公开(公告)号：EP2795294A4

公开(公告)日：2015-12-09

申请号：EP12857516

申请日：2012-12-14

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS

Inventor： MILESKY LAWRENCE ,  ZANTOS GEORGE

IPC: G01N21/01 ,  G01B11/14 ,  G01N21/25 ,  G01N21/27 ,  G01N21/84 ,  G01N35/00

CPC classification number: G01N21/8483 ,  G01B11/14 ,  G01N21/253 ,  G01N21/27 ,  G01N35/00069 ,  G01N35/04 ,  G01N2035/00148 ,  G01N2035/0491 ,  G01N2201/025 ,  G01N2201/0438 ,  G01N2201/06113

Abstract: A reagent card analyzer comprises an optical signal source configured to transmit an optical signal and an optical signal detector spaced a distance from the optical signal source to define an optical signal path into which the optical signal is transmitted, the optical signal detector configured to detect the optical signal and to output an electrical signal indicative of the optical signal. A reader is configured to read a reagent pad of a reagent card. A reagent card moving mechanism is configured to move the reagent card having the reagent pad including a leading and trailing end through the optical signal path. An optical detector interface is electrically coupled with the optical signal detector and configured to receive electrical signals and to output a pad detect signal indicative of at least one of the leading and the trailing end as the reagent card is moved through the optical signal path.

公开(公告)号：EP2741074A1

公开(公告)日：2014-06-11

申请号：EP12195532.2

申请日：2012-12-04

Applicant: F. Hoffmann-La Roche AG

Inventor： The designation of the inventor has not yet been filed

IPC: G01N21/77

CPC classification number: G01N21/75 ,  G01N21/7703 ,  G01N21/774 ,  G01N2021/752 ,  G01N2021/7776 ,  G01N2021/7793 ,  G01N2201/0438

Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines. The predetermined straight lines (7) are arranged at an angle relative to the direction of propagation of the evanescent field (11) such that the coherent light (12) diffracted by the target samples bound to the binding sites impinges under a diffraction angle relative to the straight lines onto a further optical coupler (8) arranged in a portion (10) of the planar waveguide (2) outside the beam of coherent light propagating through the planar waveguide. The further optical coupler (8) couples the diffracted coherent light (13) out of the planar waveguide (2) such as to interfere at a predetermined detection location (9) with a difference in optical path length which is an integer multiple of the predetermined wavelength.

Abstract translation: 一种用于检测结合亲和力的装置，该装置包括布置在基板（3）上的平面波导（2），并且还包括具有预定长度的光耦合器（41），用于耦合相干光（1） 预定波长进入平面波导（2），使得相干光的平行光通过平面波导（2）的外表面（21）的相干光的消逝场（11）传播通过平面波导（2） ）。 平面波导（2）的外表面（21）包括其上能够将目标样品结合到结合位点的结合位点，使得消逝场（11）的光被与结合位点结合的靶标样物衍射。 结合位置沿着彼此平行延伸的多条预定直线（7）布置，在相邻直线之间具有恒定的距离。 预定的直线（7）相对于ev逝场（11）的传播方向成一定角度排列，使得被绑定位置绑定的目标样本衍射的相干光（12）相对于 布置在平面波导（2）的部分（10）中的另外的光耦合器（8）的直线延伸穿过平面波导传播的相干光束外部。 另外的光耦合器（8）将衍射的相干光（13）耦合到平面波导（2）之外，以便以预定的检测位置（9）干涉光路长度的差异，该光程长度是预定的 波长。

公开(公告)号：EP1607735A1

公开(公告)日：2005-12-21

申请号：EP05253761.0

申请日：2005-06-16

Applicant: ORTHO-CLINICAL DIAGNOSTICS, INC.

Inventor： Jacobs, Merrit N. ,  Burkovich, Robert Anthony ,  Johnson, David Lee

IPC: G01N21/13 ,  G01N21/03 ,  G01N21/25 ,  B01L3/00 ,  G01N35/02

CPC classification number: G01N21/13 ,  G01N21/0303 ,  G01N21/253 ,  G01N2021/0357 ,  G01N2021/0367 ,  G01N2021/0371 ,  G01N2201/0438

Abstract: A device and method solves the problems of improving precision, in particular in reducing movement of a cuvette, particularly lateral or side to side movement (L) of a cuvette (50), during the measurement process. The device, which stabilizes a cuvette (50) during a measurement read in an analyzer having a cuvette path of travel (P), includes: a fixed support (30) located on a first side of the path of travel (P) and abutting a side of the cuvette (50) at a location that does not interfere with an optical window on the cuvette (50) on which the measurement read takes place; and a movable support (20) located on a second side of the path of travel (P) and biased against a side of the cuvette (50) at a location that does not interfere with the optical window on the cuvette (50) on which the measurement read takes place, and which is opposite the side abutting the fixed support (30).

Abstract translation: 一种装置和方法解决了在测量过程中提高精度的问题，特别是在减小试管的运动，特别是比色杯（50）的侧向或侧向运动（L）的运动。 在具有行程（P）的比色杯路径的分析器中读取测量期间稳定比色皿（50）的装置包括：位于行进路径（P）的第一侧上的固定支撑件（30） 在不影响进行测量读取的比色皿（50）上的光学窗口的位置处的比色皿（50）的一侧; 以及位于所述行进路径（P）的第二侧上的可移动支撑件（20），并且在不影响所述比色皿（50）上的所述光学窗口的位置处偏压所述比色杯（50）的侧面， 测量读取发生，并且与抵靠固定支撑件（30）的一侧相反。

公开(公告)号：EP0217632B1

公开(公告)日：1996-05-22

申请号：EP86307346.6

申请日：1986-09-24

Applicant: Molecular Devices Corporation

Inventor： Chow, Calvin Y.H. ,  Lacy, Michael M. ,  Humphries, Gillian M. ,  Parce, John Wallace ,  Kung, Viola T.

IPC: G01N21/25

CPC classification number: G01N21/253 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2201/0438 ,  G01N2201/08

公开(公告)号：EP0491880A4

公开(公告)日：1992-12-02

申请号：EP91900642

申请日：1990-09-19

Applicant: PARK PHARMACEUTICAL INC.

Inventor： ANDREOTTI, PETER, E. ,  MORSE, IRWIN, S. ,  THORNTHWAITE, JERRY, T. ,  HEIMER, MALCOLM, L. ,  SALINGER, JORGE, D. ,  SOBODOWSKI, JOSEPH, J.

IPC: G01N21/76 ,  G01N21/00 ,  G01N1/10

CPC classification number: G01N21/76 ,  G01N2201/0438 ,  Y10S435/808

Abstract: A luminometer for assaying bioluminescence and chemiluminescence reactions characterized by sample wells having transparent bottom walls, a light detector positioned beneath the sample wells and a reagent injector above the wells.

公开(公告)号：EP0342730A2

公开(公告)日：1989-11-23

申请号：EP89201103.2

申请日：1989-04-28

Applicant: Schouten, Theodorus

Inventor： Schouten, Theodorus

IPC: G01N15/05

CPC classification number: G01N15/05 ,  G01N35/02 ,  G01N2021/5969 ,  G01N2201/0438 ,  G01N2201/0476

Abstract: A device for determining the erythrocyte sedimentation rate (ESR) of blood samples comprises receiving means (4) for receiving blood sample tubes (3) at a number of fixed positions therein, measuring means (16) for detecting blood sample tubes placed in the receiving means and measuring ESR's of blood samples driving means (10-12) for driving the measuring means horizontally along the number of fixed positions of the receiving means, and a computer unit. The computer unit is provided with timing means for providing a position-related control signal for each identified blood sample tube when a predetermined time period has elapsed since the blood sample tube was placed in the receiving means. A control means is used to determine the position of newly placed blood sample tubes in the receiving means and for controlling the measurement of the ESR's. The measuring means may comprise a CCD-image pick-up (13) or a single optical sensor. An output means is provided with a same plurality of two colour LED's as the plurality of fixed positions in the receiving means. The device may comprise a bar code reader.

Abstract translation: 用于测定血液样本的红细胞沉降率（ESR）的装置包括：接收装置（4），用于在多个固定位置接收血样管（3）;测量装置（16），用于检测放置在接收器 指示和测量用于沿着接收装置的固定位置的数量水平地驱动测量装置的血液样本驱动装置（10-12）和计算机单元的ESR。 计算机单元设置有定时装置，用于当从采血管放置在接收装置中经过预定时间段时，为每个识别的血液样本管提供与位置有关的控制信号。 控制装置用于确定新放置的血液样品管在接收装置中的位置并用于控制ESR的测量。 测量装置可以包括CCD图像拾取器（13）或单个光学传感器。 输出装置具有与接收装置中的多个固定位置相同的多个两个彩色LED。 该装置可以包括条形码阅读器。

公开(公告)号：EP0217632A3

公开(公告)日：1989-06-07

申请号：EP86307346.6

申请日：1986-09-24

Applicant: Molecular Devices Corporation

Inventor： Chow, Calvin Y.H. ,  Lacy, Michael M. ,  Humphries, Gillian M. ,  Parce, John Wallace ,  Kung, Viola T.

IPC: G01N21/25

CPC classification number: G01N21/253 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2201/0438 ,  G01N2201/08

Abstract: A multibeam photometric measuring device includes a light assembly (12) comprising a single modulated light source along with a filter assembly (19) for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A fiber rotor arrangement (24) is provided for sequentially connecting the collimated light source to each of the plurality of fibers (34) disposed in a distributor (32). Light passing through the wells of the sample plate (40) is captured by discrete photodetector cells (44) disposed on a one-to-one correspondence opposite the wells of the plate. A reference fiber links (52) light from the light source to a separate photodetector (45) to provide a reference light signal with which the sensed photodetector signals are compared. The sensed signals are suitably multiplexed and processed by circuitry which allows control over the accuracy with which the signals are processed on the basis of their instantaneous strengths as well as reference readings taken during system initialization. Enhancement of colour distribution resulting from chromogenic reactions is provided by automatic agitation by mechanism (54) of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.

公开(公告)号：EP0217632A2

公开(公告)日：1987-04-08

申请号：EP86307346.6

申请日：1986-09-24

Applicant: Molecular Devices Corporation

Inventor： Chow, Calvin Y.H. ,  Lacy, Michael M. ,  Humphries, Gillian M. ,  Parce, John Wallace ,  Kung, Viola T.

IPC: G01N21/25

CPC classification number: G01N21/253 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2201/0438 ,  G01N2201/08

Abstract: A multibeam photometric measuring device includes a light assembly (12) comprising a single modulated light source along with a filter assembly (19) for passing only a desired band of wavelengths and an optical system for suitably focusing light from the light source. A fiber rotor arrangement (24) is provided for sequentially connecting the collimated light source to each of the plurality of fibers (34) disposed in a distributor (32).
Light passing through the wells of the sample plate (40) is captured by discrete photodetector cells (44) disposed on a one-to-one correspondence opposite the wells of the plate. A reference fiber links (52) light from the light source to a separate photodetector (45) to provide a reference light signal with which the sensed photodetector signals are compared. The sensed signals are suitably multiplexed and processed by circuitry which allows control over the accuracy with which the signals are processed on the basis of their instantaneous strengths as well as reference readings taken during system initialization.
Enhancement of colour distribution resulting from chromogenic reactions is provided by automatic agitation by mechanism (54) of the reacting agents within the sample wells before a reading is taken at each of the sampling intervals of a kinetic measurement sequence.

Abstract translation: 一种多光束测光测量装置包括：包括单个调制光源的光组件（12），以及仅用于通过所需波长带的滤波器组件（19）以及用于适当地聚焦来自光源的光的光学系统。 提供光纤转子装置（24）用于顺序地将准直光源连接到布置在分配器（32）中的多根光纤（34）中的每一根。 穿过样品板（40）的孔的光由分立的光电检测器单元（44）捕获，所述单独的光电检测器单元（44）与板的孔相对地一一对应地设置。 参考光纤将来自光源的光链接（52）到单独的光电检测器（45），以提供参考光信号，与所检测的光电检测器信号进行比较。 所感测的信号被适当地多路复用并由电路处理，该电路允许基于其瞬时强度以及在系统初始化期间获取的参考读数来控制处理信号的准确度。 在动力学测量序列的每个采样间隔进行读数之前，通过机构（54）对样品孔内的反应试剂的自动搅动来提供由显色反应导致的颜色分布的增强。