公开(公告)号：US20040250622A1

公开(公告)日：2004-12-16

申请号：US10804379

申请日：2004-03-19

Applicant: Symyx Technologies, Inc.

Inventor： Oleg Kolosov ,  Leonid Matsiev ,  John F. Varni ,  G. Cameron Dales

IPC: G01N024/00

CPC classification number: G01N29/222 ,  C09D5/008 ,  G01F23/2967 ,  G01F23/2968 ,  G01N9/002 ,  G01N11/16 ,  G01N29/036 ,  G01N2291/02836 ,  G01N2291/02872 ,  G01N2291/0427

Abstract: An improved method and assembly, wherein the method generally includes the steps of providing a coated or uncoated sensor element having an exposed sensing surface; attaching the sensor element to a platform so that the exposed sensing surface is spaced from the platform; and optionally applying a protective layer over the platform while maintaining the sensing surface as exposed. The assembly includes a resonator having a free portion with a sensing surface is incorporated onto a platform, components of the sensor are physically shielded from harsh operating conditions, the requisite space is maintained between the free portion of the resonator and the platform, and the sensing surface of the resonator remains exposed for sensing.

Abstract translation: 一种改进的方法和组件，其中所述方法通常包括以下步骤：提供具有暴露的感测表面的涂覆或未涂覆的传感器元件; 将传感器元件附接到平台，使得暴露的感测表面与平台间隔开; 并且可选地在平台上施加保护层，同时保持感测表面暴露。 该组件包括具有感测表面的自由部分的谐振器被并入到平台上，传感器的部件在物理上不受恶劣的操作条件的影响，在谐振器的自由部分和平台之间保持必要的空间，并且感测 谐振器的表面保持暴露以进行感测。

公开(公告)号：US20040177707A1

公开(公告)日：2004-09-16

申请号：US10811619

申请日：2004-03-29

Applicant: Symyx Technologies, Inc.

Inventor： Paul Mansky

IPC: C08L001/00

CPC classification number: G01N33/442 ,  B01J2219/00274 ,  B01J2219/00495 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  G01N3/02 ,  G01N19/02 ,  G01N2203/0222 ,  G01N2203/0286

Abstract: A library of materials is screened for mechanical properties such as strength, tack or other properties. A library of materials is provided. A stimulus such as a stress or force is provided to each member of the library. A response (e.g., a strain) of each of the materials due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding properties of the material samples.

Abstract translation: 对材料库筛选机械性能，如强度，粘性或其他性能。 提供材料库。 向图书馆的每个成员提供诸如压力或力量的刺激。 测量由于刺激引起的每种材料的响应（例如，应变），并且响应，刺激或两者被记录并且相关以提供数据。 此后，分析数据以得出关于材料样品的性质的结论。

公开(公告)号：US20040123650A1

公开(公告)日：2004-07-01

申请号：US10663141

申请日：2003-09-16

Applicant: Symyx Technologies, Inc.

Inventor： Oleg Kolosov ,  Leonid Matsiev

IPC: G01N011/14 ,  G01N011/00

CPC classification number: G01N35/028 ,  G01N11/14

Abstract: The present invention provides systems and methods for screening a library of material samples for a rheological property such as viscosity or elasticity. Accordingly, a library of material samples is can be provided in a substantially liquid form. The library is contacted with at least one probe for applying a stimulus to the material samples such as by moving the at least one probe within the samples. A response such as resistance to the motion of the probe is monitored and can be related to a rheological property of the samples.

Abstract translation: 本发明提供用于筛选材料样品库的流变性质如粘度或弹性的系统和方法。 因此，材料样本库可以以基本上液体的形式提供。 将文库与至少一个探针接触，以对材料样品施加刺激，例如通过移动样品中的至少一个探针。 监测对诸如探针的运动的抵抗力的响应，并且可以与样品的流变性相关。

公开(公告)号：US20040122247A1

公开(公告)日：2004-06-24

申请号：US10720380

申请日：2003-11-25

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Thomas R. Boussie ,  Gary M. Diamond ,  Christopher Goh ,  Keith A. Hall ,  Anne M. Lapointe ,  Margarete K. Leclerc ,  Cheryl Lund ,  Vince Murphy

IPC: C07F001/00

CPC classification number: C07D213/74 ,  B01J2219/00722 ,  C07B2200/11 ,  C07D213/38 ,  C07D213/61 ,  C07D213/68 ,  C07F7/00 ,  C07F7/003 ,  C07F9/58 ,  C08F4/65908 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C40B40/14 ,  C08F4/659 ,  C08F4/65904 ,  C08F2500/15 ,  C08F2500/02 ,  C08F210/10 ,  C08F212/08 ,  C08F210/14 ,  C08F4/64144 ,  C08F4/64113 ,  C08F4/64044

Abstract: New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions.

Abstract translation: 公开了新配体，组合物，金属 - 配体络合物和具有吡啶基 - 胺配体的阵列，其催化单体聚合成聚合物。 这些具有铪金属中心的这些催化剂中的某些具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，异丁烯或苯乙烯。 某些催化剂在各种聚合条件下在溶液过程中将丙烯聚合成高分子量全同立构聚丙烯是特别有效的。

公开(公告)号：US20040121448A1

公开(公告)日：2004-06-24

申请号：US10325709

申请日：2002-12-20

Applicant: Symyx Technologies, Inc.

Inventor： Christopher Goh ,  Keith Anthony Hall ,  Thomas R. Boussie ,  Vince Murphy ,  Trevor G. Frank ,  William H. Chandler JR. ,  Lynn Van Erden

IPC: C12M001/34

CPC classification number: B01J3/04 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00315 ,  B01J2219/00353 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  B01J2219/00738 ,  C40B40/14 ,  C40B50/08 ,  C40B60/14 ,  Y10T436/2575

Abstract: An apparatus and method for injection of one or more chemical components into a reaction chamber are disclosed. The apparatus includes a reaction chamber for receiving one or more libraries in a fixed position relative to the chamber and configured to form a sealed enclosure. An injection manifold is located within the reaction chamber and selectively movable relative to the libraries. The injection manifold is configured for receiving at least one fluid transfer line coupled to an external source for injection of one or more chemical components into the reaction chamber.

Abstract translation: 公开了将一种或多种化学成分注入反应室的装置和方法。 该装置包括反应室，用于接收相对于室的固定位置的一个或多个库，并构造成形成密封的外壳。 注射歧管位于反应室内并且可相对于库选择性地移动。 注入歧管被构造成用于接收至少一个连接到外部源的流体输送管线，用于将一种或多种化学成分注入反应室。

公开(公告)号：US20040110636A1

公开(公告)日：2004-06-10

申请号：US10641906

申请日：2003-08-15

Applicant: Symyx Technologies, Inc.

Inventor： Claus Lugmair ,  Alfred Hagemeyer ,  Lynn Van Erden ,  Anthony F. Volpe JR. ,  David M. Lowe ,  Yumin Liu

IPC: B01J023/02

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.

Abstract translation: 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，涉及用于同时进行诸如研磨，混合，压制，粉碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。

公开(公告)号：US20040014950A1

公开(公告)日：2004-01-22

申请号：US10421212

申请日：2003-04-23

Applicant: Symyx Technologies, Inc.

Inventor： Thomas R. Boussie ,  Oliver Brummer ,  Gary M. Diamond ,  Christopher Goh ,  Anne M. LaPointe ,  Margaret K. Leclerc ,  James A. W. Shoemaker

IPC: C07F009/02 ,  C07F005/00 ,  C07F007/28 ,  C07C395/00

CPC classification number: C08F10/00 ,  B01J31/223 ,  B01J31/2243 ,  B01J31/226 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2531/48 ,  B01J2531/49 ,  C07C37/055 ,  C07C37/62 ,  C07C39/367 ,  C07C41/16 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C215/74 ,  C07C217/80 ,  C07C323/20 ,  C07C2603/18 ,  C07C2603/24 ,  C07C2603/74 ,  C07D209/86 ,  C07F7/003 ,  C07F9/5022 ,  C08F4/65908 ,  C08F4/65912 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C08F212/08 ,  C08F4/6592 ,  C08F4/64186 ,  C08F2500/03 ,  C08F210/14 ,  C08F4/64196 ,  C08F4/64193 ,  C08F4/659 ,  C07C43/225 ,  C07C39/15 ,  C07C39/38 ,  C07C43/2055

Abstract: New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.

Abstract translation: 公开了具有桥连双芳族配体的新配体和组合物，其催化单体聚合成聚合物。 这些具有金属中心的催化剂具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，丙烯或苯乙烯。 催化剂还将丙烯聚合成全同立构聚丙烯。

公开(公告)号：US20030219906A1

公开(公告)日：2003-11-27

申请号：US10336605

申请日：2003-01-03

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Daniel M. Giaquinta ,  Martin Devenney ,  Keith A. Hall ,  Isy Goldwasser

IPC: G01N001/10

CPC classification number: C23C14/087 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00445 ,  B01J2219/00475 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00493 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/0065 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00702 ,  B01J2219/00707 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B01J2219/00756 ,  B82Y25/00 ,  B82Y30/00 ,  C01B13/185 ,  C01G51/006 ,  C01P2002/52 ,  C01P2004/54 ,  C01P2004/61 ,  C01P2004/84 ,  C01P2006/40 ,  C04B35/01 ,  C04B35/62218 ,  C09K11/08 ,  C09K11/7718 ,  C09K11/7774 ,  C09K11/7794 ,  C23C14/042 ,  C23C16/042 ,  C40B30/08 ,  C40B40/18 ,  C40B50/08 ,  C40B60/14 ,  C40B70/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/193 ,  H01F41/18 ,  H01F41/34 ,  Y10T436/11 ,  Y10T436/15 ,  Y10T436/20 ,  Y10T436/2575

Abstract: A combinatorial method for discovering or optimizing materials is disclosed. The method uses solution-based components that are mixed and dispensed into regions on a substrate for drying and/or heat-treating. The drying and/or heat-treating produces materials that can be tested for a desired property.

Abstract translation: 公开了用于发现或优化材料的组合方法。 该方法使用基于溶液的组分，其混合并分配到基底上的区域用于干燥和/或热处理。 干燥和/或热处理产生可以测试所需性质的材料。

公开(公告)号：US20030218467A1

公开(公告)日：2003-11-27

申请号：US10155207

申请日：2002-05-24

Applicant: Symyx Technologies, Inc.

Inventor： Eric D. Carlson ,  Oleg Kolosov ,  Leonid Matsiev ,  Laura T. Mazzola ,  Mikhail Spitkovsky ,  John Gallipeo

IPC: G01R027/04 ,  G01R027/32

CPC classification number: G01N29/036 ,  B01J2219/00689 ,  B01J2219/00707 ,  G01G3/13 ,  G01N5/045 ,  G01N33/15 ,  G01N2291/0257

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.

Abstract translation: 用于测量小样品量的质量的方法和装置。 该方法和装置特别适于提供固体材料的微量天平测量作为组合研究程序的一部分。 该方法和装置考虑监测保持样品的谐振器的响应并将响应与样本中的质量变化相关联。

公开(公告)号：US20030190260A1

公开(公告)日：2003-10-09

申请号：US10116862

申请日：2002-04-05

Applicant: Symyx Technologies, Inc.

Inventor： Tony N. Wheeler ,  Lynn Van Erden ,  William H. Chandler JR. ,  Richard Tiede ,  Robert J. Saxton ,  Anil Guram

IPC: G01N035/00 ,  G01N035/04

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00722 ,  B01L7/00 ,  B01L9/06 ,  C40B40/14 ,  C40B50/08 ,  C40B60/14 ,  G01N2035/00376 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.