公开(公告)号：EP0452403A1

公开(公告)日：1991-10-23

申请号：EP90902079.0

申请日：1989-12-26

Applicant: GUIDED WAVE, INC.

Inventor： LEFEBRE, David, A.

IPC: G01J3 ,  G01J1

CPC classification number: G01J3/08 ,  G01J3/42 ,  G01J2001/182 ,  G01J2003/068 ,  G01N2201/04 ,  G01N2201/0833

Abstract: Procédé et appareil spectrophotométrique approprié à une utilisation continue et à long terme. L'appareil comprend un monochromateur (13) envoyant une lumière monochromatique prédispersée aux entrées optiques d'une paire de câbles à fibre optique (34-37) et un dispositif de translation (43) pour positionner alternativement les câbles à fibre optique (34-37) au même emplacement par rapport à la sortie du monochromateur. L'un des câbles (61) conduit la lumière vers un échantillon à analyser tandis que l'autre câble (35b) établit une référence pour des mesures d'intensité de lumière. La méthode consiste à effectuer deux balayages avec la sortie du monochromateur pour chaque mesure sur l'échantillon. Les câbles à fibre optique sont déplacés entre les balayages de sorte que le câble utilisé dans le dernier balayage occupe la première position du câble utilisé dans le balayage antérieur.

公开(公告)号：US12085583B2

公开(公告)日：2024-09-10

申请号：US17319842

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: G01N33/00 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L9/00 ,  B01L9/06 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/543 ,  G01N33/569 ,  G01N33/62 ,  G01N33/68 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N33/50

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/543 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  B01L9/52 ,  B01L2300/1827 ,  B01L2300/1855 ,  G01N2015/012 ,  G01N2015/016 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N33/5005 ,  G01N35/00 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US11885801B2

公开(公告)日：2024-01-30

申请号：US17407154

申请日：2021-08-19

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： David A. Kidwell

IPC: G01N33/543 ,  G01N33/52 ,  G01N21/29 ,  G01N21/78

CPC classification number: G01N33/54388 ,  G01N21/29 ,  G01N21/78 ,  G01N33/525 ,  G01N2201/04

Abstract: The present invention provides for a release system for delaying application of chemical reagents in a lateral-flow immunoassay. A chemistry release fiber comprising a permeable membrane and a chemical release agent is used to delay chemical reagent delivery to the indicator of a lateral-flow immunoassay. Also disclosed is the related method of delaying application of chemical reagents in a lateral-flow immunoassay.

公开(公告)号：US20180230511A1

公开(公告)日：2018-08-16

申请号：US15715063

申请日：2017-09-25

Applicant: Life Technologies Corporation

Inventor： Jeffrey Marks

IPC: C12Q1/686 ,  G01N21/64 ,  G01N21/27

CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

公开(公告)号：US10018643B2

公开(公告)日：2018-07-10

申请号：US14848775

申请日：2015-09-09

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Chinmay Pangarkar ,  Samartha Anekal ,  John K. Frankovich ,  Michael Chen ,  Timothy Smith

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  B01L9/00 ,  G01N15/14 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/50 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US09952240B2

公开(公告)日：2018-04-24

申请号：US14872995

申请日：2015-10-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/50 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US09797878B2

公开(公告)日：2017-10-24

申请号：US14577257

申请日：2014-12-19

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： Alexander Alexandrovich Burukhin ,  Anna Viktorovna Zharnikova ,  Nikita Ilyich Ryzhikov ,  Dmitry Nikolaevich Mikhailov

IPC: G01N33/28 ,  G01N21/64 ,  G01N21/25

CPC classification number: G01N33/2823 ,  G01N21/253 ,  G01N21/64 ,  G01N21/91 ,  G01N21/94 ,  G01N2201/04

Abstract: A suspension of a contaminant comprising at least one solid component and colored with at least one cationic dye is prepared. The suspension is injected through a sample of the porous medium and the sample is then split. A distribution and a profile of the contaminant in the sample is determined on the basis of a distribution and an intensity of the at least one cationic dye.

公开(公告)号：US09719990B2

公开(公告)日：2017-08-01

申请号：US14859064

申请日：2015-09-18

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Paul Patel ,  Samartha Anekal

IPC: C40B30/04 ,  C12M1/34 ,  B01L3/00 ,  G01N33/543 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  B01L3/02 ,  G01N35/00 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US09645143B2

公开(公告)日：2017-05-09

申请号：US14872919

申请日：2015-10-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  James Wasson ,  Pey-Jiun Ko

IPC: G01N33/50 ,  G01N33/543 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  B01L3/02 ,  B01L3/00 ,  G01N35/00 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20160169880A1

公开(公告)日：2016-06-16

申请号：US14965665

申请日：2015-12-10

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Surekha Gangakhedkar

IPC: G01N33/543 ,  G01N35/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.