METHOD AND APPARATUS FOR MONITORING CERVICAL DIAMETER
    101.
    发明申请
    METHOD AND APPARATUS FOR MONITORING CERVICAL DIAMETER 审中-公开
    用于监测直径的方法和装置

    公开(公告)号:WO1998009565A1

    公开(公告)日:1998-03-12

    申请号:PCT/US1997015598

    申请日:1997-09-05

    CPC classification number: A61B5/1076 A61B5/412 A61B5/435 A61B2562/0261

    Abstract: An apparatus (22) for measuring cervical diameter (4') comprises a support structure (14) and measurement devices (23) for detecting changes in cervical diameter (4'), either directly or indirectly through changes in the size of the support structure (14). The support structure (14) may conform to a cervical surface, typically being a peripherally expansible lumen or expansible structure. Alternatively, the support structure may engage the vaginal wall or fornices (15). Measurement devices may include gages (23) which determine change in sizes of an expansible loop, electronic devices for measuring changes in transmitted or reflected energy, or combinations thereof. The devices are suitable for use on ambulatory patients and in out-patient situations.

    Abstract translation: 用于测量颈部直径(4')的装置(22)包括支撑结构(14)和用于检测颈部直径(4')变化的测量装置(23),直接或间接地通过支撑结构尺寸的变化 (14)。 支撑结构(14)可以符合宫颈表面,通常是周边可扩张的管腔或可膨胀的结构。 或者,支撑结构可以接合阴道壁或肋(15)。 测量装置可以包括确定可扩展回路的尺寸变化的量具(23),用于测量透射或反射能量的变化的电子装置或其组合。 这些装置适用于门诊病人和门诊病人。

    METHOD AND APPARATUS FOR DETERMINING STRESS
    102.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING STRESS 审中-公开
    用于确定应力的方法和装置

    公开(公告)号:WO1998008431A1

    公开(公告)日:1998-03-05

    申请号:PCT/GB1997002307

    申请日:1997-08-27

    CPC classification number: A61B5/01 A61B5/164

    Abstract: Stress in a subject is indicated by measuring a difference in temperature between symmetrically located left and right skin portions which are subject to asymmetrical temperature changes in response to emotional stimulus of the subject, correlating said difference against a sample data set of mean baseline resting values, and providing a signal if the temperature difference deviates from said data set by at least a predetermined amount or within a predetermined range. The method permits of lie detection and security screening by the non-invasive measurement of the left and right sides of the forehead and determining whether the differential temperature between the two sides is within first or second predetermined temperature ranges depending upon whether the left side is cooler or warmer than the right side.

    Abstract translation: 通过测量对称位置的左右皮肤部分之间的温度差异来响应受试者的压力,所述左右皮肤部分受到受试者的情绪刺激的不对称温度变化的影响,将所述差异与平均基线静息值的样本数据集相关联, 以及如果所述温度差偏离所述数据集至少预定量或在预定范围内,则提供信号。 该方法允许通过对前额左侧和右侧的非侵入性测量进行谎言检测和安全检查,并且根据左侧是较冷的方法确定两侧之间的温差是否在第一或第二预定温度范围内 或比右侧更暖。

    METHODS AND APPARATUS FOR IMAGE GUIDED ULTRASOUND DELIVERY OF COMPOUNDS THROUGH THE BLOOD BRAIN BARRIER
    103.
    发明申请
    METHODS AND APPARATUS FOR IMAGE GUIDED ULTRASOUND DELIVERY OF COMPOUNDS THROUGH THE BLOOD BRAIN BARRIER 审中-公开
    通过血脑屏障进行图像超声引导化合物的方法和装置

    公开(公告)号:WO1998007367A1

    公开(公告)日:1998-02-26

    申请号:PCT/US1997014737

    申请日:1997-08-21

    Abstract: Image guide methods and apparatus for ultrasound delivery of compounds through the blood brain barrier to selected locations in the brain, target a selected location in the brain of a patient (14), and apply ultrasound to effect in the tissues and/or fluids, at that location, a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging to confirm the location of that change. A compound, e.g., a neuro-pharmaceutical in the patient's bloodstream, is delivered to the confirmed location by applying ultrasound to effect opening of the blood brain barrier at that location, and thereby to induce uptake of the compound there.

    Abstract translation: 图像引导方法和装置,用于超声传递化合物通过血脑屏障到脑中的选定位置,靶向患者(14)的脑中的选定位置,并施加超声波以在组织和/或液体中起作用 该位置,通过成像可检测的变化。 在所选位置附近的脑部的至少一部分被成像,例如通过磁共振成像来确认该变化的位置。 化合物,例如患者血液中的神经药物,通过施加超声波将其输送到确认的位置,以在该位置打开血脑屏障,从而诱导该化合物的吸收。

    METHOD AND APPARATUS FOR MONITORING BLOOD CHEMISTRY
    104.
    发明申请
    METHOD AND APPARATUS FOR MONITORING BLOOD CHEMISTRY 审中-公开
    用于监测血液化学的方法和装置

    公开(公告)号:WO1998004191A1

    公开(公告)日:1998-02-05

    申请号:PCT/US1997013353

    申请日:1997-07-29

    Abstract: An improved system is disclosed for monitoring a patient's blood chemistry, wherein the system intermittently draws blood samples from the patient (11) into a special sensor assembly (19) having a plurality of analytical sensors (27-39), each sensitive to a particular parameter of the blood. After signals produced by these various sensors have been read, the system reinfuses the blood samples back into the patient. Withdrawal of the successive samples to a desired, optimal position within the sensor assembly (19) is achieved by monitoring signals produced by one or more of the analytical sensors (27-39), themselves. This allows a catheter that connects the sensor assembly to the patient to have a variable length and internal volume and obviates the need for a separate, dedicated sensor for detecting the arrival of the blood sample at the desired position.

    Abstract translation: 公开了一种用于监测患者血液化学的改进的系统,其中系统间歇性地将患者(11)中的血液样本吸入具有多个分析传感器(27-39)的特殊传感器组件(19),每个分析传感器对特定的 血液参数 在读取由这些各种传感器产生的信号之后,系统将血液样本重新灌注到患者体内。 通过监测由一个或多个分析传感器(27-39)本身产生的信号,将连续样品提取到传感器组件(19)内所需的最佳位置。 这允许将传感器组件连接到患者具有可变长度和内部体积的导管,并且不需要单独的专用传感器来检测血液样品到达所需位置。

    NEAR-INFRARED RAMAN SPECTROSCOPY FOR IN VITRO AND IN VIVO DETECTION OF CERVICAL PRECANCERS
    105.
    发明申请
    NEAR-INFRARED RAMAN SPECTROSCOPY FOR IN VITRO AND IN VIVO DETECTION OF CERVICAL PRECANCERS 审中-公开
    近红外拉曼光谱法检测宫颈癌

    公开(公告)号:WO1997048329A1

    公开(公告)日:1997-12-24

    申请号:PCT/US1997010204

    申请日:1997-06-19

    Abstract: Early diagnosis of cervical precancer is an important clinical goal. Optical spectroscopy has been suggested as a new technique to overcome limitations of current clinical practice. Herein, NIR Raman spectroscopy is applied to the diagnosis of cervical precancers. Using algorithms based on empirically selected peak intensities, ratios of peak intensities and a combination of Principal Component Analysis (PCA) for data reduction and Fisher Discriminant Analysis (FDA), normal tissues, inflammation and metaplasia were distinguishable from low grade and high grade precancers. The primary contributors to the tissue spectra appear to be collagen, nucleic acids, phospholipids and glucose 1-phosphate. These resuls suggest that near infrared Raman spectroscopy can be used effectively for cervical precancer diagnosis.

    Abstract translation: 子宫颈癌的早期诊断是临床的重要目标。 光谱学被认为是克服当前临床实践的局限性的新技术。 在这里,NIR拉曼光谱法被应用于子宫颈预处理的诊断。 使用基于经验选择的峰值强度的算法,峰值强度的比率和用于数据降低的主成分分析(PCA)和Fisher判别分析(FDA),正常组织,炎症和化生的组合与低等级和高级别的预处理可以区分开。 组织光谱的主要贡献者似乎是胶原,核酸,磷脂和葡萄糖1-磷酸。 这些研究表明,近红外拉曼光谱可以有效地用于子宫颈癌前期诊断。

    PROCEDURE, APPARATUS AND DETECTOR FOR THE DETERMINATION OF FRACTIONAL OXYGEN SATURATION
    106.
    发明申请
    PROCEDURE, APPARATUS AND DETECTOR FOR THE DETERMINATION OF FRACTIONAL OXYGEN SATURATION 审中-公开
    用于确定部分氧气饱和度的程序,装置和检测器

    公开(公告)号:WO1997047233A1

    公开(公告)日:1997-12-18

    申请号:PCT/FI1997000375

    申请日:1997-06-12

    Abstract: The invention relates to a procedure for determining the relative concentration or composition of different kinds of haemoglobin, such as oxyhaemoglobin, deoxyhaemoglobin and dyshaemoglobins, and/or dye components contained in blood in a non-invasive manner using the light absorption caused by different haemoglobin varieties and/or dye components, in which procedure light signals are transmitted at at least two predetermined wavelengths to a tissue comprised in the patient's blood circulation, the light signal transmitted through the target under measurement and/or reflected from it is received and the proportion of the intensity of the pulsating light signal received at each wavelength is determined in relation to the total intensity of the light transmitted through the tissue or reflected from the tissue. In the procedure, the effective extinction coefficients of blood haemoglobin derivatives and/or dye components in the tissue are determined for each light signal and/or light signal pair via a mathematical transformation from blood dye component extinction coefficients consistent with the Lambert-Beer theory and the proportion of specific blood haemoglobin derivatives and/or dye components in relation to the total amount of haemoglobin contained in the blood is determined by means of the intensity of the signals received in different wavelength ranges.

    Abstract translation: 本发明涉及使用不同血红蛋白品种引起的光吸收,以非侵入性方式测定血液中血红蛋白,血红蛋白,脱氧血红蛋白,血红蛋白,血红蛋白和/或染色成分的相对浓度或组成的方法。 和/或染料组分,其中光信号以至少两个预定波长传输到患者血液循环中包含的组织,接收测量和/或从其反射的目标发射的光信号,并且 在每个波长处接收的脉动光信号的强度相对于透过组织的光的总强度或从组织反射来确定。 在该程序中,通过与Lambert-Beer理论一致的血液染料成分消光系数的数学变换,为每个光信号和/或光信号对确定组织中血红蛋白衍生物和/或染料组分的有效消光系数,以及 通过在不同波长范围内接收的信号的强度来确定特定血红蛋白衍生物和/或染料成分与血液中所含血红蛋白总量的比例。

    PORTABLE MOTOR SYMPTOMS ASSESSMENT DEVICE
    107.
    发明申请
    PORTABLE MOTOR SYMPTOMS ASSESSMENT DEVICE 审中-公开
    便携式电机症状评估装置

    公开(公告)号:WO1997039677A1

    公开(公告)日:1997-10-30

    申请号:PCT/US1997007616

    申请日:1997-04-21

    CPC classification number: A61B5/1101 A61B5/681

    Abstract: This invention is a portable device (10) for assessing motor symptoms of a patient, including a bradykinesia testing system for measuring reaction and movement times of the patient, a tremor testing system for measuring tremors in extremities of the patient, and a rigidity testing system for measuring rigidity in the hand of a patient. The rigidity testing system includes a digital shaft encoder (44) with a rotatable shaft (24) that is actuated by the patient's fingers. A microprocessor (46) is connected to the bradykinesia, tremor, and rigidity testing systems for computing test results which are stored along with test instructions in an electronic memory (48), which is connected to the microprocessor (46). A user interface (16) is connected to the microprocessor (46) for programming in test parameters. The device is compactly housed to enable hand carried portability, and an input/output port (20) and printer port (22) are provided for transmitting test results to a host computer or printer.

    Abstract translation: 本发明是一种用于评估患者的运动症状的便携式装置(10),包括用于测量患者的反应和运动时间的运动检查系统,用于测量患者四肢震颤的震颤测试系统,以及刚度测试系统 用于测量患者手中的刚度。 刚性测试系统包括具有由患者手指致动的可旋转轴(24)的数字轴编码器(44)。 一个微处理器(46)连接到用于计算测试结果的运动休克,震颤和刚度测试系统,该测试结果与测试指令一起存储在连接到微处理器(46)的电子存储器(48)中。 用户接口(16)连接到微处理器(46),用于在测试参数中进行编程。 该设备紧凑地容纳以实现手携式便携性,并且提供输入/输出端口(20)和打印机端口(22),用于将测试结果传送到主计算机或打印机。

    SELF-FILLING BLOOD COLLECTION DEVICE
    108.
    发明申请
    SELF-FILLING BLOOD COLLECTION DEVICE 审中-公开
    自填式血液收集装置

    公开(公告)号:WO1997039676A1

    公开(公告)日:1997-10-30

    申请号:PCT/US1997007043

    申请日:1997-04-25

    CPC classification number: A61B5/153 A61B5/15003 A61B5/150213 B01L3/021

    Abstract: A self-filling blood collection device (2) has a frustum-conical body through which a channel (12) extends. The body is formed to have a lure end (4) to mate with a needle, and another end that is fitted with a hydrophilic filter (24) that allows air to pass through, but is self-sealing when exposed to fluid. The cavity volume of the channel (12) is configured to accept different minute amounts of blood for testing. An insert (26) may be fitted within the channel of the device to decrease the cavity volume so that a smaller amount of blood is collected. Once punctured with a needle attached to the lure end (4) of the device, blood from the patient will self-fill the channel (12) of the device due to the blood pressure of the patient. A vent cap may be added to the device to make it adaptable to be used with all types of blood analyzer equipment.

    Abstract translation: 自体采血装置(2)具有截头圆锥体,通道(12)延伸穿过其中。 身体形成为具有与针匹配的诱惑端(4),并且另一端装配有允许空气通过的亲水过滤器(24),但在暴露于流体时是自密封的。 通道(12)的空腔体积被配置为接受不同的微量血液进行测试。 插入物(26)可以装配在装置的通道内以减小空腔体积,从而收集较少量的血液。 一旦用连接到装置的诱饵端(4)的针刺穿,患者的血液将由于患者的血压自动填充装置的通道(12)。 可以将通气帽添加到装置中,使其适用于所有类型的血液分析仪设备。

    METHOD AND DEVICE FOR ELIMINATING ELECTRODE DRIFT
    109.
    发明申请
    METHOD AND DEVICE FOR ELIMINATING ELECTRODE DRIFT 审中-公开
    消除电极脱落的方法和装置

    公开(公告)号:WO1997038625A1

    公开(公告)日:1997-10-23

    申请号:PCT/US1997005700

    申请日:1997-04-08

    CPC classification number: A61B5/14542 A61B5/14539 A61B5/1473 A61B5/1495

    Abstract: A pH-measuring method and device (50) for monitoring and then correcting for electrode drift is provided. The device includes a pH-measuring electrode (54) and more than one reference electrodes (52a-52e). During operation, the pH-measuring device is placed in contact with a sample (51). The pH value measured at each electrode pair is due to the electrical potential difference between the pH electrode and the reference electrode. The maximum and minimum pH values are determined, and then the remaining pH values are averaged together to generate an overall average pH. The maximum and minimun pH values are subtracted from the average pH to generate a difference which is then compared to a user defined drift level to determine if a particular electrode is deficient. The pH values from deficient electrodes are not considered when the overall pH of the sample is determined.

    Abstract translation: 提供了用于监测并随后校正电极漂移的pH测量方法和装置(50)。 该装置包括pH测量电极(54)和多于一个的参考电极(52a-52e)。 在操作期间,将pH测量装置与样品(51)接触。 在每个电极对测量的pH值是由于pH电极和参比电极之间的电位差。 确定最大和最小pH值,然后将剩余的pH值平均在一起以产生总体平均pH。 从平均pH中减去最大和最小pH值以产生差异,然后将其与用户定义的漂移水平进行比较,以确定特定电极是否不足。 当确定样品的总体pH时,不考虑来自缺陷电极的pH值。

    METHOD AND APPARATUS FOR CALIBRATING AN OPTICAL PROBE
    110.
    发明申请
    METHOD AND APPARATUS FOR CALIBRATING AN OPTICAL PROBE 审中-公开
    用于校准光学探头的方法和装置

    公开(公告)号:WO1997035513A1

    公开(公告)日:1997-10-02

    申请号:PCT/US1997005370

    申请日:1997-03-25

    CPC classification number: A61B5/1459 A61B5/1495 A61B2560/0233

    Abstract: An optical body cavity probe (110, 310, 1200, 1300) is provided with a disposable flexible comformable sheath (120) having an optical window (220), or a disposable rigid sheath (320, 1210, 1310) having an optical window (420). The electronic system includes optical sources for generating the illuminating electromagnetic energy, filters or spectrum analyzers for isolating returned wavelengths of interest, and a computer for processing the returned wavelengths of interest to determine the tissue properties of interest as well as to calibrate the system. For calibration purposes, a removable calibration body (510, 910, 1010, 1220, 1330, 1430) bearing a fluorescence pattern resides on the outside of the optical window (500, 900, 1000, 1210, 1310, 1420) so as to be in the field of view of the probe when the sheath is installed over the probe. The calibration body is maintained in contact with the optical window during a calibration sequence using an adhesive, an endcap, shrink wrap material, or other suitable means. After the system is calibrated, the calibration body is removed and discarded and the investigation is begun. Once the investigation is completed, the sheath containing the optical window is removed, if present, and discarded.

    Abstract translation: 光学体腔探针(110,310,1200,1300)设置有具有光学窗口(220)的一次性柔性可成形护套(120)或具有光学窗口的一次性刚性护套(320,1210,1310) 420)。 电子系统包括用于产生照明电磁能的光源,用于隔离感兴趣的返回波长的滤光器或频谱分析器,以及用于处理感兴趣的返回波长的计算机,以确定感兴趣的组织属性以及校准系统。 为了校准目的,携带荧光图案的可拆卸校准体(510,910,1010,1220,1330,1430)驻留在光学窗口(500,900,110,1210,1310,1420)的外侧,从而为 当护套安装在探头上时,在探头的视野中。 使用粘合剂,端盖,收缩包装材料或其他合适的方法,校准体在校准序列期间保持与光学窗口接触。 校准后,校准体被取出并丢弃,开始调查。 调查完成后,如果存在,则将包含光学窗口的护套取出并丢弃。

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