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公开(公告)号：UA125802C2
公开(公告)日：2022-06-08
申请号：UAA202003509
申请日：2018-11-14
Applicant: MIRATI THERAPEUTICS INC , ARRAY BIOPHARMA INC
Inventor： BLAKE JAMES F , BURGESS LAURENCE E , CHICARELLI MARK JOSEPH , CHRISTENSEN JAMES GAIL , COOK ADAM , FELL JAY BRADFORD , FISCHER JOHN P , MARX MATTHEW ARNOLD , MEJIA MACEDONIO J , SAVECHENKOV PAVEL , VIGERS GUY P A , SMITH CHRISTOPHER RONALD , RODRIGUEZ MARTHA E
Abstract: Данийвинахідналежитьдосполук, якіінгібують KRas G12C. Зокрема, данийвинахідналежитьдосполук, якінезворотноінгібуютьактивність KRas G12C, дофармацевтичнихкомпозицій, якімістятьсполуки, іспособівїхзастосування.
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公开(公告)号：MY191016A
公开(公告)日：2022-05-28
申请号：MYPI2017702034
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： HICKEN ERIK JAMES , ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I: I and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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公开(公告)号：HUE054371T2
公开(公告)日：2021-09-28
申请号：HUE15819933
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61P29/00 , A61P37/00
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公开(公告)号：AU2017266911B2
公开(公告)日：2021-09-02
申请号：AU2017266911
申请日：2017-05-17
Applicant: ARRAY BIOPHARMA INC , MIRATI THERAPEUTICS INC
Inventor： FISCHER JOHN P , FELL JAY BRADFORD , BLAKE JAMES F , HINKLIN RONALD JAY , MEJIA MACEDONIO J , HICKEN ERIK JAMES , CHICARELLI MARK JOSEPH , GAUDINO JOHN J , VIGERS GUY P A , BURGESS LAURENCE E , MARX MATTHEW ARNOLD , CHRISTENSEN JAMES GAIL , LEE MATTHEW RANDOLF , SAVECHENKOV PAVEL , ZECCA HENRY J , TANG TONY P
IPC: C07D231/56 , A61K31/445 , C07D295/185
Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号：SI3227297T1
公开(公告)日：2021-04-30
申请号：SI201531544
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/00 , A61K31/00 , A61P29/00 , A61P37/00
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Patent Agency Ranking
公开(公告)号：AU2015357585B2
公开(公告)日：2020-07-02
申请号：AU2015357585
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
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公开(公告)号：CA2824779C
公开(公告)日：2020-01-14
申请号：CA2824779
申请日：2012-01-12
Applicant: ARRAY BIOPHARMA INC , VENTIRX PHARMACEUTICALS INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , YANG HONG WOON
IPC: C07D223/16 , A61K31/55 , A61P29/00 , A61P35/00 , C07D403/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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公开(公告)号：PL2467380T3
公开(公告)日：2017-09-29
申请号：PL10810564
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
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公开(公告)号：PL2663555T4
公开(公告)日：2017-08-31
申请号：PL12733896
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY CHARLES TODD , GRONEBERG ROBERT D , JONES ZACHARY , LYSSIKATOS JOSEPH P , YANG HONG WOON
IPC: A61K31/55 , A61P37/00 , C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
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公开(公告)号：HUE032036T2
公开(公告)日：2017-08-28
申请号：HUE12734770
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , YANG HONG WOON
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