公开(公告)号：EP3428145A1

公开(公告)日：2019-01-16

申请号：EP17763288.2

申请日：2017-03-08

Applicant: Daikin Industries, Ltd. ,  Osaka Prefecture University Public Corporation

Inventor： MATSUURA, Makoto ,  YAMAMOTO, Akinori ,  KISHIKAWA, Yosuke ,  RYU, Ilhyong ,  FUKUYAMA, Takahide ,  SUMINO, Shuhei

IPC: C07C17/275 ,  C07C19/08 ,  C07C22/08 ,  C07C41/30 ,  C07C43/174 ,  C07C67/343 ,  C07C69/24 ,  C07C69/608 ,  C07C69/612 ,  C07C69/675 ,  C07B37/02 ,  C07B61/00

Abstract: This invention solves the problem of providing an efficient, new method for producing a fluoromethylene-containing compound. The problem can be solved by a method for producing a compound represented by formula (1) or a ring-closed or ring-opened derivative of the compound, wherein R 1 represents an organic group, R X represents hydrogen or fluorine, R 2a , R 2b , R 2c , and R 2d are the same or different, and each represents -Y-R 21 or - N(-R 22 ) 2 , or R 2b and R 2c may join together to form a bond, wherein Y represents a bond, oxygen, or sulfur, R 21 represents hydrogen or an organic group, and R 22 , in each occurrence, is the same or different and represents hydrogen or an organic group; the method comprising step A of reacting a compound represented by formula (2), wherein X represents a leaving group, and other symbols are as defined above, with a compound represented by formula (3), wherein the symbols are as defined above, in the presence of a reducing agent under light irradiation.

公开(公告)号：EP2907818B1

公开(公告)日：2018-08-15

申请号：EP13846717.0

申请日：2013-10-08

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： TAKENAKA, Hiroshi ,  OHTA, Yoichiro ,  TAGUCHI, Yusuke ,  UEDA, Sayuri ,  ISHINO, Yuko ,  NAKASHIMA, Hideki ,  UEHARA, Kohki ,  KIRIHATA, Mitsunori

IPC: C07F5/04 ,  C07C229/36 ,  C07F5/02 ,  C07B59/00 ,  C07C271/22 ,  C07C251/24

CPC classification number: C07F5/025 ,  C07B59/001 ,  C07C229/08 ,  C07C229/36 ,  C07C251/24 ,  C07C271/22 ,  C07F5/027 ,  C07F5/04 ,  Y02P20/55

Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18 F-2-fluoro-4-borono-L-phenylalanine ( 18 F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR 3 R 4 , BX 3 - or BX 3 - M + (wherein X represents a halogen atom, and M + represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R 1 represents a hydrogen atom or a protecting group PG1; R 2 represents a hydrogen atom or a protecting group PG2; R 3 and R 4 independently represent OH, or R 3 , R 4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO 2 , NH 2 , Sn(R 6 ) 3 , N=N-NR 7 R 8 , OSO 2 R 9 , NR 10 R 11 , a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18 F-labeled BPA.

公开(公告)号：EP2690473B1

公开(公告)日：2018-06-06

申请号：EP13177467.1

申请日：2013-07-22

Applicant: FUJIKURA LTD. ,  Osaka Prefecture University Public Corporation

Inventor： Maruyama, Ryo ,  Kuwaki, Nobuo ,  Matsuo, Shoichiro ,  Ohashi, Masaharu

IPC: G02B6/028 ,  G02B6/036 ,  G02B6/02

CPC classification number: G02B6/0281 ,  G02B6/02047 ,  G02B6/02214 ,  G02B6/03627 ,  G02B6/4401

Abstract: An optical fiber, including (i) an inner core having an ±-power refractive index profile, (ii) an outer core having a refractive index of n1', and (iii) a cladding having a refractive index of n2 (n1'

公开(公告)号：EP2216428B1

公开(公告)日：2017-06-07

申请号：EP08852872.4

申请日：2008-10-29

Applicant: Air Water Inc. ,  Osaka Prefecture University Public Corporation

Inventor： IZUMI, Katsutoshi ,  YOKOYAMA, Takashi

IPC: C30B29/36 ,  C23C14/48 ,  C30B1/10 ,  H01L21/02 ,  H01L21/20 ,  H01L21/205 ,  H01L21/265 ,  H01L21/316 ,  H01L27/12 ,  H01L21/762

CPC classification number: H01L21/265 ,  C30B1/10 ,  C30B29/36 ,  H01L21/02381 ,  H01L21/02488 ,  H01L21/02529 ,  H01L21/02614 ,  H01L21/76251

公开(公告)号：EP2692471B1

公开(公告)日：2016-12-21

申请号：EP12763193.5

申请日：2012-03-27

Applicant: Osaka Prefecture University Public Corporation ,  Kinki University ,  Isel Co., Ltd.

Inventor： TAKASUGI Takayuki ,  KANENO Yasuyuki ,  OKI Sachio ,  HIRATA Tomotake ,  MOCHIZUKI Noboru

IPC: B23K20/12 ,  C22C19/03 ,  C22F1/10 ,  C22F1/00

CPC classification number: B23K20/125 ,  B23K20/1255 ,  C22C19/007 ,  C22C19/03 ,  C22F1/10

公开(公告)号：EP2919334A1

公开(公告)日：2015-09-16

申请号：EP13852847.6

申请日：2013-10-31

Applicant: Fujikura Ltd. ,  Nippon Telegraph and Telephone Corporation ,  Osaka Prefecture University Public Corporation ,  National University Corporation Shimane University

Inventor： MATSUO, Shoichiro ,  TAKENAGA, Katsuhiro ,  ICHI,I Kentaro ,  ONO, Hirotaka ,  TSUJIKAWA, Kyouzou ,  YAMADA, Makoto ,  MASUDA, Hiroji

IPC: H01S3/067 ,  G02B6/036 ,  G02B6/04

CPC classification number: H01S3/06754 ,  G02B6/02042 ,  G02B6/03605 ,  G02B6/03611 ,  H01S3/06729 ,  H01S3/06733 ,  H01S3/06737 ,  H01S3/091 ,  H01S3/094007 ,  H01S3/2383

Abstract: In the present invention, a plurality of cores (51) is disposed around the center axis of a first cladding (52) in the state in which a center axis distance is equal between cores adjacent to each other. The first cladding (52) has a two-layer structure formed of a solid inner layer (52A) passed through the center axis of the first cladding (52) and an outer layer (52B) enclosing the inner layer (52A) and the plurality of cores (51) with no gap. A refractive index n1 of the core (51) is provided higher than refractive indexes (n 2A ) and (n 2B ) of the inner layer (52A) and the outer layer (52B), the refractive indexes (n2A) and (n2B) of the inner layer (52A) and the outer layer (52B) are provided higher than a refractive index n3 of the second cladding 53, and the refractive index (n 2A ) of the inner layer (52A) is provided lower than the refractive index (n 2B ) of the outer layer (52B).

公开(公告)号：EP2907818A1

公开(公告)日：2015-08-19

申请号：EP13846717.0

申请日：2013-10-08

Applicant: Stella Pharma Corporation ,  Osaka Prefecture University Public Corporation

Inventor： TAKENAKA, Hiroshi ,  OHTA, Yoichiro ,  TAGUCHI, Yusuke ,  UEDA, Sayuri ,  ISHINO, Yuko ,  NAKASHIMA, Hideki ,  UEHARA, Kohki ,  KIRIHATA, Mitsunori

IPC: C07F5/04 ,  C07C229/36 ,  C07F7/22 ,  C07B59/00

CPC classification number: C07F5/025 ,  C07B59/001 ,  C07C229/08 ,  C07C229/36 ,  C07C251/24 ,  C07C271/22 ,  C07F5/027 ,  C07F5/04 ,  Y02P20/55

Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18 F-2-fluoro-4-borono-L-phenylalanine ( 18 F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR 3 R 4 , BX 3 - or BX 3 - M + (wherein X represents a halogen atom, and M + represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R 1 represents a hydrogen atom or a protecting group PG1; R 2 represents a hydrogen atom or a protecting group PG2; R 3 and R 4 independently represent OH, or R 3 , R 4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO 2 , NH 2 , Sn(R 6 ) 3 , N=N-NR 7 R 8 , OSO 2 R 9 , NR 10 R 11 , a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18 F-labeled BPA.

Abstract translation: 本发明提供：一种新型的手性4-硼 - 苯丙氨酸（BPA）衍生物; 用于生产衍生物的方法; 以及用于制造18 F-2-氟-4-羟硼基-L-苯丙氨酸的方法（18 F标记的BPA; 18F-BPA）使用所述衍生物。 由式（1）表示的化合物制备。 在该式中，R darstellt BR 3 R 4，BX 3 - 或BX 3 - M +（worin X表示卤原子，M + darstellt一价单原子阳离子，多原子阳离子或阳离子络合物）; R 1表示氢原子或保护基PG1; R 2表示氢原子或保护基PG2; R 3和R 4独立地表示OH，或R 3，R 4和B一起形成环也用作保护基团; 和Y代表卤原子，NO 2，NH 2，锡（R 6）3，N = N-NR 7 R 8，OSO 2 R 9，NR 10 R 11，substituiertem奥德unsubstituiertem phenyliodo基或substituiertem奥德unsubstituiertem 杂环碘基团。 的化合物与氟化试剂反应以制备18 F标记的BPA。

公开(公告)号：EP1988094B1

公开(公告)日：2014-06-11

申请号：EP06811315.8

申请日：2006-10-05

Applicant: Japan Science and Technology Agency ,  Osaka Prefecture University ,  Stella Chemifa Corporation

Inventor： KIRIHATA, Mitsunori ,  ASANO, Tomoyuki ,  UEHARA, Kohki

IPC: C07F5/02 ,  C07K16/00 ,  C12N5/10 ,  C12P21/08 ,  G01N33/53 ,  G01N33/577

CPC classification number: G01N33/5308 ,  C07F5/027 ,  C07K16/44 ,  G01N33/84 ,  G01N33/94

公开(公告)号：EP2692884A1

公开(公告)日：2014-02-05

申请号：EP12765196.6

申请日：2012-03-28

Applicant: Advanced Technologies, Inc. ,  Osaka Prefecture University Public Corporation

Inventor： HIRAI, Kinji ,  HIGASHI, Kenji ,  TAKIGAWA, Yorinobu ,  UESUGI, Tokuteru

IPC: C22C23/02 ,  C22F1/06 ,  C22F1/00

CPC classification number: C22C23/02 ,  C22F1/06

Abstract: The present invention provides magnesium alloy which has sufficiently high strength at room temperature and high temperature.
Disclosed is a magnesium alloy comprising: aluminum (Al): 14.0 to 23.0% by mass, calcium (Ca): 11.0% by mass or less (not including 0% by mass), strontium (Sr): 12.0% by mass or less (not including 0% by mass), and zinc (Zn): 0.2 to 1.0% by mass.

公开(公告)号：EP2123344B1

公开(公告)日：2014-01-22

申请号：EP08711388.2

申请日：2008-02-15

Applicant: Osaka Prefecture University Public Corporation ,  Japan Science and Technology Agency

Inventor： KUROKI, Tomoyuki ,  OKUBO, Masaaki ,  YAMAMOTO, Toshiaki ,  FUJISHIMA, Hidekatsu ,  OTSUKA, Keiichi

IPC: B01D53/56 ,  B01D53/74 ,  B01D53/77 ,  F01N3/035 ,  F01N3/08 ,  F23J15/04

CPC classification number: F01N3/035 ,  B01D53/56 ,  B01D53/79 ,  B01D2251/104 ,  B01D2251/20 ,  B01D2251/304 ,  B01D2251/404 ,  B01D2251/604 ,  B01D2258/012 ,  F01N3/04 ,  F01N2570/14 ,  F23J15/04 ,  F23J2219/40