公开(公告)号：US20160168613A1

公开(公告)日：2016-06-16

申请号：US14436844

申请日：2013-10-17

Applicant: UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  CHILDREN'S NATIONAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN

Inventor： Omar Bilal Ayyub ,  Adam Michael Behrens ,  Peter Kofinas ,  Marshall Lynn Summar ,  Juan Manuel Cabrera-Luque ,  Gary Cunningham ,  Anton Simeonov ,  Juan Marugan

IPC: C12Q1/00 ,  C12N11/04 ,  G01N27/327 ,  G01N33/68

CPC classification number: C12Q1/005 ,  C12N9/0018 ,  C12N9/0071 ,  C12N11/04 ,  C12N11/10 ,  G01N27/3277 ,  G01N33/6812 ,  G01N2800/04 ,  G01N2800/52

Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.

Abstract translation: 本发明涉及能够使用包含由水凝胶改性的电极的无试剂系统来测量一种或多种氨基酸的总浓度的生物传感器，该电极包含至少一种氧化至少一种至少一种至少一种底物的酶 一个氨基酸。 在一些实施方案中，生物传感器包含包含藻酸盐的水凝胶。 在一些实施方案中，生物传感器包括使用固定或附着在水凝胶上的嗜热细菌代谢酶。

公开(公告)号：US09363467B2

公开(公告)日：2016-06-07

申请号：US14093399

申请日：2013-11-29

Applicant: University of Maryland, Office of Technology Commercialization

Inventor： Ravi Garg ,  Avinash L. Varna ,  Adi Hajj-Ahmad ,  Min Wu

IPC: H04N5/913

CPC classification number: H04N5/913 ,  H04N2005/91342

Abstract: Various systems and methods may benefit from determination of environmental signatures in recordings. For example, such signatures may aid forensic analysis and alignment of media recordings, such as alignment of audio or video recordings. A method can include reading data representative of sensed light in a visual track of a video recording. The method can also include extracting an electric network frequency signal from the data representative of sensed light.

Abstract translation: 各种系统和方法可能受益于确定记录中的环境签名。 例如，这样的签名可以帮助对媒体记录进行取证分析和对齐，诸如对准音频或视频记录。 方法可以包括在视频记录的视频轨迹中读取表示感测光的数据。 该方法还可以包括从表示感测光的数据中提取电网频率信号。

公开(公告)号：US20160107192A1

公开(公告)日：2016-04-21

申请号：US14918529

申请日：2015-10-20

Applicant: The Texas A&M System Technology Commercialization

Inventor： Jaime Grunlan ,  Tyler Guin

IPC: B05D7/00

CPC classification number: B05D7/54 ,  B05D1/185 ,  B05D7/58

Abstract: A layer-by-layer deposition process for a thin film having a polyelectrolyte and a complementary species includes calibrating a buffered polyelectrolyte solution and a buffered rinse solution, depositing a polyelectrolyte layer on a substrate, and depositing a complementary species layer on the polyelectrolyte layer. Depositing a polyelectrolyte layer includes applying the buffered polyelectrolyte solution to the substrate and applying the buffered rinse solution to the substrate after the buffered polyelectrolyte solution has been applied. Depositing a complementary species layer includes applying a complementary species mixture to the substrate and applying a complementary species rinse solution to the substrate after the complementary species mixture has been applied.

Abstract translation: 用于具有聚电解质和互补物质的薄膜的逐层沉积方法包括校准缓冲的聚电解质溶液和缓冲的漂洗溶液，在基底上沉积聚电解质层，以及在聚电解质层上沉积互补物质层。 沉积聚电解质层包括将缓冲的聚电解质溶液施加到基底上，并且在缓冲的聚电解质溶液施加之后将缓冲的漂洗溶液施加到基底上。 沉积互补物质层包括将互补物质混合物施加到基底上，并且在互补物质混合物施加之后将互补物质漂洗溶液施加到基底上。

公开(公告)号：US20140314706A1

公开(公告)日：2014-10-23

申请号：US14208820

申请日：2014-03-13

Applicant: University of Maryland, Office of Technology Commercialization

Inventor： Kevin Diehn ,  Matthew Dowling ,  Srinivasa R. Raghavan ,  David R. King

IPC: A61K31/765

CPC classification number: A61K31/734 ,  A61K31/717 ,  A61K31/722 ,  A61K38/39

Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.

Abstract translation: 公开了用于治疗各种伤口形态的止血腻子，包括但不限于高度三维伤口，例如枪伤和刺痛。 油灰由弱交联或未交联的基质聚合物组成，使得形成粘弹性基质。 腻子的粘弹性质可以通过组合物调节，并使腻子符合各种伤口形貌。 同样地，在该基质中包括止血聚合物，例如壳聚糖或疏水改性的壳聚糖，以在腻子上赋予止血性和组织粘合剂。 所公开的止血聚合物防止微生物感染，并且适合于正常伤口代谢期间所需的氧传递。

公开(公告)号：US20140129967A1

公开(公告)日：2014-05-08

申请号：US14071269

申请日：2013-11-04

Applicant: University of Maryland, Office of Technology Commercialization

Inventor： Hanan SAMET ,  Brendan C. FRUIN

IPC: G06F3/048

CPC classification number: G06F1/1626 ,  G06F1/1694 ,  G06F3/0346

Abstract: Various devices may benefit from determinations of how users are using the devices. For example, hand-held or hand-operated devices may benefit from handedness detection and from modifications based on or related to such detection. A method can include determining a used hand of a user of a device. The method can also include modifying a graphical user interface of the device based on the determined used hand, wherein determination of the used hand occurs prior to any querying of the user regarding the used hand of the user.

Abstract translation: 各种设备可能受益于用户如何使用设备的确定。 例如，手持式或手动操作的装置可以从旋律检测和基于或与其相关的修改中获益。 方法可以包括确定设备的用户的使用手。 该方法还可以包括基于所确定的使用手来修改设备的图形用户界面，其中在用户对用户的使用手的任何查询之前发生所使用的手的确定。

公开(公告)号：US20220287677A1

公开(公告)日：2022-09-15

申请号：US17692372

申请日：2022-03-11

Applicant: Centre for Imaging Technology Commercialization (CIMTEC)

Inventor： Aaron FENSTER ,  Kevin BARKER

IPC: A61B8/00 ,  A61B8/08

Abstract: An actuator for moving an ultrasound transducer has a main body configured to be positioned adjacent to a target region of interest to be examined; and, a motor mounted on the main body. The motor is configured to have an ultrasound transducer connected thereto to simultaneously translate and rotate the ultrasound transducer to perform a compound scan of the target region of interest when the ultrasound transducer is connected to the motor. An ultrasound device has an ultrasound transducer movably mounted on the actuator. The actuator requires only single motor to effect both translation and rotation of the transducer thereby simplifying operation and providing a more compact device.

公开(公告)号：US10334897B2

公开(公告)日：2019-07-02

申请号：US14552535

申请日：2014-11-25

Applicant: University of Maryland, Office of Technology Commercialization

Inventor： Kevin Diehn ,  Chandamany Arya ,  Karl Engel ,  Matthew Furstenburg ,  Srinivasa R. Raghavan

IPC: A41D19/015 ,  C09D105/08 ,  C09D105/04

Abstract: A formulation for coating surfaces, for example gloves, with a tacky film comprises a hydrophobically modified biopolymer, where the hydrophobic modifications of the biopolymer correspond to between 1 and 90% of available functional groups, a plasticizer, and a volatile solvent. The formulation quickly dries into a tacky film that provides an enhanced friction of the surface.

公开(公告)号：US20180147286A1

公开(公告)日：2018-05-31

申请号：US15578226

申请日：2016-05-29

Applicant: Jindrich Kopecek ,  Jiyan Yang ,  Purdue Research Foundation Office of Technology Commercialization ,  University of Utah Research Foundation

Inventor： Stewart Andrew Low ,  Philip S. Low ,  Christopher Galliford ,  Jindrich Kopecek ,  Jiyan Yang

IPC: A61K47/42 ,  A61M5/00 ,  A61P19/00 ,  A61K9/107 ,  A61K31/404

CPC classification number: A61K47/42 ,  A61K9/1075 ,  A61K31/404 ,  A61L27/22 ,  A61L27/227 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/02 ,  A61M5/002 ,  A61P19/00 ,  C07K7/06 ,  C07K7/08

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

公开(公告)号：US20180058529A1

公开(公告)日：2018-03-01

申请号：US15563040

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： Jeffrey BAX ,  Christopher WARING ,  Aaron FENSTER ,  Jeremy CEPEK

IPC: F16D71/04 ,  F16D49/00 ,  F16D65/14

CPC classification number: F16D71/04 ,  A61N7/02 ,  F16D49/00 ,  F16D65/14 ,  F16D71/00 ,  F16D2121/14 ,  F16D2125/28 ,  F16D2125/48 ,  F16D2125/582 ,  F16D2127/06

Abstract: A self-locking brake mechanism, which utilises a cantilever to engage a brake drum to prevent the brake drum from rotating, thereby resulting in braking behaviour. Further, locking mechanisms are provided that are useful for applications involving multiple brakes. The locking mechanism, through suitable use of indexing via Geneva mechanisms, allows multiple brakes to be engaged and/or disengaged from a single point of adjustment. The multiple brakes may be engaged or disengaged in a variety of combinations to achieve a particular desired braking configuration. The user can turn a single knob to engage or disengage varying combinations of brakes so as to achieve the desired braking configuration.

公开(公告)号：US20180049721A1

公开(公告)日：2018-02-22

申请号：US15562999

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： Eliezer Azi BEN-LAVI ,  Aaron FENSTER

IPC: A61B8/08 ,  A61B8/00 ,  G06T7/32 ,  G06T3/40

CPC classification number: A61B8/5253 ,  A61B8/0891 ,  A61B8/4477 ,  A61B8/483 ,  A61B8/5223 ,  G06T3/4038 ,  G06T7/12 ,  G06T7/32 ,  G06T2207/10136 ,  G06T2207/20016 ,  G06T2207/20048 ,  G06T2207/20076 ,  G06T2207/20221 ,  G06T2207/30101

Abstract: A computer-implemented method for combining two 3-dimensional ultrasound images of a patient's body part containing blood vessels into a single 3-dimensional ultrasound image of that body part with a greater field of view. Blood vessels within the body part are used for registration. The two ultrasound images are preprocessed using a vessel enhancement algorithm to derive two corresponding enhanced images. The enhanced images can undergo a registration process based upon minimizing a mean-square-difference metric to derive an enhanced rigid transform, which represents a transform that maps the first enhanced image onto the second enhanced image. The two enhanced images are seamlessly combined via a blending process (via the use of a distance transform based weighting of the voxel values) to derive an output image.