公开(公告)号：KR1020120092754A

公开(公告)日：2012-08-22

申请号：KR1020110001219

申请日：2011-01-06

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  노민수

IPC: A61K36/287 ,  A61P17/00

Abstract: PURPOSE: A composition for promoting differentiation from human mesenchymal stem cells into adipocytes is provided to enhance skin volume and elasticity ad to improve anti-wrinkling. CONSTITUTION: An external use skin composition for promoting adipocyte differentiation contains 0.0001-30 wt% of Chrysanthemi sibirici Herba extract as an active ingredient. The composition promotes the differentiation of human mesenchymal stem cells into adipocytes. A pharmaceutical composition for promoting adipocyte differentiation contains the extract as an active ingredient. The daily dose of the extract is 0.001mg/kg/day-2000mg/kg/day.

Abstract translation: 目的：提供用于促进从人间充质干细胞分化成脂肪细胞的组合物，以增强皮肤体积和弹性，以改善抗皱纹。 构成：用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量％的菊花西布提取物作为活性成分。 该组合物促进人间充质干细胞分化为脂肪细胞。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。 提取物的日剂量为0.001mg / kg /天-2000mg / kg /天。

公开(公告)号：KR1020120059785A

公开(公告)日：2012-06-11

申请号：KR1020100121220

申请日：2010-12-01

Applicant: (주)아모레퍼시픽

Inventor： 최현정 ,  한지연 ,  김광미 ,  노민수 ,  이태룡

IPC: A61K38/39 ,  C07K14/78 ,  C07K16/18 ,  A61P35/00

Abstract: PURPOSE: A composition for a three dimensional matrix containing collagen 4, laminin, nidogen, and proteoglycan is provided to study cancer mechanism or treatment. CONSTITUTION: A composition for a three dimensional matrix contains each 0.001-30wt% of collagen IV, liminin, nidogen, and proteoglycan in a proportion. The three dimensional matrix includes a matrix for suppressing cell division or cell dedifferentiation. The cell is human pigmentary skin cells. The three dimensional matrix is prepared using the composition.

Abstract translation: 目的：提供含有胶原蛋白4，层粘连蛋白，核酸和蛋白多糖的三维基质组合物，用于研究癌症机制或治疗。 构成：用于三维基质的组合物以一定比例含有每种含量为0.001-30重量％的胶原蛋白IV，利宁肽，蛋白多糖和蛋白多糖。 三维矩阵包括用于抑制细胞分裂或细胞去分化的基质。 细胞是人类色素皮肤细胞。 使用组合物制备三维矩阵。

公开(公告)号：KR1020120058829A

公开(公告)日：2012-06-08

申请号：KR1020100120313

申请日：2010-11-30

Applicant: (주)아모레퍼시픽

Inventor： 심중현 ,  김지현 ,  김지영 ,  민대진 ,  모상현 ,  서효현 ,  김한곤 ,  이태룡 ,  노민수 ,  신동욱

IPC: A61K36/14 ,  A61K35/28 ,  A61K8/97 ,  A61K8/98 ,  A61K8/06 ,  A61Q19/00

CPC classification number: A61K36/14 ,  A61K8/00 ,  A61K8/0216 ,  A61K8/0225 ,  A61K8/06 ,  A61K8/97 ,  A61K8/981 ,  A61K35/00 ,  A61K35/12 ,  A61K35/28 ,  A61K35/545 ,  A61K36/00 ,  A61K36/13 ,  A61M35/00 ,  A61Q19/00

Abstract: PURPOSE: A composition containing Sequoia callus extract is provided to promote regeneration of adipose-derived stem cells and to recover damaged subcutaneous fat. CONSTITUTION: A composition for enhancing the stemness of adipose-derived stem cells(hADSCs) contains Sequoia callus extract as an active ingredient. The composition enhances CD29 and CD44 expression level. A composition for enhancing skin cell proliferation contains the extract as an active ingredient. The skin cell is transit-amplifying cells(TA cells). The composition contains 0.0001-10 wt% of the extract. A skin care method comprises a step of treating the composition on the skin.

Abstract translation: 目的：提供含有红杉愈伤组织提取物的组合物，以促进脂肪来源的干细胞的再生并恢复损伤的皮下脂肪。 构成：用于增强脂肪干细胞（hADSC）的干性的组合物含有红杉愈伤组织提取物作为活性成分。 该组合物增强CD29和CD44表达水平。 用于增强皮肤细胞增殖的组合物含有提取物作为活性成分。 皮肤细胞是转运扩增细胞（TA细胞）。 组合物含有0.0001-10重量％的提取物。 护肤方法包括在皮肤上处理组合物的步骤。

公开(公告)号：KR1020120058688A

公开(公告)日：2012-06-08

申请号：KR1020100116411

申请日：2010-11-22

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  오택진 ,  이명렬 ,  이종석 ,  박창훈 ,  김한곤 ,  이태룡 ,  노민수 ,  신동욱

IPC: A61K8/37 ,  A61K8/368 ,  A61K8/36 ,  A61K8/49 ,  A61K8/89 ,  A61Q17/04 ,  A61K31/41 ,  A61K31/192 ,  A61K31/215 ,  A61K31/60

CPC classification number: A61K8/37 ,  A61K8/36 ,  A61K8/368 ,  A61K8/4966 ,  A61K8/89 ,  A61K31/192 ,  A61K31/215 ,  A61K31/41 ,  A61K31/60 ,  A61Q17/04

Abstract: PURPOSE: A composition containing cinnamic acid derivatives, methoxy phenyl acrylate derivatives, and beta,beta-diphenylacrylate derivatives is provided to improve photo stability. CONSTITUTION: A composition for sun screening contains cinnamic acid derivatives, methoxy phenyl acrylate derivatives, and beta-beta-diphenyl acrylate derivatives as an active ingredient. The methoxy phenyl acrylate derivative is ethyl hexyl methoxy crylene. The beta-beta-diphenyl acrylate derivative includes octocrylene, etocrylene, or both. The composition further contains triazine derivatives, salicylic acid derivatives, and benzalmalonate derivatives.

Abstract translation: 目的：提供含有肉桂酸衍生物，甲氧基苯基丙烯酸酯衍生物和β，β-二苯基丙烯酸酯衍生物的组合物以改善光稳定性。 构成：防晒组合物含有肉桂酸衍生物，甲氧基苯基丙烯酸酯衍生物和作为活性成分的β-β-二苯基丙烯酸酯衍生物。 甲氧基苯基丙烯酸酯衍生物是乙基己基甲氧基二烯丙基。 β-β-二苯基丙烯酸酯衍生物包括辛烯丙烯，乙酰亚甲基或二者。 组合物还含有三嗪衍生物，水杨酸衍生物和亚苄基丙二酸酯衍生物。

公开(公告)号：KR1020120049634A

公开(公告)日：2012-05-17

申请号：KR1020100110992

申请日：2010-11-09

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  이명렬 ,  오택진 ,  김광미 ,  이종석 ,  박창훈 ,  김한곤 ,  노민수 ,  신동욱

IPC: G01N33/15 ,  G01N33/483

Abstract: PURPOSE: A method for evaluating efficiency of UV protector is provided to measure cell apoptosis rate and to accurately protect UV ray. CONSTITUTION: A method for evaluating efficiency of UV protector comprises: a step of applying an UV protector onto UV permeable material; a step of irradiating UV onto the upper portion of the UV permeable material; and a step of measuring cell death of skin cells. The UV permeable material is a quartz plate or band pass filter. The skin cells include keratinocytes, fibroblasts, or melanocytes. The cell death includes apoptosis and necrosis.

Abstract translation: 目的：提供一种评估紫外线保护剂效率的方法，以测量细胞凋亡率并准确保护紫外线。 构成：用于评价UV保护剂效率的方法包括：将UV保护剂涂布在UV透过性材料上的步骤; 将UV照射到UV可渗透材料的上部的步骤; 以及测量皮肤细胞的细胞死亡的步骤。 UV透光材料是石英板或带通滤光片。 皮肤细胞包括角质形成细胞，成纤维细胞或黑素细胞。 细胞死亡包括凋亡和坏死。

公开(公告)号：KR101114006B1

公开(公告)日：2012-02-21

申请号：KR1020080052041

申请日：2008-06-03

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  송민정 ,  신동욱 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61Q19/00

Abstract: 본 발명은 피부 미용 및 성형용 조성물에 관한 것으로, 보다 상세하게는 백화사설초 추출물을 유효성분으로 함유하여 사람 중간엽줄기세포를 지방세포로 분화하는 것을 촉진시킴으로써 지방세포를 생성하여 피부의 볼륨과 탄력을 부여하는 미용 또는 성형 조성물에 관한 것이다.
백화사설초 * 중간엽 줄기세포 분화 * 지방세포생성

公开(公告)号：KR1020110116370A

公开(公告)日：2011-10-26

申请号：KR1020100035746

申请日：2010-04-19

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  이명렬 ,  최현 ,  김광미 ,  노민수 ,  김한곤

IPC: A61K36/28 ,  A61K8/97 ,  A61Q19/00

CPC classification number: A61K36/28 ,  A61K8/97 ,  A61Q19/005 ,  A61Q19/007

Abstract: 본 발명은 블루메아 발사미페라 추출물을 유효 성분으로 포함하는 피부 가려움 완화 및 억제, 피부 보습, 피부 염증 완화 및 억제, 피부 면역성 증가, 피부 과민 반응 개선 또는 아토피 피부 개선 및 치료용 조성물을 개시한다.

公开(公告)号：KR100964433B1

公开(公告)日：2010-06-16

申请号：KR1020080110377

申请日：2008-11-07

Applicant: (주)아모레퍼시픽

Inventor： 노민수 ,  여현주 ,  박선미 ,  신동욱 ,  이형호 ,  김한곤

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: 본 발명은 피부 기능 향상 물질을 스크리닝(screening)하는 방법으로서, (a) 후보 물질을 피부 세포에 처리하는 단계; (b) MAP17(Membrane-Associated Protein 17kD) 유전자의 상대적 발현량 변화를 검출하는 단계; 및 (c) 상기 유전자의 발현량 변화를 유도하는 후보 물질을 피부 기능 향상 물질로 선택하는 단계를 포함한다.
즉, 본 발명은 MAP17(Membrane-Associated Protein 17kD) 유전자를 표지인자로 하여 MAP17 유전자의 발현량 변화를 통해 피부 기능 향상 물질을 검색하는 신규한 스크리닝 방법으로서, 이를 통해 피부 장벽 기능 향상, 피부 보습 유지, 피부 노화 방지 또는 피부 트러블 완화에 유용한 피부 기능 향상 물질을 효율적으로 스크리닝할 수 있다.
MAP17(Membrane-Associated Protein 17kD), 스크리닝

公开(公告)号：KR1020100025045A

公开(公告)日：2010-03-09

申请号：KR1020080083645

申请日：2008-08-27

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  이상민 ,  송민정 ,  박선미 ,  노민수 ,  김한곤

IPC: A61K31/353 ,  A61P3/10

Abstract: PURPOSE: A medicinal composition for preventing or treating diabetes and plastic surgery is provided to promote adipocyte differentiation and to enhance volume and elasticity of skin. CONSTITUTION: A medicinal composition for promoting differentiation of adipocytes contains (-)catechin, (-)epicatechin gallate, or (-)gallocatechin as an active ingredient. Adipocyte is human bone marrow mesenchymal stem cell. The (-)catechin, (-)epicatechin gallate, or (-)gallocatechin is isolated from green tea. A medicinal composition for treating and preventing type II diabetes and diabetes complication contains the (-)catechin, (-)epicatechin gallate, or (-)gallocatechin.

Abstract translation: 目的：提供用于预防或治疗糖尿病和整形手术的药物组合物，以促进脂肪细胞分化并增强皮肤的体积和弹性。 构成：用于促进脂肪细胞分化的药用组合物含有（ - ）儿茶素，（ - ）表儿茶素没食子酸酯或（ - ）儿茶素素作为活性成分。 脂肪细胞是人骨髓间充质干细胞。 （ - ）儿茶素，（ - ）表儿茶素没食子酸酯或（ - ）儿茶素可与绿茶分离。 用于治疗和预防II型糖尿病和糖尿病并发症的药物组合物含有（ - ）儿茶素，（ - ）表儿茶素没食子酸酯或（ - ）儿茶素。

公开(公告)号：KR1020100000392A

公开(公告)日：2010-01-06

申请号：KR1020080059873

申请日：2008-06-24

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  이상민 ,  박준성 ,  나용주 ,  박혜윤 ,  김덕희 ,  노민수 ,  김한곤

IPC: A61K8/49 ,  A61Q19/00

CPC classification number: A61K8/498 ,  A61K31/352 ,  A61Q19/00

Abstract: PURPOSE: A method and composition for promoting skin regeneration using icariside II is provided to promote proliferation of transient amplifying cells of epidermis base and promote skin regeneration. CONSTITUTION: An icariside II of chemical formula 1 promotes proliferation of skin cells in skin cells. The skin cell is transient amplifying cells(TA cells). A composition for promoting skin regeneration contains the icariside II as an active ingredient. The content of the active ingredient is 0.001-10 weight% based on total weight. The composition regenerates epidermis by promoting proliferation of the TA cells. The composition increases the number of TA cells which express CD71 protein (Cluster of Differentiation 71 Protein) and α6 integrin. The composition increases the expression of CD200(Cluster of Differentiation 200).

Abstract translation: 目的：提供使用艾司替丁II促进皮肤再生的方法和组合物，以促进表皮碱基瞬时扩增细胞的增殖并促进皮肤再生。 构成：化学式1的阿奇瑞德II促进皮肤细胞中皮肤细胞的增殖。 皮肤细胞是瞬时扩增细胞（TA细胞）。 用于促进皮肤再生的组合物含有作为活性成分的阿魏酸二酯。 活性成分的含量为0.001-10重量％。 该组合物通过促进TA细胞的增殖而再生表皮。 该组合物增加表达CD71蛋白（分化蛋白簇71）和α6整联蛋白的TA细胞的数量。 该组合物增加CD200（分化群集200）的表达。