IPC: A61B05/05

CPC classification number: A61B5/05

Abstract: A device for determining the degree of hydration of biological tissues has a UHF-generator (1) whose input is connected to one of the inputs of an information processing unit (3) connected through its output to the input of a UHF-circulator (4), whose input-output is connected to a radiator (5). The output of the UHF-circulator (4) is connected to another input of the unit (3) comprising, interconnected to each other, a circuit (8) for measuring the power of the UHF signal reflected from the biological tissue, an instrument drift compensating circuit (12), a circuit (13) for stabilizing the power of the UHF-generator and a control signal generator (15). To the outputs of the information processing unit (3) are connected the inputs (6, 18) of a recorder (7).

Abstract translation: 用于确定生物组织的水合度的装置具有UHF发生器（1），其输入端连接到通过其输出连接到UHF循环器（4）的输入端的信息处理单元（3）的输入之一 ），其输入输出连接到散热器（5）。 UHF循环器（4）的输出连接到单元（3）的另一个输入端，该输入端包括相互互连的电路（8），用于测量从生物组织反射的UHF信号的功率，仪器漂移 补偿电路（12），用于稳定UHF发生器的功率的电路（13）和控制信号发生器（15）。 信息处理单元（3）的输出端连接有记录器（7）的输入端（6,18）。

公开(公告)号：WO1990001899A1

公开(公告)日：1990-03-08

申请号：PCT/US1989003517

申请日：1989-08-16

Applicant: ADVANCED MAGNETICS, INCORPORATED

Inventor： ADVANCED MAGNETICS, INCORPORATED ,  LEWIS, Jerome, M. ,  MENZ, Edward, T. ,  KENNY, Francis, E. ,  GROMAN, Ernest, V. ,  JOSEPHSON, Lee

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/18 ,  A61K49/1863 ,  A61K49/1887 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08G2101/00 ,  C08J9/144 ,  C08J2375/04 ,  Y10T436/24

Abstract: The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable superparamagnetic metal oxide crystals which aggregates have an overall means diameter less than about 4000 angstroms. The preferred vascular imaging contrast agent is comprised of aggregates of iron oxide crystals having an overall mean diameter less than about 500 angstroms. These contrast agents may be associated with a macromolecular species, which assist, among other things, in the preparation of these extremely small materials, and may be dispersed or dissolved in a physiologically acceptable medium. Preferred media also stabilize the materials against further aggregation even under harsh sterilization conditions. The autoclaved biodegradable superparamagnetic iron oxides of the invention are ideally suited for a pharmaceutical preparation and enjoy several advantages over prior intravascular imaging contrast including low osmolality, low effective dose requirements, high relaxivities, long blood lifetimes, rapid biodegradability, and versatility with respect to a wide range of applicable MR data acquisition parameters.

Abstract translation: 描述了用于血管隔室的可生物降解的超顺磁性MR成像造影剂的制备和分离。 这些聚集体由单个可生物降解的超顺磁金属氧化物晶体组成，其聚集体具有小于约4000埃的整体平均直径。 优选的血管成像造影剂由总平均直径小于约500埃的氧化铁晶体的聚集体组成。 这些造影剂可以与大分子物质相关联，其特别有助于制备这些极小物质，并且可以分散或溶解在生理上可接受的介质中。 优选的介质甚至在恶劣的灭菌条件下也稳定材料以防止进一步聚集。 本发明的高压灭菌的可生物降解的超顺磁性氧化铁理想地适用于药物制剂，并且比先前的血管内成像对比包括几个优点，包括低渗透压，低有效剂量要求，高松弛度，长血液寿命，快速生物降解性和相对于 广泛的适用MR数据采集参数。