公开(公告)号：SI0810205T1

公开(公告)日：2001-06-30

申请号：SI9730125

申请日：1997-05-16

Applicant: HOECHST AG

Inventor： BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  LANG HANS JOCHEN DR ,  ALBUS UDO DR ,  LAL BANSI DR ,  GHATE VASANTRAO ANIL

IPC: C07D295/14 ,  A01N1/02 ,  A01N47/44 ,  A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07C271/22 ,  C07C279/20 ,  C07C279/22 ,  C07C303/40 ,  C07C311/19 ,  C07C315/04 ,  C07C317/50 ,  C07C319/20 ,  C07C323/62

Abstract: 1-Naphthoyl-guanidines (I) and their salts are new: R2-R8 = H; F; Cl; Br; I; CN; NO2; CF3; C2F5; or XaYbZ; X = O; S; or NR10, CR11R12, CO, CONR10, COO, SO; SO2, SO2NR10, OCO, NR10CO or NR10SO2 attached to the ring via the left hand atom; R10-R12 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-7C cycloalkyl; Y = 1-8C alkylene with 1 CH2 optionally replaced by O, S, NR13 or o-, m- or p-phenylene; R13 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-6C cycloalkyl; Z = H; 1-7C alkyl; 3-7C cycloalkyl; COR15; SO2R15; NR16R17; or is Ph or a C- or N-linked N-containing 1-9C heterocycle (each optionally mono-, di- or trisubstituted by F, Cl, Br, CF3, Me, OMe or NR21R22); a, b = 0 or 1; R15 = N=C(NH2)2; NR18R19; N(CH2)cNR18R19; or OR20; c = 2 or 3; R16 - R19 = H; 1-8C alkyl; or 1-4C perfluoroalkyl; or R16+R17 or R18+R19 = tetra- or pentamethylene with 1 CH2 optionally replaced by O, S or NQ; Q = H; Me; benzyl; or p-Cl-Ph; R20 = H; 1-6C alkyl; 1-4C perfluoroalkyl; or 3-7C cycloalkyl; R21, R22 = H; 1-4C alkyl; or 1-4C perfluoroalkyl; provided that when R4 = alkoxy, at least one of R2, R3 and R5-R8 is not H.

公开(公告)号：CZ287843B6

公开(公告)日：2001-02-14

申请号：CZ52897

申请日：1997-02-20

Applicant: HOECHST AG

Inventor： ALBUS UDO DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ WERNER DR ,  LANG HANS JOCHEN DR ,  SCHOLZ WOLFGANG DR ,  SCHWARK JAN ROBERT DR ,  WEICHERT ANDREAS DR

IPC: A61K31/165 ,  A61K31/155 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C279/10 ,  C07C279/20 ,  C07C279/22

Abstract: In the present invention there are disclosed ortho-substituted benzoylguanidines of the general formula I, in which the substituents Re2 and Re3 have meaning indicated in the claims. The invented compounds are suitable as an antiarrhythmic medicament with a cardio-protective component for prophylaxis and treatment of infarct as well as for treating angina pectoris. These novel compounds can be also used for preventive inhibition of pathological processes of lesions induced by ischemia, particularly of heart arrhythmia induced by ischemia. In the present invention there is also further described a process for preparing the compounds of the general formula I by reacting the compounds of the general formula II in which the substituents Re2 and Re3 have meaning indicated in the patent claims and L represents a readily cleavable nucleophile-substituted group with guanidine. In the present invention there is also described the use of the compounds of the general formula I for preparing a medicament as well as the medicament in which the invented compounds are comprised.

公开(公告)号：DK0659748T3

公开(公告)日：2000-10-02

申请号：DK94120069

申请日：1994-12-19

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: C07D217/26 ,  A61K31/47 ,  A61K31/472 ,  A61K31/54 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C233/65 ,  C07C235/84 ,  C07C311/16 ,  C07D213/46 ,  C07D217/24 ,  C07D279/02

Abstract: There are described acylguanidines I where X is carbonyl or sulphonyl; R(1) is H, (cyclo)alkyl, phenyl; R(2) is H, alkyl, and their pharmaceutically tolerable salts. They are obtained by reaction of a compound II with guanidine. The compounds have no undesired salidiuretic properties, but have very good antiarrhythmic properties. As a result of inhibition of the cellular Na /H exchange mechanism, they can be used for the treatment of all acute or chronic injuries induced by ischaemia.

公开(公告)号：ES2146049T3

公开(公告)日：2000-07-16

申请号：ES97109546

申请日：1997-06-12

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A01N1/02 ,  A01N47/44 ,  A61K31/10 ,  A61K31/155 ,  A61K31/18 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P35/00 ,  A61P43/00 ,  C07C279/10 ,  C07C279/20 ,  C07C279/22 ,  C07C303/40 ,  C07C311/19 ,  C07C311/47 ,  C07C317/42 ,  C07C317/50

Abstract: Benzoylguanidine compounds of formula (I) and their salts are new. R1 = R13-SOm or R14R15N-SO2; m = 1 or 2; R13 = 1-8C alkyl or perfluoroalkyl, 3-8C alkenyl or CnH2n-R16; n = 0-4; R16 = 3-8C cycloalkyl or phenyl, biphenyl or naphthyl (each optionally substituted by 1-3 F, Cl, CF3, CH3, OCH3 or NR25R26); R25, R26 = H or 1-4C alkyl or perfluoroalkyl; R14 = H, 1-8C alkyl or perfluoroalkyl, 3-8C alkenyl or CnH2n-R27; R27 = 3-8C cycloalkyl or phenyl, biphenyl or naphthyl (each optionally substituted by 1-3 F, Cl, CF3, CH3, OCH3 or NR28R29); R28, R29, R15 = H, or 1-4C alkyl or perfluoroalkyl; or R14+R15 = (CH2)a where one CH2 group may be replaced by O, S, NH, N-CH3 or N-benzyl; a = 4-5; one of R2, R3 = H and the other = CHR30R31 or C(OH)R33R34; R30 = (CH2)g-(CHOH)h-(CH2)i-(CHOH)k-R32 or (CH2)g-O-(CH2-CH2O)h-R24; R24, R32 = H or Me; g, h, i = 0-4; k = 1-4; R31, R33, R34 = H or 1-4C alkyl; or R33+R34 = 3-6C cycloalkyl; or R33 = CH2OH; R4 = 1-4C alkyl or alkoxy or F, Cl, Br, I, CN, (CH2)n'-(CF2)o-CF3; n' = 0-1; and o = 0-2.

公开(公告)号：GR3032689T3

公开(公告)日：2000-06-30

申请号：GR20000400387

申请日：2000-02-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  BRENDEL JOACHIM DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  LANG HANS JOCHEN DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/165 ,  A61K31/18 ,  A61P1/16 ,  A61P3/08 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07C279/18 ,  C07C313/02 ,  C07C313/06 ,  C07C381/10

Abstract: Sulphonimidamides of formula R1N=S(O)(R2)N(R4)(R3) (I) and their salts are new: at least one of R1-R3 = a benzoylguanidine group of formula (a) optionally substituted in the phenyl ring by 1-4 of 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, halo, CN, CF3, R22SO2, R23R24NCO, R25CO, R26R27NSO2, OR35, SR35 or NR35R36; m = 0-2; R14 = 3-8C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR15R16; R15, R16 = H or Me; R22, R23, R25, R26 = 1-8C alkyl, 2-8C alkenyl, (CH2)nR29 or CF3; or R23+R24, R26+R27 = 5-6 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R23, R25, R26 = H; n = 0-4; R29 = 3-7C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R24, R27 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R35 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2R5, SO2NR6R7 or NR32R33; R5 = 1-6C alkyl; R6, R7 = H or 1-4C alkyl; R32, R33 = H or 1-4C alkyl; or R35 = 1-9C heteroaryl optionally substituted by 1-3 of F, Cl, CF3, CH3, OMe, OH, NH2, NHMe or N(Me)2; the remaining R1-R3 = 1-8C alkyl or (CH2)pR10; or the remaining R1, R2 = H; p = 0-4; R10 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2NR17R8 or SO2R9; R17, R8 = H or 1-4C alkyl; R9 = 1-4C alkyl; and R4 = H or 1-4C alkyl.

公开(公告)号：DK0771788T3

公开(公告)日：2000-06-13

申请号：DK96116938

申请日：1996-10-22

Applicant: HOECHST AG

Inventor： SCHOLZ WOLFGANG DR ,  SCHWARK JAN-ROBERT DR ,  LANG HANS JOCHEN DR ,  KLEEMANN HEINZ-WERNER DR ,  WEICHERT ANDREAS DR ,  ALBUS UDO DR ,  BRENDEL JOACHIM DR

IPC: A61K31/165 ,  A61K31/18 ,  A61P1/16 ,  A61P3/08 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07C279/18 ,  C07C313/02 ,  C07C313/06 ,  C07C381/10

Abstract: Sulphonimidamides of formula R1N=S(O)(R2)N(R4)(R3) (I) and their salts are new: at least one of R1-R3 = a benzoylguanidine group of formula (a) optionally substituted in the phenyl ring by 1-4 of 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, halo, CN, CF3, R22SO2, R23R24NCO, R25CO, R26R27NSO2, OR35, SR35 or NR35R36; m = 0-2; R14 = 3-8C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR15R16; R15, R16 = H or Me; R22, R23, R25, R26 = 1-8C alkyl, 2-8C alkenyl, (CH2)nR29 or CF3; or R23+R24, R26+R27 = 5-6 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R23, R25, R26 = H; n = 0-4; R29 = 3-7C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R24, R27 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R35 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2R5, SO2NR6R7 or NR32R33; R5 = 1-6C alkyl; R6, R7 = H or 1-4C alkyl; R32, R33 = H or 1-4C alkyl; or R35 = 1-9C heteroaryl optionally substituted by 1-3 of F, Cl, CF3, CH3, OMe, OH, NH2, NHMe or N(Me)2; the remaining R1-R3 = 1-8C alkyl or (CH2)pR10; or the remaining R1, R2 = H; p = 0-4; R10 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2NR17R8 or SO2R9; R17, R8 = H or 1-4C alkyl; R9 = 1-4C alkyl; and R4 = H or 1-4C alkyl.

公开(公告)号：ES2142895T3

公开(公告)日：2000-05-01

申请号：ES94112895

申请日：1994-08-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  WEICHERT ANDREAS DR ,  CRAUSE PETER DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/155 ,  A61K31/185 ,  A61P9/00 ,  A61P9/10 ,  C07C277/08 ,  C07C279/20 ,  C07C279/22 ,  C07C311/37 ,  C07C311/59 ,  C07C315/04 ,  C07C317/32 ,  C07C317/44 ,  C07C323/65 ,  C07C323/67 ,  C07D207/327 ,  C07D215/54 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D295/10 ,  C07D295/155 ,  C07D521/00

Abstract: Benzoyl-guanidine derivatives (III) are new. (III) are of formula X2-CO-N=C(NH2)2 X2 = R101 = hydrogen, fluoro, chloro, hydroxy, amino or trifluoromethyl; R102 = hydrogen, fluoro, chloro, bromo, cyano, CqF2qCF3, R13SO2, R14R15NCO, R16CO or R17R18NSO2; R13, R14, R16 and R17 = 1-8C alkyl, 3-4C alkenyl, CnH2n-R20, trifluoromethyl or, except for R13, hydrogen; n = 0 or 1; q = 1-5; R20 = 3-6C cycloalkyl or phenyl, optionally substituted by 1-2 of fluoro, chloro, trifluoromethyl, methyl, methoxy or NR21R22; R21 and R22 = hydrogen or methyl; R104 = 1-8C alkyl, CnH2nR20, trifluoromethyl, (iso)quinolyl, pyrrolyl, pyridyl or imidazolyl (all these rings bonded via carbon or nitrogen and optionally substituted by 1 or 2 fluoro, chloro, trifluoromethyl, methoxy, hydroxy or amino (optionally substituted by 1 or 2 methyl)), R87SO2, R88R89NSO2, or R93-ethynyl; R87 = 1-4C alkyl or trifluoromethyl; R88 = hydrogen, 1-4C alkyl, trifluoromethyl, or (CH2)anR90; an = 0 or 1; R90 and R93 = phenyl, optionally substituted as in R20; R103 = any of a wide range of substituents . The full definitions are given in the DEFINITIONS (Full Definitions) Field.

公开(公告)号：SI0771788T1

公开(公告)日：2000-04-30

申请号：SI9630136

申请日：1996-10-22

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  BRENDEL JOACHIM DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  LANG HANS JOCHEN DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/18 ,  A61P1/16 ,  A61K31/165 ,  A61P3/08 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07C279/18 ,  C07C313/02 ,  C07C313/06 ,  C07C381/10

Abstract: Sulphonimidamides of formula R1N=S(O)(R2)N(R4)(R3) (I) and their salts are new: at least one of R1-R3 = a benzoylguanidine group of formula (a) optionally substituted in the phenyl ring by 1-4 of 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, halo, CN, CF3, R22SO2, R23R24NCO, R25CO, R26R27NSO2, OR35, SR35 or NR35R36; m = 0-2; R14 = 3-8C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR15R16; R15, R16 = H or Me; R22, R23, R25, R26 = 1-8C alkyl, 2-8C alkenyl, (CH2)nR29 or CF3; or R23+R24, R26+R27 = 5-6 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R23, R25, R26 = H; n = 0-4; R29 = 3-7C cycloalkyl, phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R24, R27 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = 4-7 methylene groups with optionally one CH2 replaced by O, S, NH, NMe or N-benzyl; or R35 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2R5, SO2NR6R7 or NR32R33; R5 = 1-6C alkyl; R6, R7 = H or 1-4C alkyl; R32, R33 = H or 1-4C alkyl; or R35 = 1-9C heteroaryl optionally substituted by 1-3 of F, Cl, CF3, CH3, OMe, OH, NH2, NHMe or N(Me)2; the remaining R1-R3 = 1-8C alkyl or (CH2)pR10; or the remaining R1, R2 = H; p = 0-4; R10 = phenyl optionally substituted by 1-3 of F, Cl, CF3, Me, OMe, SO2NR17R8 or SO2R9; R17, R8 = H or 1-4C alkyl; R9 = 1-4C alkyl; and R4 = H or 1-4C alkyl.

公开(公告)号：DK0723956T3

公开(公告)日：2000-04-17

申请号：DK96100956

申请日：1996-01-24

Applicant: HOECHST AG

Inventor： SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  LANG HANS-JOCHEN DR ,  KLEEMANN HEINZ-WERNER DR

IPC: C07D295/12 ,  A61K31/155 ,  A61K31/18 ,  A61K31/395 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/5375 ,  A61P1/16 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  C07C279/22 ,  C07C311/15 ,  C07C311/18 ,  C07C311/29 ,  C07C311/64 ,  C07C317/28 ,  C07C317/46 ,  C07C323/16 ,  C07C323/25 ,  C07C335/32 ,  C07C381/10 ,  C07D207/09 ,  C07D213/40 ,  C07D213/70 ,  C07D215/36 ,  C07D233/42 ,  C07D233/54 ,  C07D233/60 ,  C07D233/84 ,  C07D235/28 ,  C07D295/22 ,  C07D521/00

Abstract: Basic substd. benzoylguanidine derivs. of formula (I) and their salts are new. One of R1-R3 = Xf-CdH2d-B-A-R6 and the others of R1-R3 = H, F, Cl, Br, I, CN, 1-8C alkyl, 2-8C alkenyl, NR35R36 or Zh-CgH2g-R17; R6 = NR7R8, C(=NR9)NR7R8, NR10-C(=NR9)NR7R8 or basic heteroaromatic ring system with 1-9C; R7-R10 = H or 1-4C alkyl; or R7+R8 = C4H8 or CaH2a (opt. with one CH2 replaced by O, S(O)m or NR11; or R8+R9+R10 or R7+R10 = C2H4 or CcH2c (opt. with one CH2 replaced by O, S(O)m or NR11); A = CbH2b (opt. with one or two CH2 replaced by O, CO, CH(OR20), S(O)m, NR20, CONR20, NHCONR20, SO2NHCONR20, S(=O)(=NR19)NR20 or SO2NR20, or one CH2 replaced by CHR99); R7+R99 form pyrrolidine or piperidine; B = opt. substd. phenylene or naphthylene gp. of formula (i) or (ii); R12, R13 = H, Me, F, Cl, Br, I, CF3 or S(O)mR14; R14, R19 = H or 1-4C alkyl; X = O, CO, CH(OR21), SOm or NR21; R35, R36 = H or 1-6C alkyl; or R35+R36 = (CH2)4-7, with one CH2 opt. replaced by S, NH, NMe or N-benzyl; Z = O, CO, SOm, NR18, CONR18, NHCONR18 or SO2NR18; R17 = H, cyclopropyl, cyclopentyl, cyclohexyl, 1-3C perfluoroalkyl, 1-, 2- or 3-pyrrolyl (opt. substd. by 1-4 of F, Cl, Br, I, CN, 2-8C alkanoyl, 2-8C alkoxycarbonyl, CHO, COOH, CF3, Me and OMe) or 3-8C cycloalkyl or phenyl (both opt. substd. by 1-3 of F, Cl, CF3, Me, OH, OMe, NR37R38, SO2Me and SO2NH2); R11, R18, R20, R21, R37, R38 = H or Me; R4, R5 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or 1-4C perfluoroalkyl; R32-R34 = H or 1-3C alkyl; a = 5-7; b = 1-10; c = 3-5; d = 0-5; g = 0-4; f, h = 0 or 1; m = 0-2.

公开(公告)号：GR3031539T3

公开(公告)日：2000-01-31

申请号：GR990402626

申请日：1999-10-15

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/165 ,  A61K31/47 ,  A61K31/472 ,  A61P3/08 ,  A61P3/10 ,  A61P9/06 ,  A61P9/10 ,  A61P13/08 ,  A61P35/00 ,  A61P43/00 ,  C07C279/22 ,  C07D215/00 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D217/00 ,  C07D217/02 ,  C07D217/26

Abstract: New bicyclic heteroaryl-carboxy-guanidine cpds. and their salts have two fused 6-membered rings contg. up to 4 unsubstd. ring N atoms. The other ring members are C atoms, opt. substd. e.g. by halo, alkyl, alkoxy, alkenyl, alkynyl, amino, carboxyguanidine, cyano, alkylthio, acyl, carboxamido, perfluoroalkyl, (poly)hydroxyalkyl, alkanoylalkyl, aminosulphonyl, (thio)ureidosulphonyl, heteroaryl, phenoxy, phenylthio or phenylamino, where the phenyl rings are opt. substd. by heterocyclyl, (poly)hydroxyalkyl or (poly)hydroxyalkylcarbonyl; or two substits. together form a satd. gp. that completes a fused ring.