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    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS
    103.
    发明申请
    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS 审中-公开

    公开(公告)号：US20180156801A1

    公开(公告)日：2018-06-07

    申请号：US15576472

    申请日：2016-05-26

    Applicant: CREATV MICROTECH INC.

    Inventor： Daniel ADAMS ,  Cha-Mei TANG

    IPC: G01N33/574 ,  G01N33/50

    Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

    URINE PRESERVATIVE REAGENT FOR MICROFILTRATION
    104.
    发明申请
    URINE PRESERVATIVE REAGENT FOR MICROFILTRATION 审中-公开
    尿液防腐试剂

    公开(公告)号：US20160021872A1

    公开(公告)日：2016-01-28

    申请号：US14776194

    申请日：2014-03-13

    Applicant: CREATV MICROTECH, INC.

    Inventor： Peixuan ZHU ,  Daniel ADAMS ,  Cha-Mei TANG

    IPC: A01N1/02 ,  G01N33/493 ,  G01N33/574

    CPC classification number: A01N1/021 ,  A01N1/0215 ,  G01N33/493 ,  G01N33/574

    Abstract: A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents.

    Abstract translation: 公开了用于尿液的防腐剂，其在尿液中增加细胞（例如肿瘤细胞）的稳定性，持续数周。 防腐剂包括聚乙二醇（PEG），乙醇，多聚甲醛（PFA）和乙二胺四乙酸（EDTA），以及任选的pH稳定试剂。

    Polymer microfiltration devices, methods of manufacturing the same and the uses of the microfiltration devices
    108.
    发明专利
    Polymer microfiltration devices, methods of manufacturing the same and the uses of the microfiltration devices 未知

    公开(公告)号：AU2021273606A1

    公开(公告)日：2021-12-16

    申请号：AU2021273606

    申请日：2021-11-25

    Applicant: CREATV MICROTECH INC

    Inventor： TANG CHA-MEI ,  ZHANG YUNQI

    IPC: B01D25/02

    Abstract: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications.

    Use of circulating tumor cell mitotic index in cancer stratification and diagnostics
    109.
    发明专利
    Use of circulating tumor cell mitotic index in cancer stratification and diagnostics 未知

    公开(公告)号：AU2016267146B2

    公开(公告)日：2021-09-02

    申请号：AU2016267146

    申请日：2016-05-26

    Applicant: CREATV MICROTECH INC

    Inventor： ADAMS DANIEL ,  TANG CHA-MEI

    IPC: G01N33/50 ,  G01N33/574

    Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

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