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公开(公告)号：US09778192B2
公开(公告)日：2017-10-03
申请号：US14632486
申请日：2015-02-26
Applicant: KLA-Tencor Corporation
Inventor： Christophe Wouters , Steven Boeykens , Carl Smets
CPC classification number: G01N21/6489 , G01N21/8806 , G01N21/9501 , G01N21/958 , G01N2201/02 , G01N2201/061 , G01N2201/06113 , G01N2201/06193 , G01N2201/062
Abstract: An object carrier, a system and a method is disclosed for the back light inspection of transparent or semitransparent objects. The carrier has a carrier base layer with photo luminescent properties which carries the transparent or semitransparent object on top of the layer. The transparent or semitransparent object could be a wafer and the object carrier could be a wafer chuck. At least one light source being arranged above the object carrier such that excitation light emitted from the at least one light source is directed through the transparent or semitransparent object to the layer with photo luminescent properties. The light returned from the layer with photo luminescent properties is collected by an objective and registered by a sensor.
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公开(公告)号：US09575005B2
公开(公告)日：2017-02-21
申请号：US15033367
申请日：2014-11-03
Applicant: TOMRA SORTING NV
Inventor： Dirk Balthasar , Hartmut Harbeck
CPC classification number: G01N21/85 , B07C5/342 , G01N2201/06113 , G01N2201/06193 , G01N2201/062 , G01N2201/0636 , G01N2201/068
Abstract: An apparatus for inspecting a stream of matter including: a first and a second light source for emitting a first and a second light beam; a first and a second detector; a first scanning element adapted to redirect the detection area of the second detector from side to side across said stream, and a beam splitting element arranged to receive said first and second light beams, after they have been reflected against said matter, wherein said beam splitting element is adapted to guide said reflected first light beam towards said first detector and to guide said reflected second light beam towards said second detector.
Abstract translation: 一种用于检查物流的装置，包括：用于发射第一和第二光束的第一和第二光源; 第一和第二检测器; 第一扫描元件，其适于将所述第二检测器的检测区域从所述流的一侧到另一侧重定向;以及分束元件，其布置成在它们已经被反射抵靠所述物质之后接收所述第一和第二光束，其中所述光束分裂 元件适于将所述反射的第一光束引向所述第一检测器并且将所述反射的第二光束引导到所述第二检测器。
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公开(公告)号：US09404869B2
公开(公告)日：2016-08-02
申请号：US14049470
申请日：2013-10-09
Applicant: Howard Hughes Medical Institute
Inventor： Philipp Johannes Keller
CPC classification number: G01N21/6486 , A61B5/0071 , A61B2503/42 , G01N21/64 , G01N33/4833 , G01N2021/1736 , G01N2201/06193 , G01N2201/064 , G02B21/0004 , G02B21/0048 , G02B21/06 , G02B21/16 , G02B21/361 , G02B21/362 , G02B21/367 , G02B27/1013
Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.
Abstract translation: 通过生成多个光片对活体生物样本进行成像; 沿着照明轴线引导多个光片通过生物样本，使得光片沿着图像平面在空间和时间上在生物样本内重叠，并与图像平面内的生物样本光学相互作用; 并且在多个视图的每一个处，由于光片和生物样本之间的光学相互作用，沿着检测轴从生物样本记录荧光的图像。 时间重叠在时间偏移之内，其小于对应于显微镜的空间分辨率极限的分辨率时间。
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公开(公告)号：US20150346100A1
公开(公告)日：2015-12-03
申请号：US14759591
申请日：2014-01-07
Inventor： Catherine Racowsky , Manqi Deng , Daniel Needleman
IPC: G01N21/64
CPC classification number: G01N21/6408 , G01N21/6458 , G01N21/6486 , G01N2201/06193
Abstract: The invention provides novel non-invasive in vitro to methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.
Abstract translation: 本发明提供了新颖的非侵入性体外方法，用于评估具有荧光寿命成像显微镜的卵母细胞和/或胚胎的代谢状态，其可以用于例如辅助生殖技术中的卵母细胞和胚胎的评估。
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公开(公告)号：US20150168304A1
公开(公告)日：2015-06-18
申请号：US14632486
申请日：2015-02-26
Applicant: KLA-Tencor Corporation
Inventor： Christophe Wouters , Steven Boeykens , Carl Smets
IPC: G01N21/64 , G01N21/958 , G01N21/95
CPC classification number: G01N21/6489 , G01N21/8806 , G01N21/9501 , G01N21/958 , G01N2201/02 , G01N2201/061 , G01N2201/06113 , G01N2201/06193 , G01N2201/062
Abstract: An object carrier, a system and a method is disclosed for the back light inspection of transparent or semitransparent objects. The carrier has a carrier base layer with photo luminescent properties which carries the transparent or semitransparent object on top of the layer. The transparent or semitransparent object could be a wafer and the object carrier could be a wafer chuck. At least one light source being arranged above the object carrier such that excitation light emitted from the at least one light source is directed through the transparent or semitransparent object to the layer with photo luminescent properties. The light returned from the layer with photo luminescent properties is collected by an objective and registered by a sensor.
Abstract translation: 公开了用于透明或半透明物体的背光检查的物体载体，系统和方法。 载体具有带有光致发光性质的载体基层，其在层的顶部承载透明或半透明物体。 透明或半透明物体可以是晶片，物体载体可以是晶片卡盘。 至少一个光源布置在物体载体上方，使得从至少一个光源发射的激发光通过透明或半透明物体被引导到具有光发光性质的层。 由具有光发光性质的层返回的光被物镜收集并由传感器记录。
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Patent Agency Ranking
公开(公告)号：US20140099659A1
公开(公告)日：2014-04-10
申请号：US14049470
申请日：2013-10-09
Applicant: Howard Hughes Medical Institute
Inventor： Philipp Johannes Keller
IPC: G01N21/64
CPC classification number: G01N21/6486 , A61B5/0071 , A61B2503/42 , G01N21/64 , G01N33/4833 , G01N2021/1736 , G01N2201/06193 , G01N2201/064 , G02B21/0004 , G02B21/0048 , G02B21/06 , G02B21/16 , G02B21/361 , G02B21/362 , G02B21/367 , G02B27/1013
Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.
Abstract translation: 通过生成多个光片对活体生物样本进行成像; 沿着照明轴线引导多个光片通过生物样本，使得光片沿着图像平面在空间和时间上在生物样本内重叠，并与图像平面内的生物样本光学相互作用; 并且在多个视图的每一个处，由于光片和生物样本之间的光学相互作用，沿着检测轴从生物样本记录荧光的图像。 时间重叠在时间偏移之内，其小于对应于显微镜的空间分辨率极限的分辨率时间。
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公开(公告)号：US20130248697A1
公开(公告)日：2013-09-26
申请号：US13892274
申请日：2013-05-11
Applicant: Claudio Oliveira Egalon
Inventor： Claudio Oliveira Egalon
CPC classification number: G01N21/251 , G01D5/353 , G01D5/35345 , G01D5/35387 , G01F23/2927 , G01N21/17 , G01N21/64 , G01N21/645 , G01N21/648 , G01N21/76 , G01N21/7703 , G01N2021/635 , G01N2021/6484 , G01N2021/7736 , G01N2201/06193 , G01N2201/062 , G01N2201/088 , G02B6/00
Abstract: A side illuminated multi point multi parameter optical fiber sensor that requires no sensitive coating is provided. This sensor comprises an optical fiber having at least one removed cladding section as the sensitive region, at least one probing light source that side illuminates the fiber, a power supply, a detector, a signal processor and a display. The sensitive optical fiber is optically affected by the presence of a measurand medium that can fluoresce, phosphoresce, absorb and/or scatter the probing light. This probing light is guided by the fiber core towards a detector which measures the light intensity and this light intensity is correlated with a measurand.
Abstract translation: 提供不需要敏感涂层的侧面照明多点多参数光纤传感器。 该传感器包括具有至少一个去除的包层部分作为敏感区域的光纤，该侧面照射光纤的至少一个探测光源，电源，检测器，信号处理器和显示器。 敏感光纤受到可以荧光，磷光吸收，吸收和/或散射探测光的被测量介质的存在的光学影响。 该探测光由光纤芯引向测量光强度的检测器，该光强度与被测量相关。
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108.发明申请Method to Increase the Number of Detectable Photons During the Imaging of a Biological Marker 有权在生物标记成像期间增加可检测光子数量的方法公开(公告)号：US20130115647A1
公开(公告)日：2013-05-09
申请号：US13637551
申请日：2011-03-25
Applicant: Kelly Rogers , Spencer Shorte , Joseph Dragavon , Samantha Blazquez
Inventor： Kelly Rogers , Spencer Shorte , Joseph Dragavon , Samantha Blazquez
IPC: G01N21/64
CPC classification number: G01N21/6486 , B82Y15/00 , G01N21/6428 , G01N2201/06193
Abstract: The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to produce at least one first photon by luminescence; b) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. The FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals and metalloporphyrins. This method is charcterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon(s) are of a longer wavelength than each of the at least one first photon(s).
Abstract translation: 本发明涉及确定感兴趣的细胞，组织或生物体中产生光子的生物标志物的存在的方法。 该方法基于通过未发光发光（FUEL）的荧光，并且包括以下步骤：a）提供适于生物标记物的条件以通过发光产生至少一个第一光子; b）提供设置在细胞，组织或生物体附近的FUEL探针对上（FPP-U），其中步骤a）的至少一个第一光子激发FPP-U，其发射至少一个第二光子。 FPP-U可以选自量子点，碳纳米管，荧光蛋白，金刚石纳米晶体和金属卟啉。 该方法的特征在于所述生物标记和所述FPP-U不结合，并且所述至少一个第二光子中的每一个具有比所述至少一个第一光子中的每一个更长的波长。
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公开(公告)号：US20110181870A1
公开(公告)日：2011-07-28
申请号：US13121467
申请日：2009-10-01
Applicant: Stephen John Penney , John E.A. Shaw , Paul J. Taylor , Steven Ian Bennett
Inventor： Stephen John Penney , John E.A. Shaw , Paul J. Taylor , Steven Ian Bennett
CPC classification number: G01N21/53 , F21K9/64 , F21V7/06 , F21V9/30 , F21Y2115/10 , G01J1/0214 , G01J1/0422 , G01J1/08 , G01N15/0211 , G01N2021/3181 , G01N2021/4733 , G01N2201/06193 , G01N2201/0625 , G01N2201/0696 , G08B17/107 , G08B17/113 , G08B17/117
Abstract: A particulate detector (10) comprises a radiation source (12) arranged to emit radiation in at least first and second predetermined wavebands towards a sampling region (18) suspected of containing particulates, and a detection element (14), shielded from the radiation source (12), and arranged to detect radiation from the sampling region (18) at least first and second instances. The radiation source (12) is such that the emissions in the wavebands temporarily overlap. The detector is such that, at the instances at which the radiation is detected, the relative contributions from the emissions in each predetermined waveband are distinguishable, thereby allowing characteristics of the particulates to be determined. The radiation source (12) may comprise a light emitting diode (24).
Abstract translation: 微粒检测器（10）包括辐射源（12），辐射源（12）被布置成在至少第一和第二预定波段中向被怀疑含有微粒的采样区域（18）发射辐射;以及检测元件（14），其与辐射源 （12），并且被布置成在至少第一和第二实例中检测来自采样区域（18）的辐射。 辐射源（12）使得波段中的发射暂时重叠。 检测器使得在检测到辐射的情况下，来自每个预定波段中的发射的相对贡献是可区分的，从而允许确定微粒的特性。 辐射源（12）可以包括发光二极管（24）。
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公开(公告)号：US20110044858A1
公开(公告)日：2011-02-24
申请号：US12938224
申请日：2010-11-02
Applicant: Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
Inventor： Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
CPC classification number: G01J3/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/51 , G01N21/53 , G01N21/6452 , G01N2021/6419 , G01N2021/6469 , G01N2021/6484 , G01N2201/06193
Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.
Abstract translation: 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。
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