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公开(公告)号：US5007929B1
公开(公告)日：1994-08-30
申请号：US55997390
申请日：1990-07-27
Applicant: MEDICAL PRODUCTS DEV
Inventor： QUAID JOEL
CPC classification number: C08J9/26 , A61F2/0077 , A61F2/12 , A61L27/18 , A61L27/56 , B29C41/14 , B29C59/02 , B29C2059/028 , C08J2201/0446 , C08J2383/04 , C08L83/04
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公开(公告)号：US20180164298A1
公开(公告)日：2018-06-14
申请号：US15564905
申请日：2016-04-08
Applicant: President and Fellows of Harvard College
Inventor： Omar Abdel-Rahman Ali , David J. Mooney
IPC: G01N33/545 , A61K35/17 , A61L31/14 , A61L31/16 , A61L31/06 , C08J9/12 , C08J9/26 , C08J9/00 , G01N33/569
CPC classification number: G01N33/545 , A61K35/15 , A61K35/17 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/438 , A61L2300/62 , C08J9/0004 , C08J9/122 , C08J9/26 , C08J2201/032 , C08J2201/0422 , C08J2201/0446 , C08J2203/06 , C08J2203/08 , C08J2205/044 , C08J2205/05 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08J2305/12 , C08J2325/04 , C08J2329/04 , C08J2333/04 , C08J2339/00 , C08J2339/06 , C08J2367/00 , C08J2367/04 , C08J2371/02 , C08J2385/02 , C08J2389/00 , C08J2389/04 , G01N33/56972 , G01N33/5743 , G01N2800/042 , Y02A50/463 , Y02A50/475 , Y02A50/48
Abstract: Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.
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公开(公告)号：US09622847B2
公开(公告)日：2017-04-18
申请号：US15140018
申请日：2016-04-27
Applicant: Vertera, Inc.
Inventor： Wei-Hsiang Chang , Stephen Lee Laffoon , Christopher S. D. Lee , David Lee Safranski
CPC classification number: B29C67/202 , A61F2/02 , A61F2/32 , A61F2/38 , A61F2002/30065 , A61F2002/30316 , A61F2210/0076 , A61F2240/001 , B29K2071/00 , B29K2105/04 , C08J9/0085 , C08J9/26 , C08J9/32 , C08J2201/0446 , C08J2361/16 , C08J2371/00
Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.
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公开(公告)号：US20160237236A1
公开(公告)日：2016-08-18
申请号：US15140018
申请日：2016-04-27
Applicant: Vertera, Inc.
Inventor： Wei-Hsiang CHANG , Stephen Lee LAFFOON , Christopher S.D. LEE , David Lee SAFRANSKI
IPC: C08J9/26
CPC classification number: B29C67/202 , A61F2/02 , A61F2/32 , A61F2/38 , A61F2002/30065 , A61F2002/30316 , A61F2210/0076 , A61F2240/001 , B29K2071/00 , B29K2105/04 , C08J9/0085 , C08J9/26 , C08J9/32 , C08J2201/0446 , C08J2361/16 , C08J2371/00
Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.
Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将聚合物固体片的表面加热至低于聚合物熔点的加工温度，并保持加工温度，同时使致孔剂层通过聚合物表面移动以形成基体层 包含聚合物和致孔剂层的固体聚合物体。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。
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公开(公告)号：US20160107395A1
公开(公告)日：2016-04-21
申请号：US14985226
申请日：2015-12-30
Applicant: Vertera, Inc.
Inventor： Wei-Hsiang Chang , Stephen Lee Laffoon , Christopher S.D. Lee , David Lee Safranski
IPC: B29C67/20
CPC classification number: B29C43/04 , B29C33/00 , B29C44/58 , B29C67/202 , B29K2071/00 , B29L2031/753 , B29L2031/7532 , C08J9/26 , C08J2201/0446 , C08J2205/05 , C08J2300/22 , C08J2371/00
Abstract: In general, in various embodiments, the present disclosure is directed systems and methods for producing a porous surface from a solid piece of polymer. In particular, the present disclosure is directed to systems that include a track assembly, mold assembly, press assembly, and methods for using the same for producing a porous surface from a solid piece of polymer. In some embodiments, the present systems and methods are directed to processing a polymer at a temperature below a melting point of the polymer to produce a solid piece of polymer with an integrated a porous surface.
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Patent Agency Ranking
公开(公告)号：US20150374477A1
公开(公告)日：2015-12-31
申请号：US14752762
申请日：2015-06-26
Applicant: Vertera, Inc.
Inventor： Wei-Hsiang CHANG , Stephen Lee LAFFOON , Christopher S.D. LEE , David Lee SAFRANSKI
CPC classification number: A61F2/0077 , A61B6/12 , A61B6/50 , A61B90/39 , A61B2090/3966 , A61F2/44 , A61F2002/0081 , A61F2002/0086 , A61F2210/0071 , A61F2250/0098 , A61L27/18 , A61L27/50 , A61L27/56 , A61L31/06 , A61L2430/38 , B29C44/0461 , B29C44/3415 , B29C67/202 , B29K2071/00 , B29L2031/753 , B29L2031/7546 , C08J9/0085 , C08J9/26 , C08J2201/0446 , C08J2371/00 , C08L71/00
Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.
Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将固体聚合物片的表面加热至加工温度并保持加工温度，同时使致孔剂层通过聚合物的表面移位，以形成包含聚合物的固体聚合物主体的基质层，以及 致孔剂层。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。
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公开(公告)号：US20120323339A1
公开(公告)日：2012-12-20
申请号：US13518669
申请日：2010-12-23
Applicant: Beatriz Olalde Graells , María Jesús Jurado Oñate
Inventor： Beatriz Olalde Graells , María Jesús Jurado Oñate
CPC classification number: A61L27/18 , A61L27/56 , C08J9/26 , C08J9/28 , C08J2201/0422 , C08J2201/0444 , C08J2201/0446 , C08J2201/052 , C08J2205/05 , C08J2207/10 , C08J2371/12 , Y10T428/249953 , Y10T428/249986 , C08L71/00
Abstract: The present invention refers to a porous PEEK-type polymer article comprising a porous PEEK-type polymer structure and presenting at least a trimodal pore distribution. The invention describes a process for the production of said porous PEEK-type polymer article comprising: a) contacting a PEEK-type polymer with a composition comprising at least a organic solvent, b) heating at a temperature at which the PEEK-type polymer is dissolved, c) adding at least a porogen agent, d) cooling the mixture obtained in c) at a temperature at least equal or lower than the temperature at which the PEEK-type polymer precipitates, e) forming said cooled mixture into a shaped article, f) removing the organic solvent and the porogen agent, and g) recovering the PEEK-type polymer article.
Abstract translation: 本发明涉及包含多孔PEEK型聚合物结构并呈现至少三峰孔分布的多孔PEEK型聚合物制品。 本发明描述了一种生产所述多孔PEEK型聚合物制品的方法，包括：a）使PEEK型聚合物与至少包含有机溶剂的组合物接触，b）在PEEK型聚合物为 溶解，c）至少加入致孔剂，d）在至少等于或低于PEEK型聚合物沉淀的温度的温度下冷却c）中得到的混合物，e）将所述冷却的混合物形成成型制品 ，f）除去有机溶剂和致孔剂，g）回收PEEK型聚合物制品。
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108.发明申请MICRO-SPHERICAL POROUS BIOCOMPATIBLE SCAFFOLDS AND METHODS AND APPARATUS FOR FABRICATING SAME 审中-公开微球形多孔生物相容性及其制备方法及装置公开(公告)号：US20110212179A1
公开(公告)日：2011-09-01
申请号：US13126456
申请日：2009-10-30
Applicant: David Liu
Inventor： David Liu
IPC: A61K9/14 , A61K35/00 , A61K35/12 , C12N5/071 , B01J19/00 , C08G63/91 , C08F20/56 , C08F116/06 , C08J9/00 , C08G73/10 , B82Y30/00
CPC classification number: C08J9/26 , A61K9/0019 , A61K9/5031 , A61K9/5089 , A61K48/00 , A61K51/1255 , A61L24/0036 , A61L27/38 , A61L27/3834 , A61L27/3839 , A61L27/56 , A61L2430/36 , C08J9/28 , C08J2201/0446 , C08J2201/0544 , C08J2207/10 , C12N15/88
Abstract: Provided herein are bimodal porous polymer microspheres comprising macropores and micropores. Also provided herein are methods and apparatus for fabrication such microspheres. Further provided herein are methods of using bimodal porous polymer microspheres.
Abstract translation: 本文提供了包含大孔和微孔的双峰多孔聚合物微球。 本文还提供了用于制造这种微球的方法和装置。 本文还提供了使用双峰多孔聚合物微球的方法。
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公开(公告)号：US20110105635A1
公开(公告)日：2011-05-05
申请号：US12993774
申请日：2009-05-19
Applicant: Folkert Van Beijma , Jacqueline De Groot
Inventor： Folkert Van Beijma , Jacqueline De Groot
CPC classification number: C08G18/10 , A61L27/18 , A61L27/56 , A61L27/58 , C08G18/4277 , C08G18/73 , C08G18/82 , C08G2101/00 , C08G2230/00 , C08J9/26 , C08J2201/0446 , C08J2375/04 , C08L75/04 , C08G18/3206
Abstract: The present invention provides a polyurethane implant that is porous and degradable, and act as a scaffold for the repair of damaged tissue. Importantly, the implant of the present invention is biocompatible with the degradation products of the implant causing minimal immune or cytotoxic reaction. The present invention also provides for a method of making these biocompatible implants.
Abstract translation: 本发明提供一种多孔和可降解的聚氨酯植入物，并且用作修复受损组织的支架。 重要的是，本发明的植入物与植入物的降解产物是生物相容的，导致最小的免疫或细胞毒性反应。 本发明还提供了制造这些生物相容植入物的方法。
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公开(公告)号：US07816461B2
公开(公告)日：2010-10-19
申请号：US11718962
申请日：2005-11-18
Applicant: Shanfeng Wang , Michael J. Yaszemski , Lichun Lu , Bradford L. Currier
Inventor： Shanfeng Wang , Michael J. Yaszemski , Lichun Lu , Bradford L. Currier
IPC: C08G63/91
CPC classification number: A61L27/56 , A61L27/18 , A61L27/46 , B33Y70/00 , B33Y80/00 , C08G63/08 , C08G63/60 , C08G2261/126 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2367/06 , C08L67/06
Abstract: Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).
Abstract translation: 聚（丙烯酸富马酸酯）与聚（己内酯）二醇共聚以制备聚（丙烯酸富马酸酯）和聚（己内酯）的嵌段共聚物。 聚（丙烯酸富马酸酯）和聚（己内酯）的生物相容性和生物可吸收的嵌段共聚物可用于制备用于组织和/或骨骼重建的可注射和原位硬化支架。 嵌段共聚物可以通过氧化还原或光引发交联，具有或不具有另外的交联剂。 因此，共聚物既可自交联（不使用任何交联剂）和光可交联（在诸如紫外光的光子存在下）。
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