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    FLUID CONNECTORS AND FLUID FLOW PATHS FOR AN INFUSATE CADDY
    112.
    发明申请
    FLUID CONNECTORS AND FLUID FLOW PATHS FOR AN INFUSATE CADDY 审中-公开
    流体连接器和流体流动路径用于输注流体

    公开(公告)号：WO2017019642A3

    公开(公告)日：2017-03-09

    申请号：PCT/US2016043950

    申请日：2016-07-25

    Applicant: MEDTRONIC INC ,  LURA DAVID B ,  HOBOT CHRISTOPHER M ,  GERBER MARTIN T ,  MEYER THOMAS E

    Inventor： LURA DAVID B ,  HOBOT CHRISTOPHER M ,  GERBER MARTIN T ,  MEYER THOMAS E

    IPC: A61M1/16

    CPC classification number: A61M1/169 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/267 ,  A61M39/12 ,  A61M39/223 ,  A61M2205/3337 ,  A61M2205/6018 ,  A61M2209/08 ,  A61M2209/082

    Abstract: The invention relates to fluid flow paths and fluid connectors for use with detachable containers that can be seated in an infusate caddy for use in a dialysis machine. The detachable containers can contain infusates or other solutes or materials such as disinfectants or cleaners, and can be conveniently seated in the infusate caddy. The detachable containers can be removed from the infusate caddy for restocking, cleaning, or resupply, as needed. The infusate caddy can be positioned or seated in a receiving compartment of a dialysis machine, and can also be removed, as needed. The fluid path and fluid connectors of the present invention provide the required fluid fittings, valve arrangements, pumps, and paddle assemblies for using the infusate caddy.

    Abstract translation: 本发明涉及用于可拆卸容器的流体流动路径和流体连接器，所述可拆卸容器可安放在输注容器中用于透析机中。 可拆卸的容器可以包含输注液或其他溶质或材料，例如消毒剂或清洁剂，并且可以方便地坐在输注容器中。 根据需要，可以将可分离的容器从输注容器中取出以进行补充，清洁或再补给。 输注容器可以被放置或安置在透析机的接收室中，并且也可以根据需要被移除。 本发明的流体路径和流体连接器提供了用于使用注入液盒的所需的流体配件，阀装置，泵和桨叶组件。

    ZIRCONIUM PHOSPHATE RECHARGING METHOD AND APPARTUS
    113.
    发明申请
    ZIRCONIUM PHOSPHATE RECHARGING METHOD AND APPARTUS 审中-公开
    磷酸锌补充方法和APPARTUS

    公开(公告)号：WO2015199864A4

    公开(公告)日：2016-03-03

    申请号：PCT/US2015032494

    申请日：2015-05-26

    Applicant: MEDTRONIC INC ,  PUDIL BRYANT J ,  GERBER MARTIN T ,  HOBOT CHRISTOPHER M

    Inventor： PUDIL BRYANT J ,  GERBER MARTIN T ,  HOBOT CHRISTOPHER M

    IPC: B01J20/34 ,  A61M1/16 ,  B01J19/18 ,  B01J19/24 ,  B01J20/02 ,  B01J39/08

    CPC classification number: A61M1/1696 ,  B01J39/09 ,  C01B25/45

    Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer or module of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include a fluid source containing at least one recharging fluid, wherein the fluid source is fluidly connectable to at least one rechargeable sorbent module for use in sorbent dialysis in a fluid flow path. The methods and apparatuses include passing a single solution through the zirconium phosphate for ion exchanges, resulting in zirconium phosphate to maintain a substantially consistent pH in a dialysate used during dialysis.

    Abstract translation: 提供吸附剂充电的方法和相关设备。 用于再充电的方法和相关装置可以对吸附剂盒中的吸附剂材料（例如磷酸锆）的特定可再充电层或模块进行再充电。 所述方法和装置包括含有至少一个再充电流体的流体源，其中所述流体源可流体连接到至少一个可再充电吸附剂模块，以用于流体流动路径中的吸附剂透析。 所述方法和装置包括使单一溶液通过磷酸锆进行离子交换，得到磷酸锆以在透析期间使用的透析液中保持基本一致的pH。

    AN IMPLANTABLE DRUG DEPOT HAVING A REVERSIBLE PHASE TRANSITION MATERIAL FOR TREATMENT OF PAIN AND/OR INFLAMMATION
    115.
    发明申请
    AN IMPLANTABLE DRUG DEPOT HAVING A REVERSIBLE PHASE TRANSITION MATERIAL FOR TREATMENT OF PAIN AND/OR INFLAMMATION 审中-公开
    用于治疗疼痛和/或炎症的具有可逆相变材料的可植入药物存放室

    公开(公告)号：WO2011016881A3

    公开(公告)日：2011-12-15

    申请号：PCT/US2010030689

    申请日：2010-04-12

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M

    Inventor： HOBOT CHRISTOPHER M

    IPC: A61K9/50 ,  A61K9/00

    CPC classification number: A61K9/0024 ,  A61K9/0004 ,  A61K9/5031

    Abstract: Effective treatments of pain and/or inflammation are provided that utilize a reversible phase transition material of a drug depot. When heat, cold or another suitable form of energy, e.g., ultrasound energy is applied to the reversible phase transition material, the release of an analgesic and/or anti-inflammatory agent from a drug depot is increased.

    Abstract translation: 提供了利用药物贮存库的可逆相变材料的疼痛和/或炎症的有效治疗。 当加热，冷却或其他合适形式的能量（例如超声能量）施加到可逆相变材料时，增加了药物贮存库中止痛剂和/或抗炎剂的释放。

    POINT OF CARE HEPARIN DETERMINATION SYSTEM
    120.
    发明申请
    POINT OF CARE HEPARIN DETERMINATION SYSTEM 审中-公开
    治疗点肝素测定系统

    公开(公告)号：WO2005116623A3

    公开(公告)日：2006-01-26

    申请号：PCT/US2005016463

    申请日：2005-05-11

    Applicant: MEDTRONIC INC ,  BONNEMA KELVIN ,  HOBOT CHRISTOPHER M ,  MEYER RANDY ,  NIPPOLDT DOUGLAS D ,  QIN WEI ,  RAMAMURTHY NARAYANAN ,  SITKO VITALLY G ,  YE QINGSHAN

    Inventor： BONNEMA KELVIN ,  HOBOT CHRISTOPHER M ,  MEYER RANDY ,  NIPPOLDT DOUGLAS D ,  QIN WEI ,  RAMAMURTHY NARAYANAN ,  SITKO VITALLY G ,  YE QINGSHAN

    IPC: G01N27/333 ,  G01N33/487 ,  G01N33/86

    CPC classification number: G01N27/3335 ,  A61M1/3675 ,  G01N27/333 ,  G01N33/86

    Abstract: Methods and devices for point of care determination of heparin concentration in blood. Cartridges (54) including protamine ion sensitive electrodes (ISEs) (62) and reference electrodes (64) and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.

    Abstract translation: 血液中肝素浓度测定点的方法和装置。 提供了包括鱼精蛋白离子敏感电极（ISE）（62）和参考电极（64）的盒（54）以及用于自动确定药筒中肝素浓度的系统。 一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。 过量的鱼精蛋白浓度可以通过测量电极电位变化率的初始斜率来确定，并将斜率与已知的鱼精蛋白浓度斜率值进行比较。在一些药筒中，振荡压力源将血 - 鱼精蛋白混合物来回移动穿过鱼精蛋白 ISE。 一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。 鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。 聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。 一些硬链段可以包括亚甲基二苯基。 一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

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