Abstract:
The present invention relates to a composition for promoting the differentiation of human mesenchymal stem cells into adipocytes. More specifically, the present invention relates to a composition for cosmetics or plastic surgery which increases the sense of volume of specific body part by creating lipid droplets by comprising at least one species among Castaneae semen, Selaginella tamariscina, Aloe vera, Salvia miltiorrhiza, Mentha arvensis, Pinellia ternate, Triticum aestivum, Saururus chinensis, Polygala tenuifolia, and Gleditsia sinensis extracts as an active ingredient to promote the differentiation of human mesenchymal stem cells into adipocytes.
Abstract:
PURPOSE: A method for screening a material which regulates skin pigmentation is provided to screen a material for regulating skin pigmentation, and to effectively treat hyperpigmentation or hypopigmentation by regulating intracellular and intercellular signal transduction faction and transcription factor. CONSTITUTION: A method for screening a material which regulates skin pigmentation comprises: a step of treating one or more gene selected from the group consisting of IFN gamma, IL4, IL17, IL6, STAT3, STAT6, JAK1, JAK2, and JAK3 with a candidate material; and a step of selecting a candidate material which enhances or reduces gene expression as a material which regulates skin pigmentation. A candidate material which enhances gene expression is selected as a useful material which possibly suppresses pigmentation. A candidate material which reduces gene expression is selected as a useful material which possibly enhances skin pigmentation. [Reference numerals] (AA) Comparative example; (BB) Example 1; (CC) Example 2; (DD) Example 3
Abstract:
본 발명은 인간 중간엽줄기세포의 지방세포로의 분화를 촉진하는 조성물에 관한 것으로, 보다 상세하게는 계혈등, 고량강, 독활 및 천련자 추출물 중 적어도 1종 이상을 유효성분으로 함유하여 인간 중간엽줄기세포를 지방세포로 분화하는 것을 촉진시킴으로써 지방체(Lipid droplet)를 생성하여 피부의 볼륨과 탄력을 증진시키고 주름을 개선시키는 조성물에 관한 것이다. 계혈등 * 고량강 * 독활 * 천련자 * 중간엽 줄기세포 분화 * 지방세포생성
Abstract:
PURPOSE: A composition for promoting differentiation from human mesenchymal stem cells into adipocytes is provided to enhance skin volume and elasticity ad to improve anti-wrinkling. CONSTITUTION: An external use skin composition for promoting adipocyte differentiation contains 0.0001-30 wt% of Chrysanthemi sibirici Herba extract as an active ingredient. The composition promotes the differentiation of human mesenchymal stem cells into adipocytes. A pharmaceutical composition for promoting adipocyte differentiation contains the extract as an active ingredient. The daily dose of the extract is 0.001mg/kg/day-2000mg/kg/day.
Abstract translation:目的:提供用于促进从人间充质干细胞分化成脂肪细胞的组合物,以增强皮肤体积和弹性,以改善抗皱纹。 构成:用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量%的菊花西布提取物作为活性成分。 该组合物促进人间充质干细胞分化为脂肪细胞。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。 提取物的日剂量为0.001mg / kg /天-2000mg / kg /天。
Abstract:
PURPOSE: A composition for a three dimensional matrix containing collagen 4, laminin, nidogen, and proteoglycan is provided to study cancer mechanism or treatment. CONSTITUTION: A composition for a three dimensional matrix contains each 0.001-30wt% of collagen IV, liminin, nidogen, and proteoglycan in a proportion. The three dimensional matrix includes a matrix for suppressing cell division or cell dedifferentiation. The cell is human pigmentary skin cells. The three dimensional matrix is prepared using the composition.
Abstract:
PURPOSE: A composition containing Sequoia callus extract is provided to promote regeneration of adipose-derived stem cells and to recover damaged subcutaneous fat. CONSTITUTION: A composition for enhancing the stemness of adipose-derived stem cells(hADSCs) contains Sequoia callus extract as an active ingredient. The composition enhances CD29 and CD44 expression level. A composition for enhancing skin cell proliferation contains the extract as an active ingredient. The skin cell is transit-amplifying cells(TA cells). The composition contains 0.0001-10 wt% of the extract. A skin care method comprises a step of treating the composition on the skin.
Abstract:
PURPOSE: A composition containing cinnamic acid derivatives, methoxy phenyl acrylate derivatives, and beta,beta-diphenylacrylate derivatives is provided to improve photo stability. CONSTITUTION: A composition for sun screening contains cinnamic acid derivatives, methoxy phenyl acrylate derivatives, and beta-beta-diphenyl acrylate derivatives as an active ingredient. The methoxy phenyl acrylate derivative is ethyl hexyl methoxy crylene. The beta-beta-diphenyl acrylate derivative includes octocrylene, etocrylene, or both. The composition further contains triazine derivatives, salicylic acid derivatives, and benzalmalonate derivatives.
Abstract:
PURPOSE: A method for evaluating efficiency of UV protector is provided to measure cell apoptosis rate and to accurately protect UV ray. CONSTITUTION: A method for evaluating efficiency of UV protector comprises: a step of applying an UV protector onto UV permeable material; a step of irradiating UV onto the upper portion of the UV permeable material; and a step of measuring cell death of skin cells. The UV permeable material is a quartz plate or band pass filter. The skin cells include keratinocytes, fibroblasts, or melanocytes. The cell death includes apoptosis and necrosis.