Abstract:
The present invention provides methods of repairing and regenerating cartilage tissue using a soluble morphogenic protein complex comprising (a) a morphogenic protein; and (b) a morphogenic protein pro region isolated from a morphogenic protein, or a conservative substitution variant or a fragment of said pro region, wherein said pro region or variant or fragment is noncovalently linked to the morphogenic protein, and wherein said complex is more soluble in an aqueous solvent than said morphogenic protein alone.
Abstract:
A surgical tool system is described that comprises a handpiece with a power generating unit capable of driving a cutting accessory or an implantable device that is fitted into a patient; and an attachment connectable to handpiece, the attachment serving as a linkage between the power generating unit and the cutting accessory or implantable device for driving the cutting accessory or the implantable device. The handpiece comprises a coil; and the attachment comprises a first coil positioned so that when the cutting accessory or implantable device is attached to the attachment, the first coil is able to receive signals from a coil internal to the cutting accessory or implantable device; and a second coil connected to the first coil and positioned so that when the attachment is attached to the handpiece, the second coil is able to transmit signals received from the cutting accessory or implantable device coil to the handpiece coil.
Abstract:
PROBLEM TO BE SOLVED: To facilitate data reading of an accessory mounted on a motor-driven handpiece of a surgical tool system and to drive the motor-driven handpiece according to a method suitable for the mounted accessory by a control console based on the read data. SOLUTION: This fitting tool used with the surgical motor-driven handpiece includes a body part connecting a cutting accessory or a surgical implant and the surgical motor-driven handpiece to each other, a first transmit/receive head for exchanging a signal with a transmit/receive head in the surgical motor-driven handpiece, and a second transmit/receive head for exchanging a signal with a transmit/receive head in the surgical implant, wherein a signal received through the first transmit/receive head from the surgical motor-driven handpiece is transferred through the second transmit/receive head to the cutting accessory or the surgical implant, and a signal received through the second transmit/receive head from a memory of the interior of the cutting accessory or the interior of the surgical implant is transferred through the first transmit/receive head to the surgical motor-driven handpiece. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To identify biomaterial applicable to a defective part, and extraordinarily boosting a regeneration process, especially for use with other bioactive agent such as bone forming protein and other related factors, and identify and use matrix that has much durability as a bone substitutional material usable as a carrier that is mechanically durable to the bioactive agent to support treatment. SOLUTION: A porous β-TCP is provided with a porous body of β-tricalcium phosphate, having a plurality of pores. The pores are each single separate void of 20-500 μm in diameter. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide an improved means for producing a recombinant BMP and other TGF-β family protein in vitro by using a prokaryotic host and a eukaryotic organism host. SOLUTION: The TGF-βsuper-family protein is a component of latent TGF-βfamily member fused protein to refold under suitable refolding conditions, comprising a TGF-β family protein having N-terminal truncations, and the TGF-β family protein having N-terminal truncations comprises a TGF-βfamily protein C-terminal 7 cysteine domain comprising a finger 1 sub-domain, a finger 2 sub-domain, and a heel sub-domain; and a cleavable modified leader sequence operatively linked to the C-terminal domain. The leader sequence inhibits biological activity related to the C-terminal domain and the C-terminal domain comprises a leader sequence activated when cleaving a part or all of the leader sequence. COPYRIGHT: (C)2009,JPO&INPIT