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公开(公告)号：KR1020140057054A
公开(公告)日：2014-05-12
申请号：KR1020120123693
申请日：2012-11-02
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K48/00 , A61K31/7105 , G01N33/15
Abstract: Disclosed are isolated miRNA nucleic acid molecules comprising SEQ ID No. 1 or SEQ ID No. 2; a fragment or an analog thereof having hybridization ability of the miRNA to regulate expression of one or more of keratin 1 and keratin 10; or a skin external application composition comprising the same. In one aspect of the present invention, disclosed is a method of screening a keratogenesis regulatory substance using the miRNA nucleic acid molecules, or the fragment or the analog thereof.
Abstract translation: 公开了包含SEQ ID No.1或SEQ ID No.2的分离的miRNA核酸分子; 其具有miRNA调节角蛋白1和角蛋白10中的一种或多种的表达的杂交能力的片段或类似物; 或包含其的皮肤外用施用组合物。 在本发明的一个方面，公开了使用miRNA核酸分子或其片段或类似物筛选角化生成调节物质的方法。
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公开(公告)号：KR1020140052569A
公开(公告)日：2014-05-07
申请号：KR1020120118765
申请日：2012-10-25
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition comprising cellobiose as an active ingredient, and more specifically, to a skin external application composition for skin whitening which contains cellobiose as an active ingredient thereby inhibiting melanin production of skin and accordingly having a skin whitening effect.
Abstract translation: 本发明涉及包含纤维二糖作为活性成分的组合物，更具体地说，涉及含有纤维二糖作为活性成分的皮肤外用施用组合物，从而抑制皮肤的黑色素生成并因此具有皮肤美白效果。
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公开(公告)号：KR1020140017259A
公开(公告)日：2014-02-11
申请号：KR1020120083963
申请日：2012-07-31
Applicant: (주)아모레퍼시픽
IPC: A61K31/375 , A61K31/352 , A61K31/35 , A61P17/00
Abstract: The present invention relates to a whitening composition and more specifically, to a whitening composition comprising trolox. The composition of the present invention has an outstanding whitening effect by inhibiting or suppressing a generation of melanin by inhibiting activation of tyrosinase. In addition, the composition is harmless since it does not contain any cytotoxic component while having the whitening effect. The present invention has its significance in discovering a synergy effect of using vitamin C and trolox in combination.
Abstract translation: 本发明涉及一种美白组合物，更具体地说，涉及一种含有特氟洛氟的美白组合物。 通过抑制或抑制酪氨酸酶的活化来抑制或抑制黑色素的产生，本发明的组合物具有优异的美白效果。 此外，组合物是无害的，因为它不具有任何细胞毒性成分，同时具有美白效果。 本发明在发现组合使用维生素C和trolox的协同作用方面具有重要意义。
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公开(公告)号：KR1020130035935A
公开(公告)日：2013-04-09
申请号：KR1020120108461
申请日：2012-09-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A keratinocyte-adapted melanocyte and a method for preparing the same are provided to obtain melanocyte with excellent adhesion and high survival rate. CONSTITUTION: A method for preparing keratinocyte-adapted melanocytes comprises: a step of culturing keratinocytes in a keratinocyte medium; a step of removing keratinocytes from a culture; and a step of collecting cells adhered on the bottom of a dish and culturing the cells in a melanocyte medium.
Abstract translation: 目的：提供角质形成细胞适应的黑素细胞及其制备方法，以获得具有优异粘附性和高存活率的黑素细胞。 构成：一种制备角质形成细胞适应黑素细胞的方法，包括：在角质细胞培养基中培养角化细胞的步骤; 从培养物中去除角质形成细胞的步骤; 以及收集附着在皿底部并在黑素细胞培养基中培养细胞的细胞的步骤。
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公开(公告)号：KR102212623B1
公开(公告)日：2021-02-09
申请号：KR1020140045547
申请日：2014-04-16
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: A61K48/00 , A61K39/395 , A61K8/96 , A61P17/00 , A61Q19/02
Abstract: 본발명은캐드헤린11(Cadherin 11) 및 N-캐드헤린(N-cadherin) 중하나이상의발현억제물질을유효성분으로포함하는피부개선용조성물및 이를포함하는피부개선키트를제공함으로써피부과색소침착증을개선할수 있으며, 피부미백효과를제공할수 있다. 피부주름생성을방지또는완화할수 있으므로, 우수한항노화효과를제공한다. 또한, 본발명은섬유아세포(fibroblast), 각질형성세포(keratinocyte) 및멜라닌생성세포(melanocyte) 중 2종이상의공배양물을포함하는피부개선물질스크리닝시스템, 및상기피부개선물질스크리닝시스템의공배양물에후보물질을처리하는단계, 및캐드헤린11 및 N-캐드헤린중 하나이상의발현변화를측정하는단계를포함하는것을특징으로하는피부개선물질의스크리닝방법을제공함으로써, 생체외(in vitro)에서도임상적으로캐드헤린11, N-캐드헤린의발현변화를용이하게측정하여, 피부개선물질을효과적으로스크리닝할수 있다.
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Patent Agency Ranking
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公开(公告)号：KR102027451B1
公开(公告)日：2019-10-02
申请号：KR1020120123693
申请日：2012-11-02
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K31/7105 , G01N33/50
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