公开(公告)号：KR1020130101408A

公开(公告)日：2013-09-13

申请号：KR1020120022541

申请日：2012-03-05

Applicant: 한국화학연구원 ,  주식회사 한독

Inventor： 정희정 ,  김형래 ,  하재두 ,  이정옥 ,  조성윤 ,  최상운 ,  이종국 ,  박지훈

IPC: C07D498/04 ,  C07D487/04 ,  A61K31/5025 ,  A61P35/00

CPC classification number: C07D519/00

Abstract: PURPOSE: A novel triazolo pyridazine derivative is provided to effectively suppress the activity of c-Met tyrosine kinase, thereby being used as a therapeutic agent for treating various hyperproliferative disorders related to excessive cell proliferation and growth caused by abnormal kinase activity. CONSTITUTION: A triazolo pyridazine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for suppressing c-Met tyrosine kinase contains the triazolo pyridazine derivative or a pharmaceutically acceptable salt or solvate thereof as an active ingredient. A pharmaceutical composition for preventing or treating hyperproliferative disorders contains the triazolo pyridazine derivative, the pharmaceutically acceptable salt, or the solvate as an active ingredient.

Abstract translation: 目的：提供一种新的三唑并噻唑衍生物，以有效抑制c-Met酪氨酸激酶的活性，从而用作治疗与异常激酶活性引起的过度细胞增殖和生长相关的各种过度增殖性疾病的治疗剂。 构成：提供化学式1的三唑并哒嗪衍生物或其药学上可接受的盐。 用于抑制c-Met酪氨酸激酶的药物组合物含有三唑并哒嗪衍生物或其药学上可接受的盐或溶剂化物作为活性成分。 用于预防或治疗过度增殖性疾病的药物组合物含有三唑并哒嗪衍生物，药学上可接受的盐或溶剂化物作为活性成分。