公开(公告)号：US20180207272A1

公开(公告)日：2018-07-26

申请号：US15744905

申请日：2016-07-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/395 ,  C07K16/28 ,  A61P31/00 ,  A61P35/04

CPC classification number: A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61K2035/122 ,  A61K2039/5158 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/467

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US10030224B2

公开(公告)日：2018-07-24

申请号：US14929363

申请日：2015-11-01

Applicant: Ariel-University Research and Development Company Ltd. ,  Yeda Research and Development Co. Ltd. ,  Indian Institute of Technology Bombay

Inventor： Mordechai Sheves ,  Irishi N. N. Namboothiri ,  Guy Patchornik

IPC: C12N1/00 ,  C07K14/215

Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.

公开(公告)号：US20180180696A1

公开(公告)日：2018-06-28

申请号：US15738688

申请日：2016-06-26

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Aharon BLANK ,  Itai KATZ ,  Akiva FEINTUCH

IPC: G01R33/56 ,  G01R33/28 ,  G01R33/62 ,  A61B5/055 ,  A61M5/00 ,  A61K49/20

Abstract: A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

公开(公告)号：US20180161481A1

公开(公告)日：2018-06-14

申请号：US15890504

申请日：2018-02-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Noa IUSTER ,  Raya SORKIN

IPC: A61L27/52 ,  C08F2/44 ,  A61K9/00 ,  A61L27/34 ,  A61L27/44 ,  C08F2/10 ,  C09D133/06

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/0024 ,  A61L27/34 ,  A61L27/44 ,  A61L2300/626 ,  A61L2400/10 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/24 ,  A61L2430/38 ,  C08F2/10 ,  C08F2/44 ,  C09D133/066

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

公开(公告)号：US09998198B2

公开(公告)日：2018-06-12

申请号：US15346747

申请日：2016-11-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avishay Gal-Yam ,  Barak Zackay ,  Eran Ofek

IPC: H04B1/00 ,  H04B7/08 ,  H04B17/20

CPC classification number: H04B7/0851 ,  H04B17/20 ,  H04B17/318 ,  H04B17/3912

Abstract: A method for detecting a dispersed pulse in a received signal that has been dispersed by a dispersive medium includes obtaining an input array of cells, each indicating an intensity of a frequency component of the signal at a representative time. A fast dispersion measure transform (FDMT) is applied to concurrently sum the cells of the input array that lie along different dispersion curves, each curve defined by a known non-linear functional form and being uniquely characterized by a time coordinate and by a value of the dispersion measure. Application of FDMT includes initially generating a plurality of sub-arrays, each representing a frequency sub-band and iteratively combining pairs of adjacent sub-arrays in accordance with an addition rule until all of the initially generated plurality of sub-arrays are combined into an output array of the sums, in which a cell of the output array that is indicative of a transmitted pulse is identified.

公开(公告)号：US09982051B2

公开(公告)日：2018-05-29

申请号：US15821678

申请日：2017-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/7068 ,  A61K38/00 ,  A61K38/18 ,  A61K38/16 ,  A61K38/02 ,  A61K45/06 ,  A61K31/4155 ,  A61K38/14 ,  A61K38/20 ,  A61K33/36 ,  A61K31/404 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K38/00 ,  A61K38/005 ,  A61K38/02 ,  A61K38/14 ,  A61K38/168 ,  A61K38/18 ,  A61K38/208 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2121/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

公开(公告)号：US09982050B2

公开(公告)日：2018-05-29

申请号：US15821672

申请日：2017-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/16 ,  A61K31/7068 ,  A61K45/06 ,  A61K38/18 ,  A61K38/14 ,  A61K38/00 ,  A61K38/20 ,  A61K33/36 ,  A61K31/404 ,  A61K31/4155 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K38/00 ,  A61K38/005 ,  A61K38/02 ,  A61K38/14 ,  A61K38/168 ,  A61K38/18 ,  A61K38/208 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2121/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session.

公开(公告)号：US09982048B2

公开(公告)日：2018-05-29

申请号：US15821595

申请日：2017-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/16 ,  A61K31/7068 ,  A61K45/06 ,  A61K38/18 ,  A61K38/14 ,  A61K38/00 ,  A61K38/20 ,  A61K33/36 ,  A61K31/404 ,  A61K31/4155 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K38/00 ,  A61K38/005 ,  A61K38/02 ,  A61K38/14 ,  A61K38/168 ,  A61K38/18 ,  A61K38/208 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2121/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session.

公开(公告)号：US20180140648A1

公开(公告)日：2018-05-24

申请号：US15575827

申请日：2016-05-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: A61K35/747 ,  A61K35/745 ,  A61P3/08

CPC classification number: A61K35/747 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K2300/00 ,  A61P3/08 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475

Abstract: A method of improving the glucose response in glucose tolerant and intolerant subjects is provided. The method comprises providing to the subject probiotic compositions, or agents which specifically reduce bacterial species.

公开(公告)号：US20180134808A1

公开(公告)日：2018-05-17

申请号：US15865479

申请日：2018-01-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Tamar DANON ,  Netta SELA ,  Abraham SHANZER ,  Rina ARAD-YELLIN ,  Raghavendra KIKKERI

IPC: C07K16/44 ,  C07F3/06 ,  C07D233/61 ,  C07K16/40

CPC classification number: C07K16/44 ,  C07D233/61 ,  C07F3/06 ,  C07K16/40 ,  C07K2317/565 ,  C07K2317/76

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.