公开(公告)号：EP3221468A1

公开(公告)日：2017-09-27

申请号：EP15798026.9

申请日：2015-11-18

Applicant: Stichting Katholieke Universiteit ,  Stichting VU-VUmc

Inventor： NAVIS, Anna Catharina ,  LEENDERS, Wilhelmus Petrus Johannes ,  WÜRDINGER, Thomas

IPC: C12Q1/68

Abstract: The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.

Abstract translation: 本发明涉及医学和分子诊断领域。 特别涉及用于治疗，预防和/或延迟癌症的新型方法，涉及涉及检测MET的新型自身活性和细胞内突变体的诊断方法。

公开(公告)号：EP3158083A1

公开(公告)日：2017-04-26

申请号：EP15738759.8

申请日：2015-06-19

Applicant: Stichting VU-VUmc ,  InteRNA Technologies B.V.

Inventor： MEIJER, Gerrit Albert ,  DIOSDADO, Begoña ,  TIMMER, Lisette M. ,  CUPPEN, Edwin Pieter Johan Gerard ,  BEREZIKOV, Eugene ,  CERISOLI, Francesco ,  SCHAAPVELD, Roeland Quirinus Jozef

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.

Abstract translation: 公开了使用miRNA生物标志物诊断结肠直肠癌及其前体的方法，以及用于检测生物标志物的试剂盒和设备以及生物标志物的用途。 所描述的生物标志物在大便中可靠地检测到，并且与结肠直肠癌阴性患者相比在结肠直肠癌患者中表现出显着不同的表达水平。

公开(公告)号：EP2951171A1

公开(公告)日：2015-12-09

申请号：EP14701569.7

申请日：2014-01-28

Applicant: Boehringer Ingelheim International GmbH ,  Stichting VU-VUmc

Inventor： SLOBBE, Paul ,  POOT, Alex Johannes ,  VAN DONGEN, Augustinus Antonius Maria Silvester ,  NIESSEN, Heiko ,  WINDHORST, Albert Dirk

IPC: C07D405/12 ,  A61K51/04

CPC classification number: C07D405/12 ,  A61K51/0459 ,  C07B2200/05

Abstract: Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to
18 F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation
18 F-iabeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

公开(公告)号：EP2888621A1

公开(公告)日：2015-07-01

申请号：EP13759869.4

申请日：2013-08-27

Applicant: Stichting VU-VUmc

Inventor： WITTE, Stefan Michiel ,  EIKEMA, Kjeld Sijbrand Eduard

IPC: G02B21/36 ,  G06F17/14 ,  H01J37/26

CPC classification number: G02B21/365 ,  G02B21/367 ,  G03F7/70616

Abstract: The invention relates to amicroscopic imaging apparatus to provide an image of a sample. The apparatus having an illumination system to provide an illumination beam with radiation;and a sensor constructed and arranged to receive: a first image of a first diffraction pattern created by diffraction of the illumination beam on the sample; a second image of a second diffraction pattern created by diffraction of the illumination beam on the sample. The sensor may be connected with a processor running a program to retrieve phase information from the sample from the first and second image received by the sensor. The illumination system may have a first illumination device to provide the illumination beam with radiation of substantially a first wavelength; and a second illumination device to provide the illumination beam with radiation of substantially a second wavelength different than the first wavelength. The sensor may receive a first image of a first diffraction pattern created by diffraction of the illumination beam with radiation of substantially the first wavelength on the sample; and,a second image of a second diffraction pattern created by diffraction of the illumination beam with radiation of substantially the second wavelength on the sample.

Abstract translation: 一种用于提供样品图像的显微成像装置。 该装置包括用于向辐射提供照明光束的照明系统; 以及传感器，其被构造和布置成接收：通过所述样品上的所述照射光束的衍射而产生的第一衍射图案的第一图像; 以及由样品上的照明光束衍射产生的第二衍射图案的第二图像。

公开(公告)号：EP2686677A1

公开(公告)日：2014-01-22

申请号：EP12702324.0

申请日：2012-01-16

Applicant: Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg ,  Stichting VU-VUmc

Inventor： WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

IPC: G01N33/48

CPC classification number: C12Q1/6834 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及一种分析疾病标志物存在的受试者血液样本的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞中提取核酸以提供提取的无核细胞 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

公开(公告)号：BR112013023960A2

公开(公告)日：2016-12-13

申请号：BR112013023960

申请日：2012-01-16

Applicant: STICHTING VU VUMC ,  VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENS ,  WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG

Inventor： NILSSON ROLF JONAS ,  WÜRDINGER THOMAS

IPC: G01N33/48

Abstract: método de análise de uma amostra de sangue de um indivíduo para a presença de um marcador de doença a presente invenção refere-se a um método de análise de uma amostra de sangue de um individuo para a presença de um marcador de doença, o referido método compreendendo as etapas de a) extração nucleicos de células de sangue anucleadas na referida amostra de sangue para fornecer uma fração de ácidos nucléicos extraídos de células de sangue anucleadas, e b) análise da referida fração de ácidos nucléicos extraídos de células de sangue anucleadas para a presença de um marcador de doença, em que o referido marcador de doença é uma mutação específica da doença em um gene de uma célula do referido indivíduo, ou em que o referido marcador de doença é perfil de expressão de doenças específicas de genes de uma célula do referido indivíduo.

公开(公告)号：NL2011904C2

公开(公告)日：2015-06-09

申请号：NL2011904

申请日：2013-12-06

Applicant: STICHTING VU VUMC

Inventor： OSSENKOPPELE GERRIT JOHAN ,  SCHUURHUIS GERRIT JAN ,  ZEIJLEMAKER WENDELIEN

IPC: C12N5/095 ,  G01N33/574

Abstract: The present invention relates to a method for identifying Leukemic stem cells (LSC), based on measurement of the presence of a specific set of markers. The invention further relates to a container for use in performing the method. Also provided is application of the method for predicting response to therapy and/or chance of relapse of Acute Myeloid Leukemia, and application of the method in the context of screening for compounds that specifically eradicate Leukemic cells and not benign cells.

公开(公告)号：NL2011904C

公开(公告)日：2015-06-09

申请号：NL2011904

申请日：2013-12-06

Applicant: STICHTING VU VUMC

Inventor： OSSENKOPPELE GERRIT JOHAN ,  SCHUURHUIS GERRIT JAN ,  ZEIJLEMAKER WENDELIEN

IPC: C12N5/095 ,  G01N33/574

CPC classification number: G01N33/57426 ,  G01N15/14 ,  G01N33/5011 ,  G01N33/5073 ,  G01N33/57492 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2800/52

公开(公告)号：NL2010960C

公开(公告)日：2014-12-15

申请号：NL2010960

申请日：2013-06-12

Applicant: STICHTING VU VUMC

Inventor： PETERMAN ERWIN JOHANNES GERARD ,  WUITE GIJS JAN LODEWIJK ,  SITTERS GERRIT ,  KAMSMA DOUWE

IPC: B82Y35/00 ,  G02B21/32

CPC classification number: C12Q1/6837 ,  G01N29/0681 ,  G02B21/32

公开(公告)号：NL2009367C2

公开(公告)日：2014-03-03

申请号：NL2009367

申请日：2012-08-27

Applicant: STICHTING VU VUMC

Inventor： WITTE STEFAN MICHIEL ,  EIKEMA KJELD SIJBRAND EDUARD

IPC: G02B21/36 ,  G06F17/14 ,  H01J37/26

Abstract: A microscopic imaging apparatus to provide an image of a sample. The apparatus includes an illumination system to provide an illumination beam with radiation; and a sensor constructed and arranged to receive: a first image of a first diffraction pattern created by diffraction of the illumination beam on the sample; and a second image of a second diffraction pattern created by diffraction of the illumination beam on the sample.